EP0901536A1 - Dispositif d'insonorisation pour voies ferrees - Google Patents
Dispositif d'insonorisation pour voies ferreesInfo
- Publication number
- EP0901536A1 EP0901536A1 EP97922748A EP97922748A EP0901536A1 EP 0901536 A1 EP0901536 A1 EP 0901536A1 EP 97922748 A EP97922748 A EP 97922748A EP 97922748 A EP97922748 A EP 97922748A EP 0901536 A1 EP0901536 A1 EP 0901536A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- plate
- plates
- partial
- soundproofing device
- support sections
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 claims abstract description 17
- 230000002787 reinforcement Effects 0.000 claims abstract description 15
- 239000011230 binding agent Substances 0.000 claims abstract description 11
- 230000000295 complement effect Effects 0.000 claims description 9
- 239000003562 lightweight material Substances 0.000 claims description 5
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 230000001788 irregular Effects 0.000 claims description 3
- 238000005096 rolling process Methods 0.000 claims description 3
- 239000004566 building material Substances 0.000 abstract description 2
- 239000002250 absorbent Substances 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 description 12
- 238000000034 method Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 4
- 238000005304 joining Methods 0.000 description 4
- 229910000831 Steel Inorganic materials 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 230000002349 favourable effect Effects 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 239000010959 steel Substances 0.000 description 3
- 229920002430 Fibre-reinforced plastic Polymers 0.000 description 2
- 239000011358 absorbing material Substances 0.000 description 2
- 239000004035 construction material Substances 0.000 description 2
- 238000013016 damping Methods 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 239000011151 fibre-reinforced plastic Substances 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000011490 mineral wool Substances 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 238000000862 absorption spectrum Methods 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 239000011491 glass wool Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000011900 installation process Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- E—FIXED CONSTRUCTIONS
- E01—CONSTRUCTION OF ROADS, RAILWAYS, OR BRIDGES
- E01B—PERMANENT WAY; PERMANENT-WAY TOOLS; MACHINES FOR MAKING RAILWAYS OF ALL KINDS
- E01B19/00—Protection of permanent way against development of dust or against the effect of wind, sun, frost, or corrosion; Means to reduce development of noise
- E01B19/003—Means for reducing the development or propagation of noise
Definitions
- the invention relates to a soundproofing device for tracks, with sound-absorbing plates mounted on the rails of the track, which are supported on the rails by elastic profiles, the plates arranged between the rails cantilevering the space between the rails. Furthermore, the invention relates to sound-absorbing panels for such a soundproofing device.
- the plates arranged between the rails of the track consist of three layers or layers which are supported by elastic profiles on the rail foot, web and on the underside.
- the upper layer consists of steel wire fabric that can be walked on, the edge of which is glued, welded or vulcanized into the profile.
- the middle layer is designed as a sound absorption layer and consists of glass wool or rock wool. This sound absorption layer lies on the lower layer, which is designed as a perforated wall or grate and is supported in a recess in the profile in the region of the rail foot.
- the panels are also arranged on the outside of the rail and angled upward at the ends in order to form a lateral soundproofing wall.
- Such mineral wool panels have adequate sound absorption at high frequencies, but have inadequate sound absorption at low frequencies.
- a further disadvantage of this construction is that the walkable perforated wall made of steel wire mesh can detach itself from its anchoring in the profiles at higher and repeated loads, so that the sound absorption layer underneath can be damaged.
- the dust penetrating through the perforated wall can be deposited on the upper side of the sound absorption layer and thus the sound damping effect can deteriorate increasingly.
- the invention has for its object to provide a soundproofing device for tracks with sound-absorbing plates, which has good sound absorption or damping over the entire frequency range essential for the sound level of rail traffic, with a permanent mechanical Strength of the device should be guaranteed.
- the soundproofing device of the type mentioned at the outset in that the plates consist of particles of porous lightweight construction material which are joined together with a binder, and in that the plates have embedded reinforcement and are arranged uncovered.
- the airborne noise emanating in particular from the wheels of a rail vehicle and from the rails is absorbed on the surface of the plates by the pores of the particles and can also be selected if a structure is left that leaves fine spaces between the particles, via spaces or channels between the particles penetrate deeper into the plate to gradually be completely dampened there.
- the reinforcement of the panels also ensures that they can be walked on.
- the top of the plates is structured, and even better results can be achieved if the structuring is irregular.
- the top of the plates is preferably provided with ribs running parallel to the rails, which results in structuring that is simple to construct.
- the ribs have a trapezoidal cross-section, since this makes it easier to absorb obliquely incident sound waves.
- the wall of the cavity resonators and their sound openings are provided with a sound-absorbing structure, and / or if the wall of the cavity resonators and their tubular sound openings are provided with a sound-absorbing layer are provided.
- the cavities forming the cavity resonators are designed to be open at the bottom and are covered with a lower plate.
- the cavities forming the cavity resonators are designed to be open at the bottom and form a resonance cavity together with the track bedding.
- the damped resonance frequency of the cavity resonators is within a frequency range from 150 to 1000 Hz, preferably between 500 and 1000 Hz.
- a special embodiment is also provided in which the installation and removal of the plates to be provided between the two rails of a track can be accomplished in a very simple manner.
- This embodiment of the soundproofing device is characterized in that the space lying between the two rails of a track is bridged with partial plates arranged in pairs, each of which engages with at least one supporting rib in the link chambers of the rails, the partial plates of each pair of plates at their mutually facing edges are supported on one another and in this case support sections and support sections are provided alternately in a meandering manner on each section plate along the edge facing the other section plate, the support sections being formed by depressions extending from the top of the plate and facing the other section plate and under the support sections from the underside of the plate, upward depressions are formed, which are complementary to the depressions of the support sections, and the support sections of a partial plate on the support sections the other partial plate and the support sections of the other partial plate rest on the supporting sections of the one partial plate.
- the zones of the partial plates of each pair of plates to be joined in an articulated manner can simply be plugged together when the partial plates are unfolded, after which the partial plates can be inserted between the rails without problems by leveling the pair of plates, and the partial plates also become Loads not pushed apart.
- a preferred type of the last-mentioned embodiment which is characterized in that projections and recesses shaped complementarily to the projections, into which the projections engage, are provided on those surfaces on which the partial plates of a pair of plates abut one another, for mutual locking of the partial plates, offers the advantage that the cohesion of the partial plates of a pair of plates is ensured even over very long periods of time even when unfavorable vibrations act on the partial plates.
- Such a crowning can be formed on a partial plate by a surface section which extends from the edge facing the other partial plate of the pair of plates and extends away from the underside of the plate, and a subsequent surface section which approaches the underside of the plate. If one wishes to additionally provide a latching in such a configuration of the partial plates, it is advantageous if they are designed in such a way that projections pointing downward are provided on the end edges of the supporting sections and recesses complementary to these projections are provided on the supporting surfaces of the supporting sections.
- An embodiment which is particularly favorable for the course of the leveling process when installing the partial plates and for achieving the most stable possible position of the two partial plates of a pair of plates relative to one another in the installed state characterized in that the cambered shaped wings are shaped according to a toothing which, up to the leveled position of the partial plates of the respective pair of plates, enables sliding or rolling movement of the facing wings and supporting surfaces towards one another and in the leveled position of these partial plates against one another Movement of these partial plates to each other blocks.
- the reinforcement provided in the sub-panels extends over the panel surface and engages in the supporting sections and in the supporting sections and in the supporting ribs. It is also advantageous if one provides that an elastic or / or shock-absorbing insert or coating is provided between the wings provided on the support sections and the support surfaces provided on the support sections.
- a sound-absorbing plate according to the invention is characterized in that the plate consists of particles made of porous lightweight material, which are joined together with a binder, that the plate has an embedded reinforcement, and that in the plate cavity resonators with a large area of the Plate directed tubular sound openings are formed, which large area to form the top is provided when installing the plate in the track. It is advantageous here if the cavities forming the cavity resonators are designed to be open and widening towards the large area that lies on the side of the plate facing away from the tubular sound openings. A further development is characterized in that the cavities forming the cavity resonators are covered with a lower plate on the side facing away from the tubular sound openings.
- Embodiments of a plate designed according to the invention which are provided for the aforementioned formation with partial plates to be joined to form a pair of plates, are characterized in that the plate consists of particles of porous lightweight building material, which are joined together with a binder, so that the plate is an embedded one Reinforcement has that the plate is provided on one edge side with a support rib for engaging in the tab chambers of rails and on the edge side opposite this support rib has meandering succession of support sections and support sections, the support sections extending from the top of the plate and depressions extending to the edge are formed and under the support sections, from the underside of the plate, upward depressions are formed, which are complementary to the depressions of the support sections.
- cavity resonators are formed in the plate with tubular sound openings directed towards a large area of the plate, which large area is provided for forming the upper side when the plate is installed in the track. It is also advantageous here if the reinforcement provided in the plate extends over the entire surface of the plate and extends into the support sections and into the support sections and into the support rib. If desired, the plates or partial plates can also be provided with a frame running along the edge, preferably consisting of metal or fiber-reinforced plastic.
- FIG. 1 shows a plan view of a track with sound-absorbing plates arranged between the rails
- FIG. 2 shows a section along the line II-II in Fig.l
- 3 shows an embodiment of a plate in cross section
- FIG. 4 shows an enlarged detail of the surface of the plate according to FIG. 2 or 3;
- FIG. 5 shows an embodiment of a soundproofing device designed according to the invention with partial plates in a top view
- FIG. 10 shows a variant with regard to the design of the support sections and the support sections in a sectional representation corresponding to FIG. 7,
- FIG. 11 shows another embodiment of a soundproofing device designed according to the invention with partial panels, in a top view
- FIG. 16 shows a variant with regard to the design of the support sections and the support sections of the partial plates in a sectional representation corresponding to FIG. 13.
- sound-absorbing plates 3 are arranged next to one another in the longitudinal direction of the track between the rails 2.
- the generally rectangular plates 3 have, on their two edges along the rails 2, projecting support ribs 4, which are interposed with elastic profiles 5, for example made of rubber or elastomer, support on the rail base 6, on the rail web 7 and on the underside of the rail head 8 of the rails 2.
- the plates 3, the surface of which is shown enlarged in FIG. 4, consist of particles 9 made of porous lightweight material, which are joined together with a suitable binder.
- Plastic granulate, granular or spherical and fired alumina particles, granular slag particles, or similar fired natural or artificially produced materials are used as the lightweight construction material, these particles being selectively connected with a suitable plastic binder or cement, so that small spaces or channels 10 remain, which allow air ducting and drainage of penetrating rain or melt water.
- the panels 3 are provided with a reinforcement 11, for example made of steel or other metals, fiber-reinforced plastic, glass fiber mats or the like.
- the surface of the plates 3 can be increased by structuring.
- the top 12 of the plates 3 can be provided with ribs 13 which run parallel to the rails 2 and are spaced apart from one another and which, as shown in FIG. 3, have a trapezoidal cross section and a height a above the rail head 8 which are closed ⁇ not exceeding 5 cm.
- the structure can also be irregular, for example by increasing or decreasing the spacing of the ribs 13 from one another.
- a structuring of the top 12 for example, truncated cones, truncated pyramids, cylinders, cuboids, etc. can also be provided, which are arranged either at the same or at different distances from one another.
- 3 cavity resonators 14 in the manner of the Helmholz resonator are formed in the plates, the tubular sound openings of which 15 are provided on the top 12 of the plates 3.
- the cavities forming the cavity resonators 14 are frustoconical and open at the bottom, the openings formed thereby being covered by a sub-plate 16, for example glued to the plate 3, in order to form the cavity resonator 14 .
- the cavities forming the cavity resonators 14 can also be designed to deviate from the shape of a truncated cone, for example spherical, cylindrical, pyramid-shaped, etc., in order to achieve a different frequency behavior in the case of sound absorption.
- the volumes of the cavity resonators 14 and the dimensions of the tubular sound openings can be varied in order to achieve the desired frequency behavior or frequency absorption spectrum. As shown in FIG.
- the tubular sound openings 15 open perpendicular to the top 12 of the plate 3.
- the tubular sound openings 15 can also open at an angle to the top 12 of the plates 3 in order to be able to better absorb obliquely incident sound waves .
- the plates 3 with the cavity resonators 14 can be produced in a rectangular shape in which positive shapes of the cavity resonators with attached pipe pieces for the sound openings are used, whereupon the mold is filled with the particles 9 and a binder and demolded after the binder has hardened becomes.
- Prefabricated cavity resonators with attached pipe pieces as sound openings can also be used as positive forms, which either consist of a suitable sound-absorbing material or are provided on the inside with a layer of sound-absorbing material.
- sound-absorbing plates with cavity resonators can also be provided on the outside of the rails 2.
- the plate 18 shown in dash-dotted lines on the right rail 2 is at one End, similar to the plate 3 lying between rails 2, is supported on the rail 2 via an elastic profile 5 and at the other end via an elastic strip 19 and fixed by means of a fastening element, in particular a screw 20.
- the plate 21 on the left rail 2, also shown with a dash-dotted line, is supported and fixed in the same way as the plate 18, but has an end region that is angled upwards on the outside in order to form a soundproofing wall.
- the two plates 18, 21 likewise have reinforcement (not shown) and, if appropriate, a structure in the form of ribs (not shown). If desired, the plates can also be provided with a frame running along the edge.
- the space 22 lying between the two rails 2 of a track 1 is filled or bridged with paired sound-absorbing partial plates 3a, 3b.
- These sub-plates 3a, 3b have support ribs 4 which engage in the tab chambers 23 of the rails 2, and elastic profiles 5 with an approximately C-shaped cross section are inserted between the support ribs 4 and the rails 2.
- the partial plates 3a, 3b are supported with their supporting ribs 4 on the rail foot 6 and laterally against the rail web 7 and held upwards by engagement under the rail head 8.
- the partial plates 3a, 3b bridge the distance 24 between the rails 2 in a self-supporting manner.
- a plurality of support ribs 4 are provided on each of the partial plates 3a, 3b, which are arranged at a distance from one another in order to leave the fastening elements 25 provided for the rails 2 accessible.
- each pair of plates are supported on one another, so that each pair of plates forms an assembled body which bridges the distance 24 between the rails 2 in a self-supporting manner.
- the support sections 28 being formed by depressions 30 which extend from the top side 12 of the plate and extend to the edge facing the other partial plate; under the support sections 29, starting from the lower side 31 of the plate, upward depressions 32 are formed, and the support sections of the partial plate 3a lie on the supporting sections of the partial plate 3b and the supporting sections of the partial plate 3b rest on the supporting sections of the partial plate 3a;
- the depressions 30 are complementary to the depressions 32, so that the support surfaces 34 formed on the support sections 29 by the depressions 32 lie substantially snugly on the support surfaces 33 formed by the depressions 30 on the support sections 28.
- the partial plates 3a, 3b In order to insert the partial plates 3a, 3b in pairs between the rails 2 of a track, they can first be arranged in the unfolded position, as shown in FIG. 9, and in the process they can be inserted into one another with their meandering edges 26, 27 also arranges the elastic profiles 5, which have a C-shaped cross section, between the supporting ribs 4 of the partial plates 3a, 3b and the rails 2. Then the partial plates 3a, 3b are pivoted or folded down, as indicated by the arrow 35, until they assume the leveled position shown in FIGS. 5 to 7, in which the partial plates 3a, 3b of each pair of plates space 22 between bridge the rails 2 in a self-supporting manner.
- the support surfaces 33 provided in the support sections 28 have a cambered shape, and there is such a cambered shape also in the support surfaces 34 provided on the support sections 29, and this cambered shape of the named surfaces ensures that the partial plates retain their shape 3a, 3b create ge, which in the leveled position of the partial plates 3a, 3b inhibits a mutual movement of these partial plates in the direction of the plate plane (arrows 36).
- projections 37 are provided on the support surfaces 34 and recesses 38 are provided on the support surfaces 33, which are complementary to the projections 37; in the leveled position of the partial plates, the Projections 37 into the recesses 38, so that there is a mutual locking of the partial plates 3a, 3b.
- an elastic and / or shock-absorbing insert or coating can be provided between the support surfaces 33 and the support surfaces 34.
- the supporting surfaces 33 provided on the supporting sections run, starting from the edge 26 or 27 of the respective partial plate 3a or 3b, first rising steeply from the underside 31 of the plate and then becoming flatter, which is advantageous for joining the partial plates to the pairs of plates. From a geometrical point of view, it is favorable if such domed wings are shaped according to a toothing which, up to the leveled position of the partial plates 3a, 3b of the respective plate pair, enables a sliding movement or rolling movement of the mutually facing wings and supporting surfaces on one another, and in the leveled position (Fig. 5 to 7) locks these partial plates against movement to each other.
- This geometrical shape corresponding to a toothing can extend up to the top 12 of the plate.
- the projections 37 can, as shown in FIGS. 5 to 8, be provided on the end edges 39 of the support sections 29, which can bring advantages when joining the partial plates, but it is also possible to place such projections 37 elsewhere, e.g. slightly removed from the edge of the support surfaces.
- the support surfaces 33 and the support surfaces 34 are largely flat; In this case, too, recesses 38, into which projections 37 engage, are provided for mutual locking of the partial plates 3a, 3b.
- the two partial plates 3a, 3b of a pair of plates lie on one another in a meandering manner on the underside 31 of the plate, so that the mutually facing edges of the partial plates 3a , 3b run on the underside of the plate following a meandering line 43. This results in a very intimate cohesion of the partial plates 3a, 3b forming a pair of plates.
- the partial plates 3a, 3b are rounded at the mutually facing edges 26, 27 from the underside 31 of the plate upwards, the radius of curvature of this rounding being equal to or smaller than the distance 41 between the edges 26, 27 and the rail-side edges 42 of the partial plates 3a, 3b. This measure is also advantageous for an unrestrained process of inserting the partial plates.
- the reinforcement 11 provided in the partial plates extends over the entire surface extent of the partial plates 3a, 3b and, as indicated by the broken lines in FIG. 8, both in the support sections 28 and in the support sections 29 as well engages in the support ribs 4.
- cavity resonators 14 with sound openings 15 can be provided, as is the case e.g. 11 to 14 is shown.
- the plates can also be provided with frames 44, as is e.g. is indicated by dashed lines in FIG.
Landscapes
- Engineering & Computer Science (AREA)
- Architecture (AREA)
- Civil Engineering (AREA)
- Structural Engineering (AREA)
- Building Environments (AREA)
- Soundproofing, Sound Blocking, And Sound Damping (AREA)
- Railway Tracks (AREA)
- Power-Operated Mechanisms For Wings (AREA)
- Devices Affording Protection Of Roads Or Walls For Sound Insulation (AREA)
- Signal Processing Not Specific To The Method Of Recording And Reproducing (AREA)
- Noise Elimination (AREA)
- Magnetic Heads (AREA)
- Holo Graphy (AREA)
- Fittings On The Vehicle Exterior For Carrying Loads, And Devices For Holding Or Mounting Articles (AREA)
- Bridges Or Land Bridges (AREA)
Abstract
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI9730491T SI0901536T1 (en) | 1996-05-29 | 1997-05-23 | Track soundproofing arrangement |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT93496A AT403809B (de) | 1996-05-29 | 1996-05-29 | Schallschutzeinrichtung für gleise |
| AT93496 | 1996-05-29 | ||
| AT934/96 | 1996-06-11 | ||
| AT1015/96 | 1996-06-11 | ||
| AT101596 | 1996-06-11 | ||
| AT0101596A AT405426B (de) | 1996-06-11 | 1996-06-11 | Schienengleiche eindeckung für gleise |
| PCT/AT1997/000109 WO1997045592A1 (fr) | 1996-05-29 | 1997-05-23 | Dispositif d'insonorisation pour voies ferrees |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP0901536A1 true EP0901536A1 (fr) | 1999-03-17 |
| EP0901536B1 EP0901536B1 (fr) | 2002-12-11 |
Family
ID=25594370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP97922748A Expired - Lifetime EP0901536B1 (fr) | 1996-05-29 | 1997-05-23 | Dispositif d'insonorisation pour voies ferrees |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6253872B1 (fr) |
| EP (1) | EP0901536B1 (fr) |
| JP (1) | JP3822641B2 (fr) |
| CN (1) | CN100424268C (fr) |
| AT (1) | ATE229595T1 (fr) |
| AU (1) | AU738889B2 (fr) |
| CA (1) | CA2255946C (fr) |
| DE (1) | DE59708955D1 (fr) |
| DK (1) | DK0901536T3 (fr) |
| ES (1) | ES2186891T3 (fr) |
| HU (1) | HU221872B1 (fr) |
| NO (1) | NO316078B1 (fr) |
| TW (1) | TW345603B (fr) |
| WO (1) | WO1997045592A1 (fr) |
Families Citing this family (311)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19812481C2 (de) * | 1998-03-21 | 2002-08-22 | Johann Rath | Vorrichtung zur Dämpfung von Schallemissionen an Gleisanlagen |
| DE29905550U1 (de) * | 1999-03-26 | 2000-08-24 | DVG Deutsche Verpackungsmittel GmbH, 90552 Röthenbach | Absorptionsbelag zur Reduzierung der Schallabstrahlung für Gleiskörper |
| US7897140B2 (en) | 1999-12-23 | 2011-03-01 | Health Research, Inc. | Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents |
| US6481637B1 (en) * | 2000-11-20 | 2002-11-19 | Mcqueen Philip Jeffrey | Rail pad and method for strain attentuation |
| DE10111919A1 (de) * | 2001-03-13 | 2002-09-19 | Boegl Max Bauunternehmung Gmbh | Fahrwegträger |
| HU224236B1 (hu) * | 2001-12-14 | 2005-06-28 | Attila Szebeni | Vasúti acélhidaknál alkalmazható, egymáshoz csatlakoztatott elemekbõl álló, zaj- és rezgéscsökkentett mûanyag járólemezrendszer |
| US8829198B2 (en) | 2007-10-31 | 2014-09-09 | Proteotech Inc | Compounds, compositions and methods for the treatment of beta-amyloid diseases and synucleinopathies |
| AU2003248747A1 (en) | 2002-06-27 | 2004-01-19 | Health Research, Inc. | Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy |
| WO2004005289A2 (fr) | 2002-07-02 | 2004-01-15 | Health Research, Inc. | Synthese efficace de pyropheophorbide a et ses derives |
| AT6414U1 (de) * | 2002-07-17 | 2003-10-27 | Gmundner Fertigteile Gmbh | Gleisabdeckung |
| GB2399123B (en) * | 2003-03-05 | 2006-03-01 | Corus Uk Ltd | Rail damper |
| WO2004099162A1 (fr) * | 2003-04-30 | 2004-11-18 | Ricerca Biosciences, Llc. | Antagoniste de proteine bcl-2 a base de diazodioxyde polycyclique |
| US20040242886A1 (en) * | 2003-04-30 | 2004-12-02 | Sandeep Gupta | Monocyclic diazodioxide based Bcl-2 protein antagonists related applications |
| EP1628666B1 (fr) * | 2003-05-14 | 2015-09-23 | NeuroGenetic Pharmaceuticals, Inc. | Composes et leurs utilisations pour la modulation de l'amyloide-beta |
| US8916598B2 (en) | 2003-05-30 | 2014-12-23 | Proteotech Inc | Compounds, compositions, and methods for the treatment of β-amyloid diseases and synucleinopathies |
| US20100331380A1 (en) * | 2009-06-29 | 2010-12-30 | Esposito Luke A | Compounds, Compositions, and Methods for the Treatment of Beta-Amyloid Diseases and Synucleinopathies |
| WO2005090370A1 (fr) | 2004-02-05 | 2005-09-29 | The Regents Of The University Of California | Agents pharmacologiquement actifs contenant des phosphonates esterifies, et leurs procedes d'utilisation |
| US20100126797A1 (en) * | 2004-02-12 | 2010-05-27 | Humphries Eric C | Panel Assembly For Traffic Noise Barrier Wall |
| US8616331B2 (en) | 2004-02-12 | 2013-12-31 | Eric C. Humphries | Panel assembly for traffic noise barrier wall |
| US7546900B2 (en) * | 2004-02-12 | 2009-06-16 | Evonik Cyro Llc | Panel assembly for traffic noise barrier wall |
| TWI347390B (en) * | 2004-03-05 | 2011-08-21 | Gmundner Fertigteile Gmbh | Noise-reducing track cover |
| JP2007538103A (ja) | 2004-05-20 | 2007-12-27 | ザ スクリップス リサーチ インスティテュート | トランスサイレチン安定化 |
| NZ588432A (en) | 2004-09-17 | 2012-03-30 | Whitehead Biomedical Inst | Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity |
| US20060067889A1 (en) * | 2004-09-27 | 2006-03-30 | Light Sciences Corporation | Singlet oxygen photosensitizers activated by target binding enhancing the selectivity of targeted PDT agents |
| US20070131480A1 (en) * | 2004-12-06 | 2007-06-14 | Corbin Maxwell H Jr | Sound arresting barrier |
| US7464791B2 (en) * | 2005-01-27 | 2008-12-16 | Pretty Products, Llc | Acoustic mats and methods for making the same |
| US20060230699A1 (en) * | 2005-03-22 | 2006-10-19 | Keene James R | Sound control flooring systems and methods therefor |
| EP1866319B1 (fr) | 2005-04-01 | 2011-11-23 | The Regents of The University of California | Nucleosides phosphono-pent-2-en-1-yle et analogues |
| US20090156545A1 (en) * | 2005-04-01 | 2009-06-18 | Hostetler Karl Y | Substituted Phosphate Esters of Nucleoside Phosphonates |
| US8492428B2 (en) * | 2005-09-20 | 2013-07-23 | Mayo Foundation For Medical Education And Research | Small-molecule botulinum toxin inhibitors |
| US8138361B2 (en) * | 2005-12-28 | 2012-03-20 | The Trustees Of The University Of Pennsylvania | C-10 carbamates of taxanes |
| WO2007106537A2 (fr) * | 2006-03-13 | 2007-09-20 | Activx Biosciences, Inc. | Aminoquinolones utilisées comme inhibiteurs de la gsk-3 |
| EP2007373A4 (fr) * | 2006-03-29 | 2012-12-19 | Foldrx Pharmaceuticals Inc | Inhibition de la toxicité de l'alpha-synucléine |
| AU2007260579B2 (en) * | 2006-06-13 | 2012-09-06 | Newstyle Nominees Pty Ltd | Rail track crossing |
| EA021255B1 (ru) | 2006-08-28 | 2015-05-29 | Киова Хакко Кирин Ко., Лимитед | Антагонистические моноклональные антитела человека, специфичные в отношении light человека |
| CN101535304A (zh) | 2006-09-21 | 2009-09-16 | 埃迪威克斯生物科学公司 | 丝氨酸水解酶抑制剂 |
| BRPI0715579A2 (pt) | 2006-10-19 | 2015-05-26 | Auspex Pharmaceuticals Inc | "composto, composição farmacêutica e uso de um composto" |
| JP5013590B2 (ja) * | 2006-11-14 | 2012-08-29 | エンデバーハウス株式会社 | 伸縮性に優れた線路用吸音材 |
| US20080146605A1 (en) | 2006-12-19 | 2008-06-19 | Auspex Pharmaceuticals, Inc. | Preparation and utility of ccr5 inhibitors |
| WO2008079371A1 (fr) * | 2006-12-22 | 2008-07-03 | Encysive Pharmaceuticals, Inc. | Modulateurs du récepteur du c3a et leurs procédés d'utilisation |
| WO2008106167A1 (fr) * | 2007-02-28 | 2008-09-04 | Conatus Pharmaceuticals, Inc. | Polythérapie incluant des inhibiteurs de métalloprotéinases matricielles et des inhibiteurs de caspases pour le traitement de maladies hépatiques |
| BRPI0808089A2 (pt) | 2007-02-28 | 2014-07-15 | Conatus Pharmaceuticals Inc | Método para tratar uma doença do fígado, para diminuir um nível elevado de uma enzima do fígado, para inibir uma cascata de sinalização de tnf-alfa e uma cascata de sinalização de alfa-faz, para reduzir um dano ao fígado, para suprimir a apoptose excessiva em uma célula de fígado, e para inibir a replicação do vírus da hepatite c. |
| ES2693948T3 (es) | 2007-03-15 | 2018-12-14 | Auspex Pharmaceuticals, Inc. | Fenetilamina sustituida con actividad serotoninérgica y/o norepinefrinérgica |
| US7892776B2 (en) | 2007-05-04 | 2011-02-22 | The Regents Of The University Of California | Screening assay to identify modulators of protein kinase A |
| MX2010000465A (es) * | 2007-07-12 | 2010-08-30 | Tragara Pharmaceuticals Inc | Metodos y composiciones para el tratamiento de cancer, tumores y alteraciones relacionadas con tumores. |
| CN101855228B (zh) * | 2007-09-11 | 2012-10-24 | 杏林制药株式会社 | 作为gsk-3抑制剂的氰基氨基喹诺酮和四唑并氨基喹诺酮 |
| US8476261B2 (en) | 2007-09-12 | 2013-07-02 | Kyorin Pharmaceutical Co., Ltd. | Spirocyclic aminoquinolones as GSK-3 inhibitors |
| US20090264421A1 (en) * | 2007-10-05 | 2009-10-22 | Bible Keith C | Methods and Compositions for Treating Cancer |
| AU2008324609B2 (en) * | 2007-11-07 | 2015-04-23 | Wai Lun Ho | Tunable vibration absorbing device |
| CA2706465A1 (fr) | 2007-11-21 | 2009-05-28 | Pharmaxis Ltd. | Inhibiteurs de ssao/vap-1 de type haloallylamines et leurs utilisations |
| WO2009111611A2 (fr) * | 2008-03-05 | 2009-09-11 | Proteotech Inc. | Composés, compositions et méthodes pour le traitement de l’accumulation du polypeptide amyloïde des îlots (iapp) dans le diabète |
| PL2947072T3 (pl) | 2008-03-17 | 2017-05-31 | Ambit Biosciences Corporation | 1-(3-(6,7-dimetoksychinazolin-4-yloksy)fenylo)-3-(5-(1,1,1-trifluoro-2-metylopropan-2-ylo)izoksazol-3-ilo)mocznik jako modulator kinazy RAF w leczeniu chorób nowotworowych |
| US20120034155A1 (en) * | 2010-08-03 | 2012-02-09 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Artificial cells |
| CN101658533A (zh) * | 2008-08-29 | 2010-03-03 | 首都医科大学宣武医院 | 抗肿瘤药物的干细胞递送 |
| US8048204B2 (en) | 2008-09-23 | 2011-11-01 | Rwdi Air Inc. | Wall assembly |
| WO2010088450A2 (fr) | 2009-01-30 | 2010-08-05 | Celladon Corporation | Procédés de traitement de maladies associées à la modulation de serca |
| US8568793B2 (en) | 2009-02-11 | 2013-10-29 | Hope Medical Enterprises, Inc. | Sodium nitrite-containing pharmaceutical compositions |
| PL2401267T3 (pl) * | 2009-02-27 | 2014-06-30 | Ambit Biosciences Corp | Pochodne chinazoliny modulujące kinazę JAK i ich zastosowanie w metodach |
| JP5690286B2 (ja) | 2009-03-04 | 2015-03-25 | イデニク プハルマセウティカルス,インコーポレイテッド | ホスホチオフェン及びホスホチアゾールhcvポリメラーゼ阻害剤 |
| KR101748891B1 (ko) * | 2009-03-11 | 2017-06-19 | 교린 세이야꾸 가부시키 가이샤 | Gsk-3 억제제로서의 7-시클로알킬아미노퀴놀론 |
| JP2012520314A (ja) | 2009-03-11 | 2012-09-06 | アムビト ビオスシエンセス コルポラチオン | 癌治療のためのインダゾリルアミノピロロトリアジンとタキサンの併用 |
| US8146310B2 (en) * | 2009-03-11 | 2012-04-03 | Keene Building Products Co., Inc. | Noise control flooring system |
| WO2010110686A1 (fr) | 2009-03-27 | 2010-09-30 | Pathway Therapeutics Limited | Pyrimidinyl et 1,3,5-triazinyl benzimidazoles et leur utilisation en thérapie anticancéreuse |
| AU2010229468A1 (en) | 2009-03-27 | 2011-10-13 | Vetdc, Inc. | Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy |
| AR076363A1 (es) | 2009-04-22 | 2011-06-08 | Axikin Pharmaceuticals Inc | Antagonistas de ccr3 de arilsulfonamida |
| SG175748A1 (en) | 2009-04-22 | 2011-12-29 | Axikin Pharmaceuticals Inc | 2,5-disubstituted arylsulfonamide ccr3 antagonists |
| PE20120810A1 (es) | 2009-04-22 | 2012-07-08 | Axikin Pharmaceuticals Inc | Compuestos derivados de 5-ciano-2-(feniltio)bencensulfonamida como antagonistas de ccr3 |
| WO2011003870A2 (fr) | 2009-07-06 | 2011-01-13 | Creabilis S.A. | Corticostéroïdes mini-pegylés, compositions les comprenant et procédés pour les préparer et les utiliser |
| US8486939B2 (en) | 2009-07-07 | 2013-07-16 | Pathway Therapeutics Inc. | Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy |
| ES2655883T5 (es) | 2009-07-08 | 2022-04-18 | Hope Medical Entpr Inc D B A Hope Pharmaceuticals | Composiciones farmacéuticas que contienen tiosulfato de sodio |
| US8404728B2 (en) | 2009-07-30 | 2013-03-26 | Mayo Foundation For Medical Education And Research | Small-molecule botulinum toxin inhibitors |
| US9284307B2 (en) | 2009-08-05 | 2016-03-15 | Idenix Pharmaceuticals Llc | Macrocyclic serine protease inhibitors |
| BR112012003661A2 (pt) | 2009-08-19 | 2017-04-25 | Ambit Biosciences Corp | "compostos de biarila e métodos de uso dos mesmos." |
| NL2003697C2 (nl) | 2009-10-22 | 2011-04-26 | Univ Twente | Weg met geluid-diffractoren. |
| TW201120037A (en) | 2009-10-26 | 2011-06-16 | Sunesis Pharmaceuticals Inc | Compounds and methods for treatment of cancer |
| WO2011056764A1 (fr) | 2009-11-05 | 2011-05-12 | Ambit Biosciences Corp. | Imidazo[2,1-b][1,3]benzothiazoles enrichis en isotopes ou fluores |
| WO2011057214A2 (fr) | 2009-11-09 | 2011-05-12 | Neurogenetic Pharmaceuticals, Inc. | Composés de modulation de la gamma-sécrétase, procédés pour les identifier, et leurs utilisations |
| US8528286B2 (en) * | 2009-11-10 | 2013-09-10 | Keene Building Products Co., Inc. | Sound control mat |
| US20110301235A1 (en) | 2009-12-02 | 2011-12-08 | Alquest Therapeutics, Inc. | Organoselenium compounds and uses thereof |
| SG181797A1 (en) | 2009-12-18 | 2012-07-30 | Idenix Pharmaceuticals Inc | 5,5-fused arylene or heteroarylene hepatitis c virus inhibitors |
| EP2515654A4 (fr) * | 2009-12-23 | 2013-04-24 | Map Pharmaceuticals Inc | Analogues d'ergoline |
| WO2011094890A1 (fr) | 2010-02-02 | 2011-08-11 | Argusina Inc. | Dérivés phénylalanines et leur utilisation comme modulateurs non peptidiques du récepteur de glp-1 |
| EP2542542B1 (fr) | 2010-03-02 | 2015-04-22 | Axikin Pharmaceuticals, Inc. | Antagonistes de ccr3 à base d'arylsulfonamide enrichi en isotope |
| WO2011112689A2 (fr) | 2010-03-11 | 2011-09-15 | Ambit Biosciences Corp. | Sels d'indazolylpyrrolotriazine |
| WO2011116161A2 (fr) | 2010-03-17 | 2011-09-22 | Axikin Pharmaceuticals Inc. | Antagonistes du ccr3 de type arylsulfonamide |
| WO2011150201A2 (fr) | 2010-05-27 | 2011-12-01 | Ambit Biosciences Corporation | Composés azolylamide et leurs procédés d'utilisation |
| WO2011150198A1 (fr) | 2010-05-27 | 2011-12-01 | Ambit Biosciences Corporation | Composés azolyle urée et leurs procédés d'utilisation |
| WO2011153197A1 (fr) | 2010-06-01 | 2011-12-08 | Biotheryx, Inc. | Dérivés d'hydroxypyridone, compositions pharmaceutiques réalisées à partir de ces dérivés, et utilisations thérapeutiques correspondants pour traiter des maladies prolifératives |
| CA2801003A1 (fr) | 2010-06-01 | 2011-12-08 | Biotheryx, Inc. | Methodes permettant de traiter des tumeurs malignes hematologiques au moyen de 6-cyclohexyl-1-hydroxy-4-methyl-2(1h)-pyridone |
| NZ604018A (en) | 2010-06-07 | 2015-02-27 | Novomedix Llc | Furanyl compounds and the use thereof |
| MX347927B (es) | 2010-07-19 | 2017-05-19 | Summa Health System | Vitamina c y vitamina k libre de cromo, y composiciones de estas para tratar un estado o enfermedad en las que interviene nfkb. |
| US20140200270A1 (en) | 2013-01-11 | 2014-07-17 | Summa Health System | Vitamins c and k for treating polycystic diseases |
| WO2012030914A1 (fr) | 2010-09-01 | 2012-03-08 | Ambit Boisciences Corporation | Dérivés de 4-azolylaminoquinazoline et leurs méthodes d'utilisation |
| US20130303533A1 (en) | 2010-09-01 | 2013-11-14 | Ambit Biosciences Corporation | Azolopyridine and azolopyrimidine compounds and methods of use thereof |
| WO2012030910A1 (fr) | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | Dérivés de 2-cycloquinazoline et leurs méthodes d'utilisation |
| US20130296363A1 (en) | 2010-09-01 | 2013-11-07 | Ambit Biosciences Corporation | Quinoline and isoquinoline derivatives for use as jak modulators |
| EP2611812A1 (fr) | 2010-09-01 | 2013-07-10 | Ambit Biosciences Corporation | Composés thiénopyridines et thiénopyrimidines et leurs procédés d'utilisation |
| US8912324B2 (en) | 2010-09-01 | 2014-12-16 | Ambit Biosciences Corporation | Optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof |
| EP2611792B1 (fr) | 2010-09-01 | 2017-02-01 | Ambit Biosciences Corporation | Sels hydrobromiques d'une pyrazolylaminoquinazoline |
| EP2611502A1 (fr) | 2010-09-01 | 2013-07-10 | Ambit Biosciences Corporation | Composés de modulation du récepteur a3 de l'adénosine et leurs méthodes d'utilisation |
| AU2011296024B2 (en) | 2010-09-01 | 2015-05-28 | Ambit Biosciences Corporation | Quinazoline compounds and methods of use thereof |
| WO2012030912A1 (fr) | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | Dérivés de 7-cyclylquinazoline et leurs méthodes d'utilisation |
| WO2012044641A1 (fr) | 2010-09-29 | 2012-04-05 | Pathway Therapeutics Inc. | 1,3,5-triazinylbenzimidazolsulfonamides et leur utilisation en thérapie anticancéreuse |
| US20120088769A1 (en) | 2010-10-11 | 2012-04-12 | Axikin Pharmaceuticals, Inc. | Salts of arylsulfonamide ccr3 antagonists |
| US20120125711A1 (en) * | 2010-11-24 | 2012-05-24 | Stahr Richard E | Sound absorbing panel and system |
| WO2012078649A1 (fr) | 2010-12-06 | 2012-06-14 | Follica, Inc. | Procédés destinés à traiter la calvitie et à favoriser la croissance des cheveux |
| WO2012080050A1 (fr) | 2010-12-14 | 2012-06-21 | F. Hoffmann-La Roche Ag | Formes solides d'un composé de phénoxybenzènesulfonyle |
| EP3763740A1 (fr) | 2011-01-26 | 2021-01-13 | Celldex Therapeutics, Inc. | Anticorps anti-kit et leurs utilisations |
| JP2014503597A (ja) | 2011-01-31 | 2014-02-13 | セルジーン コーポレイション | シチジンアナログの医薬組成物及びその使用方法 |
| US9353100B2 (en) | 2011-02-10 | 2016-05-31 | Idenix Pharmaceuticals Llc | Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections |
| AU2012236722A1 (en) | 2011-03-28 | 2013-10-17 | Mei Pharma, Inc. | (alpha-substituted cycloalkylamino and heterocyclylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases |
| US20140088103A1 (en) | 2011-03-28 | 2014-03-27 | Mei Pharma, Inc. | (fused ring arylamino and heterocyclylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases |
| EP2691384B1 (fr) | 2011-03-28 | 2016-10-26 | MEI Pharma, Inc. | (aralkylamino- et heteroaralkylamino)-pyrimidinyl- et 1,3,5-triazinyl-benzimidazoles substitues sur la position alpha, compositions pharmaceutiques les contenant et ces composes destines a etre utilises dans le traitement des maladies proliferatives |
| US20120252721A1 (en) | 2011-03-31 | 2012-10-04 | Idenix Pharmaceuticals, Inc. | Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor |
| EP2723735A4 (fr) | 2011-06-23 | 2015-02-18 | Map Pharmaceuticals Inc | Nouveaux analogues de fluoro-ergoline |
| WO2013037482A1 (fr) | 2011-09-15 | 2013-03-21 | Phenex Pharmaceuticals Ag | Agonistes du récepteur du farnésoïde x pour le traitement et la prévention du cancer |
| MY167575A (en) | 2011-10-14 | 2018-09-20 | Ambit Biosciences Corp | Heterocyclic compounds and use thereof as modulators of type iii receptor tyrosine kinases |
| AU2012355982A1 (en) | 2011-12-19 | 2014-07-10 | Map Pharmaceuticals, Inc. | Novel iso-ergoline derivatives |
| US8946420B2 (en) | 2011-12-21 | 2015-02-03 | Map Pharmaceuticals, Inc. | Neuromodulatory compounds |
| WO2013130600A1 (fr) | 2012-02-29 | 2013-09-06 | Ambit Biosciences Corporation | Formes solides comprenant de la pyrazolylaminoquinazoline optiquement active, compositions à base de celles-ci et leurs utilisations |
| TW201341367A (zh) | 2012-03-16 | 2013-10-16 | Axikin Pharmaceuticals Inc | 3,5-二胺基吡唑激酶抑制劑 |
| SI2844637T1 (en) | 2012-05-02 | 2018-07-31 | Boehringer Ingelheim International Gmbh | Substituted 3-haloallylamine inhibitors of ssao and uses thereof |
| US9732038B2 (en) | 2012-06-14 | 2017-08-15 | Mayo Foundation For Medical Education And Research | Pyrazole derivatives as inhibitors of STAT3 |
| US9012640B2 (en) | 2012-06-22 | 2015-04-21 | Map Pharmaceuticals, Inc. | Cabergoline derivatives |
| CN104812775B (zh) | 2012-07-25 | 2019-05-03 | 塞尔德克斯医疗公司 | 抗kit抗体及其用途 |
| US9074186B2 (en) | 2012-08-15 | 2015-07-07 | Boston Medical Center Corporation | Production of red blood cells and platelets from stem cells |
| US9156799B2 (en) | 2012-09-07 | 2015-10-13 | Axikin Pharmaceuticals, Inc. | Isotopically enriched arylsulfonamide CCR3 antagonists |
| WO2014055647A1 (fr) | 2012-10-03 | 2014-04-10 | Mei Pharma, Inc. | (sulfinyl et sulfonyl benzimidazolyl) pyrimidines et triazines, compositions pharmaceutiques les contenant, et leur utilisation pour traiter les maladies prolifératives |
| US20150272924A1 (en) | 2012-11-08 | 2015-10-01 | Summa Health System | Vitamin c, vitamin k, a polyphenol, and combinations thereof for wound healing |
| AU2013352106B2 (en) | 2012-11-30 | 2018-04-26 | Novomedix, Llc | Substituted biaryl sulfonamides and the use thereof |
| CA2895829A1 (fr) | 2012-12-21 | 2014-06-26 | Map Pharmaceuticals, Inc. | Nouveaux derives de methysergide |
| US9169214B2 (en) | 2012-12-21 | 2015-10-27 | The Board Of Trustees Of The Leland Stanford Junior University | Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions |
| SG10201708143QA (en) | 2013-06-06 | 2017-11-29 | Pf Medicament | Anti-c10orf54 antibodies and uses thereof |
| WO2015005774A1 (fr) * | 2013-07-07 | 2015-01-15 | 4Silence B.V. | Dispositif de diffraction pour diffracter un son |
| CN105683182A (zh) | 2013-08-30 | 2016-06-15 | 埃姆比特生物科学公司 | 联芳基乙酰胺化合物及其使用方法 |
| NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
| WO2015042375A1 (fr) | 2013-09-20 | 2015-03-26 | Idenix Pharmaceuticals, Inc. | Inhibiteurs du virus de l'hépatite c |
| EP3450571B1 (fr) | 2014-02-24 | 2023-04-05 | Celgene Corporation | Procédés d'utilisation d'un activateur du céréblon pour l'expansion de cellules neurales et le traitement de troubles du système nerveux central |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| US20170066779A1 (en) | 2014-03-05 | 2017-03-09 | Idenix Pharmaceuticals Llc | Solid forms of a flaviviridae virus inhibitor compound and salts thereof |
| TWI705967B (zh) | 2014-03-20 | 2020-10-01 | 美商卡佩拉醫療公司 | 苯并咪唑衍生物及其醫藥組合物及使用方法 |
| CA3175724C (fr) | 2014-03-20 | 2024-01-09 | Capella Therapeutics, Inc. | Derives de benzimidazole, compositions pharmaceutiques et methodes d'utilisation |
| EP3142649B1 (fr) | 2014-05-12 | 2019-07-24 | Conatus Pharmaceuticals, Inc. | Traitement des complications de maladies hépatiques chroniques avec l'inhibiteur de caspase emricasan |
| DK3148579T3 (da) | 2014-05-28 | 2021-03-08 | Agenus Inc | Anti-gitr antistoffer og fremgangsmåder til anvendelse deraf |
| US9527815B2 (en) | 2014-06-18 | 2016-12-27 | Biotheryx, Inc. | Hydroxypyridone derivatives, pharmaceutical compositions thereof, and their therapeutic use for treating inflammatory, neurodegenerative, or immune-mediated diseases |
| US9499514B2 (en) | 2014-07-11 | 2016-11-22 | Celgene Corporation | Antiproliferative compounds and methods of use thereof |
| US20160045609A1 (en) | 2014-08-14 | 2016-02-18 | Mamoun M. Alhamadsheh | Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life |
| JP2017526713A (ja) | 2014-09-12 | 2017-09-14 | トビラ セラピューティクス, インコーポレイテッド | 線維症を処置するためのセニクリビロック併用療法 |
| EP3209658A1 (fr) | 2014-10-24 | 2017-08-30 | Biogen MA Inc. | Dérivés de diterpénoïdes et leurs procédés d'utilisation |
| EP3789039A1 (fr) | 2014-12-22 | 2021-03-10 | The Rockefeller University | Anticorps agonistes anti-mertk et leurs utilisations |
| HUE049801T2 (hu) | 2014-12-23 | 2020-10-28 | Sma Therapeutics Inc | 3,5-diaminopirazol kináz inhibitorok |
| CN113149982A (zh) | 2015-01-20 | 2021-07-23 | Xoc制药股份有限公司 | 麦角灵化合物及其用途 |
| CN107428749B (zh) | 2015-01-28 | 2020-07-24 | 上海复旦张江生物医药股份有限公司 | 取代的咪唑并[1,2-α]吡啶-2-基胺化合物及其药物组合物和使用方法 |
| KR102740384B1 (ko) | 2015-03-03 | 2024-12-06 | 키맵 리미티드 | 항체, 용도 및 방법 |
| CA2986765A1 (fr) | 2015-05-29 | 2016-12-08 | Agenus Inc. | Anticorps anti-ctla-4 et methodes d'utilisation de ceux-ci |
| WO2016210180A2 (fr) | 2015-06-23 | 2016-12-29 | Neurocrine Biosciences, Inc. | Inhibiteurs de vmat2 pour le traitement de maladies ou troubles neurologiques |
| EP3344656A1 (fr) | 2015-09-01 | 2018-07-11 | Agenus Inc. | Anticorps anti-pd1 et méthodes d'utilisation de ceux-ci |
| IL284874B2 (en) | 2015-10-30 | 2023-10-01 | Neurocrine Biosciences Inc | Valbenazine salts and polymorphs thereof |
| WO2017079566A1 (fr) | 2015-11-05 | 2017-05-11 | Conatus Pharmaceuticals, Inc. | Inhibiteurs de caspase destinés à être utilisés dans le traitement du cancer |
| US10112924B2 (en) | 2015-12-02 | 2018-10-30 | Astraea Therapeutics, Inc. | Piperdinyl nociceptin receptor compounds |
| EP4455145A3 (fr) | 2015-12-02 | 2025-03-12 | Astraea Therapeutics, LLC | Composés de récepteur de la pipéridinyl nociceptine |
| LT3394057T (lt) | 2015-12-23 | 2022-06-27 | Neurocrine Biosciences, Inc. | Sintezės būdas, skirtas pagaminti (s)-(2r,3r,11br)-3-izobutil-9,10-dimetoksi-2,3,4,6,7,11b-heksahidro-1h-pirido[2,1-a]izochinolin-2-ilo 2-amino-3-metilbutanoato di(4-metilbenzensulfonatą) |
| EP3397251A1 (fr) | 2015-12-31 | 2018-11-07 | Conatus Pharmaceuticals, Inc. | Méthodes d'utilisation d'inhibiteurs de caspase dans le traitement d'une hépatopathie |
| MX385964B (es) | 2016-01-08 | 2025-03-18 | Celgene Corp | Formas sólidas de 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolin-5-il) metil)-2,2-difluoroacetamida y sus composiciones farmacéuticas y usos. |
| EP3399978B1 (fr) | 2016-01-08 | 2020-09-09 | Celgene Corporation | Composés antiprolifératifs, leurs compositions pharmaceutiques et leurs utilisations |
| US10960013B2 (en) | 2016-03-04 | 2021-03-30 | East Carolina University | J-series prostaglandin-ethanolamides as novel therapeutics for skin and/or oral disorders |
| US10064855B2 (en) | 2016-03-08 | 2018-09-04 | Los Gatos Pharmaceuticals, Inc. | Composite nanoparticles and uses thereof |
| WO2017156183A1 (fr) | 2016-03-08 | 2017-09-14 | Los Gatos Pharmaceuticals, Inc. | Dérivés de camptothécine et leurs utilisations |
| WO2017180589A1 (fr) | 2016-04-11 | 2017-10-19 | Auspex Pharmaceuticals, Inc. | Dérivés de kétamine deutérés |
| EP4190357A1 (fr) | 2016-05-13 | 2023-06-07 | Institut Pasteur | Inhibition de recepteurs nicotiniques beta-2 de l'acetylcholine pour traiter la pathologie de la maladie d'alzheimer |
| TWI753910B (zh) | 2016-05-16 | 2022-02-01 | 美商拜歐斯瑞克斯公司 | 吡啶硫酮、其醫藥組合物及其治療增生性、炎性、神經退化性或免疫介導疾病之治療用途 |
| MX389710B (es) | 2016-05-27 | 2025-03-20 | Agenus Inc | Anticuerpos anti proteina inmunoglobulina de linfocitos t y dominio de mucina 3 (tim-3) y métodos para usarlos. |
| DE102016111064A1 (de) * | 2016-06-16 | 2017-12-21 | Vossloh-Werke Gmbh | Elastisches Element für einen Befestigungspunkt für eine Schiene für Schienenfahrzeuge und Befestigungspunkt |
| CN106087611B (zh) * | 2016-06-20 | 2019-07-12 | 勾厚渝 | 轨道交通构件 |
| EP3481864A1 (fr) | 2016-07-08 | 2019-05-15 | Staten Biotechnology B.V. | Anticorps anti-apoc3 et leurs méthodes d'utilisation |
| US10919904B2 (en) | 2016-08-17 | 2021-02-16 | North Carolina State University | Northern-southern route to synthesis of bacteriochlorins |
| MX390121B (es) | 2016-09-19 | 2025-03-20 | Mei Pharma Inc | Combinaciones de un inhibidor de btk y un inhibidor de pi3k para tratar neoplasias malignas hematológicas. |
| KR102576042B1 (ko) | 2016-10-11 | 2023-09-07 | 아게누스 인코포레이티드 | 항-lag-3 항체 및 이의 사용 방법 |
| US11779604B2 (en) | 2016-11-03 | 2023-10-10 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses and methods |
| KR102431830B1 (ko) | 2016-11-07 | 2022-08-16 | 주식회사 뉴라클사이언스 | 서열 유사성을 가진 항-패밀리 19, 멤버 a5 항체 및 그것의 사용 방법 |
| WO2018089692A1 (fr) | 2016-11-09 | 2018-05-17 | Phloronol, Inc. | Dérivés d'eckol, procédés de synthèse et utilisations associées |
| WO2018089427A1 (fr) | 2016-11-09 | 2018-05-17 | Novomedix, Llc | Sels de nitrite de 1,1-dimethylbiguanide, compositions pharmaceutiques et méthodes d'utilisation |
| WO2018102252A1 (fr) | 2016-11-30 | 2018-06-07 | North Carolina State University | Procédés de fabrication de macrocycles bactériochlorines comprenant un noyau isocyclique annelé et des composés apparentés |
| JP7105774B2 (ja) | 2016-12-01 | 2022-07-25 | イグナイタ インコーポレイテッド | がん治療のための方法 |
| TW202345829A (zh) | 2016-12-02 | 2023-12-01 | 美商紐羅克里生物科學有限公司 | 戊苯那嗪(valbenazine)於治療精神分裂症或情感性精神分裂症之用途 |
| CN118634323A (zh) | 2016-12-07 | 2024-09-13 | 艾吉纳斯公司 | 抗体和其使用方法 |
| FI3551660T3 (fi) | 2016-12-07 | 2023-12-11 | Agenus Inc | Anti-ctla-4-vasta-aineita ja niiden käyttömenetelmiä |
| KR20230169457A (ko) | 2017-01-27 | 2023-12-15 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 특정 vmat2 억제제의 투여 방법 |
| AU2018220515B2 (en) | 2017-02-17 | 2022-06-30 | DayLife LLC | Universal antivenom |
| CN116730920A (zh) | 2017-02-17 | 2023-09-12 | 文涵治疗有限公司 | Ag-10的制备方法、其中间体及其盐 |
| WO2018164996A1 (fr) | 2017-03-06 | 2018-09-13 | Neurocrine Biosciences, Inc. | Posologie pour la valbénazine |
| KR20190133198A (ko) | 2017-03-27 | 2019-12-02 | 셀진 코포레이션 | 면역원성의 감소를 위한 방법 및 조성물 |
| JP7297672B2 (ja) | 2017-04-13 | 2023-06-26 | アジェナス インコーポレイテッド | 抗cd137抗体およびその使用方法 |
| CA3059133A1 (fr) | 2017-04-21 | 2018-10-25 | Staten Biotechnology B.V. | Anticorps anti-apoc3 et leurs methodes d'utilisation |
| US20200179352A1 (en) | 2017-04-26 | 2020-06-11 | Neurocrine Biosciences, Inc. | Use of valbenazine for treating levodopa-induced dyskinesia |
| RS64576B1 (sr) | 2017-05-01 | 2023-10-31 | Agenus Inc | Anti-tigit antitela i postupci njihove primene |
| JOP20190219A1 (ar) | 2017-05-09 | 2019-09-22 | Cardix Therapeutics LLC | تركيبات صيدلانية وطرق لعلاج أمراض القلب والأوعية الدموية |
| US10085999B1 (en) | 2017-05-10 | 2018-10-02 | Arixa Pharmaceuticals, Inc. | Beta-lactamase inhibitors and uses thereof |
| CA3067416A1 (fr) | 2017-06-27 | 2019-01-03 | Neuracle Science Co., Ltd. | Utilisation d'anticorps anti-fam19a5 pour le traitement de cancers |
| CN111344011B (zh) | 2017-06-27 | 2024-01-26 | 纽洛可科学有限公司 | 抗fam19a5抗体用于治疗纤维化的用途 |
| JP7076059B2 (ja) | 2017-06-27 | 2022-05-27 | ニューラクル サイエンス カンパニー リミテッド | 抗fam19a5抗体及びその用途 |
| JP6904616B2 (ja) | 2017-06-27 | 2021-07-21 | ニューラクル サイエンス カンパニー リミテッド | 緑内障治療のための配列相同性を有するファミリー、メンバーa5抗体の用途 |
| ES2953032T3 (es) | 2017-09-01 | 2023-11-07 | Univ East Carolina | Métodos ex vivo para la activación de las células inmunológicas |
| RS66714B1 (sr) | 2017-09-21 | 2025-05-30 | Neurocrine Biosciences Inc | Formulacija visoke doze valbenazina i sastavi, postupci i kompleti povezani sa njim |
| CN111263820B (zh) | 2017-10-02 | 2024-07-02 | 纽洛可科学有限公司 | 抗序列相似家族19成员a5抗体用于治疗和诊断情绪障碍的用途 |
| CA3076920A1 (fr) | 2017-10-04 | 2019-04-11 | The Regents Of The University Of California | Oligosaccharides immunomodulateurs |
| MX2020003421A (es) | 2017-10-10 | 2020-07-20 | Neurocrine Biosciences Inc | Metodos para la administracion de ciertos inhibidores del transportador vesicular de monoamina 2 (vmat2). |
| KR20250070134A (ko) | 2017-10-10 | 2025-05-20 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 특정 vmat2 억제제의 투여 방법 |
| CA3080103A1 (fr) | 2017-10-31 | 2019-05-09 | Staten Biotechnology B.V. | Anticorps anti-apoc3 et leurs procedes d'utilisation |
| WO2019139871A1 (fr) | 2018-01-10 | 2019-07-18 | Cura Therapeutics Llc | Compositions pharmaceutiques comprenant des acides dicarboxyliques et leurs applications thérapeutiques |
| AU2019207491A1 (en) | 2018-01-10 | 2020-07-30 | Cura Therapeutics, Llc | Pharmaceutical compositions comprising phenylsulfonamides, and their therapeutic applications |
| MA52137A (fr) | 2018-03-23 | 2021-01-27 | Eidos Therapeutics Inc | Méthodes de traitement de l'amylose ttr à l'aide d'ag10 |
| AU2019259798A1 (en) | 2018-04-24 | 2020-11-12 | Neuracle Science Co., Ltd. | Use of anti-family with sequence similarity 19, member A5 antibodies for the treatment of neuropathic pain |
| KR20240056644A (ko) | 2018-05-10 | 2024-04-30 | 주식회사 뉴라클사이언스 | 서열 유사성 19, 멤버 a5 항체를 갖는 항-패밀리 및 그의 사용 방법 |
| EP3806856A1 (fr) | 2018-06-14 | 2021-04-21 | Neurocrine Biosciences, Inc. | Composés inhibiteurs de vmat2, compositions et méthodes associées |
| CN108836091B (zh) * | 2018-06-27 | 2020-12-04 | 贵州筑信达创科技有限公司 | 导轨 |
| CN108533609B (zh) * | 2018-06-27 | 2020-03-10 | 贵州筑信达创科技有限公司 | 导轨及滑动件的组合结构 |
| EP3814327A1 (fr) | 2018-06-29 | 2021-05-05 | Histogen, Inc. | Dérivés d'acide (s)-3-(2-(4-(benzyl)-3-oxopipérazin-1-yl)acétamido)-4-oxo-5-(2,3,5,6-tétrafluorophénoxy)pentanoïque et composés apparentés utilisés en tant qu'inhibiteurs de caspase pour le traitement de maladies cardiovasculaires |
| IL280199B2 (en) | 2018-07-20 | 2025-08-01 | Pf Medicament | Receptor for vista |
| MA53239A (fr) | 2018-08-15 | 2022-05-04 | Neurocrine Biosciences Inc | Procédés d'administration de certains inhibiteurs de vmat2 |
| AU2019321583C1 (en) | 2018-08-17 | 2025-11-27 | Eidos Therapeutics, Inc. | Formulations of AG10 |
| AU2019352017A1 (en) | 2018-10-03 | 2021-05-06 | Staten Biotechnology B.V. | Antibodies specific for human and cynomolgus ApoC3 and methods of use thereof |
| AU2019363368A1 (en) | 2018-10-16 | 2021-05-13 | Neuracle Science Co., Ltd. | Use of anti-FAM19A5 antibodies |
| CN113365650A (zh) | 2018-11-16 | 2021-09-07 | 新免疫技术有限公司 | 用il-7蛋白和免疫检查点抑制剂的组合治疗肿瘤的方法 |
| WO2020118042A1 (fr) | 2018-12-05 | 2020-06-11 | Jacobs Wagner Christine | Peptidoglycane de borrelia burgdorferi en tant qu'agent diagnostique et cible pour une intervention thérapeutique dans des pathologies associées à la maladie de lyme |
| KR20200071198A (ko) | 2018-12-10 | 2020-06-19 | 네오이뮨텍, 인코퍼레이티드 | Nrf2 발현 조절 기반 T 세포 항암면역치료법 |
| EP3898609A1 (fr) | 2018-12-19 | 2021-10-27 | Shy Therapeutics LLC | Composés interagissant avec la superfamille ras pour le traitement de cancers, de maladies inflammatoires, de rasopathies et de maladie fibrotique |
| JP7239216B2 (ja) | 2018-12-27 | 2023-03-14 | ニューラクル サイエンス カンパニー リミテッド | 粥状硬化症を治療するための抗fam19a5抗体の使用 |
| CN113195533B (zh) | 2019-01-02 | 2024-04-26 | 纽洛可科学有限公司 | 抗序列相似家族19成员a5的抗体及其使用方法 |
| TWI839461B (zh) | 2019-02-06 | 2024-04-21 | 美商戴斯阿爾法股份有限公司 | Il-17a調節物及其用途 |
| ES2978570T3 (es) | 2019-02-26 | 2024-09-16 | Inspirna Inc | Anticuerpos anti-MERTK de alta afinidad y sus usos |
| WO2020181165A1 (fr) | 2019-03-07 | 2020-09-10 | Conatus Pharmaceuticals Inc. | Inhibiteurs de caspase et leurs procédés d'utilisation |
| CN114222802B (zh) | 2019-05-20 | 2025-07-11 | 尼尔瓦纳科学股份有限公司 | 窄发射染料、包含其的组合物以及制备和使用其的方法 |
| JP7754724B2 (ja) | 2019-05-20 | 2025-10-15 | ニルバナ サイエンシーズ インク. | 発光波長の範囲が狭い発光染料、それを含む組成物及びそれを製造及び使用する方法 |
| AU2020311404A1 (en) | 2019-07-11 | 2022-03-03 | Cura Therapeutics, Llc | Sulfone compounds and pharmaceutical compositions thereof, and their therapeutic applications for the treatment of neurodegenerative diseases |
| AU2020310190A1 (en) | 2019-07-11 | 2022-02-24 | Cura Therapeutics, Llc | Phenyl compounds and pharmaceutical compositions thereof, and their therapeutic applications |
| US10940141B1 (en) | 2019-08-23 | 2021-03-09 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
| KR20220053007A (ko) | 2019-08-30 | 2022-04-28 | 아게누스 인코포레이티드 | 항-cd96 항체 및 이의 사용 방법 |
| JP7566889B2 (ja) | 2019-09-16 | 2024-10-15 | ダイス・アルファ・インコーポレイテッド | Il-17aモジュレーターおよびその使用 |
| KR102337657B1 (ko) * | 2019-11-06 | 2021-12-09 | 한국철도기술연구원 | 철도진동저감용 조립식 블록 및 이를 이용한 블록 구조물 |
| US20230057939A1 (en) | 2020-01-13 | 2023-02-23 | Neoimmunetech, Inc. | Method of treating a tumor with a combination of il-7 protein and a bispecific antibody |
| CN113136745B (zh) * | 2020-01-17 | 2024-10-25 | 洛阳双瑞橡塑科技有限公司 | 一种轨道道床吸音减振装置 |
| WO2021151001A1 (fr) | 2020-01-22 | 2021-07-29 | Outpace Bio, Inc. | Polypeptides chimères |
| US20230210952A1 (en) | 2020-02-05 | 2023-07-06 | Washington University | Method of treating a solid tumor with a combination of an il-7 protein and car-bearing immune cells |
| US12006643B2 (en) * | 2020-05-27 | 2024-06-11 | Mute Wall Systems, Inc. | Sound dampening barrier wall |
| EP4157271A1 (fr) | 2020-05-29 | 2023-04-05 | Boulder Bioscience LLC | Procédés pour une thrombectomie endovasculaire améliorée à l'aide de 3,3'-diindolylméthane |
| WO2021257828A1 (fr) | 2020-06-18 | 2021-12-23 | Shy Therapeutics, Llc | Thiénopyrimidines qui interagissent avec la superfamille ras pour le traitement de cancers, de maladies inflammatoires, de rasopathies et d'une maladie fibreuse |
| EP4149471A4 (fr) | 2020-06-30 | 2024-07-10 | Prosetta Biosciences, Inc. | Dérivés d'isoquinoléine, leurs procédés de synthèse et leurs utilisations |
| WO2022061348A1 (fr) | 2020-09-16 | 2022-03-24 | Biotheryx, Inc. | Agents de dégradation de protéine sos1, compositions pharmaceutiques de ceux-ci, et leurs applications thérapeutiques |
| TW202231269A (zh) | 2020-10-23 | 2022-08-16 | 美商拜歐斯瑞克斯公司 | Kras蛋白降解劑、其醫藥組合物及其治療應用 |
| US20240101629A1 (en) | 2020-11-02 | 2024-03-28 | Neoimmunetech, Inc. | Use of interleukin-7 for the treatment of coronavirus |
| CN116615236A (zh) | 2020-11-05 | 2023-08-18 | 新免疫技术有限公司 | 用il-7蛋白和核苷酸疫苗的组合治疗肿瘤的方法 |
| CN112712784B (zh) * | 2020-11-30 | 2024-12-31 | 南京华秦光声科技有限责任公司 | 一种低频宽带平板吸声结构 |
| AU2021402911A1 (en) | 2020-12-14 | 2023-07-06 | Biotheryx, Inc. | Pde4 degraders, pharmaceutical compositions, and therapeutic applications |
| US20240124483A1 (en) | 2021-01-27 | 2024-04-18 | Shy Therapeutics, Llc | Methods for the Treatment of Fibrotic Disease |
| US20240309015A1 (en) | 2021-01-27 | 2024-09-19 | Shy Therapeutics, Llc | Methods for the Treatment of Fibrotic Disease |
| IL305752A (en) | 2021-03-10 | 2023-11-01 | Dice Molecules Sv Inc | INTEGRIN INHIBITORS OF ALPHA V BETA 6 AND ALPHA V BETA 1 AND THEIR USES |
| WO2022226166A1 (fr) | 2021-04-22 | 2022-10-27 | Protego Biopharma, Inc. | Imidazolidinediones et imidazolidinones spirocycliques pour le traitement d'une amylose à chaîne légère |
| EP4347568A1 (fr) | 2021-05-27 | 2024-04-10 | Protego Biopharma, Inc. | Hétéroaryl-diamides activateurs d'ire1/xbp1s |
| WO2022251644A1 (fr) | 2021-05-28 | 2022-12-01 | Lyell Immunopharma, Inc. | Cellules immunitaires déficientes en nr4a3 et leurs utilisations |
| JP2024520676A (ja) | 2021-06-02 | 2024-05-24 | ライエル・イミュノファーマ・インコーポレイテッド | Nr4a3欠損免疫細胞及びその使用 |
| CA3218481A1 (fr) | 2021-06-14 | 2022-12-22 | argenx BV | Anticorps anti-il-9 et leurs procedes d'utilisation |
| WO2022266249A1 (fr) | 2021-06-16 | 2022-12-22 | Biotheryx, Inc. | Agents de dégradation de protéine kras, compositions pharmaceutiques associées, et leurs applications thérapeutiques |
| JP2024522768A (ja) | 2021-06-16 | 2024-06-21 | バイオセリックス, インコーポレイテッド | Sos1タンパク質分解剤、その医薬組成物及びそれらの治療的応用 |
| US20240277857A1 (en) | 2021-09-29 | 2024-08-22 | Nbios, Inc. | Coiled-coil fusion protein |
| AU2022368836A1 (en) | 2021-10-22 | 2024-05-02 | Prosetta Biosciences, Inc. | Novel host-targeted pan-respiratory antiviral small molecule therapeutics |
| KR20240115979A (ko) | 2021-11-08 | 2024-07-26 | 프로젠토스 테라퓨틱스, 인크. | 혈소판-유래 성장 인자 수용체(pdgfr) 알파 억제제 및 이의 용도 |
| EP4456907A1 (fr) | 2021-12-30 | 2024-11-06 | NeoImmuneTech, Inc. | Procédé de traitement d'une tumeur avec une combinaison d'une protéine il-7 et d'un antagoniste du vegf |
| WO2023129577A1 (fr) | 2022-01-03 | 2023-07-06 | Lilac Therapeutics, Inc. | Promédicaments à base de thiol cyclique |
| JP2025501308A (ja) | 2022-01-03 | 2025-01-17 | ライラック セラピューティクス, インク. | 非環式チオールプロドラッグ |
| WO2023157989A1 (fr) | 2022-02-17 | 2023-08-24 | 주식회사 노벨티노빌리티 | Conjugué anticorps-médicament |
| JP2025507621A (ja) | 2022-03-02 | 2025-03-21 | ミトパワー, インク. | ニコチン酸及びリボースから誘導体化した新規プロドラッグ |
| WO2023192904A1 (fr) | 2022-03-30 | 2023-10-05 | Biomarin Pharmaceutical Inc. | Oligonucléotides de saut d'exon de dystrophine |
| GB2619907A (en) | 2022-04-01 | 2023-12-27 | Kanna Health Ltd | Novel crystalline salt forms of mesembrine |
| AR129053A1 (es) | 2022-04-14 | 2024-07-10 | Bristol Myers Squibb Co | Nuevos compuestos gspt1 y métodos de uso de los nuevos compuestos |
| AU2023265665A1 (en) | 2022-05-05 | 2024-10-10 | Biomarin Pharmaceutical Inc. | Method of treating duchenne muscular dystrophy |
| IL316794A (en) | 2022-05-10 | 2025-01-01 | Biotheryx Inc | CDK protease inhibitors, pharmaceuticals and therapeutic applications |
| KR20250027283A (ko) | 2022-05-19 | 2025-02-25 | 라이엘 이뮤노파마, 인크. | nr4a3을 표적하는 폴리뉴클레오타이드 및 이의 용도 |
| JP2025531869A (ja) | 2022-09-09 | 2025-09-25 | イノヴォ セラピューティクス、インコーポレイテッド | CK1αおよびDUAL CK1α/GSPT1分解化合物 |
| EP4593826A1 (fr) | 2022-09-30 | 2025-08-06 | Boulder Bioscience LLC | Compositions comprenant du 3,3'-diindolylméthane pour traiter une blessure fermée à la tête non hémorragique |
| JP2025537484A (ja) | 2022-10-21 | 2025-11-18 | ダイアゴナル・セラピューティクス・インコーポレイテッド | Il-18受容体に対するヘテロマーアゴニスト抗体 |
| WO2024092040A1 (fr) | 2022-10-26 | 2024-05-02 | Protego Biopharma, Inc. | Composés hétéroaryle bicycliques contenant un spirocycle |
| US20240174673A1 (en) | 2022-10-26 | 2024-05-30 | Protego Biopharma, Inc. | Spirocycle Containing Pyridine Compounds |
| EP4608838A1 (fr) | 2022-10-26 | 2025-09-03 | Protego Biopharma, Inc. | Composés de pyridone contenant un spirocycle |
| KR20250089492A (ko) | 2022-11-07 | 2025-06-18 | 네오이뮨텍, 인코퍼레이티드 | 비메틸화된 mgmt 프로모터를 갖는 종양의 치료 방법 |
| WO2024118810A1 (fr) | 2022-11-30 | 2024-06-06 | Protego Biopharma, Inc. | Activateurs de ire1/xbp1 diamide de pyrazole cyclique |
| EP4626864A1 (fr) | 2022-11-30 | 2025-10-08 | Protego Biopharma, Inc. | Diamides hétéroaryles linéaires comme activateurs d'ire1/xbp1s |
| KR102870410B1 (ko) * | 2022-12-09 | 2025-10-16 | 한국전자기술연구원 | 방음재 및 소음 제어 시스템 |
| WO2024194685A2 (fr) | 2023-03-17 | 2024-09-26 | Oxitope Pharma B.V. | Anticorps anti-phosphocholine et leurs procédés d'utilisation |
| AU2024240129A1 (en) | 2023-03-17 | 2025-10-09 | Oxitope Pharma B.V. | Anti-phosphocholine antibodies and methods of use thereof |
| EP4688147A1 (fr) | 2023-04-07 | 2026-02-11 | Diagonal Therapeutics Inc. | Anticorps agonistes bispécifiques pour activer un récepteur de type 1 (alk1) |
| AU2024254039A1 (en) | 2023-04-07 | 2025-10-02 | Diagonal Therapeutics Inc. | Hinge-modified bispecific antibodies |
| WO2024226471A2 (fr) | 2023-04-24 | 2024-10-31 | Biomarin Pharmaceutical Inc. | Compositions et méthodes de traitement de troubles liés à stxbp1 |
| TW202448485A (zh) | 2023-05-05 | 2024-12-16 | 美商拜奧馬林製藥公司 | 肌萎縮蛋白外顯子跳躍寡核苷酸 |
| EP4709725A1 (fr) | 2023-05-09 | 2026-03-18 | Progentos Therapeutics, Inc. | Composés hétérocycliques et leurs utilisations |
| AU2024276812A1 (en) | 2023-05-19 | 2025-11-06 | Diagonal Therapeutics Inc. | Bispecific agonistic antibodies to il12 receptor |
| KR20260033048A (ko) | 2023-07-03 | 2026-03-10 | 네오이뮨텍, 인코퍼레이티드 | 이종이합체 fc 분자 및 이의 용도 |
| WO2025046298A2 (fr) | 2023-09-01 | 2025-03-06 | iTeos Belgium SA | Anticorps anti-trem2 et procédés d'utilisation |
| AU2024344247A1 (en) | 2023-09-19 | 2026-05-07 | Kancure Pte. Ltd. | Survivin-targeted compounds |
| IL327069A (en) | 2023-09-27 | 2026-05-01 | Isosterix Inc | Mist inhibitors |
| WO2025085416A1 (fr) | 2023-10-16 | 2025-04-24 | Bristol-Myers Squibb Company | Composés gspt1 et procédés d'utilisation des composés |
| AU2024366926A1 (en) | 2023-10-23 | 2026-03-12 | Diagonal Therapeutics Inc. | Heteromeric agonistic antibodies to il-18 receptor |
| GB2636969A (en) | 2023-11-24 | 2025-07-09 | Ontrack Therapeutics Ltd | Novel crystalline salt forms |
| WO2025133707A1 (fr) | 2023-12-19 | 2025-06-26 | Vectory Therapeutics B.V. | Anticorps anti-tdp-43 et leurs utilisations |
| WO2025147691A1 (fr) | 2024-01-04 | 2025-07-10 | Innovo Therapeutics, Inc. | Compositions et procédés de dégradation de protéine de translocation nucléaire de récepteur d'hydrocarbure aryle |
| WO2025179161A1 (fr) | 2024-02-21 | 2025-08-28 | Innovo Therapeutics, Inc. | Composés de dégradation de protéines |
| WO2025201633A1 (fr) | 2024-03-26 | 2025-10-02 | Chen Gefei | Agent pour réduire la formation d'amyloïdes |
| WO2025255341A1 (fr) | 2024-06-05 | 2025-12-11 | Protego Biopharma, Inc. | Activateurs de tétrahydrofuranyle ire1/xbp1s |
| WO2026080748A2 (fr) | 2024-10-09 | 2026-04-16 | Diagonal Therapeutics Inc. | Anticorps du récepteur de la protéine morphogénétique osseuse de type 2 (bmprii) |
| WO2026080752A2 (fr) | 2024-10-09 | 2026-04-16 | Diagonal Therapeutics Inc. | Nouvel anticorps dirigé contre la kinase 1 de type récepteur de l'activine (alk1) |
| WO2026080757A2 (fr) | 2024-10-09 | 2026-04-16 | Diagonal Therapeutics Inc. | Anticorps du récepteur de l'activine de type ii a/b (actriia/b) |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3991848A (en) * | 1974-08-16 | 1976-11-16 | Frigitemp | Acoustical board |
| US4142468A (en) * | 1976-04-20 | 1979-03-06 | Charles Birnstiel | Elevated rail transit guideway with noise attenuators |
| US4093120A (en) | 1977-01-24 | 1978-06-06 | Park Rubber Company | Railroad crossing structure |
| DE7711191U1 (de) | 1977-04-07 | 1978-09-28 | Straetner Geb. Buss, Anita, 4300 Essen | Fahrbahnplatte fuer schienengleiche bahnuebergaenge |
| DE7719283U1 (de) | 1977-06-20 | 1977-10-27 | Gummiwerk Kraiburg Gmbh & Co, 8264 Waldkraiburg | Platte fuer schienengleiche bahnuebergaenge |
| DE3602313A1 (de) * | 1986-01-27 | 1987-07-30 | Clouth Gummiwerke Ag | Schallabsorbierender laermschutz insbesondere fuer schotterlose gleise |
| DE3827547C2 (de) * | 1988-08-13 | 2000-09-21 | Zueblin Ag | Schallabsorptionskonstruktion für schotterlose Eisenbahnoberbauten |
| US4960184A (en) * | 1989-11-09 | 1990-10-02 | Bruce Woodward | Sound absorbing structure |
| DE4243102A1 (en) * | 1991-12-20 | 1993-07-01 | Bold Karl Gmbh & Co | Noise protection and sight wall with carrier girder construction |
| DE69405881T2 (de) * | 1994-02-11 | 1998-03-19 | Autostrade Concess Const | Schalldämpfender strassenbelag und verfahren zu dessen herstellung |
| DE4414566C2 (de) * | 1994-04-27 | 1997-11-20 | Freudenberg Carl Fa | Luftschalldämpfer |
| DE4417402A1 (de) | 1994-05-18 | 1995-11-23 | Gruenzweig & Hartmann Montage | Schallschutzeinrichtung zur Schalldämpfung und -dämmung an Gleiskörpern |
| NL194553C (nl) * | 1994-06-06 | 2002-07-02 | Veldhoen Raalte B V | Inrichting voor de geluidsisolatie van een spoorbaan. |
| DE29515935U1 (de) * | 1995-10-07 | 1995-11-30 | Deutsche Asphalt GmbH, 63263 Neu-Isenburg | Schallabsorber für einen schotterlosen Eisenbahnoberbau |
| IT1293307B1 (it) * | 1997-07-09 | 1999-02-16 | Dieselbox Sa | Barriera antirumore a pannelli trasparenti,dotata di caratteristiche fonoisolanti e fonoassorbenti |
-
1997
- 1997-05-19 TW TW086106684A patent/TW345603B/zh not_active IP Right Cessation
- 1997-05-23 DK DK97922748T patent/DK0901536T3/da active
- 1997-05-23 AU AU28801/97A patent/AU738889B2/en not_active Ceased
- 1997-05-23 US US09/194,505 patent/US6253872B1/en not_active Expired - Lifetime
- 1997-05-23 HU HU9903612A patent/HU221872B1/hu not_active IP Right Cessation
- 1997-05-23 ES ES97922748T patent/ES2186891T3/es not_active Expired - Lifetime
- 1997-05-23 CA CA002255946A patent/CA2255946C/fr not_active Expired - Fee Related
- 1997-05-23 AT AT97922748T patent/ATE229595T1/de active
- 1997-05-23 JP JP54125697A patent/JP3822641B2/ja not_active Expired - Fee Related
- 1997-05-23 CN CNB971950490A patent/CN100424268C/zh not_active Expired - Fee Related
- 1997-05-23 WO PCT/AT1997/000109 patent/WO1997045592A1/fr not_active Ceased
- 1997-05-23 EP EP97922748A patent/EP0901536B1/fr not_active Expired - Lifetime
- 1997-05-23 DE DE59708955T patent/DE59708955D1/de not_active Expired - Lifetime
-
1998
- 1998-11-30 NO NO19985600A patent/NO316078B1/no not_active IP Right Cessation
Non-Patent Citations (1)
| Title |
|---|
| See references of WO9745592A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3822641B2 (ja) | 2006-09-20 |
| NO316078B1 (no) | 2003-12-08 |
| ES2186891T3 (es) | 2003-05-16 |
| WO1997045592A1 (fr) | 1997-12-04 |
| CA2255946A1 (fr) | 1997-12-04 |
| AU738889B2 (en) | 2001-09-27 |
| US6253872B1 (en) | 2001-07-03 |
| HUP9903612A2 (hu) | 2000-02-28 |
| HUP9903612A3 (en) | 2001-08-28 |
| NO985600L (no) | 1998-11-30 |
| CA2255946C (fr) | 2006-03-14 |
| CN100424268C (zh) | 2008-10-08 |
| HU221872B1 (hu) | 2003-02-28 |
| TW345603B (en) | 1998-11-21 |
| DK0901536T3 (da) | 2003-04-07 |
| CN1219989A (zh) | 1999-06-16 |
| AU2880197A (en) | 1998-01-05 |
| DE59708955D1 (de) | 2003-01-23 |
| JP2000510921A (ja) | 2000-08-22 |
| EP0901536B1 (fr) | 2002-12-11 |
| NO985600D0 (no) | 1998-11-30 |
| ATE229595T1 (de) | 2002-12-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0901536B1 (fr) | Dispositif d'insonorisation pour voies ferrees | |
| EP0904461B1 (fr) | Recouvrement de niveau avec des rails, pour voies ferrees | |
| WO2013075159A1 (fr) | Dispositif anti-bruit | |
| EP0214524B1 (fr) | Moellon ou pavé en béton ou en matériau similaire | |
| DE19705531C2 (de) | Vorrichtung zur Überbrückung von Dehnfugen | |
| EP0149697A1 (fr) | Couvre-joint pour joints de dilatation dans des chaussées, en particulier dans des tabliers de pont | |
| DE4430769C2 (de) | Eisenbahnoberbau mit einem auf einer durchgehenden Tragplatte aus Stahlbeton aufgelagerten Gleisrost | |
| DE3134473A1 (de) | Schotterloser oberbau fuer schienenbahnen | |
| DE102007037339A1 (de) | Gabionenkorb mit lärmdämmender, monolithischer Schicht aus Beton | |
| DE3827547C2 (de) | Schallabsorptionskonstruktion für schotterlose Eisenbahnoberbauten | |
| DE202011052057U1 (de) | Lärmschutzvorrichtung | |
| DE19514458A1 (de) | Schallabsorbierendes Wandelement | |
| DE29515935U1 (de) | Schallabsorber für einen schotterlosen Eisenbahnoberbau | |
| DE3544481A1 (de) | Schallschutzwand und dafuer geeignetes wandelement | |
| EP2817456B1 (fr) | Dispositif anti-bruit | |
| AT403809B (de) | Schallschutzeinrichtung für gleise | |
| EP1721045B1 (fr) | Garnissage pour voie ferree reduisant les nuisances sonores | |
| DE8717982U1 (de) | Schallabsorbierendes Bauelement | |
| DE19540357C1 (de) | Eisenbahnbrücke und Kulisse zur Schalldämpfung an dieser | |
| DE19635788A1 (de) | Schalldämpfungselement für Schienentrassen mit fester Fahrbahn | |
| EP1136622B1 (fr) | Recouvrement de voie ferrée | |
| EP0166719A2 (fr) | Joint d'étanchéité profilé | |
| AT512391B1 (de) | Lärmschutzvorrichtung | |
| DE2856367A1 (de) | Plattenbelag fuer daecher sowie tragelemente fuer diese | |
| DE2607538A1 (de) | Verbundformsteinelement |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 19981130 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT CH DE DK ES FI FR GB IT LI LU PT SE |
|
| AX | Request for extension of the european patent |
Free format text: SI PAYMENT 981130 |
|
| 17Q | First examination report despatched |
Effective date: 20000830 |
|
| GRAG | Despatch of communication of intention to grant |
Free format text: ORIGINAL CODE: EPIDOS AGRA |
|
| GRAG | Despatch of communication of intention to grant |
Free format text: ORIGINAL CODE: EPIDOS AGRA |
|
| GRAH | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOS IGRA |
|
| GRAH | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOS IGRA |
|
| GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
| AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AT CH DE DK ES FI FR GB IT LI LU PT SE |
|
| AX | Request for extension of the european patent |
Free format text: SI PAYMENT 19981130 |
|
| REF | Corresponds to: |
Ref document number: 229595 Country of ref document: AT Date of ref document: 20021215 Kind code of ref document: T |
|
| REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D Free format text: NOT ENGLISH |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP |
|
| REF | Corresponds to: |
Ref document number: 59708955 Country of ref document: DE Date of ref document: 20030123 |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: NV Representative=s name: A. BRAUN, BRAUN, HERITIER, ESCHMANN AG PATENTANWAE |
|
| REG | Reference to a national code |
Ref country code: DK Ref legal event code: T3 |
|
| GBT | Gb: translation of ep patent filed (gb section 77(6)(a)/1977) |
Effective date: 20030329 |
|
| REG | Reference to a national code |
Ref country code: ES Ref legal event code: FG2A Ref document number: 2186891 Country of ref document: ES Kind code of ref document: T3 |
|
| ET | Fr: translation filed | ||
| PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
| 26N | No opposition filed |
Effective date: 20030912 |
|
| REG | Reference to a national code |
Ref country code: SI Ref legal event code: IF |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: PFA Owner name: GMUNDNER FERTIGTEILE GESELLSCHAFT M.B.H. & CO. KG Free format text: GMUNDNER FERTIGTEILE GESELLSCHAFT M.B.H. & CO. KG.#KUFERZEILE 30-32#A-4810 GMUNDEN (AT) -TRANSFER TO- GMUNDNER FERTIGTEILE GESELLSCHAFT M.B.H. & CO. KG.#KUFERZEILE 30-32#A-4810 GMUNDEN (AT) |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: CH Payment date: 20120529 Year of fee payment: 16 Ref country code: DK Payment date: 20120522 Year of fee payment: 16 Ref country code: LU Payment date: 20120530 Year of fee payment: 16 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: FR Payment date: 20120529 Year of fee payment: 16 Ref country code: GB Payment date: 20120425 Year of fee payment: 16 Ref country code: SE Payment date: 20120518 Year of fee payment: 16 Ref country code: FI Payment date: 20120523 Year of fee payment: 16 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: IT Payment date: 20120516 Year of fee payment: 16 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: DE Payment date: 20120730 Year of fee payment: 16 Ref country code: ES Payment date: 20120504 Year of fee payment: 16 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: PT Payment date: 20120427 Year of fee payment: 16 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: AT Payment date: 20120525 Year of fee payment: 16 |
|
| REG | Reference to a national code |
Ref country code: PT Ref legal event code: MM4A Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20131125 |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL |
|
| REG | Reference to a national code |
Ref country code: SE Ref legal event code: EUG |
|
| REG | Reference to a national code |
Ref country code: AT Ref legal event code: MM01 Ref document number: 229595 Country of ref document: AT Kind code of ref document: T Effective date: 20130531 |
|
| GBPC | Gb: european patent ceased through non-payment of renewal fee |
Effective date: 20130523 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20130531 Ref country code: AT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20130531 Ref country code: CH Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20130531 Ref country code: SE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20130524 Ref country code: PT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20131125 Ref country code: DE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20131203 |
|
| REG | Reference to a national code |
Ref country code: DK Ref legal event code: EBP Effective date: 20130531 |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R119 Ref document number: 59708955 Country of ref document: DE Effective date: 20131203 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: FI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20130523 Ref country code: IT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20130523 |
|
| REG | Reference to a national code |
Ref country code: FR Ref legal event code: ST Effective date: 20140131 |
|
| REG | Reference to a national code |
Ref country code: SI Ref legal event code: KO00 Effective date: 20140225 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GB Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20130523 Ref country code: DK Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20130531 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: FR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20130531 |
|
| REG | Reference to a national code |
Ref country code: ES Ref legal event code: FD2A Effective date: 20140610 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: ES Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20130524 |
|
| PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20130523 |