ES2001460A6 - Metodo para la proteccion de metionina presente en una cadena polipeptida contra la oxidacion irreversible y su ulterior oxidacion. rsible y su ulterior desproteccion. - Google Patents
Metodo para la proteccion de metionina presente en una cadena polipeptida contra la oxidacion irreversible y su ulterior oxidacion. rsible y su ulterior desproteccion.Info
- Publication number
- ES2001460A6 ES2001460A6 ES8603467A ES8603467A ES2001460A6 ES 2001460 A6 ES2001460 A6 ES 2001460A6 ES 8603467 A ES8603467 A ES 8603467A ES 8603467 A ES8603467 A ES 8603467A ES 2001460 A6 ES2001460 A6 ES 2001460A6
- Authority
- ES
- Spain
- Prior art keywords
- methionine
- polypeptide chain
- protection
- irreversible oxidation
- oxidation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000003647 oxidation Effects 0.000 title abstract 3
- 238000007254 oxidation reaction Methods 0.000 title abstract 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 title abstract 2
- 230000002427 irreversible effect Effects 0.000 title abstract 2
- 229930182817 methionine Natural products 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical class S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Materials For Medical Uses (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
METODO PARA LA PROTECCION DE METIONINA PRESENTE EN UNA CADENA POLIPEPTIDA CONTRA LA OXIDACION IRREVERSIBLE Y SU ULTERIOR DESPROTECCION. EL OBJETO DE LA INVENCION ES UN METODO PARA PROTEGER LA METIONINA EN UNA CADENA POLIPEPTIDA CONTRA LA OXIDACION IRREVERSIBLE, DEBIDA A MEDIOS OXIDANTES, MEDIANTE ALKILACION CON UN HALOGENURO DE ALKILO, OBTENIENDO UNA SAL DE SULFONIO RESISTENTE A POSTERIOR OXIDACION, ASI COMO LA ULTERIOR DESPROTECCION DE LA METIONINA, REACCIONANDO DICHA SAL DE SULFONIO CON UN DI- O POLI-TIOL, OBTENIENDOSE UN RESIDUO DE METIONINA INTACTO.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8603467A ES2001460A6 (es) | 1985-12-18 | 1986-12-17 | Metodo para la proteccion de metionina presente en una cadena polipeptida contra la oxidacion irreversible y su ulterior oxidacion. rsible y su ulterior desproteccion. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT48955/85A IT1200162B (it) | 1985-12-18 | 1985-12-18 | Protezione della metionina in una catena polipeptidica dalla ossidazione irreversibile |
| ES8603467A ES2001460A6 (es) | 1985-12-18 | 1986-12-17 | Metodo para la proteccion de metionina presente en una cadena polipeptida contra la oxidacion irreversible y su ulterior oxidacion. rsible y su ulterior desproteccion. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2001460A6 true ES2001460A6 (es) | 1988-05-16 |
Family
ID=11269152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8603467A Expired ES2001460A6 (es) | 1985-12-18 | 1986-12-17 | Metodo para la proteccion de metionina presente en una cadena polipeptida contra la oxidacion irreversible y su ulterior oxidacion. rsible y su ulterior desproteccion. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0226827B1 (es) |
| JP (1) | JPS62201898A (es) |
| AT (1) | ATE85343T1 (es) |
| AU (1) | AU606851B2 (es) |
| DE (1) | DE3687702T2 (es) |
| DK (1) | DK572286A (es) |
| ES (1) | ES2001460A6 (es) |
| FI (1) | FI94134C (es) |
| IL (1) | IL80742A0 (es) |
| IT (1) | IT1200162B (es) |
| NO (1) | NO865122L (es) |
| ZA (1) | ZA868958B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2831090A4 (en) * | 2012-03-26 | 2015-11-11 | Univ California | Preparation of functionalized polypeptides, peptides and proteins by the alkylation of thioether groups |
| WO2014134203A1 (en) | 2013-02-26 | 2014-09-04 | The Regents Of The University Of California | Amphiphilic derivatives of thioether containing block copolypeptides |
| US10351591B2 (en) | 2015-03-20 | 2019-07-16 | The Regents Of The University Of California | Polypeptides, peptides, and proteins functionalized by alkylation of thioether groups via ring-opening reactions |
| EP3124495A1 (en) | 2015-07-31 | 2017-02-01 | Centre National de la Recherche Scientifique (C.N.R.S.) | Derivatives of elastin-like polypeptides and uses thereof |
| WO2017189860A1 (en) | 2016-04-27 | 2017-11-02 | The Regents Of The University Of California | Preparation of functional homocysteine residues in polypeptides and peptides |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1234977B (it) * | 1985-03-22 | 1992-06-09 | Serono Ist Farm | Espressione in e. coli polipeptidi ibridi contenenti la sequenza del fattore di rilascio dell'ormone della crescita |
-
1985
- 1985-12-18 IT IT48955/85A patent/IT1200162B/it active
-
1986
- 1986-11-20 DE DE8686116075T patent/DE3687702T2/de not_active Expired - Fee Related
- 1986-11-20 EP EP86116075A patent/EP0226827B1/en not_active Expired - Lifetime
- 1986-11-20 AT AT86116075T patent/ATE85343T1/de not_active IP Right Cessation
- 1986-11-24 IL IL80742A patent/IL80742A0/xx not_active IP Right Cessation
- 1986-11-26 ZA ZA868958A patent/ZA868958B/xx unknown
- 1986-11-27 DK DK572286A patent/DK572286A/da not_active Application Discontinuation
- 1986-12-04 AU AU66089/86A patent/AU606851B2/en not_active Ceased
- 1986-12-17 JP JP61299018A patent/JPS62201898A/ja active Pending
- 1986-12-17 ES ES8603467A patent/ES2001460A6/es not_active Expired
- 1986-12-17 NO NO865122A patent/NO865122L/no unknown
- 1986-12-18 FI FI865200A patent/FI94134C/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE3687702T2 (de) | 1993-06-09 |
| EP0226827A2 (en) | 1987-07-01 |
| FI94134C (fi) | 1995-07-25 |
| DE3687702D1 (de) | 1993-03-18 |
| FI865200A0 (fi) | 1986-12-18 |
| AU6608986A (en) | 1987-06-25 |
| FI865200L (fi) | 1987-06-19 |
| ATE85343T1 (de) | 1993-02-15 |
| IT8548955A0 (it) | 1985-12-18 |
| NO865122L (no) | 1987-06-19 |
| NO865122D0 (no) | 1986-12-17 |
| AU606851B2 (en) | 1991-02-21 |
| EP0226827B1 (en) | 1993-02-03 |
| EP0226827A3 (en) | 1988-08-31 |
| IL80742A0 (en) | 1987-02-27 |
| IT1200162B (it) | 1989-01-05 |
| JPS62201898A (ja) | 1987-09-05 |
| DK572286A (da) | 1987-06-19 |
| DK572286D0 (da) | 1986-11-27 |
| ZA868958B (en) | 1987-07-29 |
| FI94134B (fi) | 1995-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SA6 | Expiration date (snapshot 920101) |
Free format text: 2006-12-17 |
|
| FD1A | Patent lapsed |
Effective date: 20010201 |