EP2121473A2 - Emballage pour bouteilles de faible volume - Google Patents

Emballage pour bouteilles de faible volume

Info

Publication number
EP2121473A2
EP2121473A2 EP07845276A EP07845276A EP2121473A2 EP 2121473 A2 EP2121473 A2 EP 2121473A2 EP 07845276 A EP07845276 A EP 07845276A EP 07845276 A EP07845276 A EP 07845276A EP 2121473 A2 EP2121473 A2 EP 2121473A2
Authority
EP
European Patent Office
Prior art keywords
packaging
bottles
packaging part
bottle
parts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP07845276A
Other languages
German (de)
English (en)
Inventor
Alois Hammerl
Josef Kranzinger
Wolfgang Schmitzberger
Heinz Schnait
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ebewe Pharma GmbH Nfg KG
Original Assignee
Ebewe Pharma GmbH Nfg KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ebewe Pharma GmbH Nfg KG filed Critical Ebewe Pharma GmbH Nfg KG
Publication of EP2121473A2 publication Critical patent/EP2121473A2/fr
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/321—Both sheets being recessed
    • B65D75/323—Both sheets being recessed and forming several compartments

Definitions

  • the present invention relates to a packaging for small-volume bottles, such as ampoules, with a first packaging part for receiving the lower portion of at least two bottles and a second packaging part for receiving the upper portion of at least two bottles, wherein the first and the second packaging part each at least two having recesses spaced apart from one another, which depressions are molded into the packaging part in a dimensionally stable manner and surrounded by substantially planar webs at their openings, the first and second packaging parts being fluid-tightly and detachably connected to one another via these webs.
  • Bottles with health-related content e.g. toxic or cytotoxic substances, etc., pose a significant risk to unprotected handling personnel.
  • the outside of the bottle may be wetted with the contents, with the risk of contamination during handling ,
  • the package includes a container for holding the bottle and a A closure cap for sealing the container, both the container and the closure cap being provided with spacer ribs distributed over its inner circumference, which hold a received bottle at a distance from the inner periphery of the container and with a press fit, the closure cap further comprising a closure of the Bottle overflows.
  • cytotoxic substances are often concentrated and bottled and transported in small quantities. Only immediately before the application, ie the treatment of the patient, the substances are removed and diluted for infusion or injection purposes.
  • ampoules having a capacity of 1 to 20 ml are used.
  • ampoules such as piercing ampoules made of glass or plastic, which are also referred to as vials.
  • These ampoules are closed with a rubber stopper, which is held with a crimp cap made of aluminum or plastic and can be pierced, for example by means of a cannula, to remove the contents of the bottle.
  • specially designed adapters are available for removing the contents from such ampoules.
  • a further development of known blister packs is the packaging of the European patent EP 0 703 157, which instead of the substantially planar cover layer provides a cover layer in which also molded recesses are present, so that form cavities in the closure of the blister packaging in which the pharmaceutical units are.
  • This packaging should also be suitable for receiving ampoules, depending on the shape of the wells.
  • the shape of the recesses in such a package alone does not ensure that ampoules containing, for example, health-relevant ingredients, such as toxic or cytotoxic substances, are kept safe during transport and subsequent handling.
  • the invention therefore has for its object to provide a package for small-volume bottles, such as ampoules, which can accommodate at least two such bottles and ensures improved grip of the bottles during transport and subsequent handling.
  • the invention further sets itself the goal of providing such a package, which is liquid-tight and thus leak-proof and material and cost-economical to produce.
  • the recesses are provided with distributed over its circumference spacer ribs, which center the bottle and the closures at a distance from the inner circumference of the recess and with Hold the press fit.
  • the spacer ribs are formed by indentations formed in a stable manner in the wall of the recess.
  • a package which largely excludes a Nachaussendringen surface contamination of FIa see in their entire area due to the spacer construction and offers a leakage protection in the event of damage to the bottle.
  • the support of the bottle during transport and during the removal of the upper part of the bottle forming the second packaging part is improved in a separation of the bottles and further handling of the bottle in the partially packaged state.
  • the height of the depression in the first packaging part is smaller than the height of the bottle to be accommodated.
  • the recesses have substantially the shape of a cylinder or a truncated cone.
  • the clear width of the openings of the depressions in the first packaging part has a size such that it is possible to place conventional adapters onto, for example, the ampoules for taking out the contents, without the ampoule being removed from the first packaging part must become.
  • the webs present between the depressions preferably have lines of weakening, such as perforations, in order to allow a separation of packaged bottles, for example by simply bending them off.
  • the weakening lines in the webs preferably run centrally and parallel to the respective outer edges of the first and / or the second packaging part.
  • the second packaging part preferably has a width greater than the first packaging part and notches or indentations at regular intervals at its longitudinal edges and has wings.
  • the material from which the packaging according to the invention is made is preferably translucent or transparent plastic. This allows the integrity of the bottle and its level to be checked from the outside.
  • the dimensional stability should be mentioned in order to avoid deformation of the depressions by impressions and thus possible damage to the bottle contained therein.
  • the plastics must also be inert and resistant to them in the event of contact with the toxic content, whether due to contamination of the external surfaces of the bottle when it is filled or due to damage.
  • plastics are further selected which are easy to process, such as thermoplastics, from which the packaging parts and the recesses provided therein by conventional methods of plastics technology, such as extrusion, pressing, injection molding, deep drawing, etc., can be made.
  • Suitable plastic materials are, for example, polyethylene terephthalate, polystyrene, polyvinyl chloride, polycarbonate, polyamide, polyethylene and polypropylene, acrylic-butadiene-styrene copolymer, impact-resistant polystyrene, styrene-acrylonitrile copolymer and a graft polymer of styrene and acrylonitrile on acrylic rubber.
  • molded-in recesses are provided in the packaging according to the invention in the corner regions of the first and / or the second packaging part, the height of which is less than the height of the recesses for mounting. would be the bottles. These recesses ensure that the packaging parts are held at a predefined distance from one another during stacking prior to their use, and so also that deformations of the recesses for receiving the bottles are avoided.
  • the second packaging part When packaging the bottles they are automatically inserted in a known manner in the first packaging part. Subsequently, the second packaging part is placed precisely over it and the two parts of the packaging are detachably connected to one another on the webs in a known manner.
  • the connection of the two packaging parts is such as to ensure an intact connection, which is unsolvable by the normal stress during transport and handling in the packaged state, which is furthermore liquid-tight, but at the same time a detachment or removal of the second packaging part from the first packaging part without excessive effort is possible.
  • sterilization of the individual packaging parts, the bottles and / or the filled and sealed packaging is preferably carried out by customary means, for example by UV irradiation or ionizing radiation, in order to provide ready-to-use sterile bottles.
  • customary means for example by UV irradiation or ionizing radiation.
  • the usual wiping disinfection of the puncture site in the septum prior to insertion of the Injektornadel can be avoided.
  • sterilization of the internal sections and areas of the packaging according to the invention is ensured by this measure.
  • the method for packaging small-volume bottles includes the steps of blending first and second packaging parts, placing bottles in the first packaging parts, placing the second packaging parts on the bottle-filled first packaging parts, joining the first and second packaging parts the method further comprises one or more sterilization steps which can be performed on the first and second packaging parts, the bottles, the bottle-filled first packaging parts and / or the bottle-filled and optionally sealed packaging.
  • the package of the invention is preferably used for packaging small volume bottles, such as vials, having cytotoxic content.
  • the filled package according to the invention is stackable in the usual way, whereby a packaging of several such packages in an overpack, such as a cardboard packaging, is possible.
  • Fig. 1 is a perspective view of an inventive
  • Fig. 2 is a plan view of the package according to the invention
  • Fig. 3 is a bottom view of the package according to the invention
  • 4 and 5 shows sectional views of the cavities formed by the depressions along the line AA or C to C;
  • FIG. 6 shows a sectional view of the recesses provided in the corner regions for improving the stackability.
  • FIG. 7 shows an isolated element of the packaging according to the invention in a perspective view
  • Fig. 8 is an isolated element of the first packaging part (without content) in a perspective view
  • FIG. 9 and FIG. 10 shows an isolated element of the first packaging part, which contains a bottle with conventional adapters, in each case in a perspective view.
  • FIG. 1 shows a perspective view of a packaging 1 according to the invention with a first packaging part 2 and a second packaging part 3.
  • the packaging parts 2 and 3 recesses 4, 4 'are provided.
  • the depressions 4, 4 ' have the shape of a truncated cone and rib-shaped indentations 5, 5' along their circumference.
  • two of the corner regions are preferably truncated conical recesses 6, 6 'provided for improved stacking of the packaging parts.
  • the second packaging part 3 has indentations 7 at its two longitudinal edges, which indentations (not shown) can also be embodied in the same way.
  • wings 8 are formed at both longitudinal edges of the second packaging part, which detachment of the second packaging part 3 from the first Packaging part 2 easier.
  • the wings 8 can have any shape and dimension as long as they can be gripped with the hands or a tool.
  • the recesses 4 ' are arranged spaced from each other in two likewise mutually parallel rows.
  • the weakening lines 9 ' preferably extend centrally in the webs 10' and parallel to the longitudinal edge of a rectangle to be inscribed in the second packaging part 3.
  • 3 shows the packaging according to the invention in a bottom view. As can be seen from this view, the first packaging part 2 has a smaller width than the second packaging part 3, which opens up the possibility of providing the indentations 7 and the wings 8 exclusively on the second packaging part 3.
  • the first packaging part 2 also has two mutually parallel and to the outer edge of the packaging part 2 extending rows of depressions 4, around the openings webs 10 are formed.
  • the first packaging part 2 also has weakening lines 9.
  • each five indentations 5, in the recesses 4 'of the second packaging part 3 each three molded indentations 5 'are provided.
  • the bottle 12 is centered and fixed by the molded rib-shaped indentations 5, 5' at a distance from the inner circumference of the recesses.
  • the bottle shown is a standard piercing ampule.
  • the packaging 1 enables the separation of the bottles 12 in the packaged state. Such a singulated element is shown in FIG.
  • the first packaging part 2 corresponding to this individual element is shown (without contents) in FIG. 8.
  • the recesses 4 preferably have inner diameters at their openings, which allow the bottles 12 to be provided with known adapters, for example for removal or dilution, without the bottles 12 having to be removed from the first packaging part 2 for the purpose of safe handling of the bottles 12 contributes.
  • the packaging 1 may be not only rectangular but may also have a square shape and a number of recesses 4, 4 'different in number from the number shown.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Packages (AREA)
  • Stackable Containers (AREA)

Abstract

L'invention concerne un emballage (1) pour bouteilles (12) de faible volume, cet emballage comprenant une première partie d'emballage (2) et une deuxième partie d'emballage (3), ces deux parties d'emballage (2,3) présentant chacune au moins deux évidements (4,4') moulés de manière indéformable et espacés l'un de l'autre, lesquels évidements ont des ouvertures entourées d'éléments de liaison (10,10') sensiblement plats qui relient les parties d'emballage (2,3) de manière libérable et étanche aux liquides. Les évidements (4,4') sont dotés de nervures de séparation (5,5') réparties sur leur périphérie, ces nervures servant à fixer les bouteilles (12) et leurs fermetures.
EP07845276A 2006-12-04 2007-12-04 Emballage pour bouteilles de faible volume Pending EP2121473A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0200906A AT504573B1 (de) 2006-12-04 2006-12-04 Verpackung für kleinvolumige flaschen
PCT/AT2007/000545 WO2008067576A2 (fr) 2006-12-04 2007-12-04 Emballage pour bouteilles de faible volume

Publications (1)

Publication Number Publication Date
EP2121473A2 true EP2121473A2 (fr) 2009-11-25

Family

ID=39064399

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07845276A Pending EP2121473A2 (fr) 2006-12-04 2007-12-04 Emballage pour bouteilles de faible volume

Country Status (6)

Country Link
US (1) US20100155271A1 (fr)
EP (1) EP2121473A2 (fr)
AT (1) AT504573B1 (fr)
AU (1) AU2007329159A1 (fr)
CA (1) CA2707532A1 (fr)
WO (1) WO2008067576A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH702668B1 (de) * 2010-02-04 2015-04-15 Christian Schütz Setverpackung, umfassend eine Mehrzahl von Fläschchen oder eine Mehrzahl von Fläschchenverschlüssen.
DE202011051492U1 (de) * 2011-09-30 2011-12-20 Wiebold-Confiserie Gmbh & Co. Kg Pralinenverpackung
DE102013114896B4 (de) * 2013-12-27 2015-08-27 Schott Ag Verpackungsstruktur und Verfahren zur sterilen Verpackung von Behältern für Substanzen für medizinische, pharmazeutische oder kosmetische Anwendungen sowie Verfahren zur Weiterverarbeitung von Behältern unter Verwendung der Verpackungsstruktur
US11161633B2 (en) 2017-12-22 2021-11-02 West Pharmaceutical Services, Inc. Packaging system for aseptic filling of small volume vials
USD937408S1 (en) * 2020-07-03 2021-11-30 Novandi Chemistry AB Container to transport chemical substances
CN118354730A (zh) * 2021-11-11 2024-07-16 奥斯丁医疗风险投资股份有限公司 用于制备治疗颗粒的装置和系统

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3503493A (en) * 1968-01-08 1970-03-31 Hoffmann La Roche Medicament packaging device
US3603453A (en) * 1969-06-09 1971-09-07 Parke Davis & Co Pharmacal package construction
CA1097233A (fr) * 1977-07-20 1981-03-10 George K. E. Gregory Emballages
GB2101094B (en) * 1981-07-07 1984-10-24 Cito Pac Verpackungs Gmbh Blister pack strip
GB8525498D0 (en) * 1985-10-16 1985-11-20 Scient Applied Research Sar Container for eggs
DE3601350A1 (de) * 1986-01-18 1987-07-23 Bachmann Horst Vorrichtung und verfahren zur verpackung von feinmechanischen und/oder elektronischen bauteilen
US5244092A (en) * 1989-12-06 1993-09-14 Canon Kabushiki Kaisha Package for ink jet cartridge
US5302358A (en) * 1993-01-15 1994-04-12 H. W. Andersen Products, Inc. Sterilizing apparatus
CH689305A5 (de) * 1994-08-23 1999-02-15 Alusuisse Lonza Services Ag Blisterpackung.
AR029768A1 (es) * 1999-10-18 2003-07-16 Novartis Ag Paquete de plastico para un producto farmaceutico y metodo para fabricar y esterilizar un paquete farmaceutico
AT4611U1 (de) * 2000-12-06 2001-09-25 Ebewe Arzneimittel Transportverpackung für flaschen
US6588180B2 (en) * 2001-02-02 2003-07-08 R. P. Scherer Technologies, Inc. Constricted neck blister pack and apparatus and method for making the same
US7431171B2 (en) * 2006-09-11 2008-10-07 Lamarche Paul Two piece container incorporating nesting characteristics and including interengageable hinge supports for upwardly supporting a lid upon a base

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2008067576A2 *

Also Published As

Publication number Publication date
WO2008067576A2 (fr) 2008-06-12
US20100155271A1 (en) 2010-06-24
AU2007329159A1 (en) 2008-06-12
WO2008067576A3 (fr) 2008-10-09
CA2707532A1 (fr) 2008-06-12
AT504573B1 (de) 2010-09-15
AT504573A1 (de) 2008-06-15

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