ATE398615T1 - Piperazinyl-, piperidinyl- und morpholinylderivate als neue inhibitoren von histon-deacetylase - Google Patents

Piperazinyl-, piperidinyl- und morpholinylderivate als neue inhibitoren von histon-deacetylase

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Publication number
ATE398615T1
ATE398615T1 AT03711979T AT03711979T ATE398615T1 AT E398615 T1 ATE398615 T1 AT E398615T1 AT 03711979 T AT03711979 T AT 03711979T AT 03711979 T AT03711979 T AT 03711979T AT E398615 T1 ATE398615 T1 AT E398615T1
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AT
Austria
Prior art keywords
piperazinyl
piperidinyl
histone deacetylase
new inhibitors
morpholinyl derivatives
Prior art date
Application number
AT03711979T
Other languages
English (en)
Inventor
Emelen Kristof Van
Original Assignee
Janssen Pharmaceutica Nv
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Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE398615T1 publication Critical patent/ATE398615T1/de

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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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AT03711979T 2002-03-13 2003-03-11 Piperazinyl-, piperidinyl- und morpholinylderivate als neue inhibitoren von histon-deacetylase ATE398615T1 (de)

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JP4648628B2 (ja) 2002-03-13 2011-03-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼの新規な阻害剤としてのカルボニルアミノ誘導体
CA2476583C (en) * 2002-03-13 2011-07-05 Kristof Van Emelen Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase
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TWI319387B (en) 2002-04-05 2010-01-11 Astrazeneca Ab Benzamide derivatives
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US7253204B2 (en) 2004-03-26 2007-08-07 Methylgene Inc. Inhibitors of histone deacetylase
CN1964962A (zh) 2004-06-14 2007-05-16 霍夫曼-拉罗奇有限公司 噻吩异羟肟酸衍生物以及它们作为hdac抑制剂的应用
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PT1776358E (pt) * 2004-07-28 2009-08-13 Janssen Pharmaceutica Nv Derivados de propenilpiperazina substituída como novos inibidores de histona-desacetilase
HRP20120327T1 (hr) 2004-07-28 2012-05-31 Janssen Pharmaceutica Nv Supstituirani indolil alkil amino derivati kao novi inhibitori histonske deacetilaze
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