EP1323737A3 - Blutbildendes Fusionsprotein mit Il-3 Varianten - Google Patents

Blutbildendes Fusionsprotein mit Il-3 Varianten Download PDF

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Publication number
EP1323737A3
EP1323737A3 EP03002133A EP03002133A EP1323737A3 EP 1323737 A3 EP1323737 A3 EP 1323737A3 EP 03002133 A EP03002133 A EP 03002133A EP 03002133 A EP03002133 A EP 03002133A EP 1323737 A3 EP1323737 A3 EP 1323737A3
Authority
EP
European Patent Office
Prior art keywords
variant
hematopoiesis
fusion protein
hil
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03002133A
Other languages
English (en)
French (fr)
Other versions
EP1323737A2 (de
Inventor
Christopher S. Bauer
Mark Allen Abrams
Sarah Ruth Braford-Goldberg
Maire Helena Caparon
Alan Michael Easton
Barbare Kure Klein
John Patrick Mckearn
Peter O. Olins
Kumnan Paik
John Warren Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of EP1323737A2 publication Critical patent/EP1323737A2/de
Publication of EP1323737A3 publication Critical patent/EP1323737A3/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP03002133A 1994-02-04 1995-01-25 Blutbildendes Fusionsprotein mit Il-3 Varianten Withdrawn EP1323737A3 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US192299 1994-02-04
US08/192,299 US5738849A (en) 1992-11-24 1994-02-04 Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
EP95908514A EP0742796B1 (de) 1994-02-04 1995-01-25 Blutbildendes fusionprotein mit il-3 varianten

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP95908514A Division EP0742796B1 (de) 1994-02-04 1995-01-25 Blutbildendes fusionprotein mit il-3 varianten

Publications (2)

Publication Number Publication Date
EP1323737A2 EP1323737A2 (de) 2003-07-02
EP1323737A3 true EP1323737A3 (de) 2003-10-15

Family

ID=22709107

Family Applications (2)

Application Number Title Priority Date Filing Date
EP95908514A Expired - Lifetime EP0742796B1 (de) 1994-02-04 1995-01-25 Blutbildendes fusionprotein mit il-3 varianten
EP03002133A Withdrawn EP1323737A3 (de) 1994-02-04 1995-01-25 Blutbildendes Fusionsprotein mit Il-3 Varianten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP95908514A Expired - Lifetime EP0742796B1 (de) 1994-02-04 1995-01-25 Blutbildendes fusionprotein mit il-3 varianten

Country Status (12)

Country Link
US (4) US5738849A (de)
EP (2) EP0742796B1 (de)
JP (1) JPH09508524A (de)
AT (1) ATE237641T1 (de)
AU (1) AU700220B2 (de)
CA (1) CA2182483C (de)
DE (1) DE69530374T2 (de)
DK (1) DK0742796T3 (de)
ES (1) ES2197191T3 (de)
NZ (1) NZ279624A (de)
PT (1) PT742796E (de)
WO (1) WO1995021197A1 (de)

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US5738849A (en) * 1992-11-24 1998-04-14 G. D. Searle & Co. Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
IL123832A0 (en) * 1995-10-05 1998-10-30 Searle & Co Multi-functional hematopoietic receptor antagonists
US6066318A (en) * 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6967092B1 (en) 1996-10-25 2005-11-22 Mc Kearn John P Multi-functional chimeric hematopoietic receptor agonists
PL333023A1 (en) * 1996-10-25 1999-11-08 Searle & Co Chimerical antagonists of haeomogenic multifunctional receptors
AU721196B2 (en) * 1996-10-25 2000-06-29 G.D. Searle & Co. Circularly permuted erythropoietin receptor agonists
US6165476A (en) * 1997-07-10 2000-12-26 Beth Israel Deaconess Medical Center Fusion proteins with an immunoglobulin hinge region linker
ES2590912T3 (es) 1997-12-08 2016-11-24 Merck Patent Gmbh Proteínas de fusión heterodiméricas útiles para inmunoterapia dirigida y estimulación general del sistema inmunitario
US20030105294A1 (en) * 1998-02-25 2003-06-05 Stephen Gillies Enhancing the circulating half life of antibody-based fusion proteins
ES2267263T3 (es) * 1998-04-15 2007-03-01 Emd Lexigen Research Center Corp. Coadministracion de un inhibidor de la angiogenesis para reforzar la respuesta inmunologica por medio de la mediacion de una proteina de fusion de una citoquina con un anticuerpo.
US7067110B1 (en) 1999-07-21 2006-06-27 Emd Lexigen Research Center Corp. Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
SK782002A3 (en) 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
MXPA02001417A (es) * 1999-08-09 2002-08-12 Lexigen Pharm Corp Complejos multiples de citosina-anticuerpo.
AU7825500A (en) * 1999-10-07 2001-04-23 Pharmacia Corporation Inhibition enzyme linked immunosorbent assay (iELISA) for the detection and quantification of antibodies in biological samples
CA2391080A1 (en) 1999-11-12 2001-05-25 Merck Patent Gesellschaft Mit Beschraenkter Haftung Erythropoietin forms with improved properties
US6646110B2 (en) * 2000-01-10 2003-11-11 Maxygen Holdings Ltd. G-CSF polypeptides and conjugates
US6555660B2 (en) * 2000-01-10 2003-04-29 Maxygen Holdings Ltd. G-CSF conjugates
US6831158B2 (en) * 2000-01-10 2004-12-14 Maxygen Holdings Ltd. G-CSF conjugates
HUP0204475A2 (en) 2000-02-11 2003-04-28 Merck Patent Gmbh Enhancing the circulating half-life of antibody-based fusion proteins
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US6703360B2 (en) * 2000-04-07 2004-03-09 Heska Corporation Compositions and methods related to canine IgG and canine IL-13 receptors
KR20030064275A (ko) * 2000-06-29 2003-07-31 메르크 파텐트 게엠베하 면역싸이토카인 흡수 증강제와의 조합 치료에 의한항체-싸이토카인 융합 단백질 매개 면역 반응 증강
US7118737B2 (en) 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
KR20030057529A (ko) * 2000-09-08 2003-07-04 그리폰 테라퓨틱스, 인코포레이티드 합성 적혈구생성 자극 단백질
RU2003129528A (ru) * 2001-03-07 2005-04-10 Мерк Патент ГмбХ (DE) Способ экспрессии белков, содержащих в качестве компонента гибридный изотип антитела
WO2002079415A2 (en) * 2001-03-30 2002-10-10 Lexigen Pharmaceuticals Corp. Reducing the immunogenicity of fusion proteins
EP1383785B1 (de) 2001-05-03 2011-03-16 Merck Patent GmbH Rekombinanter, tumorspezifischer antikörper und dessen verwendung
EP1425304B9 (de) * 2001-07-11 2010-09-08 Maxygen, Inc. G-csf konjugate
DK1454138T3 (da) * 2001-12-04 2012-02-13 Merck Patent Gmbh Immunocytokiner med moduleret selektivitet
US7048922B2 (en) * 2002-05-29 2006-05-23 Demao Yang Stimulation of hematopoiesis by ex vivo activated immune cells
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WO2004055056A1 (en) * 2002-12-17 2004-07-01 Merck Patent Gmbh Humanized antibody (h14.18) of the mouse 14.18 antibody binding to gd2 and its fusion with il-2
EP1702069A2 (de) * 2004-01-05 2006-09-20 EMD Lexigen Research Center Corp. Auf onkofötales fibronectin gerichtetes interleukin-12
CN1993460A (zh) * 2004-07-12 2007-07-04 索林集团意大利有限公司 用于培养人细胞的装置和方法
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
KR20080027291A (ko) 2005-06-01 2008-03-26 맥시겐 홀딩스 엘티디 피이지화된 지-씨에스에프 폴리펩타이드 및 그 제조방법
JP2009502205A (ja) * 2005-08-02 2009-01-29 プラネット・バイオテクノロジー・インコーポレイテッド 炭疽菌の処置および予防のための改良されたキメラ毒素受容体タンパクおよびキメラ毒素受容体タンパク質
PL1966238T3 (pl) 2005-12-30 2012-09-28 Merck Patent Gmbh Warianty interleukiny-12p40 o polepszonej stabilności
WO2008036374A2 (en) * 2006-09-21 2008-03-27 Medistem Laboratories, Inc. Allogeneic stem cell transplants in non-conditioned recipients
EP2201120B1 (de) * 2007-09-21 2013-12-25 Cadila Healthcare Limited Zur hohen expression von peptiden geeignete gcsf-fusionsproteinsysteme
WO2011151716A1 (en) 2010-06-04 2011-12-08 Lupin Limited Process for the purification of recombinant human il-11

Citations (4)

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Also Published As

Publication number Publication date
HK1013655A1 (en) 1999-09-03
EP0742796A1 (de) 1996-11-20
JPH09508524A (ja) 1997-09-02
US5858347A (en) 1999-01-12
CA2182483A1 (en) 1995-08-10
PT742796E (pt) 2003-08-29
DK0742796T3 (da) 2003-08-11
EP0742796B1 (de) 2003-04-16
US6132991A (en) 2000-10-17
US5738849A (en) 1998-04-14
US6074639A (en) 2000-06-13
ATE237641T1 (de) 2003-05-15
CA2182483C (en) 2002-04-02
AU700220B2 (en) 1998-12-24
AU1680595A (en) 1995-08-21
ES2197191T3 (es) 2004-01-01
EP1323737A2 (de) 2003-07-02
DE69530374D1 (de) 2003-05-22
DE69530374T2 (de) 2003-12-18
NZ279624A (en) 1998-05-27
WO1995021197A1 (en) 1995-08-10

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