EP1001027A3 - Verfahren zur Herstellung von Pantothensäure durch Verstärkung von für Ketopantoat-Reduktase kodierende Nukleotidsequenzen - Google Patents

Verfahren zur Herstellung von Pantothensäure durch Verstärkung von für Ketopantoat-Reduktase kodierende Nukleotidsequenzen Download PDF

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Publication number
EP1001027A3
EP1001027A3 EP99118670A EP99118670A EP1001027A3 EP 1001027 A3 EP1001027 A3 EP 1001027A3 EP 99118670 A EP99118670 A EP 99118670A EP 99118670 A EP99118670 A EP 99118670A EP 1001027 A3 EP1001027 A3 EP 1001027A3
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EP
European Patent Office
Prior art keywords
pantothenic acid
nucleotide sequences
amplification
ketopantoate
microorganisms
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Granted
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EP99118670A
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English (en)
French (fr)
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EP1001027B1 (de
EP1001027A2 (de
EP1001027B2 (de
Inventor
Frank Dr. Elischewski
Jörn Dr. Kalinowski
Alfred Prof. Dr. Pühler
Nikole Dr. Dusch
Jürgen Dr. Dohmen
Mike Dr. Farwick
Georg Dr. Thierbach
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Evonik Operations GmbH
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Degussa GmbH
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Application filed by Degussa GmbH filed Critical Degussa GmbH
Publication of EP1001027A2 publication Critical patent/EP1001027A2/de
Publication of EP1001027A3 publication Critical patent/EP1001027A3/de
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

Die Erfindung betrifft ein Verfahren zur Herstellung und Verbesserung D-Pantothensäure produzierender Mikroorganismen durch Verstärken für die Ketopantoatreduktase codierender Nucleotidsequenzen, insbesondere des panE-Gens, einzeln oder kombiniert miteinander, und gegebenenfalls zusätzlich des ilvC-Gens, die diese Nucleotidsequenzen enthaltende Mikroorganismen und ein Verfahren zur Herstellung D-Pantothensäure bestehend aus der Fermentation dieser Mikroorganismen, der Anreicherung der Pantothensäure im Medium oder in den Zellen der Mikroorganismen und dem Isolieren der D-Pantothensäure.
EP99118670A 1998-10-09 1999-09-22 Verfahren zur Herstellung von Pantothensäure durch Verstärkung von für Ketopantoat-Reduktase kodierende Nukleotidsequenzen Expired - Lifetime EP1001027B2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19846499A DE19846499A1 (de) 1998-10-09 1998-10-09 Verfahren zur Herstellung von Pantothensäure durch Verstärkung von für Ketopantoat-Reduktase kodierenden Nukleotidsequenzen
DE19846499 1998-10-09

Publications (4)

Publication Number Publication Date
EP1001027A2 EP1001027A2 (de) 2000-05-17
EP1001027A3 true EP1001027A3 (de) 2001-08-16
EP1001027B1 EP1001027B1 (de) 2004-05-06
EP1001027B2 EP1001027B2 (de) 2009-06-24

Family

ID=7883894

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99118670A Expired - Lifetime EP1001027B2 (de) 1998-10-09 1999-09-22 Verfahren zur Herstellung von Pantothensäure durch Verstärkung von für Ketopantoat-Reduktase kodierende Nukleotidsequenzen

Country Status (17)

Country Link
US (1) US6171845B1 (de)
EP (1) EP1001027B2 (de)
JP (1) JP2000116387A (de)
KR (1) KR20000028952A (de)
CN (1) CN1254758A (de)
AT (1) ATE266098T1 (de)
AU (1) AU5357099A (de)
BR (1) BR9904449A (de)
CA (1) CA2284117A1 (de)
DE (2) DE19846499A1 (de)
ES (1) ES2221280T3 (de)
HU (1) HUP9903458A3 (de)
IL (1) IL132292A0 (de)
MX (1) MXPA99009107A (de)
PL (1) PL335926A1 (de)
SK (1) SK137799A3 (de)
ZA (1) ZA996367B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19855314A1 (de) * 1998-12-01 2000-06-08 Degussa Verfahren zur fermentiven Herstellung von D-Pantothensäure unter Verwendung von Stämmen der Familie Enterobacteriaceae
DE19855313A1 (de) * 1998-12-01 2000-06-08 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure durch Verstärkung des panD-Gens in Mikroorganismen
US8232081B2 (en) 1999-09-21 2012-07-31 Basf Se Methods and microorganisms for production of panto-compounds
DE10101501A1 (de) * 2001-01-12 2002-08-01 Forschungszentrum Juelich Gmbh Verfahren zur fermentativen Herstellung von Pantothensäure
BR0206587A (pt) * 2001-01-19 2005-12-13 Basf Ag Processo para a produção de uma composição de pantotenato livre de hmbpa, produto, composição de pantotenato livre de hmbpa, composição sintetizada por um microorganismo possuindo uma rota biossintética de pantotenato desregulada, microorganismo recombinante para a produção de composições de pantotenato livres de hmbpa, e, processo para a produção de uma composição de pantotenato: hmbpa seletivamente misturada
PL369009A1 (en) * 2001-01-19 2005-04-18 Basf Aktiengesellschaft Microorganisms and processes for enhanced production of pantothenate
DE10106459A1 (de) * 2001-02-13 2002-08-14 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
DE10106460A1 (de) * 2001-02-13 2002-08-14 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
DE10106461A1 (de) * 2001-02-13 2002-08-14 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
CN1294271C (zh) 2001-02-21 2007-01-10 巴斯福股份公司 制备作为动物饲料添加剂的d－泛酸和/或其盐的方法
RU2003128532A (ru) 2001-02-21 2005-03-27 Басф Акциенгезелльшафт (De) Способ получения d-пантотеновой кислоты и/или ее солей, используемых в качестве добавок при производстве кормов для животных
DE10108225A1 (de) 2001-02-21 2002-10-10 Basf Ag Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln
US6623944B2 (en) 2001-03-14 2003-09-23 Degussa Ag Process for preparation of D-pantothenic acid and/or salts thereof
JP2002330763A (ja) 2001-05-02 2002-11-19 Ajinomoto Co Inc 発酵法による目的物質の製造法
US20030073219A1 (en) * 2001-05-21 2003-04-17 Blundell Tom L. Crystal structure
DE10128780A1 (de) * 2001-06-13 2002-12-19 Degussa Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
DE10147960A1 (de) * 2001-09-28 2003-04-10 Degussa Verfahren zur fermentativen Herstellung von D-Panthothensäure und/oder deren Salzen
MXPA04012812A (es) 2002-07-03 2005-02-24 Basf Ag Microorganismos y proceso para la produccion aumentada de pantotenato.
US20060099692A1 (en) * 2002-07-03 2006-05-11 Yocum R R Microorganisms and processes for enhanced production of pantothenate
DE10344200A1 (de) * 2003-09-22 2005-05-04 Basf Ag Verfahren zur Herstellung eines D-Pantothensäure und/oder deren Salze enthaltendes Tierfuttersupplement
CN101448950B (zh) 2006-05-16 2014-02-12 帝斯曼知识产权资产管理有限公司 用于生产泛醇的工艺
US8765426B2 (en) 2011-04-07 2014-07-01 E I Du Pont De Nemours And Company Pantothenic acid biosynthesis in zymomonas
CN109868254B (zh) * 2019-03-14 2021-02-19 浙江工业大学 一种高产泛酸的基因工程菌、构建方法及应用
CN113278569B (zh) * 2021-05-11 2022-04-19 浙江工业大学 无质粒、无诱导剂使用的产d-泛酸基因工程菌及构建方法
CN116024278B (zh) * 2022-12-16 2024-05-07 黑龙江新和成生物科技有限公司 一种发酵法制备d-泛酸的方法
KR102879056B1 (ko) * 2023-01-27 2025-10-30 씨제이제일제당 (주) 글루타미시박터 할로피토콜라 유래 판토에이트-베타-알라닌 리가아제의 활성이 강화된 미생물 및 이의 용도
CN116463272A (zh) * 2023-02-22 2023-07-21 浙江工业大学 一种高产d-泛酸的基因工程菌、构建方法及应用
CN116590209A (zh) * 2023-06-13 2023-08-15 浙江工业大学 一种产d-泛酸的基因工程菌、构建方法及应用
WO2025239726A1 (ko) * 2024-05-17 2025-11-20 씨제이제일제당 (주) 판토텐산 생산능을 가지는 코리네박테리움 속 미생물 및 이를 이용한 판토텐산 생산방법
WO2025244515A1 (ko) * 2024-05-24 2025-11-27 씨제이제일제당 (주) 옥타노일트랜스퍼라아제의 활성이 강화된 미생물 및 이의 용도

Non-Patent Citations (6)

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Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1983, PRIMERANO D A ET AL: "ROLE OF ACETO HYDROXY ACID ISOMERO REDUCTASE IN BIOSYNTHESIS OF PANTOTHENIC-ACID IN SALMONELLA-TYPHIMURIUM", XP002170048, Database accession no. PREV198376072046 *
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Also Published As

Publication number Publication date
EP1001027B1 (de) 2004-05-06
IL132292A0 (en) 2001-03-19
ES2221280T3 (es) 2004-12-16
MXPA99009107A (es) 2012-02-21
EP1001027A2 (de) 2000-05-17
HUP9903458A2 (hu) 2000-12-28
EP1001027B2 (de) 2009-06-24
DE59909391D1 (de) 2004-06-09
KR20000028952A (ko) 2000-05-25
ATE266098T1 (de) 2004-05-15
HUP9903458A3 (en) 2001-04-28
ZA996367B (en) 2000-04-13
US6171845B1 (en) 2001-01-09
SK137799A3 (en) 2000-09-12
CA2284117A1 (en) 2000-04-09
AU5357099A (en) 2000-04-13
BR9904449A (pt) 2000-11-14
JP2000116387A (ja) 2000-04-25
DE19846499A1 (de) 2000-04-20
HU9903458D0 (en) 1999-12-28
CN1254758A (zh) 2000-05-31
PL335926A1 (en) 2000-04-10

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