BRPI9814499A - Peptídeo amida opióide sintético ou um sal farmaceuticamente aceitavel do mesmo, e, composição farmacêutica - Google Patents

Peptídeo amida opióide sintético ou um sal farmaceuticamente aceitavel do mesmo, e, composição farmacêutica

Info

Publication number
BRPI9814499A
BRPI9814499A BRPI9814499A BRPI9814499A BR PI9814499 A BRPI9814499 A BR PI9814499A BR PI9814499 A BRPI9814499 A BR PI9814499A BR PI9814499 A BRPI9814499 A BR PI9814499A
Authority
BR
Brazil
Prior art keywords
pharmaceutically acceptable
pharmaceutical composition
acceptable salt
amide peptide
synthetic opioid
Prior art date
Application number
Other languages
English (en)
Inventor
D Schteingart Claudio
Sueiras Diaz Javier
Louis Junien Jean
A Trojnar Jerzy
J M Riviere Pierre
W Vanderah Todd
Original Assignee
Cara Therapeutics Inc
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cara Therapeutics Inc, Ferring Bv filed Critical Cara Therapeutics Inc
Publication of BRPI9814499A publication Critical patent/BRPI9814499A/pt
Publication of BRPI9814499B1 publication Critical patent/BRPI9814499B1/pt
Publication of BRPI9814499B8 publication Critical patent/BRPI9814499B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BRPI9814499A 1997-12-23 1998-12-22 Peptídeo amida opióide sintético ou um sal farmaceuticamente aceitavel do mesmo, e, composição farmacêutica BRPI9814499B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/997,208 US5965701A (en) 1997-12-23 1997-12-23 Kappa receptor opioid peptides
PCT/US1998/027282 WO1999032510A1 (en) 1997-12-23 1998-12-22 Kappa receptor opioid peptides

Publications (3)

Publication Number Publication Date
BRPI9814499A true BRPI9814499A (pt) 2000-10-10
BRPI9814499B1 BRPI9814499B1 (pt) 2014-10-21
BRPI9814499B8 BRPI9814499B8 (pt) 2021-11-09

Family

ID=25543752

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI9814499-5A BR9814499B1 (pt) 1997-12-23 1998-12-22 Peptídeo amida opióide sintético ou um sal farmaceuticamente aceitavel do mesmo, e, composição farmacêutica
BRPI9814499A BRPI9814499B8 (pt) 1997-12-23 1998-12-22 Peptídeo amida opióide sintético ou um sal farmaceuticamente aceitavel do mesmo, e, composição farmacêutica

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI9814499-5A BR9814499B1 (pt) 1997-12-23 1998-12-22 Peptídeo amida opióide sintético ou um sal farmaceuticamente aceitavel do mesmo, e, composição farmacêutica

Country Status (32)

Country Link
US (1) US5965701A (pt)
EP (1) EP1042359B1 (pt)
JP (1) JP4275852B2 (pt)
KR (1) KR100629548B1 (pt)
CN (1) CN1154655C (pt)
AR (1) AR014167A1 (pt)
AT (1) ATE301670T1 (pt)
AU (1) AU747806B2 (pt)
BR (2) BR9814499B1 (pt)
CA (1) CA2315878C (pt)
CR (1) CR5936A (pt)
CZ (1) CZ297281B6 (pt)
DE (1) DE69831176T2 (pt)
DK (1) DK1042359T3 (pt)
EE (1) EE04440B1 (pt)
ES (1) ES2247735T3 (pt)
HR (1) HRP20000415B1 (pt)
HU (1) HU227640B1 (pt)
IL (3) IL136742A0 (pt)
MY (1) MY117542A (pt)
NO (1) NO327080B1 (pt)
NZ (1) NZ505183A (pt)
PL (1) PL195842B1 (pt)
PT (1) PT1042359E (pt)
RU (1) RU2217437C2 (pt)
SK (1) SK286135B6 (pt)
TR (1) TR200001985T2 (pt)
TW (1) TW580502B (pt)
UA (1) UA68366C2 (pt)
UY (1) UY25327A1 (pt)
WO (1) WO1999032510A1 (pt)
ZA (1) ZA9811801B (pt)

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DE10116978A1 (de) 2001-04-05 2002-10-10 Merck Patent Gmbh Kappa-Opiatagonisten für die Behandlung von Erkrankungen der Blase
JP4239592B2 (ja) * 2001-05-08 2009-03-18 東レ株式会社 敗血症治療剤
WO2003080149A2 (en) 2002-03-20 2003-10-02 Mannkind Corporation Inhalation apparatus
PL1786784T3 (pl) 2004-08-20 2011-04-29 Mannkind Corp Kataliza syntezy diketopiperazyn
KR101644250B1 (ko) 2004-08-23 2016-07-29 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
CN104324362B (zh) 2005-09-14 2018-04-24 曼金德公司 以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法
IN2015DN00888A (pt) 2006-02-22 2015-07-10 Mannkind Corp
EP2040733A2 (en) * 2006-05-26 2009-04-01 Cara Therapeutics, Inc. Method for elevating prolactin in mammals
CA2653077A1 (en) * 2006-05-26 2007-12-06 Cara Therapeutics, Inc. N-oxides of kappa opioid receptor peptides
US8906859B2 (en) * 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
US8236766B2 (en) * 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
US7713937B2 (en) * 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
RU2500685C2 (ru) 2006-11-10 2013-12-10 Кара Терапеутикс, Инк Синтетические пептидные амиды
WO2008077194A1 (en) * 2006-12-22 2008-07-03 Xenome Ltd Receptor agonists
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
ES2929343T3 (es) 2008-06-13 2022-11-28 Mannkind Corp Inhalador de polvo seco accionado por aspiración para la administración de fármacos
KR101628410B1 (ko) 2008-06-20 2016-06-08 맨카인드 코포레이션 흡입 활동에 관한 실시간 프로파일링을 위한 대화형 장치 및 방법
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
DK2405963T3 (da) 2009-03-11 2013-12-16 Mannkind Corp Apparat, system og fremgangsmåde til at måle modstand i en inhalator
CN104721825B (zh) 2009-06-12 2019-04-12 曼金德公司 具有确定比表面积的二酮哌嗪颗粒
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
IL223742A (en) 2010-06-21 2016-06-30 Mannkind Corp A dry powder inhaler and preparation for it
AU2012236150B2 (en) 2011-04-01 2016-03-31 Mannkind Corporation Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
BR112014009686A2 (pt) 2011-10-24 2018-08-07 Mannkind Corp composição analgésica inalável, pó seco e método para tratar dor
CN104619369B (zh) 2012-07-12 2018-01-30 曼金德公司 干粉药物输送系统和方法
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
AU2014228415B2 (en) 2013-03-15 2018-08-09 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
MX375448B (es) 2013-07-18 2025-03-06 Mannkind Corp Composiciones farmacéuticas en polvo seco estables al calor y métodos.
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
JP5807140B1 (ja) * 2014-06-26 2015-11-10 積水メディカル株式会社 合成ペンタペプチドの製造法
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
EP3294315A2 (en) * 2015-05-11 2018-03-21 Cadila Healthcare Limited Novel short-chain peptides as kappa opioid receptors (kor) agonist
CN107098876B (zh) * 2016-02-23 2021-04-06 江苏恒瑞医药股份有限公司 苯基丙酰胺类衍生物、其制备方法及其在医药上的应用
CN109563133B (zh) * 2016-09-27 2020-09-11 四川科伦博泰生物医药股份有限公司 多酰胺化合物及其用途
CA3069820C (en) * 2017-07-21 2022-12-06 Sichuan Haisco Pharmaceutical Co., Ltd. Peptide amide compounds, preparation method thereof and use in medicine
MX2020005932A (es) 2017-12-06 2020-08-24 Jiangsu Hengrui Medicine Co Sal de derivado de fenilpropionamida y su metodo de preparacion.
CN111148526B (zh) 2018-05-16 2023-03-10 江苏恒瑞医药股份有限公司 一种kor受体激动剂药物组合物
WO2021013085A1 (zh) * 2019-07-25 2021-01-28 四川海思科制药有限公司 一种肽酰胺盐及其制备方法和在医药上的用途
CN114127086B (zh) * 2019-07-25 2023-10-20 四川海思科制药有限公司 氘代肽酰胺类化合物及其制备方法和在医药上的用途
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Also Published As

Publication number Publication date
CZ297281B6 (cs) 2006-10-11
HUP0100626A2 (hu) 2001-08-28
DK1042359T3 (da) 2005-11-28
CA2315878C (en) 2010-11-16
TW580502B (en) 2004-03-21
HRP20000415A2 (en) 2000-12-31
EE200000370A (et) 2001-10-15
NO20003245D0 (no) 2000-06-21
IL136742A0 (en) 2001-06-14
HUP0100626A3 (en) 2001-12-28
UA68366C2 (en) 2004-08-16
JP4275852B2 (ja) 2009-06-10
NO20003245L (no) 2000-08-23
AU1940299A (en) 1999-07-12
TR200001985T2 (tr) 2000-11-21
CN1154655C (zh) 2004-06-23
PT1042359E (pt) 2005-11-30
KR20010033450A (ko) 2001-04-25
PL195842B1 (pl) 2007-10-31
NO327080B1 (no) 2009-04-20
BRPI9814499B8 (pt) 2021-11-09
KR100629548B1 (ko) 2006-09-27
IL178471A0 (en) 2007-02-11
HU227640B1 (en) 2011-10-28
EE04440B1 (et) 2005-02-15
WO1999032510A9 (en) 1999-09-23
NZ505183A (en) 2001-09-28
HK1029349A1 (en) 2001-03-30
EP1042359B1 (en) 2005-08-10
JP2001526295A (ja) 2001-12-18
UY25327A1 (es) 2000-12-29
AR014167A1 (es) 2001-02-07
DE69831176T2 (de) 2006-04-20
BRPI9814499B1 (pt) 2014-10-21
US5965701A (en) 1999-10-12
WO1999032510A1 (en) 1999-07-01
BR9814499B1 (pt) 2014-10-21
ATE301670T1 (de) 2005-08-15
ES2247735T3 (es) 2006-03-01
IL136742A (en) 2006-12-31
MY117542A (en) 2004-07-31
ZA9811801B (en) 1999-06-22
RU2217437C2 (ru) 2003-11-27
CN1283201A (zh) 2001-02-07
HRP20000415B1 (en) 2004-06-30
CA2315878A1 (en) 1999-07-01
SK286135B6 (sk) 2008-04-07
CR5936A (es) 2006-08-18
PL341308A1 (en) 2001-04-09
EP1042359A1 (en) 2000-10-11
BR9814499A (pt) 2000-10-10
SK9602000A3 (en) 2001-01-18
AU747806B2 (en) 2002-05-23
CZ20002382A3 (cs) 2000-12-13
DE69831176D1 (de) 2005-09-15

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