EP0949946A4 - Traitement de liquides biologiques - Google Patents

Traitement de liquides biologiques

Info

Publication number
EP0949946A4
EP0949946A4 EP97954595A EP97954595A EP0949946A4 EP 0949946 A4 EP0949946 A4 EP 0949946A4 EP 97954595 A EP97954595 A EP 97954595A EP 97954595 A EP97954595 A EP 97954595A EP 0949946 A4 EP0949946 A4 EP 0949946A4
Authority
EP
European Patent Office
Prior art keywords
biological fluid
obtaining
leukocyte
container
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97954595A
Other languages
German (de)
English (en)
Other versions
EP0949946A1 (fr
Inventor
Judy Angelbeck
Barry Wenz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pall Corp
Original Assignee
Pall Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pall Corp filed Critical Pall Corp
Publication of EP0949946A1 publication Critical patent/EP0949946A1/fr
Publication of EP0949946A4 publication Critical patent/EP0949946A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A61M1/0218—Multiple bag systems for separating or storing blood components with filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
    • B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0439—White blood cells; Leucocytes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2221/00—Applications of separation devices
    • B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues

Definitions

  • stored and/or non-stored components typically include undesirable material such as bacteria and/or leukocytes.
  • Bacteria can contaminate the blood or blood component during blood collection and/or storage.
  • One source of bacterial contamination may be the blood donor's skin, which may contain one or more varieties of bacteria, e.g., gram positive bacteria such as Staphylococcus epidermidis. and S ⁇ aureus, and/or gram negative bacteria. Since swabbing the donor's skin (e.g. , with alcohol) prior to venipuncture may be inadequate to assure sterility, the bacteria may pass into the blood collection container, and the bacteria may reproduce while the blood or blood component is stored. Moreover, since some phlebotomy needles may cut a disc of skin when the phlebotomy needle is inserted into the donor, the bacteria-containing skin plug can pass with the blood into the blood collection container, and the bacteria can reproduce during storage.
  • Figure 4B illustrates another embodiment of a biological fluid pooling system that can be used in accordance with the invention.
  • the illustrated system includes a plurality of containers 12, each suitable for holding a biological fluid such as buffy coat, in fluid communication via conduits 160 with a first receiving container 118a for pooled buffy coat.
  • the illustrated system in Figure 4B also includes a filter assembly 26, such as a leukocyte depletion assembly, interposed between the first receiving container 118a and a second receiving container 118a.
  • the system also includes an additional container 20, e.g., for holding an additive or wash solution.
  • pooled biological fluid is then recovered in the receiving or transfer container 118a and, in accordance with the invention, the introduction of air or gas into the receiving container can be minimized, so the biological fluid is recovered without collecting excess air.
  • gas may be introduced behind the biological fluid retained in the system. Using the illustrative system illustrated in Figure 3 for reference, the gas that was initially introduced into the containers 18a through either the gas inlet 80 or the gas outlet 82 will follow the biological fluid as it flows through the conduits. This increases the recovery of the biological fluid, since the gas following the biological fluid "chases" the fluid from the conduits.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des procédés et systèmes pour traiter un liquide biologique, utilisant un dispositif de phlébotomie (1) en vue d'obtenir la séparation des divers composants du liquide biologique.
EP97954595A 1996-12-24 1997-12-19 Traitement de liquides biologiques Withdrawn EP0949946A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3414596P 1996-12-24 1996-12-24
PCT/US1997/023558 WO1998028057A1 (fr) 1996-12-24 1997-12-19 Traitement de liquides biologiques
US34145P 2008-03-05

Publications (2)

Publication Number Publication Date
EP0949946A1 EP0949946A1 (fr) 1999-10-20
EP0949946A4 true EP0949946A4 (fr) 2001-02-14

Family

ID=21874592

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97954595A Withdrawn EP0949946A4 (fr) 1996-12-24 1997-12-19 Traitement de liquides biologiques

Country Status (5)

Country Link
EP (1) EP0949946A4 (fr)
JP (1) JP2001507353A (fr)
AU (1) AU736156B2 (fr)
CA (1) CA2271440A1 (fr)
WO (1) WO1998028057A1 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6592613B1 (en) 1998-01-16 2003-07-15 Terumo Kabushiki Kaisha Blood collecting apparatus and blood collecting method using blood collecting apparatus
US7445756B2 (en) 1999-06-03 2008-11-04 Fenwal, Inc. Fluid processing sets and organizers for the same
US7025877B1 (en) 1999-06-03 2006-04-11 Baxter International Inc. Processing set for processing and treating a biological fluid
US6387086B2 (en) 1999-07-29 2002-05-14 Baxter International Inc. Blood processing set including an integrated blood sampling system
AU6498600A (en) 1999-07-29 2001-02-19 Baxter International Inc. Sampling tube holder for blood sampling system
US7435231B2 (en) 1999-07-29 2008-10-14 Fenwal, Inc. Biological sample device receiver
EP1224258A2 (fr) * 1999-10-29 2002-07-24 Pall Corporation Traitement de fluide biologique
JP2002173433A (ja) * 2000-12-04 2002-06-21 Terumo Corp 白血球除去血液製剤の調製方法および血液セット
US7264608B2 (en) 2001-12-05 2007-09-04 Fenwal, Inc. Manual processing systems and methods for providing blood components conditioned for pathogen inactivation
JP4837893B2 (ja) 2001-12-10 2011-12-14 カリディアンビーシーティー、インコーポレーテッド 赤血球を白血球減少させる方法および装置
US20040009542A1 (en) * 2002-05-03 2004-01-15 Gambro, Inc. Apparatus and method for detecting bacteria in blood products
ITRM20030467A1 (it) * 2003-10-10 2005-04-11 Advance Holdings Ltd Contenitore monouso per la centrifugazione ed il trattamento di un materiale biologico fluido.
PT2430977T (pt) * 2009-05-14 2020-03-26 Biotechnology Inst I Mas D Sl Método para a preparação de pelo menos um composto do sangue, e dispositivo de amostragem para utilização na realização do referido método
US8535241B2 (en) 2011-10-13 2013-09-17 Magnolia Medical Technologies, Inc. Fluid diversion mechanism for bodily-fluid sampling
US9060724B2 (en) 2012-05-30 2015-06-23 Magnolia Medical Technologies, Inc. Fluid diversion mechanism for bodily-fluid sampling
US9022951B2 (en) 2012-05-30 2015-05-05 Magnolia Medical Technologies, Inc. Fluid diversion mechanism for bodily-fluid sampling
US9204864B2 (en) 2012-08-01 2015-12-08 Magnolia Medical Technologies, Inc. Fluid diversion mechanism for bodily-fluid sampling
ES2878047T3 (es) 2012-10-11 2021-11-18 Magnolia Medical Technologies Inc Sistema para administrar un fluido a un paciente con contaminación reducida
DE102012022826B4 (de) * 2012-11-22 2022-10-13 Hubert Wöllenstein Verfahren zur Herstellung eines gepoolten Thrombozytenkonzentrats
CA3136331C (fr) 2012-11-30 2024-05-21 Magnolia Medical Technologies, Inc. Mecanisme de deviation de fluide par une seringue pour l'echantillonnage de liquide organique
US10772548B2 (en) 2012-12-04 2020-09-15 Magnolia Medical Technologies, Inc. Sterile bodily-fluid collection device and methods
EP3305196B8 (fr) 2012-12-04 2023-03-08 Magnolia Medical Technologies, Inc. Dispositif stérile de recueil de fluide corporel
US10159778B2 (en) 2014-03-24 2018-12-25 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US9782707B2 (en) 2014-03-24 2017-10-10 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US9968738B2 (en) 2014-03-24 2018-05-15 Fenwal, Inc. Biological fluid filters with molded frame and methods for making such filters
US9796166B2 (en) 2014-03-24 2017-10-24 Fenwal, Inc. Flexible biological fluid filters
US10376627B2 (en) 2014-03-24 2019-08-13 Fenwal, Inc. Flexible biological fluid filters
US11135343B2 (en) 2016-12-01 2021-10-05 Fenwal, Inc. Blood component pooling device, system and method
IL271054B2 (en) 2017-06-09 2024-05-01 Magnolia Medical Technologies Inc Fluid control devices and methods of using the same
CN111212597B (zh) 2017-09-12 2023-04-11 木兰医药技术股份有限公司 流体控制装置及其使用方法
JP7553455B2 (ja) 2019-02-08 2024-09-18 マグノリア メディカル テクノロジーズ，インコーポレイテッド 体液採取及び分配のための装置及び方法
EP4717174A3 (fr) 2019-12-11 2026-06-17 Magnolia Medical Technologies, Inc. Dispositifs de transfert de fluide avec dosage à base d'écoulement intégré

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2058577A5 (fr) * 1969-09-17 1971-05-28 Medicoplast Labor
US4280497A (en) * 1979-10-09 1981-07-28 Cutter Laboratories, Inc. Container for platelet storage
US4670013A (en) * 1982-12-27 1987-06-02 Miles Laboratories, Inc. Container for blood and blood components
WO1989009025A1 (fr) * 1988-03-31 1989-10-05 Maria Hansby Unite de collecte de sang et son emploi

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68902698C5 (de) * 1988-06-23 2005-07-14 Asahi Medical Co. Ltd. Verfahren zur Trennung von Blut in Blutkomponenten und Einheit zur Trennung von Blutkomponenten.
US5100564A (en) * 1990-11-06 1992-03-31 Pall Corporation Blood collection and processing system
CA2072378C (fr) * 1991-11-21 2000-12-26 Vlado Ivan Matkovich Methode d'assemblage de plusieurs receptables contenant un fluide biologique
US5549834A (en) * 1991-12-23 1996-08-27 Baxter International Inc. Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes
CA2083075A1 (fr) * 1992-06-10 1993-12-11 Vlado I. Matkovich Systeme pour le traitement du materiau de la zone de transition

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2058577A5 (fr) * 1969-09-17 1971-05-28 Medicoplast Labor
US4280497A (en) * 1979-10-09 1981-07-28 Cutter Laboratories, Inc. Container for platelet storage
US4670013A (en) * 1982-12-27 1987-06-02 Miles Laboratories, Inc. Container for blood and blood components
WO1989009025A1 (fr) * 1988-03-31 1989-10-05 Maria Hansby Unite de collecte de sang et son emploi

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9828057A1 *

Also Published As

Publication number Publication date
JP2001507353A (ja) 2001-06-05
CA2271440A1 (fr) 1998-07-02
AU736156B2 (en) 2001-07-26
WO1998028057A1 (fr) 1998-07-02
EP0949946A1 (fr) 1999-10-20
AU5900898A (en) 1998-07-17

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