EP0906126A1 - Pansement - Google Patents

Pansement

Info

Publication number
EP0906126A1
EP0906126A1 EP97926340A EP97926340A EP0906126A1 EP 0906126 A1 EP0906126 A1 EP 0906126A1 EP 97926340 A EP97926340 A EP 97926340A EP 97926340 A EP97926340 A EP 97926340A EP 0906126 A1 EP0906126 A1 EP 0906126A1
Authority
EP
European Patent Office
Prior art keywords
wound dressing
wound
dressing according
layer
section
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97926340A
Other languages
German (de)
English (en)
Inventor
Staffan Bowald
Gudmund Dvärsäter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Publication of EP0906126A1 publication Critical patent/EP0906126A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0203—Adhesive bandages or dressings with fluid retention members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/023—Adhesive bandages or dressings wound covering film layers without a fluid retention layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/425—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/64—Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00902—Plasters containing means
    • A61F2013/0091—Plasters containing means with disinfecting or anaesthetics means, e.g. anti-mycrobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00902—Plasters containing means
    • A61F2013/00927—Plasters containing means with biological activity, e.g. enzymes for debriding wounds or others, collagen or growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00902—Plasters containing means
    • A61F2013/00927—Plasters containing means with biological activity, e.g. enzymes for debriding wounds or others, collagen or growth factors
    • A61F2013/00931—Plasters containing means with biological activity, e.g. enzymes for debriding wounds or others, collagen or growth factors chitin

Definitions

  • the present invention relates to wound dressings for dressing of wounds on internal or external tissue structures of living human or animal bodies.
  • EP-A-0349505 (Astra Meditec AB) it is taught that the healing of soft tissue in mammals including man can be improved by the use of a porous flexible sheet of a protein-free bioresorbable polymer having a pore size which permits passage of water and salts therethrough but which locks out cells and other tissue particles.
  • the sheet is disclosed as causing a specific stimulating effect on the formation of macrophages in soft tissue, the macrophages releasing a growth factor which stimulates tissue healing.
  • EP-A-0349505 makes known forming a non-woven sheet of poly(3- hydroxybutyrate) having the requisite properties by pressing together solution-spun fibres of poly(3-hydroxybutyrate) manufactured in accordance with US-A-4603070 (Steel et al).
  • Such a dressing is relatively simple to manufacture. Moreover, the dressing is easy to apply and can be adapted to facilitate easy removal.
  • the dressing furthermore provides thermal insulation to maintain the body temperature in the vicinity of the wound surface and keeps the wound moist while removing excessive fluid from the wound. Ensuring that the upper section is essentially impermeable to bacteria also means that a barrier is presented to prevent infection from occurring.
  • the wound dressing of the invention may be left in place for a relatively long period. This means that fewer changes of dressing are needed than were hitherto, thus avoiding disturbing the healing process with less pain for the patient
  • the use of an upper section which is vapour permeable ensures that the wound is kept moist, irrespective of how effective the removal of excessive fluid from the wound may be. Preventing the wound from drying out results in pain being controlled.
  • the wound dressing is an integral structure.
  • Having the lower section of the wound dressing as a lower wound dressing layer, for instance a sheet, means that it can be easily put in position and used as a barrier facilitating the transport of exudate from the wound and retaining it away from the wound.
  • the wound dressing further comprises an intermediate section between the upper and lower sections which is adapted to absorb liquid.
  • the intermediate section may be of any suitable material, for example treated cellulose fibres or polyacrylic acids.
  • a hydrocoUoid is particularly suitable.
  • a hydrocoUoid is normally able to absorb four to six times its own volume of fluid, and new hydrocoUoids have been reported that absorb twenty times their own volume.
  • HydrocoUoids also are adhesive to the skin, so the hydrocoUoid can perform the dual function of intermediate absorbent layer and adhesive edge for the dressing.
  • the intermediate section of the second and third forms of the invention may be in the form of an intermediate wound dressing layer or instead be part of the upper or lower wound dressing layer of the wound dressing.
  • one or more of the wound dressing layers are in the form of one or more wound dressing sheets.
  • the wound dressing consists of the upper and lower wound dressing layers with the lower dressing layer being adhered to a lower surface of the upper wound dressing layer.
  • the wound dressing comprises the intermediate wound dressing layer the upper and lower wound dressing layers are respectively adhered to upper and lower surfaces of the intermediate wound dressing layer.
  • the lower wound dressing layer is releasably secured to the balance of the wound dressing.
  • the lower wound dressing layer may be releasably secured to the lower surface of the upper wound dressing layer or the lower surface of the intermediate wound dressing layer.
  • the lower section of the wound dressing is substantiaUy free of volatile solvent
  • the lower wound dressing layer is presented by a layer of particles of the bioresorbable material.
  • the particles may be supported in a matrix material, for example a gel matrix comprising hyaluronic acid.
  • the bioresorbable particulate material of the lower wound dressing layer is adhered to the lower surface of the upper or intermediate wound dressing layer by mixing the particles in a solvent, coating the mixture to the lower surface and then evaporating the solvent.
  • Chloroform may be mentioned as a suitable solvent
  • the lower section when the wound dressing dresses the wound the lower section is presented by a layer of loose particles or fibres of the bioresorbable material positioned on the wound.
  • the lower wound dressing layer may be a gel comprising the bioresorbable material coated onto the wound or one or more lower wound dressing sheets laid over the wound.
  • the bioresorbable material of the lower wound dressing layer is in fibre form, for example supported in a matrix such as a gel matrix formed from hyaluronic acid.
  • the lower wound dressing layer may take the form of one or more lower wound dressing fibre sheets, for example formed from non- woven fibres in which case the lower surface of the lower wound dressing layer may to advantage be roughened to expose ends of the fibres.
  • the bioresorbable material of the lower section is a polymer.
  • the polymer is protein-free, examples of which being poly(3-hydroxybutyrate) (PHB), polylactic acids, polyglycoUc acid, copolymers of glycolic acid and lactic acid, copolymers of lactic acid and ⁇ -aminocapronic acid, lactide polymers, polydesoxazon, copolymers of poly(3-hydroxybutyrate) and 3-hydroxyvalerate, polyesters of succinic acid and cross-linked hyaluronic acid.
  • PHB poly(3-hydroxybutyrate)
  • polylactic acids polyglycoUc acid
  • copolymers of glycolic acid and lactic acid copolymers of lactic acid and ⁇ -aminocapronic acid
  • lactide polymers polydesoxazon
  • copolymers of poly(3-hydroxybutyrate) and 3-hydroxyvalerate polyesters of succinic acid and cross-linked hyaluronic acid.
  • a protein-free bioresorbable polymer in the lower section appears to stimulate healing during degradation by stimulating macrophages, by forming a barrier against the surrounding and working as a scaffold for ceU growth.
  • the macrophage invasion caused by protein-free polymers covers the wound with tissue and controls the wound pain effectively in the first day or two. Vascularization and microcirculation occur, again stimulated by the polymer.
  • degradation of certain protein-free polymers such as PHB has a bacteriostatic and fungistatic effect and facUitates the wound heaUng of skin.
  • the invading macrophages also have a bactericidal effect.
  • the wound dressing can be left in place for a longer period owing to the bacteriostatic and fungistatic properties and the wound healing environment created beneath the dressing. Fewer changes of dressing means less disturbance of the healing process and less pain for the patient.
  • Poly(3-hydroxybutyrate) is the preferred material for the lower section because Applicant has found that PHB has the abUity to attract macrophages to the wound site at a greater rate than other polymers tested. The PHB also appears to lead to an increased vascularization, perhaps through a macrophage effect promoted by the PHB. In addition, the dressing period is further enhanced when PHB is used due to the fact that the bacteriostatic and fungistatic properties increase over time with the degradation of the PHB.
  • the lower section is formed as a fibrous PHB sheet, for instance a non-woven sheet, having hydrophobic fibres
  • the nature of the PHB fibres is such that the sheet has a capUlary capacity which aids in the exudate being drawn away from the wound and retained in the region between the sheet and the upper section.
  • a non-woven PHB fibre sheet wUl sweU during the first ten days or so by adding blood components and ceUs from the surrounding tissue owing to its construction despite the fibres being hydrophobic.
  • poly(3-hydroxybutyrate) is selected oligo(3-hydroxybutyrate), e.g. having 3 to 10 monomer units, may also be included in the lower section or may constitute the lower section.
  • the wound dressing is flexible thereby enabUng the dressing to follow the contour of the wound, for example a recessed wound.
  • the lower wound dressing layer is adapted to foUow the contour of the wound, for example by being flexible.
  • the lower section of the various forms of wound dressing according to the invention may support one or more growth factors.
  • the upper wound dressing layer of the wound dressing comprises a polymeric material.
  • the polymeric material may be bioresorbable and may further be protein-free.
  • the upper section may comprise poly(3-hydroxybutyrate).
  • the upper section may comprise a non- bioresorbable non-biodegradable material, non-limiting polymeric examples being polyurethane and polytetrafluoroethylene.
  • the intermediate wound dressing layer presents the adhesive edge.
  • a method of treatment of a wound on a tissue structure of a Uving human or animal body comprising the steps of applying to the wound a fluid permeable lower layer of a bioresorbable material which promotes healing processes in the wound and overlaying the lower layer with a vapour permeable, bacteria impermeable upper layer.
  • Fig. 2 is a cross-sectional side view of a second wound dressing in accordance with the present invention.
  • a wound dressing 10 in accordance with the present invention comprises a layer 1 of a bioresorbable material which promotes wound healing processes, in this case poly(3-hydroxybuty ⁇ ate) (hereinafter "PHB"), applied to a skin wound 2 in the form of a fibrous non-woven sheet substantially free of volatile solvent, and an exterior microporous layer 3 of a polyurethane polymer.
  • PHB poly(3-hydroxybuty ⁇ ate)
  • the pores of the exterior polymer layer 3 have a pore size of less than 0.22 ⁇ m. This renders the layer 3 permeable to vapour and gases whUst maintaining the layer 3 essentiaUy impermeable to bacteria.
  • a second wound dressing 110 in accordance with the present invention which comprises a layer 101 of PHB applied to a skin wound 102 in the form of a fibrous non-woven sheet substantiaUy free of volatile solvent and an exterior microporous layer 103 of a polyurethane polymer.
  • the PHB layer 101 is in the form of a patch completely surrounded by the exterior polymer layer 103 with a 10 to 15 mm margin (m) of the exterior polymer layer 103 around the PHB patch 101 being left.
  • the size of the PHB patch 101 itself may vary according to the size of the wound 102.
  • arrintermediate absorbent layer 105 of a hydrocoUoid material is provided. This absorbs exudate that is transported away from the wound 102 by the PHB patch 101 and promotes the transport away of further exudate.
  • the microporosity of the polyurethane exterior layer 103 means that the exudate can be slowly dispersed whUe still keeping the wound 102 moist and at the same time excluding bacteria. Vapour from the skin surrounding the wound 102 will also be able to pass through the exterior polymer layer 103.
  • TM dressing comprising a sheet of polyurethane (Tagerderm ) were used to dress a skin wound of a mammaUan body.
  • the dressing in accordance with the invention consisted of a lower section in the form of a non-woven fibre sheet of PHB and an upper section of a polyurethane sheet
  • the wound dressing of the invention produced an improved healed wound compared to the polyurethane sheet wound dressing. This was characterised by the healed wound covered by the wound dressing of the invention having a thicker and better quality layer of epithelial ceUs in the regenerated tissue than in the healed wound covered by the polyurethane sheet wound dressing.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne un pansement (10; 110; 210) pour panser une blessure (2; 102, 202) sur une structure tissulaire d'un corps humain ou animal. Ce pansement comporte une section (1; 101; 201) qui, lorsqu'il est appliqué sur la blessure, est adjacente à cette dernière, cette section inférieure étant perméable aux fluides et comprenant un matériau biorésorbable qui accélère le processus de cicatrisation, et une section supérieure (3; 103; 203) qui, lorsque le pansement est appliqué sur la blessure, recouvre la section inférieure, cette section supérieure étant perméable à la vapeur et imperméable aux bactéries. Ce pansement peut présenter une structure monobloc, une structure intégrée ou bien il peut être formé lors du pansage de la blessure.
EP97926340A 1996-06-03 1997-05-30 Pansement Withdrawn EP0906126A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9602200 1996-06-03
SE9602200A SE9602200D0 (sv) 1996-06-03 1996-06-03 Wound dressing
PCT/SE1997/000946 WO1997046265A1 (fr) 1996-06-03 1997-05-30 Pansement

Publications (1)

Publication Number Publication Date
EP0906126A1 true EP0906126A1 (fr) 1999-04-07

Family

ID=20402870

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97926340A Withdrawn EP0906126A1 (fr) 1996-06-03 1997-05-30 Pansement

Country Status (20)

Country Link
EP (1) EP0906126A1 (fr)
JP (1) JP2000511446A (fr)
KR (1) KR20000016251A (fr)
CN (1) CN1226178A (fr)
AR (1) AR007386A1 (fr)
BR (1) BR9709639A (fr)
CA (1) CA2255627A1 (fr)
CZ (1) CZ388398A3 (fr)
HU (1) HUP0003151A3 (fr)
ID (1) ID17733A (fr)
IL (1) IL127107A0 (fr)
IS (1) IS4898A (fr)
NO (1) NO985628L (fr)
NZ (1) NZ332950A (fr)
PL (1) PL330307A1 (fr)
SE (1) SE9602200D0 (fr)
TR (1) TR199802501T2 (fr)
TW (1) TW347318B (fr)
WO (1) WO1997046265A1 (fr)
ZA (1) ZA974846B (fr)

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FR2781679B1 (fr) * 1998-07-31 2001-06-08 Lhd Lab Hygiene Dietetique Nouveau pansement hydrocellulaire etanche et utilisation d'une masse adhesive hydrocolloide
EP1274378B1 (fr) * 1999-03-02 2005-12-28 Tatjana Meyer-Schwarz Pansement adhesif dote de protuberances et destine a etre applique sur la peau
US7619130B2 (en) 2000-07-18 2009-11-17 Coloplast A/S Multi-layer wound dressing formed as a single unit
GB0025084D0 (en) * 2000-10-13 2000-11-29 Cambridge Meditech Improvements in detection
US7041868B2 (en) 2000-12-29 2006-05-09 Kimberly-Clark Worldwide, Inc. Bioabsorbable wound dressing
US7700819B2 (en) * 2001-02-16 2010-04-20 Kci Licensing, Inc. Biocompatible wound dressing
DE60207606T2 (de) 2001-12-21 2006-07-27 Coloplast A/S Artikel zur wundbehandlung
WO2005000372A1 (fr) * 2003-06-26 2005-01-06 Zuiko Corporation Materiau a appliquer sur une blessure et kit renfermant un tel materiau
RU2254145C1 (ru) * 2003-10-14 2005-06-20 "Красноярская государственная медицинская академия Министерства здравоохранения Российской Федерации" (ГОУ ВПО КРАСГМА МИНЗДРАВА РОССИИ) Раневое покрытие на основе коллаген-хитозанового комплекса
DE102004063599B4 (de) 2004-12-30 2007-07-12 Bayer Innovation Gmbh Verkürzte Wundheilungsprozesse mittels neuartiger Faservliese
CN103170005A (zh) * 2011-12-23 2013-06-26 闳晖实业股份有限公司 伤口敷料
US9561136B2 (en) 2014-03-13 2017-02-07 Gregory Troy Williams Bandage
JP6506311B2 (ja) * 2014-06-05 2019-04-24 ユニバーシティ・オブ・ジ・ウィトウォーターズランド・ヨハネスブルクＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｔｈｅ Ｗｉｔｗａｔｅｒｓｒａｎｄ， Ｊｏｈａｎｎｅｓｂｕｒｇ 創傷被覆材
KR101577140B1 (ko) 2014-06-30 2015-12-11 박성훈 필름형 용해성 창상피복재
CN105688260A (zh) * 2016-03-21 2016-06-22 江苏广达医材集团有限公司 一种生物可降解医用腹部手术伤口敷料
JP6974351B2 (ja) 2016-05-04 2021-12-01 コロプラスト アクティーゼルスカブ 中和剤マトリックスを備える接着ウェハ
CN105816903A (zh) * 2016-05-12 2016-08-03 东华大学 一种载药透明质酸纳米纤维复合敷料及其制备方法
RU2020117765A (ru) 2017-11-08 2021-12-08 Колопласт А/С Клейкая пластина с матрицей с нейтрализатором
US11491254B2 (en) 2017-11-08 2022-11-08 Coloplast A/S Adhesive wafer with a neutralizer matrix
CN109125781B (zh) * 2018-11-16 2021-09-07 南阳市中心医院 一种肝胆外科抗菌敷料

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BR9709639A (pt) 1999-08-10
ID17733A (id) 1998-01-22
NZ332950A (en) 2000-05-26
TW347318B (en) 1998-12-11
WO1997046265A1 (fr) 1997-12-11
CN1226178A (zh) 1999-08-18
SE9602200D0 (sv) 1996-06-03
CZ388398A3 (cs) 1999-04-14
JP2000511446A (ja) 2000-09-05
TR199802501T2 (xx) 1999-02-22
IL127107A0 (en) 1999-09-22
CA2255627A1 (fr) 1997-12-11
PL330307A1 (en) 1999-05-10
NO985628D0 (no) 1998-12-02
AU719419B2 (en) 2000-05-11
ZA974846B (en) 1998-12-02
AU3112897A (en) 1998-01-05
HUP0003151A3 (en) 2002-05-28
IS4898A (is) 1998-11-19
AR007386A1 (es) 1999-10-27
HUP0003151A2 (hu) 2001-02-28
NO985628L (no) 1999-02-03
KR20000016251A (ko) 2000-03-25

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