EP2569013A4 - Humanisierte und chimäre monoklonale antikörper gegen cd47 - Google Patents

Humanisierte und chimäre monoklonale antikörper gegen cd47

Info

Publication number
EP2569013A4
EP2569013A4 EP11781385.7A EP11781385A EP2569013A4 EP 2569013 A4 EP2569013 A4 EP 2569013A4 EP 11781385 A EP11781385 A EP 11781385A EP 2569013 A4 EP2569013 A4 EP 2569013A4
Authority
EP
European Patent Office
Prior art keywords
humanized
chimeric
monoclonal antibodies
antibodies anti
monoclonal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP11781385.7A
Other languages
English (en)
French (fr)
Other versions
EP2569013A2 (de
EP2569013B1 (de
Inventor
Jie Liu
Irving L Weissman
Ravindra Majeti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Priority to EP20198499.4A priority Critical patent/EP3789038B1/de
Priority to EP16200105.1A priority patent/EP3181149A1/de
Priority to HRP20170254TT priority patent/HRP20170254T1/hr
Priority to EP23214925.2A priority patent/EP4349868A3/de
Publication of EP2569013A2 publication Critical patent/EP2569013A2/de
Publication of EP2569013A4 publication Critical patent/EP2569013A4/de
Application granted granted Critical
Publication of EP2569013B1 publication Critical patent/EP2569013B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP11781385.7A 2010-05-14 2011-05-13 Humanisierte und chimäre monoklonale antikörper gegen cd47 Active EP2569013B1 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP20198499.4A EP3789038B1 (de) 2010-05-14 2011-05-13 Humanisierte und chimäre monoklonale antikörper gegen cd47
EP16200105.1A EP3181149A1 (de) 2010-05-14 2011-05-13 Humanisierte und chimäre monoklonale antikörper gegen cd47
HRP20170254TT HRP20170254T1 (hr) 2010-05-14 2011-05-13 Humanizirana i kimerna monoklonska protutijela usmjerena na cd47
EP23214925.2A EP4349868A3 (de) 2010-05-14 2011-05-13 Humanisierte und chimäre monoklonale antikörper gegen cd47

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39565210P 2010-05-14 2010-05-14
PCT/US2011/036535 WO2011143624A2 (en) 2010-05-14 2011-05-13 Humanized and chimeric monoclonal antibodies to cd47

Related Child Applications (3)

Application Number Title Priority Date Filing Date
EP23214925.2A Division EP4349868A3 (de) 2010-05-14 2011-05-13 Humanisierte und chimäre monoklonale antikörper gegen cd47
EP16200105.1A Division EP3181149A1 (de) 2010-05-14 2011-05-13 Humanisierte und chimäre monoklonale antikörper gegen cd47
EP20198499.4A Division EP3789038B1 (de) 2010-05-14 2011-05-13 Humanisierte und chimäre monoklonale antikörper gegen cd47

Publications (3)

Publication Number Publication Date
EP2569013A2 EP2569013A2 (de) 2013-03-20
EP2569013A4 true EP2569013A4 (de) 2015-04-08
EP2569013B1 EP2569013B1 (de) 2016-11-23

Family

ID=44915009

Family Applications (4)

Application Number Title Priority Date Filing Date
EP23214925.2A Pending EP4349868A3 (de) 2010-05-14 2011-05-13 Humanisierte und chimäre monoklonale antikörper gegen cd47
EP16200105.1A Ceased EP3181149A1 (de) 2010-05-14 2011-05-13 Humanisierte und chimäre monoklonale antikörper gegen cd47
EP20198499.4A Active EP3789038B1 (de) 2010-05-14 2011-05-13 Humanisierte und chimäre monoklonale antikörper gegen cd47
EP11781385.7A Active EP2569013B1 (de) 2010-05-14 2011-05-13 Humanisierte und chimäre monoklonale antikörper gegen cd47

Family Applications Before (3)

Application Number Title Priority Date Filing Date
EP23214925.2A Pending EP4349868A3 (de) 2010-05-14 2011-05-13 Humanisierte und chimäre monoklonale antikörper gegen cd47
EP16200105.1A Ceased EP3181149A1 (de) 2010-05-14 2011-05-13 Humanisierte und chimäre monoklonale antikörper gegen cd47
EP20198499.4A Active EP3789038B1 (de) 2010-05-14 2011-05-13 Humanisierte und chimäre monoklonale antikörper gegen cd47

Country Status (13)

Country Link
US (6) US9017675B2 (de)
EP (4) EP4349868A3 (de)
JP (6) JP6166177B2 (de)
AU (5) AU2011252851B2 (de)
CA (2) CA2797720C (de)
DK (2) DK2569013T3 (de)
ES (2) ES2616010T3 (de)
HR (2) HRP20170254T1 (de)
HU (2) HUE060541T2 (de)
LT (1) LT3789038T (de)
PL (1) PL3789038T3 (de)
PT (2) PT3789038T (de)
WO (1) WO2011143624A2 (de)

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CA3108119C (en) 2008-01-15 2024-01-16 The Board Of Trustees Of The Leland Stanford Junior University Markers of acute myeloid leukemia stem cells
EP4311863A3 (de) 2009-05-15 2024-04-10 University Health Network Zusammensetzungen und verfahren zur behandlung von blutkrebs mit targeting der sirp-alpha-cd47-interaktion
EP4349868A3 (de) * 2010-05-14 2024-08-28 The Board of Trustees of the Leland Stanford Junior University Humanisierte und chimäre monoklonale antikörper gegen cd47
WO2013023015A2 (en) 2011-08-11 2013-02-14 Albert Einstein College Of Medicine Of Yeshiva University Targets for diagnosis, prognosis and therapy of acute myeloid leukemia and myelodysplastic syndromes
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RU2015122228A (ru) * 2012-12-12 2017-01-19 Васкулокс Инк. Терапевтические антитела к CD47
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