EP0880357A4 - Synthese d'acides amines, de peptides et de peptidomimetiques a limitation conformationnelle par metathese catalytique avec fermeture du cycle - Google Patents

Synthese d'acides amines, de peptides et de peptidomimetiques a limitation conformationnelle par metathese catalytique avec fermeture du cycle

Info

Publication number
EP0880357A4
EP0880357A4 EP96919234A EP96919234A EP0880357A4 EP 0880357 A4 EP0880357 A4 EP 0880357A4 EP 96919234 A EP96919234 A EP 96919234A EP 96919234 A EP96919234 A EP 96919234A EP 0880357 A4 EP0880357 A4 EP 0880357A4
Authority
EP
European Patent Office
Prior art keywords
peptidomimetics
conformational
peptides
synthesis
limitation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96919234A
Other languages
German (de)
English (en)
Other versions
EP0880357A1 (fr
Inventor
Robert H Grubbs
J Scott Miller
Helen E Blackwell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology
Original Assignee
California Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology filed Critical California Institute of Technology
Publication of EP0880357A1 publication Critical patent/EP0880357A1/fr
Publication of EP0880357A4 publication Critical patent/EP0880357A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP96919234A 1996-01-17 1996-06-07 Synthese d'acides amines, de peptides et de peptidomimetiques a limitation conformationnelle par metathese catalytique avec fermeture du cycle Withdrawn EP0880357A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1017096P 1996-01-17 1996-01-17
US10170P 1996-01-17
PCT/US1996/009591 WO1997026002A1 (fr) 1996-01-17 1996-06-07 Synthese d'acides amines, de peptides et de peptidomimetiques a limitation conformationnelle par metathese catalytique avec fermeture du cycle

Publications (2)

Publication Number Publication Date
EP0880357A1 EP0880357A1 (fr) 1998-12-02
EP0880357A4 true EP0880357A4 (fr) 1999-05-12

Family

ID=21744291

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96919234A Withdrawn EP0880357A4 (fr) 1996-01-17 1996-06-07 Synthese d'acides amines, de peptides et de peptidomimetiques a limitation conformationnelle par metathese catalytique avec fermeture du cycle

Country Status (3)

Country Link
EP (1) EP0880357A4 (fr)
AU (1) AU6162996A (fr)
WO (1) WO1997026002A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
US6582726B1 (en) * 2000-06-21 2003-06-24 Smithkline Beecham Corporation Cross linked solid supports for solid phase synthesis
CA2420098A1 (fr) * 2000-08-19 2002-02-28 University Of Florida Polymeres fonctionnalises
WO2008048121A2 (fr) * 2006-10-18 2008-04-24 Lincoln University Composés et compositions
AU2008232709C1 (en) 2007-03-28 2015-01-15 President And Fellows Of Harvard College Stitched polypeptides
CN102203126A (zh) 2008-09-22 2011-09-28 爱勒让治疗公司 用于制备纯化的多肽组合物的方法
KR20170058446A (ko) 2010-08-13 2017-05-26 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
AR088392A1 (es) 2011-10-18 2014-05-28 Aileron Therapeutics Inc Macrociclos peptidomimeticos
CA2862038C (fr) 2012-02-15 2021-05-25 Aileron Therapeutics, Inc. Macrocycles peptidomimetiques
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
BR112015009470A2 (pt) 2012-11-01 2019-12-17 Aileron Therapeutics Inc aminoácidos dissubstituídos e seus métodos de preparação e uso
KR20150131244A (ko) 2013-03-13 2015-11-24 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스테이플드 및 스티치드 폴리펩티드 및 그의 용도
CA2915354A1 (fr) 2013-06-14 2014-12-18 President And Fellows Of Harvard College Modulateurs stabilises du recepteur de l'insuline polypeptidique
CN114805527A (zh) 2014-05-21 2022-07-29 哈佛大学的校长及成员们 Ras抑制肽和其用途
SG11201702175YA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and formulations thereof
WO2016049359A1 (fr) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques et leurs utilisations
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2020023502A1 (fr) 2018-07-23 2020-01-30 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques et utilisations associées
US12415171B2 (en) 2018-12-21 2025-09-16 Microsoft Technology Licensing, Llc Regulation of DNA synthesis by nucleotides linked to protecting groups
US11584956B2 (en) * 2018-12-21 2023-02-21 Microsoft Technology Licensing, Llc Selectively controllable cleavable linkers
US12226746B2 (en) 2019-06-07 2025-02-18 Microsoft Technology Licensing, Llc Reversing bias in polymer synthesis electrode array
US11773422B2 (en) 2019-08-16 2023-10-03 Microsoft Technology Licensing, Llc Regulation of polymerase using cofactor oxidation states
US11896945B2 (en) 2019-10-09 2024-02-13 Microsoft Technology Licensing, Llc High surface area coatings for solid-phase synthesis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
SCOTT J.MILLER ET AL.: "Synthesis of Conformationally Restricted Amino Acids and Peptides Employing Olefin Metathesis", J.AM.CHEM.SOC., vol. 117, 1995, pages 5855 - 6, XP002093028 *
SCOTT.J.MILLER ET AL: "Catalytic Ring-Closing Metathesis of Dienes: Application to the Synthesis of Eight-Membered Rings", J.AM.CHEM.SOC, vol. 117, 1995, pages 2108 - 9, XP002093029 *
See also references of WO9726002A1 *
THOMAS D.CLERK ET AL.: "Supramolecular Design by Covalent Capture. Design of a Peptide cylinder via Hydrogen-Bond-Promoted Intermolecular Olefin Metathesis", J.AM.CHEM.SOC., vol. 117, 1995, pages 12364 - 5, XP002093030 *

Also Published As

Publication number Publication date
AU6162996A (en) 1997-08-11
WO1997026002A1 (fr) 1997-07-24
EP0880357A1 (fr) 1998-12-02

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