NO20040198L - Dolastatin 10 derivater - Google Patents

Dolastatin 10 derivater

Info

Publication number
NO20040198L
NO20040198L NO20040198A NO20040198A NO20040198L NO 20040198 L NO20040198 L NO 20040198L NO 20040198 A NO20040198 A NO 20040198A NO 20040198 A NO20040198 A NO 20040198A NO 20040198 L NO20040198 L NO 20040198L
Authority
NO
Norway
Prior art keywords
dolastatin
derivatives
Prior art date
Application number
NO20040198A
Other languages
English (en)
Inventor
Toshihiko Fujii
Takehiro Okada
Mikio Taniguchi
Fumio Watanabe
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20040198L publication Critical patent/NO20040198L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO20040198A 2001-07-19 2004-01-16 Dolastatin 10 derivater NO20040198L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01117410 2001-07-19
PCT/EP2002/007931 WO2003008378A1 (en) 2001-07-19 2002-07-17 Dolastatin 10 derivatives

Publications (1)

Publication Number Publication Date
NO20040198L true NO20040198L (no) 2004-02-19

Family

ID=8178073

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20040198A NO20040198L (no) 2001-07-19 2004-01-16 Dolastatin 10 derivater

Country Status (30)

Country Link
US (1) US6737409B2 (no)
EP (1) EP1412328B1 (no)
JP (1) JP2004534859A (no)
KR (2) KR20060057652A (no)
CN (1) CN1553897A (no)
AR (1) AR036175A1 (no)
AT (1) ATE341537T1 (no)
BR (1) BR0211289A (no)
CA (1) CA2453987A1 (no)
CO (1) CO5550462A2 (no)
DE (1) DE60215179T2 (no)
DK (1) DK1412328T3 (no)
ES (1) ES2272763T3 (no)
GT (1) GT200200154A (no)
HR (1) HRP20040043A2 (no)
HU (1) HUP0401253A2 (no)
IL (1) IL159890A0 (no)
MX (1) MXPA04000577A (no)
MY (1) MY127718A (no)
NO (1) NO20040198L (no)
NZ (1) NZ530655A (no)
PA (1) PA8551001A1 (no)
PE (1) PE20030258A1 (no)
PL (1) PL367682A1 (no)
PT (1) PT1412328E (no)
RU (1) RU2296750C2 (no)
SI (1) SI1412328T1 (no)
UY (1) UY27388A1 (no)
WO (1) WO2003008378A1 (no)
ZA (1) ZA200400334B (no)

Families Citing this family (37)

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US7256257B2 (en) 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
AU2003228354B8 (en) * 2002-03-22 2010-03-04 Eisai R&D Management Co., Ltd. Hemiasterlin derivatives and uses thereof in the treatment of cancer
US7064211B2 (en) 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
SI1545613T1 (sl) 2002-07-31 2011-11-30 Seattle Genetics Inc Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni
US7498298B2 (en) 2003-11-06 2009-03-03 Seattle Genetics, Inc. Monomethylvaline compounds capable of conjugation to ligands
CA2567914A1 (en) * 2004-06-02 2005-12-15 F. Hoffmann-La Roche Ag Synthesis of amino-alkoxy-heptanoic alkyl ester
WO2006132670A2 (en) 2004-11-12 2006-12-14 Seattle Genetics, Inc. Auristatins having an aminobenzoic acid unit at the n terminus
JP2008523002A (ja) * 2004-12-13 2008-07-03 エフ．ホフマン−ラ ロシュ アーゲー 少なくとも１つのドラスタチン１０誘導体を含有する新規な医薬組成物
JP2008523001A (ja) * 2004-12-13 2008-07-03 エフ．ホフマン−ラ ロシュ アーゲー ３−ピロリジン−２−イル−プロピオン酸誘導体を製造するための新規な方法
US20060161076A1 (en) * 2005-01-06 2006-07-20 Diamics, Inc. Systems and methods for collection of cell clusters
US20060189893A1 (en) * 2005-01-06 2006-08-24 Diamics, Inc. Systems and methods for detecting abnormal cells
AU2006205909A1 (en) * 2005-01-13 2006-07-20 F. Hoffmann-La Roche Ag New one-step synthesis of useful disubstituted amines
US7772177B2 (en) 2005-05-18 2010-08-10 Aegera Therapeutics, Inc. BIR domain binding compounds
US8871720B2 (en) * 2005-07-07 2014-10-28 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus
JP5171621B2 (ja) 2005-07-07 2013-03-27 シアトル ジェネティックス， インコーポレイテッド フェニルアラニン側鎖修飾をｃ末端に有するモノメチルバリン化合物
US7750116B1 (en) 2006-02-18 2010-07-06 Seattle Genetics, Inc. Antibody drug conjugate metabolites
AU2007250443B2 (en) 2006-05-16 2013-06-13 Pharmascience Inc. IAP BIR domain binding compounds
US20080003652A1 (en) * 2006-06-28 2008-01-03 Hans Iding Novel enzymatic process for the manufacture of Boc-Dap-Oh priority to related application(s)
NZ583318A (en) 2007-07-16 2012-07-27 Genentech Inc Humanized anti-cd79b antibodies and immunoconjugates and methods of use
DK2474557T3 (da) 2007-07-16 2014-11-10 Genentech Inc Anti-CD79b-antistoffer og immunkonjugater og fremgangsmåder til anvendelse
SG187517A1 (en) 2008-01-31 2013-02-28 Genentech Inc Anti-cd79b antibodies and immunoconjugates and methods of use
EP2265283B1 (en) 2008-03-18 2014-09-03 Seattle Genetics, Inc. Auristatin drug linker conjugates
TW201129384A (en) 2010-02-10 2011-09-01 Immunogen Inc CD20 antibodies and uses thereof
WO2011098904A1 (en) 2010-02-12 2011-08-18 Aegera Therapeutics, Inc. Iap bir domain binding compounds
CN103200950B (zh) 2010-06-10 2016-03-16 西雅图基因公司 新颖的耳他汀衍生物及其用途
US8987209B2 (en) 2010-09-29 2015-03-24 Seattle Genetics, Inc. N-carboxyalkyl-auristatin and the use thereof
US9029406B2 (en) 2011-03-16 2015-05-12 Seattle Genetics, Inc N-carboxyalkylauristatins and use thereof
KR20140037105A (ko) * 2011-05-27 2014-03-26 암브룩스, 인코포레이티드 비-천연 아미노산 연결된 돌라스타틴 유도체를 함유하는 조성물, 이를 수반하는 방법, 및 용도
KR102356286B1 (ko) * 2011-05-27 2022-02-08 암브룩스, 인코포레이티드 비-천연 아미노산 연결된 돌라스타틴 유도체를 함유하는 조성물, 이를 수반하는 방법, 및 용도
AU2013318779B2 (en) 2012-09-20 2016-07-28 Celltrion, Inc. Dolastatin-10 derivative, method of producing the same and anticancer drug composition containing the same
RU2729194C2 (ru) 2013-12-27 2020-08-05 Займворкс Инк. Сульфонамидсодержащие связывающие системы для лекарственных конъюгатов
PT3262071T (pt) 2014-09-23 2020-06-16 H Hoffnabb La Roche Ag Métodos de utilização de imunoconjugados anti-cd79b
CN105949277B (zh) * 2015-05-05 2019-03-01 成都永泰诺科技有限公司 一种抗肿瘤化合物及其用途
ES2948846T3 (es) * 2016-03-29 2023-09-20 Toray Industries Derivado peptídico y uso del mismo
CN109021065B (zh) * 2017-06-08 2021-10-01 复旦大学 一种制备海兔毒素Dolastatin10的方法
JP7695885B2 (ja) 2019-02-12 2025-06-19 アンブルックス，インコーポレイテッド 抗体－ｔｌｒアゴニストコンジュゲートを含有する組成物、その方法、及び使用
MX2024002571A (es) 2021-09-03 2024-03-20 Toray Industries Composicion farmaceutica para tratamiento y/o prevencion de cancer.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2700165B1 (fr) * 1993-01-07 1995-02-17 Rhone Poulenc Rorer Sa Dérivés de pyrrolidine, leur préparation et les médicaments les contenant.
US6323315B1 (en) 1999-09-10 2001-11-27 Basf Aktiengesellschaft Dolastatin peptides

Also Published As

Publication number Publication date
AR036175A1 (es) 2004-08-18
DE60215179D1 (de) 2006-11-16
US20030055002A1 (en) 2003-03-20
PA8551001A1 (es) 2003-09-17
CO5550462A2 (es) 2005-08-31
RU2296750C2 (ru) 2007-04-10
DK1412328T3 (da) 2007-02-12
ATE341537T1 (de) 2006-10-15
HUP0401253A2 (hu) 2004-12-28
MXPA04000577A (es) 2004-04-20
CN1553897A (zh) 2004-12-08
US6737409B2 (en) 2004-05-18
GT200200154A (es) 2003-05-16
KR100611540B1 (ko) 2006-08-10
BR0211289A (pt) 2004-08-03
PT1412328E (pt) 2007-01-31
KR20060057652A (ko) 2006-05-26
UY27388A1 (es) 2003-01-31
ZA200400334B (en) 2005-06-29
PL367682A1 (en) 2005-03-07
CA2453987A1 (en) 2003-01-30
EP1412328A1 (en) 2004-04-28
MY127718A (en) 2006-12-29
ES2272763T3 (es) 2007-05-01
SI1412328T1 (sl) 2007-02-28
DE60215179T2 (de) 2007-10-18
HRP20040043A2 (en) 2004-08-31
NZ530655A (en) 2006-08-31
RU2004105145A (ru) 2005-07-10
WO2003008378A1 (en) 2003-01-30
EP1412328B1 (en) 2006-10-04
JP2004534859A (ja) 2004-11-18
IL159890A0 (en) 2004-06-20
PE20030258A1 (es) 2003-03-19
KR20040023661A (ko) 2004-03-18

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