EP1171126A4 - 6-azaindolverbindungen als antagonisten des gonadotropin freisetzendes hormons - Google Patents

6-azaindolverbindungen als antagonisten des gonadotropin freisetzendes hormons

Info

Publication number
EP1171126A4
EP1171126A4 EP00917762A EP00917762A EP1171126A4 EP 1171126 A4 EP1171126 A4 EP 1171126A4 EP 00917762 A EP00917762 A EP 00917762A EP 00917762 A EP00917762 A EP 00917762A EP 1171126 A4 EP1171126 A4 EP 1171126A4
Authority
EP
European Patent Office
Prior art keywords
releasing hormone
gonadotropin releasing
hormone antagonists
azaindole compounds
azaindole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00917762A
Other languages
English (en)
French (fr)
Other versions
EP1171126A1 (de
Inventor
Thomas F Walsh
Feroze Ujjainwalla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1171126A1 publication Critical patent/EP1171126A1/de
Publication of EP1171126A4 publication Critical patent/EP1171126A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP00917762A 1999-03-10 2000-03-06 6-azaindolverbindungen als antagonisten des gonadotropin freisetzendes hormons Withdrawn EP1171126A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12364899P 1999-03-10 1999-03-10
US123648P 1999-03-10
PCT/US2000/005815 WO2000053179A1 (en) 1999-03-10 2000-03-06 6-azaindole compounds as antagonists of gonadotropin releasing hormone

Publications (2)

Publication Number Publication Date
EP1171126A1 EP1171126A1 (de) 2002-01-16
EP1171126A4 true EP1171126A4 (de) 2002-03-27

Family

ID=22409967

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00917762A Withdrawn EP1171126A4 (de) 1999-03-10 2000-03-06 6-azaindolverbindungen als antagonisten des gonadotropin freisetzendes hormons

Country Status (5)

Country Link
EP (1) EP1171126A4 (de)
JP (1) JP2002538204A (de)
AU (1) AU3868900A (de)
CA (1) CA2367116A1 (de)
WO (1) WO2000053179A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0022670D0 (en) 2000-09-15 2000-11-01 Astrazeneca Ab Molecules
SE0100566D0 (sv) 2001-02-20 2001-02-20 Astrazeneca Ab Compounds
SE0101692D0 (sv) 2001-05-14 2001-05-14 Astrazeneca Ab Compounds
DE60318716T2 (de) 2002-08-21 2009-01-08 Astrazeneca Ab Thieno-pyrrole verbindungen als antagonisten der gonadotropin-freisetzenden hormonrezeptoren
TW200413351A (en) 2002-08-21 2004-08-01 Astrazeneca Ab Chemical compounds
GB0219472D0 (en) 2002-08-21 2002-10-02 Astrazeneca Ab Chemical compounds
ES2286493T3 (es) 2002-08-21 2007-12-01 Astrazeneca Ab Derivados de pirazol como inhibidores de gnrh.
TW200407127A (en) 2002-08-21 2004-05-16 Astrazeneca Ab Chemical compounds
JP2008501758A (ja) 2004-06-09 2008-01-24 グラクソ　グループ　リミテッド ピロロピリジン誘導体
KR20070116060A (ko) 2005-03-01 2007-12-06 와이어쓰 신놀린 화합물 및 간 ｘ 수용체 조절제로서의 이의 용도

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756507A (en) * 1995-12-14 1998-05-26 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US5780437A (en) * 1995-12-14 1998-07-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US5849764A (en) * 1995-12-14 1998-12-15 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4544663A (en) * 1984-05-07 1985-10-01 Sandoz, Inc. Indolamine derivatives as anti-fertility agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756507A (en) * 1995-12-14 1998-05-26 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US5780437A (en) * 1995-12-14 1998-07-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US5849764A (en) * 1995-12-14 1998-12-15 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GOULET M T: "CHAPTER 18. GONADOTROPIN RELEASING HORMONE ANTAGONISTS", ANNUAL REPORTS IN MEDICINAL CHEMISTRY, SAN DIEGO, US, 1995, pages 169 - 177, XP002928176, ISSN: 0065-7743 *
See also references of WO0053179A1 *

Also Published As

Publication number Publication date
JP2002538204A (ja) 2002-11-12
EP1171126A1 (de) 2002-01-16
CA2367116A1 (en) 2000-09-14
AU3868900A (en) 2000-09-28
WO2000053179A1 (en) 2000-09-14

Similar Documents

Publication Publication Date Title
EP1161431A4 (de) 6-azaindol-verbindungen als antagonisten des gonadotropin-freisetzungs hormones
EP1171135A4 (de) 6-azaindolverbindungen als antagonisten des gonadotropin freisetzendes hormons
EP1067930A4 (de) Antagonisten des gonadoliberins
EE200100483A (et) Põletikuvastaste vahenditena kasutatavad ühendid
NO20026252L (no) Aza-broforbundet-bicykliske aminosyrederivater som <alfa>4 integrin antagonister
MA27011A1 (fr) Derives de dihydro-benzo[b] [1,4] diazepine-2-one utilises comme antagonistes i de mglur2
DZ3218A1 (fr) Pyrimidine-7-ones 5-(2-substitutees-5-heterocyclylsulphonylpyride-3-yl)-dihydropyrazolo[4,3-d] servant d'inhibiteurs de la phosphodiesterase
PL367064A1 (en) Dihydro-benzo [b] [1,4] diazepin-2-one derivatives as mglur2 antagonists ii
DE69921351D1 (de) 4-aroyl-piperidin-ccr-3 rezeptor antagonisten iii
EP1150965A4 (de) Benzazepin derivate als alpha-v intgrin rezeptor antagonisten
EP1229910A4 (de) Integrinrezeptorantagonisten
PL356990A1 (en) Isoxazolecarboxamide derivatives as alpha1-adrenergic receptor antagonists
EP1027046A4 (de) Antagonisten des gonadotropin freisetzenden hormons
IL135863A0 (en) Cyclopentene derivatives useful as antagonists of the motilin receptor
AU4834900A (en) Antagonists of gonadotropin releasing hormone
NZ513732A (en) Heterocyclic benzenesulphonamide compounds as bradykinine antagonists
PL350536A1 (en) Biphenyl derivatives as antagonists of the neurokinine-1 receptor
DE50008020D1 (de) Substituierte pyrrolidin-2,3,4-trion-derivate wirksam als nmda-rezeptor-antagonisten
EP1062215A4 (de) Antagonisten des gonadotropin freisetzenden hormons
EP1165076A4 (de) 6-azaindolverbindungen als antagonisten des gonadoliberins
MA26544A1 (fr) Derives de pyrrolopyrrolone comme inhibiteurs d'elastase de neutrophiles
IL143451A0 (en) NEW- β-AMIDE AND β-SULFONAMIDE CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN RECEPTOR ANTAGONISTS
NO20011309D0 (no) Benzotieno [3,2-c]pyridiner som<alfa>2-antagonister
GB9805717D0 (en) Antagonists of gonadotropin releasing hormone
GB9823087D0 (en) Antagonists of gonadotropin releasing hormone

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20011010

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL PAYMENT 20011010;LT PAYMENT 20011010;LV PAYMENT 20011010;MK PAYMENT 20011010;RO PAYMENT 20011010;SI PAYMENT 20011010

A4 Supplementary search report drawn up and despatched

Effective date: 20020208

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20020503