EP3786152A4 - Verfahren zur herstellung einer aromatischen nitrilverbindung - Google Patents

Verfahren zur herstellung einer aromatischen nitrilverbindung Download PDF

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Publication number
EP3786152A4
EP3786152A4 EP19793649.5A EP19793649A EP3786152A4 EP 3786152 A4 EP3786152 A4 EP 3786152A4 EP 19793649 A EP19793649 A EP 19793649A EP 3786152 A4 EP3786152 A4 EP 3786152A4
Authority
EP
European Patent Office
Prior art keywords
preparation
nitrile compound
aromatic nitrile
aromatic
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19793649.5A
Other languages
English (en)
French (fr)
Other versions
EP3786152A1 (de
EP3786152B1 (de
Inventor
Masaki NAGAHAMA
Hideki OOMIYA
Daiki OKADO
Hirotsugu TANIIKE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ube Corp
Original Assignee
API Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by API Corp filed Critical API Corp
Priority to EP24219154.2A priority Critical patent/EP4520753A3/de
Publication of EP3786152A1 publication Critical patent/EP3786152A1/de
Publication of EP3786152A4 publication Critical patent/EP3786152A4/de
Application granted granted Critical
Publication of EP3786152B1 publication Critical patent/EP3786152B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/20—Preparation of carboxylic acid nitriles by dehydration of carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/33—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/34—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfuric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/06—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/305—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with sulfur or sulfur-containing compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C07C57/40—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/194—Radicals derived from thio- or thiono carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
EP19793649.5A 2018-04-26 2019-04-26 Verfahren zur herstellung einer aromatischen nitrilverbindung Active EP3786152B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP24219154.2A EP4520753A3 (de) 2018-04-26 2019-04-26 Verfahren zur herstellung einer aromatischen nitrilverbindung

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862663014P 2018-04-26 2018-04-26
US201862780445P 2018-12-17 2018-12-17
PCT/JP2019/018065 WO2019208807A1 (ja) 2018-04-26 2019-04-26 芳香族ニトリル化合物の製造方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP24219154.2A Division EP4520753A3 (de) 2018-04-26 2019-04-26 Verfahren zur herstellung einer aromatischen nitrilverbindung

Publications (3)

Publication Number Publication Date
EP3786152A1 EP3786152A1 (de) 2021-03-03
EP3786152A4 true EP3786152A4 (de) 2021-06-16
EP3786152B1 EP3786152B1 (de) 2024-12-25

Family

ID=68294176

Family Applications (2)

Application Number Title Priority Date Filing Date
EP24219154.2A Pending EP4520753A3 (de) 2018-04-26 2019-04-26 Verfahren zur herstellung einer aromatischen nitrilverbindung
EP19793649.5A Active EP3786152B1 (de) 2018-04-26 2019-04-26 Verfahren zur herstellung einer aromatischen nitrilverbindung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP24219154.2A Pending EP4520753A3 (de) 2018-04-26 2019-04-26 Verfahren zur herstellung einer aromatischen nitrilverbindung

Country Status (9)

Country Link
US (2) US12054448B2 (de)
EP (2) EP4520753A3 (de)
JP (1) JP7399850B2 (de)
KR (2) KR102796989B1 (de)
CN (3) CN118439973A (de)
CA (1) CA3098437C (de)
ES (1) ES3015171T3 (de)
PL (1) PL3786152T3 (de)
WO (1) WO2019208807A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3567027B1 (de) * 2017-03-01 2022-01-19 API Corporation Verfahren zur herstellung von n-benzyl-2-bromo-3-methoxypropionamid und zwischenstoffen davon
WO2021085468A1 (ja) * 2019-10-29 2021-05-06 株式会社エーピーアイ コーポレーション 高純度２－ナフチルアセトニトリル及びその製造方法
EP4174049B1 (de) * 2020-08-31 2025-11-26 UBE Corporation Verfahren zur herstellung von 2-(halogenmethyl)naphthalin und 2-naphthylacetonitril
CN115784929B (zh) * 2022-12-21 2023-10-13 浦拉司科技（上海）有限责任公司 一种巴豆腈的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61268650A (ja) * 1985-05-21 1986-11-28 Otsuka Pharmaceut Factory Inc ナフトキノン誘導体
JP2001039904A (ja) 1999-07-29 2001-02-13 Sumikin Chemical Co Ltd ブロモアルキルナフタレンの製造方法
SE0201938D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New process
ZA200801825B (en) 2005-07-27 2009-12-30 Dov Pharmaceutical Inc Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: Preparation and use to treat neuropsychiatric disorders
JP2010268650A (ja) * 2009-05-18 2010-11-25 Daikin Ind Ltd アキシャルギャップ型回転電機
WO2014001939A1 (en) 2012-06-30 2014-01-03 Alembic Pharmaceuticals Limited Process for preparation of agomelatine and crystalline form i thereof
EP3080080A4 (de) 2013-12-09 2017-08-16 Neurovance, Inc. Neuartige zusammensetzungen
WO2021085468A1 (ja) 2019-10-29 2021-05-06 株式会社エーピーアイ コーポレーション 高純度２－ナフチルアセトニトリル及びその製造方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
A HULKENBERG ET AL: "An efficient one-pot synthesis of nitriles from acid chlorides", TETRAHEDRON LETTERS, vol. 23, no. 14, 1982, Amsterdam , NL, pages 1505 - 1508, XP055751666, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(00)87144-0 *
HUBER V J ET AL: "Preparation of Nitriles from Carboxylic Acids: A New, Synthetically Useful Example of the Smiles Rearrangement", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 54, no. 32, 6 August 1998 (1998-08-06), pages 9281 - 9288, XP004127405, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(98)00581-X *
NEWMAN MELVIN S.: "NEW SYNTHESES OF PICENE", JOURNAL OF ORGANIC CHEMISTRY, vol. 09, no. 6, 1944, Washington, pages 518 - 528, XP055798169, ISSN: 0022-3263, DOI: 10.1021/jo01188a005 *
See also references of WO2019208807A1 *

Also Published As

Publication number Publication date
US20210078940A1 (en) 2021-03-18
KR20240121346A (ko) 2024-08-08
CA3098437A1 (en) 2019-10-31
US20240351978A1 (en) 2024-10-24
WO2019208807A1 (ja) 2019-10-31
CN118439973A (zh) 2024-08-06
US12054448B2 (en) 2024-08-06
CN120441453A (zh) 2025-08-08
EP3786152A1 (de) 2021-03-03
EP4520753A2 (de) 2025-03-12
CN112041298A (zh) 2020-12-04
KR102796989B1 (ko) 2025-04-18
CA3098437C (en) 2025-04-01
EP3786152B1 (de) 2024-12-25
JPWO2019208807A1 (ja) 2021-04-30
KR20210005663A (ko) 2021-01-14
JP7399850B2 (ja) 2023-12-18
EP4520753A3 (de) 2025-05-28
ES3015171T3 (en) 2025-04-29
PL3786152T3 (pl) 2025-04-28

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