EP2126044A4 - Compositions de cellules souches et de cellules progénitrices récupérées à partir de moëlle osseuse ou de sang ombilical, système et procédé pour leur préparation - Google Patents

Compositions de cellules souches et de cellules progénitrices récupérées à partir de moëlle osseuse ou de sang ombilical, système et procédé pour leur préparation

Info

Publication number
EP2126044A4
EP2126044A4 EP07796720A EP07796720A EP2126044A4 EP 2126044 A4 EP2126044 A4 EP 2126044A4 EP 07796720 A EP07796720 A EP 07796720A EP 07796720 A EP07796720 A EP 07796720A EP 2126044 A4 EP2126044 A4 EP 2126044A4
Authority
EP
European Patent Office
Prior art keywords
stem
preparation
bone marrow
cord blood
progenitor cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07796720A
Other languages
German (de)
English (en)
Other versions
EP2126044A1 (fr
Inventor
Philip H Coelho
Bruce A Baker
John R Chapman
Junzhi Li
Robert S Childers
Prince Emmanuel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thermogenesis Holdings Inc
Original Assignee
Thermogenesis Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thermogenesis Corp filed Critical Thermogenesis Corp
Publication of EP2126044A1 publication Critical patent/EP2126044A1/fr
Publication of EP2126044A4 publication Critical patent/EP2126044A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A61M1/0236—Multiple bag systems for separating or storing blood components with sampling means, e.g. sample bag or sampling port
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0429—Red blood cells; Erythrocytes
    • A61M2202/0437—Blood stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A61M2205/331—Optical measuring means used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • External Artificial Organs (AREA)
EP07796720A 2007-03-28 2007-07-06 Compositions de cellules souches et de cellules progénitrices récupérées à partir de moëlle osseuse ou de sang ombilical, système et procédé pour leur préparation Withdrawn EP2126044A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66421207A 2007-03-28 2007-03-28
PCT/US2007/015560 WO2008121120A1 (fr) 2007-03-28 2007-07-06 Compositions de cellules souches et de cellules progénitrices récupérées à partir de moelle osseuse ou de sang ombilical, système et procédé pour leur préparation

Publications (2)

Publication Number Publication Date
EP2126044A1 EP2126044A1 (fr) 2009-12-02
EP2126044A4 true EP2126044A4 (fr) 2010-04-07

Family

ID=39808561

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07796720A Withdrawn EP2126044A4 (fr) 2007-03-28 2007-07-06 Compositions de cellules souches et de cellules progénitrices récupérées à partir de moëlle osseuse ou de sang ombilical, système et procédé pour leur préparation

Country Status (4)

Country Link
EP (1) EP2126044A4 (fr)
JP (2) JP2010537624A (fr)
CN (2) CN103555559B (fr)
WO (1) WO2008121120A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011095964A1 (fr) * 2010-02-03 2011-08-11 Fuil Technologies Limited Procédé et dispositif pour séparer un composant liquide d'un milieu liquide
JP5635177B2 (ja) * 2010-03-18 2014-12-03 シンジェン， インコーポレーテッド 血液または骨髄中の一定細胞集団をその他のものを枯渇させることにより精製するための方法
CN102618438A (zh) * 2012-04-11 2012-08-01 章毅 用于脐带血干细胞的检测和筛查系统
WO2015149098A1 (fr) * 2014-03-31 2015-10-08 Liporegena Gmbh Dispositif pour prélever et diviser en portions du tissu adipeux
EP2987515A1 (fr) * 2014-08-19 2016-02-24 Reapplix APS Centrifugeuse et méthode de centrifugation d'un échantillon sanguin
JP6976864B2 (ja) * 2015-12-29 2021-12-08 サーモゲネシス コーポレーション 細胞分離装置、システム、及び方法
EP3565614A1 (fr) * 2017-01-08 2019-11-13 Cesca Therapeutics Inc. Dispositifs et procédés de biotraitement d'échantillons cellulaires
US12274717B2 (en) 2017-01-11 2025-04-15 Sungkwang Medical Foundation PCNT as a target protein for treatment or diagnosis of brain-nervous system diseases
JP7133617B2 (ja) 2017-09-28 2022-09-08 テルモ株式会社 生体成分採取システム及び回路内圧取得方法
JP7261791B2 (ja) 2017-09-28 2023-04-20 テルモ株式会社 生体成分採取用デバイス、生体成分採取システム、及び生体成分採取システムの動作方法
JP7404357B2 (ja) 2018-11-01 2023-12-25 テルモ株式会社 生体成分採取システムおよび生体成分採取システムの作動方法
US11697799B2 (en) * 2019-04-15 2023-07-11 Ossium Health, Inc. System and method for extraction and cryopreservation of bone marrow
CN110093253A (zh) * 2019-06-04 2019-08-06 河南省人民医院 一次性使用去红细胞骨髓采集袋及方法
CN113980894B (zh) * 2021-12-27 2022-03-15 深圳博雅感知医疗科技有限公司 制备骨髓浓缩细胞的方法及其用于治疗卵巢早衰的用途
CN116064388A (zh) * 2022-12-28 2023-05-05 中博瑞康(上海)生物技术有限公司 一种全自动骨髓干细胞分离方法及装置
CN116251681A (zh) * 2023-03-04 2023-06-13 何红晨 一种富血小板血浆自动提取装置

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6103522A (en) * 1994-07-20 2000-08-15 Fred Hutchinson Cancer Research Center Human marrow stromal cell lines which sustain hematopoiesis
JPH1084950A (ja) * 1996-09-13 1998-04-07 Asahi Medical Co Ltd 造血幹細胞の採取方法、採取器および採取装置
JP4412621B2 (ja) * 1997-01-24 2010-02-10 旭化成クラレメディカル株式会社 細胞分離方法
CA2278208C (fr) * 1997-01-24 2011-09-20 Asahi Medical Co., Ltd. Procede de separation des cellules
JPH119270A (ja) * 1997-06-26 1999-01-19 Asahi Medical Co Ltd 有核細胞分離回収方法および有核細胞分離回収器
US20020051762A1 (en) * 1998-01-23 2002-05-02 Shahin Rafii Purified populations of endothelial progenitor cells
US7241281B2 (en) * 2002-04-08 2007-07-10 Thermogenesis Corporation Blood component separation method and apparatus
ITMI20030897A1 (it) * 2003-04-30 2004-11-01 Crb Nederland B V Procedimento e apparecchiatura per frazionare sangue.
EP1906729B1 (fr) * 2005-06-02 2012-03-28 Stemcyte, Inc. Compositions de sang ombilical non appauvri en globules rouges et appauvri en plasma, et leurs methodes d'utilisation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BOIRET NATHALIE ET AL: "CD34+CDw90(Thy-1)+ subset colocated with mesenchymal progenitors in human normal bone marrow hematon units is enriched in colony-forming unit megakaryocytes and long-term culture-initiating cells.", EXPERIMENTAL HEMATOLOGY (NEW YORK), vol. 31, no. 12, December 2003 (2003-12-01), pages 1275 - 1283, XP002569567, ISSN: 0301-472X *
DENG J -P ET AL: "Isolation and culture of bone marrow mesenchymal stem cells by red blood cell lysis method", JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH 20070121 CN, vol. 11, no. 3, 21 January 2007 (2007-01-21), pages 579 - 582, XP001539971, ISSN: 1673-8225 *
GASTENS M H ET AL: "Good manufacturing practice-compliant expansion of marrow-derived stem and progenitor cells for cell therapy", CELL TRANSPLANTATION, ELSEVIER SCIENCE, US, vol. 16, no. 7, 1 January 2007 (2007-01-01), pages 685 - 696, XP008093571, ISSN: 0963-6897 *
See also references of WO2008121120A1 *
TSUBAKI K ET AL: "Concentration of progenitor cells collected from bone marrow fluid using a continuous flow cell separator.", THERAPEUTIC APHERESIS : OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY FOR APHERESIS AND THE JAPANESE SOCIETY FOR APHERESIS FEB 2001, vol. 5, no. 1, February 2001 (2001-02-01), pages 46 - 48, XP002569566, ISSN: 1091-6660 *

Also Published As

Publication number Publication date
HK1193428A1 (en) 2014-09-19
WO2008121120A1 (fr) 2008-10-09
CN103555559B (zh) 2015-04-22
JP2010537624A (ja) 2010-12-09
JP5832591B2 (ja) 2015-12-16
CN103555559A (zh) 2014-02-05
CN101707891A (zh) 2010-05-12
JP2014176389A (ja) 2014-09-25
EP2126044A1 (fr) 2009-12-02

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: LI, JUNZHI

Inventor name: CHILDERS, ROBERT, S.

Inventor name: CHAPMAN, JOHN, R.

Inventor name: EMMANUEL, PRINCE

Inventor name: BAKER, BRUCE, A.

Inventor name: COELHO, PHILIP, H.

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 5/0775 20100101ALI20100225BHEP

Ipc: C12N 5/0789 20100101ALI20100225BHEP

Ipc: C12N 5/00 20060101AFI20081023BHEP

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