EP1027046A4 - Antagonistes de l'hormone de liberation de la gonadothrophine - Google Patents

Antagonistes de l'hormone de liberation de la gonadothrophine

Info

Publication number: EP1027046A4
Authority: EP; European Patent Office
Prior art keywords: gonadothrophin; hormone antagonists; release hormone; release; antagonists
Prior art date: 1997-10-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP98954019A

Other languages

German (de)

English (en)

Other versions

EP1027046A1 (fr

Inventor

Lin Chu

Mark T Goulet

Thomas F Walsh

Stephanie L Witkin

Matthew J Wyvratt

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-28

Filing date

1998-10-27

Publication date

2002-04-03

1998-05-07 Priority claimed from GBGB9809789.2A external-priority patent/GB9809789D0/en

1998-10-27 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

2000-08-16 Publication of EP1027046A1 publication Critical patent/EP1027046A1/fr

2002-04-03 Publication of EP1027046A4 publication Critical patent/EP1027046A4/fr

Status Withdrawn legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Anesthesiology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Dermatology (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)

EP98954019A 1997-10-28 1998-10-27 Antagonistes de l'hormone de liberation de la gonadothrophine Withdrawn EP1027046A4 (fr)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US6330597P	1997-10-28	1997-10-28
GB9809789		1998-05-07
GBGB9809789.2A GB9809789D0 (en)	1998-05-07	1998-05-07	Antagonists of gonadotropin releasing hormone
PCT/US1998/022799 WO1999021553A1 (fr)	1997-10-28	1998-10-27	Antagonistes de l'hormone de liberation de la gonadothrophine
US63305P		2008-01-31

Publications (2)

Publication Number	Publication Date
EP1027046A1 EP1027046A1 (fr)	2000-08-16
EP1027046A4 true EP1027046A4 (fr)	2002-04-03

Family

ID=26313619

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP98954019A Withdrawn EP1027046A4 (fr)	1997-10-28	1998-10-27	Antagonistes de l'hormone de liberation de la gonadothrophine

Country Status (5)

Country	Link
EP (1)	EP1027046A4 (fr)
JP (1)	JP2001520996A (fr)
AU (1)	AU1124399A (fr)
CA (1)	CA2308454A1 (fr)
WO (1)	WO1999021553A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0017256D0 (en)	2000-07-13	2000-08-30	Merck Sharp & Dohme	Therapeutic agents
GB0022670D0 (en)	2000-09-15	2000-11-01	Astrazeneca Ab	Molecules
SE0100566D0 (sv)	2001-02-20	2001-02-20	Astrazeneca Ab	Compounds
SE0101692D0 (sv)	2001-05-14	2001-05-14	Astrazeneca Ab	Compounds
GB0219472D0 (en)	2002-08-21	2002-10-02	Astrazeneca Ab	Chemical compounds
ES2298545T3 (es)	2002-08-21	2008-05-16	Astrazeneca Ab	Compuestos de tieno-pirrol como antagonistas de la hormona liberadora de gonadotropina.
TW200413351A (en)	2002-08-21	2004-08-01	Astrazeneca Ab	Chemical compounds
US7253290B2 (en)	2002-08-21	2007-08-07	Astrazeneca Ab	Pyrazole derivatives as GnRH inhibitors
TW200407127A (en)	2002-08-21	2004-05-16	Astrazeneca Ab	Chemical compounds
WO2005118539A1 (fr)	2004-06-01	2005-12-15	F.Hoffmann-La Roche Ag	3-amino-1-arylpropyl indoles utiles comme inhibiteurs de la reabsorption de la monoamine
DE102004033902A1 (de)	2004-07-14	2006-02-16	Zentaris Gmbh	Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's)
BRPI0619263A2 (pt)	2005-11-30	2011-09-27	Hoffmann La Roche	indóis de 3-amino-1-arilpropila e indóis aza-substituìdos, métodos para prepará-los, composição farmacêutica e uso dos referidos indóis
CA2632284A1 (fr)	2005-11-30	2007-06-07	F. Hoffmann-La Roche Ag	3-amino-2-arylpropyl azaindoles et leurs utilisations
CA2631048A1 (fr)	2005-11-30	2007-06-07	F. Hoffmann-La Roche Ag	Procede de synthese de 3-amino-1-arylpropyle indoles
EP2095818A1 (fr)	2008-02-29	2009-09-02	AEterna Zentaris GmbH	Utilisation d'antagonistes LHRH dans des doses n'impliquant pas de castration
US8378107B2 (en)	2008-10-01	2013-02-19	Panmira Pharmaceuticals, Llc	Heteroaryl antagonists of prostaglandin D2 receptors
IL241595B2 (en) *	2013-03-15	2025-10-01	Abbvie Inc	Composition for use in methods of treating heavy menstrual bleeding associated with uterine fibroids
US20170158702A1 (en) *	2015-12-02	2017-06-08	Kyras Therapeutics, Inc.	Multivalent ras binding compounds
HUE066335T2 (hu)	2018-10-05	2024-07-28	Annapurna Bio Inc	Vegyületek és készítmények APJ receptor aktivitáshoz kapcsolódó állapotok kezelésére

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2181559A1 (en) *	1972-04-28	1973-12-07	Aec Chimie Organique Bio	N-Phenylalkyl-N-3-indolylalkyl-alkylamines - with sedative, neuroleptic, analgesic, hypotensive, antiserotonin, adrenolytic activity
GB1562825A (en) *	1975-10-29	1980-03-19	Lilly Co Eli	N-(2-(5-methoxa-6-halo-indol-3-yl)-ethyl)-amides methods for their preparation and their use
US4544663A (en) *	1984-05-07	1985-10-01	Sandoz, Inc.	Indolamine derivatives as anti-fertility agents
US5030640A (en) *	1989-01-05	1991-07-09	Merck & Co., Inc.	Novel β-adrenergic agonists and pharmaceutical compositions thereof
WO1998055119A1 (fr) *	1997-06-05	1998-12-10	Merck & Co., Inc.	Antagonistes de l'hormone de liberation de la gonadotrophine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA795239B (en) *	1978-10-12	1980-11-26	Glaxo Group Ltd	Heterocyclic compounds
SK77298A3 (en) *	1995-12-14	1999-01-11	Merck & Co Inc	Nonpeptide derivatives, pharmaceutical composition containing them and their use
US5756507A (en) *	1995-12-14	1998-05-26	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone

1998
- 1998-10-27 WO PCT/US1998/022799 patent/WO1999021553A1/fr not_active Ceased
- 1998-10-27 JP JP2000517711A patent/JP2001520996A/ja not_active Withdrawn
- 1998-10-27 CA CA002308454A patent/CA2308454A1/fr not_active Abandoned
- 1998-10-27 EP EP98954019A patent/EP1027046A4/fr not_active Withdrawn
- 1998-10-27 AU AU11243/99A patent/AU1124399A/en not_active Abandoned

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2181559A1 (en) *	1972-04-28	1973-12-07	Aec Chimie Organique Bio	N-Phenylalkyl-N-3-indolylalkyl-alkylamines - with sedative, neuroleptic, analgesic, hypotensive, antiserotonin, adrenolytic activity
GB1562825A (en) *	1975-10-29	1980-03-19	Lilly Co Eli	N-(2-(5-methoxa-6-halo-indol-3-yl)-ethyl)-amides methods for their preparation and their use
US4544663A (en) *	1984-05-07	1985-10-01	Sandoz, Inc.	Indolamine derivatives as anti-fertility agents
US5030640A (en) *	1989-01-05	1991-07-09	Merck & Co., Inc.	Novel β-adrenergic agonists and pharmaceutical compositions thereof
WO1998055119A1 (fr) *	1997-06-05	1998-12-10	Merck & Co., Inc.	Antagonistes de l'hormone de liberation de la gonadotrophine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9921553A1 *

Also Published As

Publication number	Publication date
EP1027046A1 (fr)	2000-08-16
CA2308454A1 (fr)	1999-05-06
JP2001520996A (ja)	2001-11-06
WO1999021553A1 (fr)	1999-05-06
AU1124399A (en)	1999-05-17

Legal Events

Date	Code	Title	Description
2000-06-30	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2000-08-16	17P	Request for examination filed	Effective date: 20000529
2000-08-16	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE
2000-08-16	AX	Request for extension of the european patent	Free format text: AL PAYMENT 20000529;LT PAYMENT 20000529;LV PAYMENT 20000529;MK PAYMENT 20000529;RO PAYMENT 20000529;SI PAYMENT 20000529
2002-04-03	A4	Supplementary search report drawn up and despatched	Effective date: 20020219
2002-04-03	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE
2002-04-03	RIC1	Information provided on ipc code assigned before grant	Free format text: 7A 61K 31/405 A, 7A 61K 31/35 B, 7C 07D 209/04 B, 7C 07D 209/14 B, 7C 07D 209/42 B, 7A 61P 5/24 B, 7C 07D 453/06 B, 7C 07D 487/08 B
2002-10-25	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2002-12-11	18D	Application deemed to be withdrawn	Effective date: 20020503

Publication	Publication Date	Title
EP0934305A4 (fr)	2001-04-11	Antagonistes de l'integrine
EP1011667A4 (fr)	2001-03-28	Antagonistes de l'hormone de liberation de la gonadotrophine
EP0946164A4 (fr)	2000-08-23	Antagonistes de l'integrine
EP1027046A4 (fr)	2002-04-03	Antagonistes de l'hormone de liberation de la gonadothrophine
EP1007026A4 (fr)	2002-08-07	Antagonistes d'integrine
EP0986385A4 (fr)	2001-05-16	Antagonistes de gonadoliberine
DE69812096D1 (de)	2003-04-17	Neuropeptid y rezeptorantagonisten
PT1009732E (pt)	2003-10-31	1-amino-alquilciclo-hexanos antagonistas do receptor nmda
DE69734833D1 (de)	2006-01-12	Vitronektin rezeptor antagonisten
DK0880892T3 (da)	2003-01-13	Midler med reguleret frigivelse
ID23168A (id)	2000-03-23	Reseptor anatagonis vitronektin
EP0918522A4 (fr)	1999-08-18	Antagonistes de la gonadoliberine
EP1067930A4 (fr)	2002-09-18	Antagonistes de l'hormone liberant la gonadotropine (gnrh)
ID24726A (id)	2000-08-03	Antagonis-antagonis reseptor trombin
NO20002126L (no)	2000-05-04	Formulering med forlenget frigjøring
GB2310860B (en)	2000-10-11	Stable release agents
ID19801A (id)	1998-08-06	Turunan-turunan 5'-deoksi-sitidina
EP0901471A4 (fr)	1999-08-25	Antagonistes de la gonadoliberine
ID24162A (id)	2000-07-13	Antagonis-antagonis reseptor vitronektin
EP0920319A4 (fr)	2002-05-02	Antagonistes de la gonadoliberine
EP1062215A4 (fr)	2001-03-14	Antagonistes de l'hormone de liberation de la gonadotrophine
EP0999205A4 (fr)	2000-05-31	Composes d'aminocycloalcane
DE69812401D1 (de)	2003-04-24	Schnellkupplung
ID22978A (id)	1999-12-23	Antagonis reseptor endotelin
GB9719386D0 (en)	1997-11-12	Antagonists of gonadotropin releasing hormone