IT1200162B - Protezione della metionina in una catena polipeptidica dalla ossidazione irreversibile - Google Patents

Protezione della metionina in una catena polipeptidica dalla ossidazione irreversibile

Info

Publication number: IT1200162B
Authority: IT; Italy
Prior art keywords: methionine; formula; protection; irreversible oxidation; iii
Prior art date: 1985-12-18

Application number

IT48955/85A

Other languages

English (en)

Other versions

IT8548955A0 (it

Inventor

Umberto Canosi

Stefano Villa

Original Assignee

Serono Ist Farm

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-12-18

Filing date

1985-12-18

Publication date

1989-01-05

1985-12-18 Application filed by Serono Ist Farm filed Critical Serono Ist Farm

1985-12-18 Publication of IT8548955A0 publication Critical patent/IT8548955A0/it

1985-12-18 Priority to IT48955/85A priority Critical patent/IT1200162B/it

1986-11-20 Priority to AT86116075T priority patent/ATE85343T1/de

1986-11-20 Priority to EP86116075A priority patent/EP0226827B1/en

1986-11-20 Priority to DE8686116075T priority patent/DE3687702T2/de

1986-11-24 Priority to IL80742A priority patent/IL80742A0/xx

1986-11-26 Priority to ZA868958A priority patent/ZA868958B/xx

1986-11-27 Priority to DK572286A priority patent/DK572286A/da

1986-12-04 Priority to AU66089/86A priority patent/AU606851B2/en

1986-12-17 Priority to NO865122A priority patent/NO865122L/no

1986-12-17 Priority to ES8603467A priority patent/ES2001460A6/es

1986-12-17 Priority to JP61299018A priority patent/JPS62201898A/ja

1986-12-18 Priority to FI865200A priority patent/FI94134C/fi

1989-01-05 Application granted granted Critical

1989-01-05 Publication of IT1200162B publication Critical patent/IT1200162B/it

Links

FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 title abstract 2
230000002427 irreversible effect Effects 0.000 title abstract 2
229930182817 methionine Natural products 0.000 title abstract 2
230000003647 oxidation Effects 0.000 title 1
238000007254 oxidation reaction Methods 0.000 title 1
DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 abstract 2
JUIKUQOUMZUFQT-UHFFFAOYSA-N 2-bromoacetamide Chemical compound NC(=O)CBr JUIKUQOUMZUFQT-UHFFFAOYSA-N 0.000 abstract 1
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical class S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000029936 alkylation Effects 0.000 abstract 1
238000005804 alkylation reaction Methods 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000010511 deprotection reaction Methods 0.000 abstract 1
VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 abstract 1
PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 abstract 1
INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 abstract 1
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
150000003573 thiols Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Materials For Medical Uses (AREA)
Adhesives Or Adhesive Processes (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

IT48955/85A 1985-12-18 1985-12-18 Protezione della metionina in una catena polipeptidica dalla ossidazione irreversibile IT1200162B (it)

Priority Applications (12)

Application Number	Priority Date	Filing Date	Title
IT48955/85A IT1200162B (it)	1985-12-18	1985-12-18	Protezione della metionina in una catena polipeptidica dalla ossidazione irreversibile
AT86116075T ATE85343T1 (de)	1985-12-18	1986-11-20	Schutz von methionin in einer polypeptid-kette von irreversibler oxydation.
EP86116075A EP0226827B1 (en)	1985-12-18	1986-11-20	Protection of methionine in a polypeptide chain from irreversible oxidation
DE8686116075T DE3687702T2 (de)	1985-12-18	1986-11-20	Schutz von methionin in einer polypeptid-kette von irreversibler oxydation.
IL80742A IL80742A0 (en)	1985-12-18	1986-11-24	Method of protecting methionine in a polypeptide chain from irreversible oxidation
ZA868958A ZA868958B (en)	1985-12-18	1986-11-26	Protection of methionine in a polypeptide chain from irreversible oxidation
DK572286A DK572286A (da)	1985-12-18	1986-11-27	Fremgangsmaade til beskyttelse af aminosyrestruktur
AU66089/86A AU606851B2 (en)	1985-12-18	1986-12-04	Protection of methionine in a polypeptide chain from irreversible oxidation
NO865122A NO865122L (no)	1985-12-18	1986-12-17	Beskyttelse av methionin i en polypeptidkjede mot irreversibel oxydasjon.
ES8603467A ES2001460A6 (es)	1985-12-18	1986-12-17	Metodo para la proteccion de metionina presente en una cadena polipeptida contra la oxidacion irreversible y su ulterior oxidacion. rsible y su ulterior desproteccion.
JP61299018A JPS62201898A (ja)	1985-12-18	1986-12-17	不可逆的酸化からポリペプチド鎖中のメチオニンの保護
FI865200A FI94134C (fi)	1985-12-18	1986-12-18	Menetelmä metioniinia sisältävän polypeptidin erottamiseksi hybridiproteiinista

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT48955/85A IT1200162B (it)	1985-12-18	1985-12-18	Protezione della metionina in una catena polipeptidica dalla ossidazione irreversibile

Publications (2)

Publication Number	Publication Date
IT8548955A0 IT8548955A0 (it)	1985-12-18
IT1200162B true IT1200162B (it)	1989-01-05

Family

ID=11269152

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT48955/85A IT1200162B (it)	1985-12-18	1985-12-18	Protezione della metionina in una catena polipeptidica dalla ossidazione irreversibile

Country Status (12)

Country	Link
EP (1)	EP0226827B1 (it)
JP (1)	JPS62201898A (it)
AT (1)	ATE85343T1 (it)
AU (1)	AU606851B2 (it)
DE (1)	DE3687702T2 (it)
DK (1)	DK572286A (it)
ES (1)	ES2001460A6 (it)
FI (1)	FI94134C (it)
IL (1)	IL80742A0 (it)
IT (1)	IT1200162B (it)
NO (1)	NO865122L (it)
ZA (1)	ZA868958B (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2831090A4 (en) *	2012-03-26	2015-11-11	Univ California	Preparation of functionalized polypeptides, peptides and proteins by the alkylation of thioether groups
US9718921B2 (en)	2013-02-26	2017-08-01	The Regents Of The University Of California	Amphiphilic derivatives of thioether containing block copolypeptides
US10351591B2 (en)	2015-03-20	2019-07-16	The Regents Of The University Of California	Polypeptides, peptides, and proteins functionalized by alkylation of thioether groups via ring-opening reactions
EP3124495A1 (en)	2015-07-31	2017-02-01	Centre National de la Recherche Scientifique (C.N.R.S.)	Derivatives of elastin-like polypeptides and uses thereof
EP3448872A4 (en)	2016-04-27	2019-12-11	The Regents of the University of California	PREPARATION OF FUNCTIONAL HOMOCYSTEINRESTES IN POLYPEPTIDES AND PEPTIDES

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1234977B (it) *	1985-03-22	1992-06-09	Serono Ist Farm	Espressione in e. coli polipeptidi ibridi contenenti la sequenza del fattore di rilascio dell'ormone della crescita

1985
- 1985-12-18 IT IT48955/85A patent/IT1200162B/it active
1986
- 1986-11-20 AT AT86116075T patent/ATE85343T1/de not_active IP Right Cessation
- 1986-11-20 EP EP86116075A patent/EP0226827B1/en not_active Expired - Lifetime
- 1986-11-20 DE DE8686116075T patent/DE3687702T2/de not_active Expired - Fee Related
- 1986-11-24 IL IL80742A patent/IL80742A0/xx not_active IP Right Cessation
- 1986-11-26 ZA ZA868958A patent/ZA868958B/xx unknown
- 1986-11-27 DK DK572286A patent/DK572286A/da not_active Application Discontinuation
- 1986-12-04 AU AU66089/86A patent/AU606851B2/en not_active Ceased
- 1986-12-17 NO NO865122A patent/NO865122L/no unknown
- 1986-12-17 ES ES8603467A patent/ES2001460A6/es not_active Expired
- 1986-12-17 JP JP61299018A patent/JPS62201898A/ja active Pending
- 1986-12-18 FI FI865200A patent/FI94134C/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO865122D0 (no)	1986-12-17
FI94134B (fi)	1995-04-13
ATE85343T1 (de)	1993-02-15
FI865200A0 (fi)	1986-12-18
IL80742A0 (en)	1987-02-27
DE3687702D1 (de)	1993-03-18
AU606851B2 (en)	1991-02-21
EP0226827A3 (en)	1988-08-31
FI94134C (fi)	1995-07-25
NO865122L (no)	1987-06-19
EP0226827B1 (en)	1993-02-03
FI865200L (fi)	1987-06-19
IT8548955A0 (it)	1985-12-18
DK572286D0 (da)	1986-11-27
ZA868958B (en)	1987-07-29
AU6608986A (en)	1987-06-25
DE3687702T2 (de)	1993-06-09
DK572286A (da)	1987-06-19
JPS62201898A (ja)	1987-09-05
EP0226827A2 (en)	1987-07-01
ES2001460A6 (es)	1988-05-16

Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19931203

Publication	Publication Date	Title
DK0699191T3 (da)	1999-08-23	Sulfonamider og derivater deraf, der modulerer aktiviteten af endotelin
DK0556498T3 (da)	1996-02-05	1:1-metal-methioninkomplekser i L-form
IT1200162B (it)	1989-01-05	Protezione della metionina in una catena polipeptidica dalla ossidazione irreversibile
BR8907772A (pt)	1991-10-01	Composto,processo de controle de vegetacao indesejavel e composicao herbicida
ES8505999A1 (es)	1985-07-01	Metodo de preparacion de teofilinas 7-substituidas
BE870598A (fr)	1979-03-19	Agents anticorrosifs miscibles a l'eau qui renferment des acides amino-alcanoiques sulfonyles a l'azote
IT1177373B (it)	1987-08-26	Sali della 5'-metiltio-5'-deossiadenosina con acidi solfonici a lunga catena alchilica
ZA891434B (en)	1990-10-31	Azolylmethyloxiranes and fungicides containing these compounds
DE69506903D1 (de)	1999-02-04	Erhöhte solubiliierung von komplexsalzen von methionin mit zink und mangan durch zusatz von ferriionen
DE58907160D1 (de)	1994-04-14	1-Chlor-1-azolyl-methyloxirane und diese enthaltende Fungizide.
IT1137585B (it)	1986-09-10	Pezzo a mano comportante un meccanismo di comando a leve della pinza di serraggio dell'utensile
BE875693A (fr)	1979-08-16	Procede de fabrication d'une lampe etanche a faisceau
IT1184157B (it)	1987-10-22	Metodo di illuminazione di ambienti in genere in particolare di ambienti di lavoro cosiddetti a spazio aperto
DE69306113D1 (de)	1997-01-02	5-amino-2-phenoxysulfonanilid-derivate
JPS5328123A (en)	1978-03-16	Zinc compounds
SE8103598L (sv)	1981-12-10	Antiinflammatoriska medel for yttre anvendning
IT8548214A0 (it)	1985-06-13	Complesso di giroscopio a laser con corpo vibrato
IT7982804A0 (it)	1979-02-27	Concentrazione dell'energia solare per mezzo di corpo trasparente
ES544394A0 (es)	1986-01-16	Un procedimiento para la fabricacion de una pasta de un al- quil (primario) sulfato de sodio
JPS6473345A (en)	1989-03-17	Method for processing silver halide color photographic sensitive material
DK0496720T3 (da)	1995-07-31	Fremgangsmåde til fremstilling af hemiketaler og hemithioketaler
DK0407854T3 (da)	1994-07-25	1-Halogen-vinylazoler og fungicider indeholdende disse
IT1109555B (it)	1985-12-23	Braccio guidalama per catena dentata per motosegatrici portatili di tipo perfezionato
SU1053465A1 (ru)	1999-11-27	2-[2'-(2''-циклопентенил)фениламино]-2-оксоэтилпиридинийхлорид в качестве ингибитора кислотной коррозии стали
JPS5589272A (en)	1980-07-05	N-substituted-4-phenylthiazolin-2-one compound and repellent of organisms-in-water made from the compound