EP0814827A4 - Wachstumsfaktor-b, spezifisch für vaskuläre endothelzellen - Google Patents
Wachstumsfaktor-b, spezifisch für vaskuläre endothelzellenInfo
- Publication number
- EP0814827A4 EP0814827A4 EP96909573A EP96909573A EP0814827A4 EP 0814827 A4 EP0814827 A4 EP 0814827A4 EP 96909573 A EP96909573 A EP 96909573A EP 96909573 A EP96909573 A EP 96909573A EP 0814827 A4 EP0814827 A4 EP 0814827A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- endothelial cells
- vascular endothelial
- growth factor
- polypeptides
- vegf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US569063 | 1990-08-17 | ||
| US39765195A | 1995-03-01 | 1995-03-01 | |
| US397651 | 1995-03-01 | ||
| US08/469,427 US5607918A (en) | 1995-03-01 | 1995-06-06 | Vascular endothelial growth factor-B and DNA coding therefor |
| US08/569,063 US5928939A (en) | 1995-03-01 | 1995-12-06 | Vascular endothelial growth factor-b and dna coding therefor |
| PCT/US1996/002957 WO1996026736A1 (en) | 1995-03-01 | 1996-03-01 | Vascular endothelial growth factor-b |
| US469427 | 1999-12-23 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP0814827A1 EP0814827A1 (de) | 1998-01-07 |
| EP0814827A4 true EP0814827A4 (de) | 1999-11-10 |
| EP0814827B1 EP0814827B1 (de) | 2003-07-23 |
Family
ID=27410265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP96909573A Expired - Lifetime EP0814827B1 (de) | 1995-03-01 | 1996-03-01 | Wachstumsfaktor-b, spezifisch für vaskuläre endothelzellen |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US5928939A (de) |
| EP (1) | EP0814827B1 (de) |
| JP (2) | JP3275024B2 (de) |
| CN (1) | CN1146440C (de) |
| AT (1) | ATE245437T1 (de) |
| AU (1) | AU741856B2 (de) |
| CA (1) | CA2211687C (de) |
| DE (1) | DE69629181T2 (de) |
| DK (1) | DK0814827T3 (de) |
| ES (1) | ES2202432T3 (de) |
| NO (1) | NO973933L (de) |
| NZ (1) | NZ305091A (de) |
| PT (1) | PT814827E (de) |
| WO (1) | WO1996026736A1 (de) |
Families Citing this family (119)
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|---|---|---|---|---|
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| US7153827B1 (en) | 1994-03-08 | 2006-12-26 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 and methods of use |
| EP0751992B1 (de) * | 1994-03-08 | 2005-11-09 | Human Genome Sciences, Inc. | Vaskularer endothelialer wachstumsfaktor 2 |
| US5932540A (en) | 1994-03-08 | 1999-08-03 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| US6040157A (en) * | 1994-03-08 | 2000-03-21 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| US6734285B2 (en) | 1994-03-08 | 2004-05-11 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 proteins and compositions |
| US7597886B2 (en) | 1994-11-07 | 2009-10-06 | Human Genome Sciences, Inc. | Tumor necrosis factor-gamma |
| US5928939A (en) * | 1995-03-01 | 1999-07-27 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-b and dna coding therefor |
| US7160991B1 (en) * | 1995-03-02 | 2007-01-09 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor polypeptides |
| JPH11500139A (ja) * | 1995-03-02 | 1999-01-06 | アムラド・オペレイションズ・プロプライエタリー・リミテッド | 新規成長因子およびそれをコードする遺伝子配列 |
| US7429646B1 (en) | 1995-06-05 | 2008-09-30 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor-like 2 |
| EP0873348A4 (de) * | 1995-06-06 | 2000-11-08 | Human Genome Sciences Inc | Menschlicher vaskularer endothelialer wachtumsfaktor 3 |
| US7423125B2 (en) * | 1995-08-01 | 2008-09-09 | Vegenics Limited | Antibodies to VEGF-C |
| ES2202469T5 (es) | 1995-09-08 | 2011-06-06 | Genentech, Inc. | Proteína relacionada con el vegf. |
| WO1997012972A2 (en) | 1995-09-29 | 1997-04-10 | Universita'degli Studi Di Siena | Regulated genes and uses thereof |
| AU1116297A (en) | 1995-11-08 | 1997-05-29 | Immunex Corporation | Flk-1 binding protein |
| US6994989B1 (en) | 1995-11-08 | 2006-02-07 | Immunex Corp. | FLK-1 binding proteins |
| US7357927B2 (en) | 1996-03-12 | 2008-04-15 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US6713061B1 (en) | 1996-03-12 | 2004-03-30 | Human Genome Sciences, Inc. | Death domain containing receptors |
| WO1997033904A1 (en) | 1996-03-12 | 1997-09-18 | Human Genome Sciences, Inc. | Death domain containing receptors |
| US7964190B2 (en) | 1996-03-22 | 2011-06-21 | Human Genome Sciences, Inc. | Methods and compositions for decreasing T-cell activity |
| US6635743B1 (en) | 1996-03-22 | 2003-10-21 | Human Genome Sciences, Inc. | Apoptosis inducing molecule II and methods of use |
| CA2263890C (en) | 1996-08-23 | 2013-05-14 | Ludwig Institute For Cancer Research | Recombinant vascular endothelial cell growth factor d (vegf-d) |
| WO1998024811A2 (en) * | 1996-12-06 | 1998-06-11 | Zymogenetics, Inc. | Vascular endothelial growth factor |
| ZA9711456B (en) * | 1996-12-20 | 1998-06-30 | Ludwig Inst Cancer Res | VEGF-B/receptor complex and uses thereof. |
| WO1998039035A1 (en) | 1997-03-07 | 1998-09-11 | The Wistar Institute Of Anatomy & Biology | Method and compositions for healing tissue defects and inducing hypervascularity in mammalian tissue |
| JP2001524828A (ja) * | 1997-04-25 | 2001-12-04 | コラテラル・セラピューティクス | 切断型vegf関連蛋白質 |
| US6281175B1 (en) | 1997-09-23 | 2001-08-28 | Scimed Life Systems, Inc. | Medical emulsion for lubrication and delivery of drugs |
| EP1053326A2 (de) | 1998-02-06 | 2000-11-22 | Collateral Therapeutics | Varianten des angiogenen faktors vaskularer endothelialzell-wachstumsfaktor: vegf |
| US20030118567A1 (en) * | 1999-03-26 | 2003-06-26 | Stewart Duncan John | Cell-based therapy for the pulmonary system |
| DE19813774A1 (de) * | 1998-03-27 | 1999-09-30 | Max Planck Gesellschaft | Parapockenvirus-kodierter vaskulärer Endothelzell Wachstumsfaktor (PPV-VEGF) |
| JP2002534061A (ja) | 1998-11-10 | 2002-10-15 | ルードヴィッヒ・インスティテュート・フォア・キャンサー・リサーチ | 血小板由来増殖因子d、それをコードするdna、及びその利用法 |
| US6783953B1 (en) | 1998-12-22 | 2004-08-31 | Janssen Pharmaceutica N.V. | Vascular endothelial growth factor-X |
| AU3693000A (en) * | 1999-01-29 | 2000-08-18 | Licentia Ltd | Platelet-derived growth factor/vascular endothelial growth factor-like growth factor h, and uses thereof |
| US7223724B1 (en) | 1999-02-08 | 2007-05-29 | Human Genome Sciences, Inc. | Use of vascular endothelial growth factor to treat photoreceptor cells |
| EP2357192A1 (de) | 1999-02-26 | 2011-08-17 | Human Genome Sciences, Inc. | Menschliches alpha-Endokin und Verfahren zu seiner Verwendung |
| NZ513780A (en) * | 1999-03-03 | 2001-09-28 | Ludwig Inst Cancer Res | Heart abnormalities in vascular endothelial growth factor B (VEGF-B) deficient animals and methods relating to these heart abnormalities |
| AU4662400A (en) * | 1999-04-26 | 2000-11-10 | Helsinki University Licensing Ltd | Role of vascular endothelial growth factor-b (vegf-b) in developing bones and uses thereof |
| CA2375617A1 (en) * | 1999-06-07 | 2000-12-14 | Edwards Lifesciences Corporation | Targeted angiogenesis |
| WO2001008684A1 (en) * | 1999-07-28 | 2001-02-08 | The Board Of Trustees Of The Leland Stanford Junior University | Nicotine in therapeutic angiogenesis and vasculogenesis |
| US8188043B2 (en) * | 1999-07-28 | 2012-05-29 | The Board Of Trustees Of The Leland Stanford Jr. University | Nicotine in therapeutic angiogenesis and vasculogenesis |
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| AUPQ592100A0 (en) * | 2000-02-29 | 2000-03-23 | Council Of The Queensland Institute Of Medical Research, The | A method of treatment and prophylaxis |
| US20030104977A1 (en) * | 2000-03-31 | 2003-06-05 | Ugo Ripamonti | Methods for inducing angiogenesis using morphogenic proteins and stimulatory factors |
| EP1274720A4 (de) | 2000-04-12 | 2004-08-18 | Human Genome Sciences Inc | Albumin enthaltende fusionsproteine |
| CA2409948A1 (en) * | 2000-05-17 | 2001-11-22 | Xuri Li | Methods for detecting for the presence of tumor cells and for screening for anti-tumor agents |
| CN1461342A (zh) * | 2000-07-26 | 2003-12-10 | 路德维格癌症研究所 | 糖基化vegf-b和增加可溶性vegf-b量的方法 |
| US7273751B2 (en) * | 2000-08-04 | 2007-09-25 | Human Genome Science, Inc. | Vascular endothelial growth factor-2 |
| AU2001296521A1 (en) * | 2000-10-02 | 2002-04-15 | St. Elizabeth's Medical Center Of Boston, Inc. | Use of lymphangiogenic agents to treat lymphatic disorders |
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| US7611711B2 (en) | 2001-01-17 | 2009-11-03 | Vegenics Limited | VEGFR-3 inhibitor materials and methods |
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| CN107661492A (zh) * | 2017-08-31 | 2018-02-06 | 中山大学中山眼科中心 | Vegf‑b的新用途 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990013649A1 (en) * | 1989-05-12 | 1990-11-15 | Genentech, Inc. | Production of vascular endothelial cell growth factor and dna encoding same |
| WO1991002058A1 (en) * | 1989-07-27 | 1991-02-21 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
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| EP0751992B1 (de) * | 1994-03-08 | 2005-11-09 | Human Genome Sciences, Inc. | Vaskularer endothelialer wachstumsfaktor 2 |
| US5607918A (en) * | 1995-03-01 | 1997-03-04 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-B and DNA coding therefor |
| US5928939A (en) * | 1995-03-01 | 1999-07-27 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-b and dna coding therefor |
| JPH11500139A (ja) * | 1995-03-02 | 1999-01-06 | アムラド・オペレイションズ・プロプライエタリー・リミテッド | 新規成長因子およびそれをコードする遺伝子配列 |
| EP0873348A4 (de) * | 1995-06-06 | 2000-11-08 | Human Genome Sciences Inc | Menschlicher vaskularer endothelialer wachtumsfaktor 3 |
-
1995
- 1995-12-06 US US08/569,063 patent/US5928939A/en not_active Expired - Lifetime
-
1996
- 1996-03-01 AT AT96909573T patent/ATE245437T1/de active
- 1996-03-01 JP JP52645096A patent/JP3275024B2/ja not_active Expired - Fee Related
- 1996-03-01 EP EP96909573A patent/EP0814827B1/de not_active Expired - Lifetime
- 1996-03-01 US US08/609,443 patent/US5840693A/en not_active Expired - Lifetime
- 1996-03-01 ES ES96909573T patent/ES2202432T3/es not_active Expired - Lifetime
- 1996-03-01 CN CNB961922036A patent/CN1146440C/zh not_active Expired - Fee Related
- 1996-03-01 CA CA2211687A patent/CA2211687C/en not_active Expired - Lifetime
- 1996-03-01 DK DK96909573T patent/DK0814827T3/da active
- 1996-03-01 NZ NZ305091A patent/NZ305091A/en not_active IP Right Cessation
- 1996-03-01 WO PCT/US1996/002957 patent/WO1996026736A1/en not_active Ceased
- 1996-03-01 PT PT96909573T patent/PT814827E/pt unknown
- 1996-03-01 DE DE69629181T patent/DE69629181T2/de not_active Expired - Lifetime
- 1996-03-01 AU AU53021/96A patent/AU741856B2/en not_active Expired
-
1997
- 1997-05-06 US US08/851,896 patent/US6331301B1/en not_active Expired - Lifetime
- 1997-08-27 NO NO973933A patent/NO973933L/no unknown
-
2000
- 2000-02-02 JP JP2000024574A patent/JP3297687B2/ja not_active Expired - Lifetime
-
2001
- 2001-09-25 US US09/961,756 patent/US20030170253A1/en not_active Abandoned
-
2004
- 2004-09-24 US US10/948,736 patent/US7341996B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990013649A1 (en) * | 1989-05-12 | 1990-11-15 | Genentech, Inc. | Production of vascular endothelial cell growth factor and dna encoding same |
| WO1991002058A1 (en) * | 1989-07-27 | 1991-02-21 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
Non-Patent Citations (2)
| Title |
|---|
| CONN, GREG ET AL: "Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor", PROC. NATL. ACAD. SCI. U. S. A. (1990), 87(7), 2628-32, 1990, XP002114935 * |
| LEUNG, DAVID W. ET AL: "Vascular endothelial growth factor is a secreted angiogenic mitogen", SCIENCE (WASHINGTON, D. C., 1883-) (1989), 246(4935), 1306-9, 1989, XP000083690 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20050064493A1 (en) | 2005-03-24 |
| DK0814827T3 (da) | 2003-11-10 |
| JP2000228982A (ja) | 2000-08-22 |
| US5840693A (en) | 1998-11-24 |
| US7341996B2 (en) | 2008-03-11 |
| AU741856B2 (en) | 2001-12-13 |
| ATE245437T1 (de) | 2003-08-15 |
| US20030170253A1 (en) | 2003-09-11 |
| PT814827E (pt) | 2003-11-28 |
| EP0814827B1 (de) | 2003-07-23 |
| US5928939A (en) | 1999-07-27 |
| DE69629181D1 (de) | 2003-08-28 |
| CA2211687A1 (en) | 1996-09-06 |
| EP0814827A1 (de) | 1998-01-07 |
| WO1996026736A1 (en) | 1996-09-06 |
| CN1176603A (zh) | 1998-03-18 |
| NZ305091A (en) | 1998-11-25 |
| NO973933D0 (no) | 1997-08-27 |
| DE69629181T2 (de) | 2004-05-13 |
| HK1008485A1 (en) | 1999-07-30 |
| AU5302196A (en) | 1996-09-18 |
| NO973933L (no) | 1997-09-01 |
| JPH10510718A (ja) | 1998-10-20 |
| ES2202432T3 (es) | 2004-04-01 |
| CA2211687C (en) | 2011-05-24 |
| US6331301B1 (en) | 2001-12-18 |
| JP3297687B2 (ja) | 2002-07-02 |
| CN1146440C (zh) | 2004-04-21 |
| JP3275024B2 (ja) | 2002-04-15 |
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