EP3509956A1 - Logement pour contenant flexible - Google Patents
Logement pour contenant flexibleInfo
- Publication number
- EP3509956A1 EP3509956A1 EP18705541.3A EP18705541A EP3509956A1 EP 3509956 A1 EP3509956 A1 EP 3509956A1 EP 18705541 A EP18705541 A EP 18705541A EP 3509956 A1 EP3509956 A1 EP 3509956A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- housing
- container
- foam
- flexible container
- housing according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/02—Internal fittings
- B65D25/10—Devices to locate articles in containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1468—Containers characterised by specific material properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/16—Holders for containers
- A61J1/165—Cooled holders, e.g. for medications, insulin, blood or plasma
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/14—Linings or internal coatings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
- B65D77/02—Wrapped articles enclosed in rigid or semi-rigid containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
- B65D77/04—Articles or materials enclosed in two or more containers disposed one within another
- B65D77/06—Liquids or semi-liquids or other materials or articles enclosed in flexible containers disposed within rigid containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/02—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage
- B65D81/022—Containers made of shock-absorbing material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/02—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage
- B65D81/05—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents
- B65D81/107—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents using blocks of shock-absorbing material
- B65D81/113—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents using blocks of shock-absorbing material of a shape specially adapted to accommodate contents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
Definitions
- the present invention relates to a housing for a flexible container for transporting liquids, in particular medicines.
- liquids in particular medicines.
- other liquids that occur in the (bio-) pharmaceutical production process can be transported by means of a flexible container in such a housing.
- Flexible containers used to transport medicines in a housing are also referred to as a "single use bag.” This usually occurs when frozen, with the flexible container placed in the housing before freezing, and then the liquid is frozen by cooling the assembly ,
- the volume expansion during freezing (about 8%) creates a not to be underestimated pressure on the housing and the flexible container. This introduces the risk of mechanical damage and, as a result, leaks in the mechanical container.
- Object of the present invention is to reduce the mechanical stress of the flexible container and the housing over the prior art during freezing.
- a housing having the features of claim 1.
- This is done by an elastic foam - in other words: by at least one body of elastic foam - with which the housing is lined.
- This can in particular at least partially - preferably substantially completely - compensate for the occurring during freezing volume expansion of the container arranged in the housing.
- Protection is also desired for an arrangement comprising a housing according to the invention and a flexible container filled with a liquid, in particular a drug.
- protection for the use of a housing according to the invention is sought, wherein a liquid, in particular a drug is filled into the flexible container, the filled container is placed in the housing and the liquid is frozen by cooling the assembly of housing and container.
- Liquids that can be transported in the flexible container, z. As protein solutions, end products of a purification, antibody solutions and other high-quality intermediates in the pharmaceutical production cycle, and of course medicines themselves.
- the foam has a decreasing elasticity with decreasing temperature below the freezing point. It can also be provided that the foam substantially at a temperature between 0 ° C to - 30 ° C, preferably between -5 ° C and -25 ° C and more preferably between -10 ° C and -20 ° C, cures , These measures can help to ensure that the flexible container in the housing lies in a precisely matched "bed” in the housing, thereby absorbing all the forces acting on the flexible container and the housing, thereby at least reducing damage due to clamping or the like.
- the foam is formed so that the process of curing is reversible
- the housing can be reused, if desired.
- the curing of the foam may also be referred to as setting. It is not about the curing in the production of the foam, but the change in the elasticity properties under the effect of cold.
- the housing is lined with the foam so that the container - preferably including any attachments - is completely surrounded by the foam when the container is arranged in the housing.
- a foam block in the housing may be beneficial, which can accommodate the attachments (by deformation).
- the housing may be formed substantially cuboid. This can facilitate, for example, easy stacking of the housing.
- Fig. 1 is a sectional side view of a housing according to the invention
- Fig. 2 is a sectional plan view thereof.
- the flexible container 2 is disposed within the housing 1.
- the housing 1 is lined with foam 3 and a foam block 5. Freezes the liquid within the container 2, the container 2 expands. This volume expansion is from the foam 3 and taken up the foam block 5, so that between the container 2 and the housing 1 no - or at least not significant - creates tension.
- the housing 1 is designed completely enclosing.
- the housing 1 may consist of plastics and / or metal.
- the cover layers are each made of stainless steel and the side walls made of a polyethylene (concrete: high density polyethylene, HDPE).
- the foam 3 may preferably be designed so that it is relatively flexible and flexible at room temperature (and low negative temperatures) and cures at lower temperatures (-15 ° C. and colder) and encloses the container 2 arranged in the housing 1 and protects it from relative movement ,
- the thus protected container 2 can therefore not be bent or compressed, because the relative movement to the housing 1 is indeed prevented.
- cracks and leaks can be prevented on the container 2, for example made of plastic.
- so-called visco-elastic foam can be used, which cures at certain negative temperatures.
- the freezing of the assembly of housing 1 and 2 filled container can be done for example by contact cooling or circulating air cooling systems or in other ways.
- contact cooling systems the top surfaces of the housing 1 (also referred to as "shell") are located on cooled surfaces.
- circulating air cooling systems the housings 1 are surrounded by cooled air.
- the individual sides of the housing 1, in particular the cover surfaces (ie top and bottom), can be made of relatively thin material, in particular steel, in order to achieve rapid heat conduction (or cooling conduction).
- the housing 1 according to the invention can - as already mentioned - be reused, in particular if the foam 3 is formed so that the curing at low temperatures is reversible.
- a simple use of the housing 1 is conceivable.
- the housing 1 can be easily disassembled for simple recycling measures.
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Food Science & Technology (AREA)
- Packages (AREA)
- Buffer Packaging (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP24212454.3A EP4484329A3 (fr) | 2017-01-16 | 2018-01-15 | Boîtier pour un récipient souple |
| EP22153960.4A EP4032824B1 (fr) | 2017-01-16 | 2018-01-15 | Logement pour un récipient souple |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT600042017 | 2017-01-16 | ||
| ATGM50100/2017U AT15857U1 (de) | 2017-01-16 | 2017-05-24 | Gehäuse für einen flexiblen Behälter |
| PCT/AT2018/060010 WO2018129576A1 (fr) | 2017-01-16 | 2018-01-15 | Logement pour contenant flexible |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP22153960.4A Division EP4032824B1 (fr) | 2017-01-16 | 2018-01-15 | Logement pour un récipient souple |
| EP22153960.4A Division-Into EP4032824B1 (fr) | 2017-01-16 | 2018-01-15 | Logement pour un récipient souple |
| EP24212454.3A Division EP4484329A3 (fr) | 2017-01-16 | 2018-01-15 | Boîtier pour un récipient souple |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP3509956A1 true EP3509956A1 (fr) | 2019-07-17 |
| EP3509956B1 EP3509956B1 (fr) | 2022-03-09 |
Family
ID=62839098
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP22153960.4A Active EP4032824B1 (fr) | 2017-01-16 | 2018-01-15 | Logement pour un récipient souple |
| EP18705541.3A Active EP3509956B1 (fr) | 2017-01-16 | 2018-01-15 | Logement pour contenant flexible |
| EP24212454.3A Pending EP4484329A3 (fr) | 2017-01-16 | 2018-01-15 | Boîtier pour un récipient souple |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP22153960.4A Active EP4032824B1 (fr) | 2017-01-16 | 2018-01-15 | Logement pour un récipient souple |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP24212454.3A Pending EP4484329A3 (fr) | 2017-01-16 | 2018-01-15 | Boîtier pour un récipient souple |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US11207239B2 (fr) |
| EP (3) | EP4032824B1 (fr) |
| CN (1) | CN109890716B (fr) |
| DK (1) | DK3509956T3 (fr) |
| ES (1) | ES2999645T3 (fr) |
| WO (1) | WO2018129576A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT521596A1 (de) | 2018-09-05 | 2020-03-15 | Single Use Support Gmbh | Kühlplattenanordnung und Verfahren |
| WO2020100028A1 (fr) | 2018-11-12 | 2020-05-22 | Smartfreez, Lda | Isolant pour empêcher des dommages et une rupture de récipient provoqués par la congélation de solutions aqueuses contenant des matériaux biologiques |
| EP3926277A1 (fr) | 2020-06-19 | 2021-12-22 | Single Use Support GmbH | Congélateur à plaques |
| EP3964453B1 (fr) | 2020-09-02 | 2024-10-30 | Single Use Support GmbH | Arrangement comprenant un conteneur et un sac, procédé et utilisation |
| EP4014947B1 (fr) | 2020-12-16 | 2024-07-10 | Single Use Support GmbH | Procédé de protection de tubes |
| US12239127B2 (en) | 2021-07-28 | 2025-03-04 | Sartorius Stedim North America Inc. | Thermal capacitors, systems, and methods for rapid freezing or heating of biological materials |
| EP4166884A1 (fr) | 2021-10-15 | 2023-04-19 | Single Use Support GmbH | Plaque de refroidissement et procédé de fabrication d'une plaque de refroidissement |
| EP4169499A1 (fr) | 2021-10-19 | 2023-04-26 | Single Use Support GmbH | Procédé et dispositif de refroidissement ou de chauffage de fluides bio-pharmaceutiques |
| CN114471754A (zh) * | 2021-12-27 | 2022-05-13 | 利穗科技(苏州)有限公司 | 一种用于生物材料水溶液的容器 |
| CN116853682A (zh) * | 2022-03-28 | 2023-10-10 | 浙江菜鸟供应链管理有限公司 | 一种包装设备和一种包装检测系统 |
| EP4718004A1 (fr) | 2024-09-30 | 2026-04-01 | Single Use Support GmbH | Dispositif de congélation ou de décongélation |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2258163C3 (de) * | 1972-11-28 | 1975-05-28 | Fridolin 7717 Immendingen Wais | Vorrichtung zur sterilen Füllung, drucksicheren Lagerung und Handhabung sowie zur beliebig häufigen Entnahme von Flüssigkeiten |
| NL8501555A (nl) * | 1985-05-30 | 1986-12-16 | Nutricia Nv | Met sondevoeding gevulde verpakking. |
| US4723974A (en) * | 1985-07-26 | 1988-02-09 | Ammerman Stephen W | Transporting container for an amputated extremity |
| US4738364A (en) * | 1987-03-24 | 1988-04-19 | Medicool, Inc. | Portable medicine protector |
| IT220372Z2 (it) * | 1989-04-03 | 1993-09-20 | Qts Srl | Contenitore termico portatile per fiale di insulina ed altro materiale occorrente per iniezioni a diabetici e medicinali simili. |
| US6401484B2 (en) * | 1999-09-30 | 2002-06-11 | Gano, Iii John Henry | Transport container |
| US6554133B1 (en) * | 2000-07-11 | 2003-04-29 | Hewlett-Packard Development Company, L.P. | Container package for packaging electronic devices including multimedia devices such as entire computer system including a computer case, a monitor, and a printer |
| US6381981B1 (en) * | 2001-05-02 | 2002-05-07 | Advanced Tissue Sciences, Inc. | Container for shipping and storing frozen products |
| GB2383402A (en) * | 2001-08-10 | 2003-06-25 | Adrian Peter Copeland | Heat-insulated container |
| DE10155150C2 (de) | 2001-11-12 | 2003-09-11 | Ghassan Sowan | Versandtasche für thermisch empfindliches Material und damit aufgebaute Transportverpackung |
| EP1396440A1 (fr) * | 2002-09-05 | 2004-03-10 | The Procter & Gamble Company | Produit emballé comprenant des poches flexibles remplies de liquide |
| US7278278B2 (en) * | 2003-06-12 | 2007-10-09 | 21St Century Medicine, Inc. | Cryogenic storage system |
| US7240513B1 (en) * | 2004-04-12 | 2007-07-10 | Conforti Carl J | Thermally-controlled package |
| US8146762B2 (en) | 2006-03-09 | 2012-04-03 | Nalge Nunc International Corporation | Flexible container handling system |
| US9950830B2 (en) * | 2007-04-23 | 2018-04-24 | Coldkeepers, Llc | Insulated liners and containers |
| US8177123B2 (en) * | 2008-09-24 | 2012-05-15 | Sartorius Stedim North America Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
| US9301520B2 (en) * | 2007-12-21 | 2016-04-05 | Sartorius Stedim North America Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
| WO2014081839A2 (fr) * | 2012-11-20 | 2014-05-30 | Ohio State Innovation Foundation | Dispositif d'isolation pour poche de sang |
| CN203959080U (zh) * | 2014-05-22 | 2014-11-26 | 青岛市中心医院 | 恒温输液袋收集器 |
-
2018
- 2018-01-15 CN CN201880003960.XA patent/CN109890716B/zh active Active
- 2018-01-15 EP EP22153960.4A patent/EP4032824B1/fr active Active
- 2018-01-15 EP EP18705541.3A patent/EP3509956B1/fr active Active
- 2018-01-15 ES ES22153960T patent/ES2999645T3/es active Active
- 2018-01-15 DK DK18705541.3T patent/DK3509956T3/da active
- 2018-01-15 WO PCT/AT2018/060010 patent/WO2018129576A1/fr not_active Ceased
- 2018-01-15 EP EP24212454.3A patent/EP4484329A3/fr active Pending
-
2019
- 2019-04-02 US US16/373,177 patent/US11207239B2/en active Active
-
2021
- 2021-10-22 US US17/508,008 patent/US11602487B2/en active Active
-
2025
- 2025-05-12 US US19/204,905 patent/US20250268794A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4032824A1 (fr) | 2022-07-27 |
| CN109890716A (zh) | 2019-06-14 |
| EP3509956B1 (fr) | 2022-03-09 |
| US20220047457A1 (en) | 2022-02-17 |
| EP4484329A3 (fr) | 2025-03-19 |
| DK3509956T3 (da) | 2022-04-11 |
| EP4032824B1 (fr) | 2024-12-18 |
| US20250268794A1 (en) | 2025-08-28 |
| EP4484329A2 (fr) | 2025-01-01 |
| WO2018129576A1 (fr) | 2018-07-19 |
| CN109890716B (zh) | 2022-04-26 |
| US11602487B2 (en) | 2023-03-14 |
| EP4032824C0 (fr) | 2024-12-18 |
| US11207239B2 (en) | 2021-12-28 |
| ES2999645T3 (en) | 2025-02-26 |
| US20190224074A1 (en) | 2019-07-25 |
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