EP0897983A3 - Anticorps contre CD40-L - Google Patents

Anticorps contre CD40-L Download PDF

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Publication number
EP0897983A3
EP0897983A3 EP98113461A EP98113461A EP0897983A3 EP 0897983 A3 EP0897983 A3 EP 0897983A3 EP 98113461 A EP98113461 A EP 98113461A EP 98113461 A EP98113461 A EP 98113461A EP 0897983 A3 EP0897983 A3 EP 0897983A3
Authority
EP
European Patent Office
Prior art keywords
antibody against
immunogen
disclosed
isolated antibody
antibody immunoreactive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP98113461A
Other languages
German (de)
English (en)
Other versions
EP0897983A2 (fr
EP0897983B1 (fr
Inventor
Richard J. Armitage
William C. Fanslow
Melanie K. Springs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunex Corp
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27120174&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0897983(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immunex Corp filed Critical Immunex Corp
Publication of EP0897983A2 publication Critical patent/EP0897983A2/fr
Publication of EP0897983A3 publication Critical patent/EP0897983A3/fr
Application granted granted Critical
Publication of EP0897983B1 publication Critical patent/EP0897983B1/fr
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP98113461A 1991-10-25 1992-10-23 Anticorps contre CD40-L Revoked EP0897983B1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US78370791A 1991-10-25 1991-10-25
US783707 1991-10-25
US80572391A 1991-12-05 1991-12-05
US805723 1991-12-05
PCT/US1992/008990 WO1993008207A1 (fr) 1991-10-25 1992-10-23 Nouvelle cytokine
EP92925017A EP0667901B2 (fr) 1991-10-25 1992-10-23 Nouvelle cytokine

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP92925017A Division EP0667901B2 (fr) 1991-10-25 1992-10-23 Nouvelle cytokine

Publications (3)

Publication Number Publication Date
EP0897983A2 EP0897983A2 (fr) 1999-02-24
EP0897983A3 true EP0897983A3 (fr) 1999-03-17
EP0897983B1 EP0897983B1 (fr) 2003-05-07

Family

ID=27120174

Family Applications (2)

Application Number Title Priority Date Filing Date
EP92925017A Expired - Lifetime EP0667901B2 (fr) 1991-10-25 1992-10-23 Nouvelle cytokine
EP98113461A Revoked EP0897983B1 (fr) 1991-10-25 1992-10-23 Anticorps contre CD40-L

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP92925017A Expired - Lifetime EP0667901B2 (fr) 1991-10-25 1992-10-23 Nouvelle cytokine

Country Status (12)

Country Link
EP (2) EP0667901B2 (fr)
JP (2) JP3308534B2 (fr)
KR (1) KR100283541B1 (fr)
AT (2) ATE274055T1 (fr)
AU (1) AU661360B2 (fr)
CA (2) CA2312667C (fr)
DE (2) DE69233051T2 (fr)
DK (3) DK0822199T3 (fr)
ES (2) ES2198025T3 (fr)
FI (2) FI116850B (fr)
NO (2) NO317625B1 (fr)
WO (1) WO1993008207A1 (fr)

Families Citing this family (76)

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US7405270B2 (en) 1991-10-25 2008-07-29 Immunex Corporation CD40-Ligand lacking native-pattern glycosylation
US5962406A (en) * 1991-10-25 1999-10-05 Immunex Corporation Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same
US5716805A (en) * 1991-10-25 1998-02-10 Immunex Corporation Methods of preparing soluble, oligomeric proteins
US5981724A (en) * 1991-10-25 1999-11-09 Immunex Corporation DNA encoding CD40 ligand, a cytokine that binds CD40
US7070777B1 (en) * 1991-11-15 2006-07-04 The Trustees Of Columbia University In The City Of New York Method for inhibiting inflammation with an antibody that binds the 5C8 protein
US5474771A (en) 1991-11-15 1995-12-12 The Trustees Of Columbia University In The City Of New York Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same
US6472510B1 (en) 1992-02-14 2002-10-29 Bristol-Myers Squibb Company CD40 receptor ligands
US5874082A (en) * 1992-07-09 1999-02-23 Chiron Corporation Humanized anti-CD40 monoclonal antibodies and fragments capable of blocking B cell proliferation
US5397703A (en) 1992-07-09 1995-03-14 Cetus Oncology Corporation Method for generation of antibodies to cell surface molecules
AU5098493A (en) * 1992-08-21 1994-03-15 Schering Corporation Cd40 ligand, anti cd40 antibodies, and soluble cd40
US5540926A (en) * 1992-09-04 1996-07-30 Bristol-Myers Squibb Company Soluble and its use in B cell stimulation
EP0612529B1 (fr) * 1993-01-22 2000-04-05 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Agent thérapeutique pour NIDDM
AU677995B2 (en) * 1993-01-22 1997-05-15 Immunex Corporation Detection and treatment of mutations in a CD40 ligand gene
NZ273208A (en) * 1993-09-02 2000-12-22 Dartmouth College Suppressing a humoral immune response against a thymus dependant (TD) antigen
US5869049A (en) * 1993-09-02 1999-02-09 Trustees Of Dartmouth College Methods of inducing T cell unresponsiveness to bone marrow with gp39 antagonists
ES2143553T3 (es) 1993-09-02 2000-05-16 Dartmouth College Anticuerpos anti-gp39 y sus utilizaciones.
ZA946765B (en) 1993-09-02 1996-02-15 Dartmouth College Methods of prolonged suppression of humoral immunity
WO1995014487A1 (fr) * 1993-11-24 1995-06-01 The Australian National University Traitement d'une maladie virale avec le peptide cd40l
ES2222463T3 (es) * 1993-12-23 2005-02-01 Immunex Corporation Uso de anticuerpos monoclonales o ligandos oligomericos solubles en la fabricacion de un medicamento para la prevencion o tratamiento de trastornos neoplasicos.
US5683693A (en) * 1994-04-25 1997-11-04 Trustees Of Dartmouth College Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40
ATE309267T1 (de) 1994-04-28 2005-11-15 Boehringer Ingelheim Pharma Methode zur proliferation und differenzierung von b-zellen und verwendungen dafür
ES2179187T3 (es) * 1995-03-01 2003-01-16 Immunex Corp Oriteuba qye se yba a cd40 para estimular una respuesta inmune.
AU2556195A (en) 1995-03-13 1996-10-02 Regents Of The University Of Michigan, The CD40 binding compositions and methods of using same
IL122174A (en) * 1995-06-07 2004-07-25 Immunex Corp Dna encoding a cd40l mutein and a cd40l polypeptide encoded by said dna
WO1997000895A1 (fr) * 1995-06-22 1997-01-09 Biogen, Inc. Cristaux de fragments du ligand cd40 et leur utilisation
US6440418B1 (en) 1995-11-07 2002-08-27 Idec Pharmaceuticals Corporation Methods of treating autoimmune diseases with gp39-specific antibodies
US6001358A (en) 1995-11-07 1999-12-14 Idec Pharmaceuticals Corporation Humanized antibodies to human gp39, compositions containing thereof
US6340459B1 (en) 1995-12-01 2002-01-22 The Trustees Of Columbia University In The City Of New York Therapeutic applications for the anti-T-BAM (CD40-L) monoclonal antibody 5C8 in the treatment of reperfusion injury in non-transplant recipients
DE69728269T2 (de) * 1996-06-14 2005-03-10 University Of Washington, Seattle Absorbtionsverbessertes differentielles extraktionsverfahren
EP0961824A4 (fr) * 1996-07-10 2003-01-29 Immunex Corp Procede d'activation de cellules dendritiques
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US7070771B1 (en) 1996-12-09 2006-07-04 Regents Of The University Of California Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
US6271349B1 (en) 1996-12-23 2001-08-07 Immunex Corporation Receptor activator of NF-κB
DE69740107D1 (de) * 1996-12-23 2011-03-10 Immunex Corp Rezeptor aktivator von nf-kappa b, rezeptor is mitglied der tnf rezeptor superfamilie
AU762574B2 (en) 1998-05-14 2003-06-26 Immunex Corporation Method of inhibiting osteoclast activity
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AU6934600A (en) * 1999-08-27 2001-03-26 Board Of Regents, The University Of Texas System Cd40 ligand and cd40 agonist compositions and methods of use
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EP1322383B9 (fr) 2000-10-02 2006-09-06 Chiron Corporation Methodes therapeutiques pour lutter contre les cellules b malignes avec des anticorps antagonistes anti-cd40
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AU2014239557B2 (en) 2013-03-15 2019-01-03 The Board Of Trustees Of The University Of Arkansas Compositions and methods of enhancing immune responses to enteric pathogens
US10786547B2 (en) 2015-07-16 2020-09-29 Biokine Therapeutics Ltd. Compositions, articles of manufacture and methods for treating cancer
UA123398C2 (uk) 2015-08-05 2021-03-31 Янссен Байотек, Інк. Виділене антагоністичне антитіло, яке специфічно зв'язує cd154, та фармацевтична композиція, яка його містить
WO2017083604A1 (fr) 2015-11-12 2017-05-18 Amgen Inc. Amélioration pharmacocinétique médiée par la triazine de composés thérapeutiques
KR102767638B1 (ko) 2016-05-03 2025-02-20 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 면역자극 및 항원 폴리펩티드를 포함하는 효모 백신 벡터, 및 그를 이용하는 방법
JP6972022B2 (ja) 2016-05-11 2021-11-24 アムジエン・インコーポレーテツド グルタミンシンセターゼ遺伝子内相補ベクターを用いた高レベルのヘテロマータンパク質発現細胞の直接選択
US11267856B2 (en) * 2017-02-27 2022-03-08 Shattuck Labs, Inc. CSF1R-CD40L chimeric proteins
US20190367579A1 (en) 2017-02-27 2019-12-05 Shattuck Labs, Inc. Tigit- and light-based chimeric proteins

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0555880A2 (fr) * 1992-02-14 1993-08-18 Bristol-Myers Squibb Company Récepteur CD40CR et ses ligands

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5540926A (en) * 1992-09-04 1996-07-30 Bristol-Myers Squibb Company Soluble and its use in B cell stimulation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0555880A2 (fr) * 1992-02-14 1993-08-18 Bristol-Myers Squibb Company Récepteur CD40CR et ses ligands

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ARMITAGE R J ET AL: "MOLECULAR AND BIOLOGICAL CHARACTERIZATION OF A MURINE LIGAND FOR CD40", NATURE, vol. 357, 7 May 1992 (1992-05-07), pages 80 - 82, XP002024662 *
CLARK ET AL: "CD40: A CYTOKINE RECEPTOR IN SEARCH OF A LIGAND", TISSUE ANTIGENS, vol. 35, 1990, pages 33 - 36, XP002090410 *
NOELLE ET AL: "A 39-KDA PROTEIN ON ACTIVATED HELPER T CELLS BINDS CD40 AND TRANSDUCES THE SIGNAL FOR COGNATE ACTIVATION OF B CELLS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, vol. 89, July 1992 (1992-07-01), pages 6550 - 6554, XP002090411 *

Also Published As

Publication number Publication date
DE69233402T2 (de) 2005-09-15
FI981765A0 (fi) 1998-08-17
CA2121798C (fr) 2007-07-24
NO980030D0 (no) 1998-01-05
EP0897983A2 (fr) 1999-02-24
CA2312667A1 (fr) 1993-04-29
KR100283541B1 (ko) 2001-03-02
EP0667901B1 (fr) 2004-08-18
FI941837L (fi) 1994-05-30
ATE239790T1 (de) 2003-05-15
FI116828B (fi) 2006-03-15
DE69233051D1 (de) 2003-06-12
DK0667901T4 (da) 2008-11-10
HK1019343A1 (en) 2000-02-03
WO1993008207A1 (fr) 1993-04-29
FI981765L (fi) 1998-08-17
AU661360B2 (en) 1995-07-20
ES2227513T5 (es) 2009-04-01
DE69233051T2 (de) 2004-03-11
DK0897983T3 (da) 2003-08-11
DK0667901T3 (da) 2004-12-27
EP0667901B2 (fr) 2008-10-15
CA2312667C (fr) 2002-11-19
JPH07504083A (ja) 1995-05-11
JP3308534B2 (ja) 2002-07-29
NO941422D0 (no) 1994-04-19
DE69233402D1 (de) 2004-09-23
JPH10150994A (ja) 1998-06-09
CA2121798A1 (fr) 1993-04-29
ATE274055T1 (de) 2004-09-15
FI941837A0 (fi) 1994-04-20
NO317625B1 (no) 2004-11-29
EP0667901A1 (fr) 1995-08-23
NO980030L (no) 1998-01-05
EP0897983B1 (fr) 2003-05-07
DE69233402T3 (de) 2009-06-25
JP2877788B2 (ja) 1999-03-31
ES2198025T3 (es) 2004-01-16
NO941422L (fr) 1994-06-27
AU3122693A (en) 1993-05-21
NO320073B1 (no) 2005-10-17
EP0667901A4 (fr) 1995-06-22
FI116850B (fi) 2006-03-15
DK0822199T3 (da) 2004-12-27
ES2227513T3 (es) 2005-04-01

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