EP2185560A4 - Heteroarylamidanaloge - Google Patents

Heteroarylamidanaloge

Info

Publication number
EP2185560A4
EP2185560A4 EP08797591A EP08797591A EP2185560A4 EP 2185560 A4 EP2185560 A4 EP 2185560A4 EP 08797591 A EP08797591 A EP 08797591A EP 08797591 A EP08797591 A EP 08797591A EP 2185560 A4 EP2185560 A4 EP 2185560A4
Authority
EP
European Patent Office
Prior art keywords
heteroarylamidanaloge
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08797591A
Other languages
English (en)
French (fr)
Other versions
EP2185560A1 (de
Inventor
Rajagopal Bakthavatchalam
David C Ihle
Scott M Capitosti
David J Wustrow
Jun Yuan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of EP2185560A1 publication Critical patent/EP2185560A1/de
Publication of EP2185560A4 publication Critical patent/EP2185560A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP08797591A 2007-08-10 2008-08-11 Heteroarylamidanaloge Withdrawn EP2185560A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95525007P 2007-08-10 2007-08-10
PCT/US2008/072760 WO2009023623A1 (en) 2007-08-10 2008-08-11 Heteroaryl amide analogues

Publications (2)

Publication Number Publication Date
EP2185560A1 EP2185560A1 (de) 2010-05-19
EP2185560A4 true EP2185560A4 (de) 2011-10-05

Family

ID=40351102

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08797591A Withdrawn EP2185560A4 (de) 2007-08-10 2008-08-11 Heteroarylamidanaloge

Country Status (14)

Country Link
EP (1) EP2185560A4 (de)
JP (2) JP2010535816A (de)
KR (1) KR20100066422A (de)
CN (1) CN101778850A (de)
AU (1) AU2008286946B2 (de)
BR (1) BRPI0812594A2 (de)
CA (1) CA2691512A1 (de)
CO (1) CO6251319A2 (de)
EA (1) EA020332B1 (de)
IL (1) IL202550A0 (de)
NZ (1) NZ582056A (de)
SG (1) SG183699A1 (de)
UA (1) UA99729C2 (de)
WO (1) WO2009023623A1 (de)

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ES2380908T3 (es) * 2009-04-14 2012-05-21 Affectis Pharmaceuticals Ag Antagonistas de p2x7r novedosos y su uso
WO2012110190A1 (en) * 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
RS58718B1 (sr) * 2011-05-12 2019-06-28 Proteostasis Therapeutics Inc Regulatori proteostaze
WO2012163456A1 (en) * 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163792A1 (en) * 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
KR101995088B1 (ko) 2011-07-22 2019-07-02 이도르시아 파마슈티컬스 리미티드 Ｐ2ｘ7 수용체 길항제로서의 헤테로시클릭 아미드 유도체
NZ628910A (en) * 2012-01-20 2016-02-26 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
JOP20130213B1 (ar) * 2012-07-17 2021-08-17 Takeda Pharmaceuticals Co معارضات لمستقبلht3-5
PL2931717T3 (pl) 2012-12-12 2017-05-31 Actelion Pharmaceuticals Ltd. Pochodne indolokarboksyamidu jako antagoniści receptora p2x7
US9556117B2 (en) 2012-12-18 2017-01-31 Actelion Pharmaceuticals Ltd. Indole carboxamide derivatives as P2X7 receptor antagonists
WO2014115078A1 (en) 2013-01-22 2014-07-31 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
KR102222220B1 (ko) 2013-01-22 2021-03-03 이도르시아 파마슈티컬스 리미티드 Ｐ2ｘ7 수용체 길항제로서의 헤테로시클릭 아미드 유도체
AP2015008663A0 (en) 2013-02-19 2015-08-31 Pfizer Azabenzimidazole compounds as inhibitors of PDE4 isozymes for the treatment of cns and other disorders
TWI599567B (zh) * 2013-03-14 2017-09-21 健生藥品公司 Ｐ２ｘ７調節劑
US9040534B2 (en) 2013-03-14 2015-05-26 Janssen Pharmaceutica Nv [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators
TWI627174B (zh) 2013-03-14 2018-06-21 比利時商健生藥品公司 Ｐ２ｘ７調控劑
EP2970271B1 (de) 2013-03-14 2017-11-08 Janssen Pharmaceutica NV P2x7-modulatoren
KR102301753B1 (ko) * 2013-07-17 2021-09-15 더 글로벌 얼라이언스 포 티비 드러그 디벨롭먼트, 잉크. 아자인돌 화합물, 이의 합성, 및 이의 사용 방법
GB201317363D0 (en) 2013-10-01 2013-11-13 Eisai Ltd Novel compounds
WO2015073528A1 (en) 2013-11-12 2015-05-21 Proteostasis Therapeutics, Inc. Proteasome activity enhancing compounds
EP3172210B1 (de) 2014-07-24 2020-01-15 Pfizer Inc Pyrazolopyrimidin verbindungen
SG11201700243YA (en) 2014-08-06 2017-02-27 Pfizer Imidazopyridazine compounds
WO2016039977A1 (en) 2014-09-12 2016-03-17 Janssen Pharmaceutica Nv P2x7 modulators
JP6625616B2 (ja) 2014-09-12 2019-12-25 ヤンセン ファーマシューティカ エヌ．ベー． Ｐ２ｘ７調節ｎ−アシル−トリアゾロピラジン
CN106795172B (zh) 2014-09-29 2020-07-28 武田药品工业株式会社 1-(1-甲基-1h-吡唑-4-基)-n-((1r,5s,7s)-9-甲基-3-氧杂-9-氮杂双环[3.3.1]壬-7-基)-1h-吲哚-3-甲酰胺的晶型
EP3233841A1 (de) * 2014-12-15 2017-10-25 Merck Patent GmbH Indol- und azaindolderivate und deren verwendung bei neurodegenerativen erkrankungen
JP6462493B2 (ja) 2015-05-29 2019-01-30 株式会社デンソー 進入判定装置、進入判定方法
CA3010615C (en) 2016-01-14 2024-02-20 Beth Israel Deaconess Medical Center, Inc. Mast-cell modulators and uses thereof
TW201819361A (zh) 2016-09-03 2018-06-01 印度商托仁特生技有限公司 新穎吲唑化合物
TW202035409A (zh) 2018-09-28 2020-10-01 比利時商健生藥品公司 單醯基甘油脂肪酶調節劑
MY205440A (en) 2018-09-28 2024-10-21 Janssen Pharmaceutica Nv Monoacylglycerol lipase modulators
AU2020358948A1 (en) 2019-09-30 2022-05-26 Janssen Pharmaceutica Nv Radiolabelled MGL PET ligands
BR112022019077A2 (pt) 2020-03-26 2022-12-27 Janssen Pharmaceutica Nv Moduladores da monoacilglicerol lipase
CN116323581B (zh) * 2020-09-22 2025-05-30 苏州恩华生物医药科技有限公司 吲哚衍生物及其应用
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US4803198A (en) * 1981-08-08 1989-02-07 Kali-Chemie Pharma Gmbh 1-Phenyl-2-aminocarbonylindole compounds, preparation thereof and pharmaceutical compositions containing them
US5399559A (en) * 1992-06-05 1995-03-21 Shell Research Limited Fungicidal indole derivatives
US5424329A (en) * 1993-08-18 1995-06-13 Warner-Lambert Company Indole-2-carboxamides as inhibitors of cell adhesion
EP1310488A1 (de) * 2000-08-09 2003-05-14 Mitsubishi Pharma Corporation Kondensierte bizyklische amidverbindungen und ihre medizinische verwendung
US20030199689A1 (en) * 2001-11-22 2003-10-23 Marc Nazare New indole derivatives as factor Xa inhibitors
WO2004056768A2 (en) * 2002-12-20 2004-07-08 Bayer Healthcare Ag Use of substituted 2,5-diamidoindoles for the treatment of urological diseases
WO2005009947A2 (fr) * 2003-07-24 2005-02-03 Aventis Pharma S.A. Produits aryl-heteroaromatiques, compositions les contenant et utilisation
WO2005014529A1 (en) * 2003-08-08 2005-02-17 Astrazeneca Ab 2- adamantyl derivatives as p2x7 receptor antagonists.
US20050165049A1 (en) * 2004-01-23 2005-07-28 Christopher Hulme Vanilloid receptor ligands and their use in treatments
WO2006072736A1 (fr) * 2005-01-07 2006-07-13 Sanofi-Aventis DERIVES DE N- (HETEROARYL) -1H-IND0LE-2-CARB0XAMIDΞS ET LEUR UTILISATION COMME LIGANDS DU RECEPTEUR VANILLOIDE TRPVl
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4374846A (en) * 1979-08-02 1983-02-22 Kali-Chemie Pharma Gmbh N-Amino alkyl indole compounds compositions containing same, and a method of using same in therapy of disorders of gastrointestinal motility
US4803198A (en) * 1981-08-08 1989-02-07 Kali-Chemie Pharma Gmbh 1-Phenyl-2-aminocarbonylindole compounds, preparation thereof and pharmaceutical compositions containing them
US5399559A (en) * 1992-06-05 1995-03-21 Shell Research Limited Fungicidal indole derivatives
US5424329A (en) * 1993-08-18 1995-06-13 Warner-Lambert Company Indole-2-carboxamides as inhibitors of cell adhesion
EP1310488A1 (de) * 2000-08-09 2003-05-14 Mitsubishi Pharma Corporation Kondensierte bizyklische amidverbindungen und ihre medizinische verwendung
US20030199689A1 (en) * 2001-11-22 2003-10-23 Marc Nazare New indole derivatives as factor Xa inhibitors
WO2004056768A2 (en) * 2002-12-20 2004-07-08 Bayer Healthcare Ag Use of substituted 2,5-diamidoindoles for the treatment of urological diseases
WO2005009947A2 (fr) * 2003-07-24 2005-02-03 Aventis Pharma S.A. Produits aryl-heteroaromatiques, compositions les contenant et utilisation
WO2005014529A1 (en) * 2003-08-08 2005-02-17 Astrazeneca Ab 2- adamantyl derivatives as p2x7 receptor antagonists.
US20050165049A1 (en) * 2004-01-23 2005-07-28 Christopher Hulme Vanilloid receptor ligands and their use in treatments
US20070149602A1 (en) * 2004-08-05 2007-06-28 Sanofi-Aventis N-(1h-indolyl)-1h-indole-2-carboxamide derivatives, their preparation and their therapeutic use
WO2006072736A1 (fr) * 2005-01-07 2006-07-13 Sanofi-Aventis DERIVES DE N- (HETEROARYL) -1H-IND0LE-2-CARB0XAMIDΞS ET LEUR UTILISATION COMME LIGANDS DU RECEPTEUR VANILLOIDE TRPVl
WO2006100208A1 (en) * 2005-03-21 2006-09-28 N.V. Organon 1-benzylindole-2-carboxamide derivatives

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CONNOR ET AL.: "Novel Benzothiophene-, Benzofuran-, and Naphthalenecarboxamidotetraz oles as Potential Antiallergy Agents", J. MED. CHEM., vol. 35, 1 January 1992 (1992-01-01), pages 958 - 965, XP002303235, ISSN: 0022-2623, DOI: 10.1021/JM00083A023 *
NAZARE ET AL.: "Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents", BIOORG. MED. CHEM. LETT., vol. 14, no. 16, 1 May 2004 (2004-05-01), pages 4191 - 4195, XP002546716, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2004.06.020 *
NAZARE ET AL.: "Probing the Subpockets of Factor Xa Reveals Two Binding Modes for Inhibitors Based on a 2-Carboxyindole Scaffold: A Study Combining Structure-Activity Relationship and X-ray Crystallography", J. MED. CHEM., vol. 48, no. 14, 1 January 2005 (2005-01-01), pages 4511 - 4525, XP002546715, ISSN: 0022-2623, [retrieved on 20050611], DOI: 10.1021/JM0490540 *
OELGEN ET AL.: "Synthesis and antioxidant properties of novel N-substituted indole-2-carboxamide and indole-3-acetamide derivatives", ARCHIV DER PHARMAZIE, vol. 7, 1 January 2002 (2002-01-01), pages 331 - 338, XP002275101, ISSN: 0365-6233, DOI: 10.1002/1521-4184(200209)335:7<331::AID-ARDP331>3.0.CO;2-7 *
See also references of WO2009023623A1 *

Also Published As

Publication number Publication date
JP2010535816A (ja) 2010-11-25
CO6251319A2 (es) 2011-02-21
UA99729C2 (en) 2012-09-25
CA2691512A1 (en) 2009-02-19
AU2008286946B2 (en) 2013-11-21
EA020332B1 (ru) 2014-10-30
KR20100066422A (ko) 2010-06-17
NZ582056A (en) 2012-08-31
SG183699A1 (en) 2012-09-27
BRPI0812594A2 (pt) 2015-06-23
IL202550A0 (en) 2010-06-30
EA200971085A1 (ru) 2010-06-30
AU2008286946A1 (en) 2009-02-19
JP2015110566A (ja) 2015-06-18
CN101778850A (zh) 2010-07-14
EP2185560A1 (de) 2010-05-19
WO2009023623A1 (en) 2009-02-19

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