ES2000823A6 - Metodo para la produccion de compuestos analogos a la vitamina d - Google Patents

Metodo para la produccion de compuestos analogos a la vitamina d

Info

Publication number
ES2000823A6
ES2000823A6 ES8600822A ES8600822A ES2000823A6 ES 2000823 A6 ES2000823 A6 ES 2000823A6 ES 8600822 A ES8600822 A ES 8600822A ES 8600822 A ES8600822 A ES 8600822A ES 2000823 A6 ES2000823 A6 ES 2000823A6
Authority
ES
Spain
Prior art keywords
lower alkyl
hydroxy
hydrogen
stands
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600822A
Other languages
English (en)
Inventor
Martin John Calverley
Ernst Torndal Binderup
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26289597&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2000823(A6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB858519502A external-priority patent/GB8519502D0/en
Application filed by Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharmaceutical Products Ltd AS
Publication of ES2000823A6 publication Critical patent/ES2000823A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

ESTA INVENCION SE REFIERE A UN METODO PARA LA PRODUCCION DE COMPUESTOS ANALOGOS DE VITAMINA D REPRESENTADOS POR LA FORMULA GENERAL I, CUYA NOMENCLATURA Y RADICALES SE ESPECIFICAN EN LA MEMORIA DESCRIPTIVA; SEGUN EL CUAL UN COMPUESTO DE FORMULA IV, EN EL QUE R1, R2, R3, R4, R5, (X), Z Y Z'' SON COMO SE DEFINEN EN LA MEMORIA, SE SOMETE A UNA FOTO-ISOMERIZACION DE TRIPLETE SENSIBILIZADO Y, SI ES NECESARIO, A LA DESPROTECCION DEL GRUPO(S) HIDROXI, SIENDO ARBITRARIA LA SECUENCIA DE ESTAS REACCIONES.
ES8600822A 1985-08-02 1986-08-01 Metodo para la produccion de compuestos analogos a la vitamina d Expired ES2000823A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858519502A GB8519502D0 (en) 1985-08-02 1985-08-02 Chemical compounds
PH34061A PH25496A (en) 1985-08-02 1986-08-11 New vitamin d analogues

Publications (1)

Publication Number Publication Date
ES2000823A6 true ES2000823A6 (es) 1988-03-16

Family

ID=26289597

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600822A Expired ES2000823A6 (es) 1985-08-02 1986-08-01 Metodo para la produccion de compuestos analogos a la vitamina d

Country Status (16)

Country Link
US (1) US4866048A (es)
EP (1) EP0227826B1 (es)
JP (1) JPH07100685B2 (es)
KR (1) KR940010767B1 (es)
AU (1) AU603340B2 (es)
CA (1) CA1307288C (es)
DE (1) DE3666587D1 (es)
DK (1) DK166617B1 (es)
ES (1) ES2000823A6 (es)
GR (1) GR862029B (es)
HK (1) HK63492A (es)
IE (1) IE58545B1 (es)
PH (1) PH25496A (es)
PT (1) PT83119B (es)
SG (1) SG64192G (es)
WO (1) WO1987000834A1 (es)

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US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
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US5789397A (en) * 1991-01-08 1998-08-04 Bone Care International, Inc. Methods for preparation and use of 1A,24(S)-dihydroxy vitamin D2
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US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
US5182396A (en) * 1991-03-29 1993-01-26 Nisshin Flour Milling Co., Ltd. 1-hydroxyvitamin d derivatives
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ATE143007T1 (de) * 1991-07-05 1996-10-15 Duphar Int Res Vitamin-d derivat, verfahren zu dessen herstellung sowie zwischenprodukte dafür
US5225569A (en) * 1991-08-09 1993-07-06 Hoffmann-La Roche Inc. Process for precursors to calcitriol and related compounds
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US20040043971A1 (en) * 1995-04-03 2004-03-04 Bone Care International, Inc. Method of treating and preventing hyperparathyroidism with active vitamin D analogs
US6242434B1 (en) 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
US20020183288A1 (en) * 1995-04-03 2002-12-05 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
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US6566353B2 (en) 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
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CN103694156B (zh) * 2014-01-07 2015-09-02 成都医路康医学技术服务有限公司 一种银屑病治疗药物钙泊三醇的制备方法
CN105348164B (zh) * 2015-10-29 2017-03-29 无锡福祈制药有限公司 一种1α‑羟基维生素D2的制备方法
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CN107501150A (zh) * 2016-06-14 2017-12-22 江苏吉贝尔药业股份有限公司 两种他卡西醇中间体的制备方法
UA124972C2 (uk) 2016-07-29 2021-12-22 Янссен Фармацевтика Нв Способи лікування раку передміхурової залози
CN110156836A (zh) * 2019-06-10 2019-08-23 成家钢 一种环丙基羰基亚甲基三苯基磷的制备方法
CN111662221B (zh) * 2020-06-29 2022-04-19 重庆华邦胜凯制药有限公司 一种卡泊三醇杂质的制备方法
CN115177586A (zh) * 2022-08-31 2022-10-14 江苏知原药业股份有限公司 一种卡泊三醇组合物

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Also Published As

Publication number Publication date
GR862029B (en) 1986-12-24
SG64192G (en) 1992-09-04
US4866048A (en) 1989-09-12
HK63492A (en) 1992-08-28
KR940010767B1 (ko) 1994-11-11
PT83119A (en) 1986-09-01
DK142987D0 (da) 1987-03-20
AU6196186A (en) 1987-03-05
IE861894L (en) 1987-02-02
EP0227826B1 (en) 1989-10-25
JPH07100685B2 (ja) 1995-11-01
DK166617B1 (da) 1993-06-21
PH25496A (en) 1991-07-24
PT83119B (pt) 1989-03-30
WO1987000834A1 (en) 1987-02-12
AU603340B2 (en) 1990-11-15
KR870700600A (ko) 1987-12-30
DE3666587D1 (en) 1989-11-30
DK142987A (da) 1987-03-20
EP0227826A1 (en) 1987-07-08
JPS63500661A (ja) 1988-03-10
IE58545B1 (en) 1993-10-06
CA1307288C (en) 1992-09-08

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