EP4554567A4 - Neue 3,5-disubstituierte-1,2,4-oxadiazol-derivate und ihre verwendung als inhibitoren von kohlenstoffanhydrase i und ii enzymen - Google Patents

Neue 3,5-disubstituierte-1,2,4-oxadiazol-derivate und ihre verwendung als inhibitoren von kohlenstoffanhydrase i und ii enzymen

Info

Publication number
EP4554567A4
EP4554567A4 EP23843483.1A EP23843483A EP4554567A4 EP 4554567 A4 EP4554567 A4 EP 4554567A4 EP 23843483 A EP23843483 A EP 23843483A EP 4554567 A4 EP4554567 A4 EP 4554567A4
Authority
EP
European Patent Office
Prior art keywords
disubstigulated
enzymes
inhibitors
novel
oxadiazole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23843483.1A
Other languages
English (en)
French (fr)
Other versions
EP4554567A2 (de
Inventor
Hayrunnisa Nadaroglu
Mehlika Dilek Altintop
Kaan Kucukoglu
Nagihan Faydali
Dilek Bul
Belgin Sever
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anadolu Universitesi
Atatuerk Ueniversitesi Bilimsel Arastirma Projeleri Birimi
Original Assignee
Anadolu Universitesi
Atatuerk Ueniversitesi Bilimsel Arastirma Projeleri Birimi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anadolu Universitesi, Atatuerk Ueniversitesi Bilimsel Arastirma Projeleri Birimi filed Critical Anadolu Universitesi
Priority claimed from PCT/TR2023/050576 external-priority patent/WO2024019685A2/en
Publication of EP4554567A2 publication Critical patent/EP4554567A2/de
Publication of EP4554567A4 publication Critical patent/EP4554567A4/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
EP23843483.1A 2022-07-22 2023-06-16 Neue 3,5-disubstituierte-1,2,4-oxadiazol-derivate und ihre verwendung als inhibitoren von kohlenstoffanhydrase i und ii enzymen Pending EP4554567A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR202211716 2022-07-22
PCT/TR2023/050576 WO2024019685A2 (en) 2022-07-22 2023-06-16 Novel 3,5-disubstituted-1,2,4-oxadiazole derived compounds and inhibitory activity of these compounds on carbonic anhydrase i and ii enzymes

Publications (2)

Publication Number Publication Date
EP4554567A2 EP4554567A2 (de) 2025-05-21
EP4554567A4 true EP4554567A4 (de) 2025-10-29

Family

ID=95477317

Family Applications (1)

Application Number Title Priority Date Filing Date
EP23843483.1A Pending EP4554567A4 (de) 2022-07-22 2023-06-16 Neue 3,5-disubstituierte-1,2,4-oxadiazol-derivate und ihre verwendung als inhibitoren von kohlenstoffanhydrase i und ii enzymen

Country Status (1)

Country Link
EP (1) EP4554567A4 (de)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB924608A (en) * 1959-09-29 1963-04-24 Francesco Angelini Improvements in or relating to 1.2.4-oxadiazoles and processes for producing the same
US3991067A (en) * 1971-05-19 1976-11-09 Glaxo Laboratories Limited Mono- or disubstituted 1,2,4,oxadiazoles which are substituted by at least 1-N-substituted carbamoyl group
CN110903262A (zh) * 2019-12-06 2020-03-24 中国人民解放军军事科学院军事医学研究院 噁二唑取代苯磺酰胺类化合物及其制备方法与作为碳酸酐酶抑制剂的应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB924608A (en) * 1959-09-29 1963-04-24 Francesco Angelini Improvements in or relating to 1.2.4-oxadiazoles and processes for producing the same
US3991067A (en) * 1971-05-19 1976-11-09 Glaxo Laboratories Limited Mono- or disubstituted 1,2,4,oxadiazoles which are substituted by at least 1-N-substituted carbamoyl group
CN110903262A (zh) * 2019-12-06 2020-03-24 中国人民解放军军事科学院军事医学研究院 噁二唑取代苯磺酰胺类化合物及其制备方法与作为碳酸酐酶抑制剂的应用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 30 July 2009 (2009-07-30), XP093314428, Database accession no. 1170444-94-6 *
KUCUKOGLU KAAN ET AL: "Synthesis, in silico and in vitro evaluation of new 3,5-disubstituted-1,2,4-oxadiazole derivatives as carbonic anhydrase inhibitors and cytotoxic agents", JOURNAL OF MOLECULAR STRUCTURE, vol. 1276, 1 March 2023 (2023-03-01), NL, pages 134699, XP093313994, ISSN: 0022-2860, Retrieved from the Internet <URL:https://pdf.sciencedirectassets.com/271369/1-s2.0-S0022286022X00264/1-s2.0-S0022286022023444/main.pdf?hash=4ed763bdf75da1503280c8bced404c447163b4ee4a09d48a35ef6fe3f419389b&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S0022286022023444&tid=spdf-8e852823-e971-4afb-8f9e-e4e> DOI: 10.1016/j.molstruc.2022.134699 *
KUMAR SHUBHAM ET AL: "Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER MASSON, AMSTERDAM, NL, vol. 209, 15 October 2020 (2020-10-15), XP086407144, ISSN: 0223-5234, [retrieved on 20201015], DOI: 10.1016/J.EJMECH.2020.112923 *

Also Published As

Publication number Publication date
EP4554567A2 (de) 2025-05-21

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