ES2002467A6 - Procedimiento para la preparacion de un antigeno peptido inmunogenico correspondiente a la proteina circumsporozoito de plasmodium vivax - Google Patents

Procedimiento para la preparacion de un antigeno peptido inmunogenico correspondiente a la proteina circumsporozoito de plasmodium vivax

Info

Publication number
ES2002467A6
ES2002467A6 ES8600237A ES8600237A ES2002467A6 ES 2002467 A6 ES2002467 A6 ES 2002467A6 ES 8600237 A ES8600237 A ES 8600237A ES 8600237 A ES8600237 A ES 8600237A ES 2002467 A6 ES2002467 A6 ES 2002467A6
Authority
ES
Spain
Prior art keywords
procedure
vivax
protein
preparation
immunogenic peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600237A
Other languages
English (en)
Inventor
David E Arnot
Vicenzo Enea
Ruth S Nussenzweig
Victor N Nussenzweig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New York University NYU
Original Assignee
New York University NYU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York University NYU filed Critical New York University NYU
Publication of ES2002467A6 publication Critical patent/ES2002467A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN ANTIGENO PEPTIDO INMUNOGENICO CORRESPONDIENTE A LA PROTEINA CINCUMSPOROZOITO DE PLASMODIUM VIVAX. EL PROCEDIMIENTO CONSISTE EN SINTETIZAR BIOLOGICAMENTE EL ANTIGENO PEPTIDICO POR FRACCIONAMIENTO DE DNA AISLADO DE LA FASE DE SANGRE DE P. VIVAX, IDENTIFICANDO Y AISLANDO EL DNA GENOMICO DE P. VIVAX QUE CODIFICA EL GEN PARA DICHA PROTEINA CIRCUMSPOROZOITO POR HIBRIDACION CON UN FRAGMENTO DE DNA DEL GEN CIRCUMSPOROZOITO DE P. CYNOMOLGI, INSERTANDO Y CLONANDO DICHO DNA QUE CODIFICA DICHA PROTEINA CIRCUMSPOROZOITO EN VENTORES BATERIOFAGOS EMBL3, INSERTANDO DICHO VECTOR EN UN MICROORGANISMO APROPIADO CAPAZ DE EXPRESAR EL MENCIONADO VECTOR Y TRADUCIENDOLO PARA OBTENER EL ANTIGENO PEPTIDICO DESEADO. EL ANTIGENO OBTENIDO ES UTIL PARA PREPARAR VACUNAS CONTRA MALARIA PRODUCIDA POR P. VIVAX.
ES8600237A 1985-07-12 1986-07-11 Procedimiento para la preparacion de un antigeno peptido inmunogenico correspondiente a la proteina circumsporozoito de plasmodium vivax Expired ES2002467A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75464585A 1985-07-12 1985-07-12

Publications (1)

Publication Number Publication Date
ES2002467A6 true ES2002467A6 (es) 1988-08-16

Family

ID=25035714

Family Applications (2)

Application Number Title Priority Date Filing Date
ES8600237A Expired ES2002467A6 (es) 1985-07-12 1986-07-11 Procedimiento para la preparacion de un antigeno peptido inmunogenico correspondiente a la proteina circumsporozoito de plasmodium vivax
ES8801174A Expired ES2006631A6 (es) 1985-07-12 1988-04-15 Procedimiento para la preparacion de un antigeno peptido inmunogenico correspondiente a la proteina circumsporozoito de plasmodium vivax.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES8801174A Expired ES2006631A6 (es) 1985-07-12 1988-04-15 Procedimiento para la preparacion de un antigeno peptido inmunogenico correspondiente a la proteina circumsporozoito de plasmodium vivax.

Country Status (13)

Country Link
US (1) US5700906A (es)
EP (1) EP0229829B1 (es)
JP (1) JPS63500591A (es)
AT (1) ATE118784T1 (es)
AU (1) AU590599B2 (es)
DE (1) DE3650242T2 (es)
DK (1) DK124087D0 (es)
ES (2) ES2002467A6 (es)
IL (1) IL79277A0 (es)
NZ (1) NZ216823A (es)
PT (1) PT82975B (es)
WO (1) WO1987000533A1 (es)
ZA (1) ZA865235B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826957A (en) * 1985-07-12 1989-05-02 New York University Immunogenic recombinant yeast expression product and method for purifying it
US4693994A (en) * 1985-11-19 1987-09-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Protective synthetic peptide against malaria and encoding gene
IL85905A0 (en) * 1987-03-30 1988-09-30 Univ New York Immunogenic recombinant yeast expression product and method for purifying it
IT1226711B (it) * 1988-08-05 1991-02-05 Eniricerche Spa Antigeni sintetici utili per la diagnosi della malaria da plasmodium vivax.
US6333406B1 (en) 1988-08-12 2001-12-25 Joseph W. Inselburg Gene encoding protein antigens of Plasmodium falciparum and uses therefor
GB8819209D0 (en) * 1988-08-12 1988-09-14 Research Corp Ltd Polypeptide & dna encoding same
SE8904100D0 (sv) * 1989-12-05 1989-12-05 Astra Ab New analysis method
NZ233255A (en) * 1989-04-11 1993-02-25 Chiron Corp Plasmodium cs protein analogues lacking one or more of the repeat epitopes, and containing at least one nonrepeat flanking epitope
CA2031197A1 (en) * 1989-04-12 1990-10-13 James P. Tam Dendritic polymer of multiple antigen peptide system useful as anti-malarial vaccine
WO1993011157A1 (en) * 1991-11-27 1993-06-10 The Council Of The Queensland Institute Of Medical Research MALARIAL VACCINE AND PEPTIDES COMPRISING HUMAN T-CELL EPITOPE OF CIRCUMSPOROZOITE PROTEIN OF $i(P.VIVAX)
US7083777B1 (en) * 1999-04-02 2006-08-01 The Brigham And Women's Hospital, Inc. Immunomodulating polymers
JP4112860B2 (ja) * 1999-12-17 2008-07-02 ショット アクチエンゲゼルシャフト 乗員の拘束システムの誘導作動式点火カプセルおよび点火カプセル用のテスト回路
SV2003000753A (es) 2000-12-05 2003-06-16 Brigham & Womens Hospital Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico
US20040176283A1 (en) * 2002-04-01 2004-09-09 Robinson John A. Methods and compositions for the design of synthetic vaccines
WO2004089407A2 (en) 2003-03-31 2004-10-21 The Brigham And Women's Hospital, Inc. Zwitterionic immunomodulators for the treatment of asthma and allergy
TWI380996B (zh) 2004-09-17 2013-01-01 Hoffmann La Roche 抗ｏｘ４０ｌ抗體
US7749519B2 (en) * 2005-12-09 2010-07-06 Kim Lee Sim Unique DNA and polypeptide sequences based on the circumsporozoite protein of Plasmodium vivax
US8206726B2 (en) 2006-02-06 2012-06-26 The Brigham And Women's Hospital, Inc. Zwitterionic polysaccharides for promotion of immune system maturation and health
US9364525B2 (en) * 2006-07-18 2016-06-14 Glaxosmithkline Biologicals Sa Vaccines for malaria
US9539281B2 (en) 2011-07-12 2017-01-10 The Brigham And Women's Hospital, Inc. Lipid-containing PSA compositions, methods of isolation and methods of use thereof
US9169304B2 (en) 2012-05-01 2015-10-27 Pfenex Inc. Process for purifying recombinant Plasmodium falciparum circumsporozoite protein
US20140272993A1 (en) * 2013-03-15 2014-09-18 The Translational Genomics Research Institute Method of sequencing a full microrna profile from cerebrospinal fluid
JP6918365B2 (ja) 2015-08-19 2021-08-11 プレジデント アンド フェローズ オブ ハーバード カレッジ 脂質化ｐｓａ組成物および方法
US11491181B2 (en) 2016-07-15 2022-11-08 President And Fellows Of Harvard College Glycolipid compositions and methods of use

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2145092B (en) * 1983-01-28 1988-04-07 Univ New York Protective peptide antigen
US4466917A (en) * 1981-02-12 1984-08-21 New York University Malaria vaccine
US4559602A (en) * 1983-01-27 1985-12-17 Bates Jr John K Signal processing and synthesizing method and apparatus
US4769235A (en) * 1984-01-27 1988-09-06 New York University Immunodominant epitope of the circumsporozoite surface protein
WO1985003724A1 (en) * 1984-02-21 1985-08-29 National Research Development Corporation Improvements in or relating to the production of malaria vaccines
US4707357A (en) * 1984-06-26 1987-11-17 The United States Of America As Represented By The Secretary Of The Army Immunologically active peptides capable of inducing immunization against malaria and genes encoding therefor
ZA855232B (en) * 1984-07-23 1986-02-26 Univ New York Protective peptide antigen corresponding to plasmodium falciparum circumsporozoite protein
NZ213303A (en) * 1984-09-12 1988-09-29 Univ New York Plasmodium protein, dna sequence and vaccine
US4826957A (en) * 1985-07-12 1989-05-02 New York University Immunogenic recombinant yeast expression product and method for purifying it
US4693994A (en) * 1985-11-19 1987-09-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Protective synthetic peptide against malaria and encoding gene

Also Published As

Publication number Publication date
EP0229829A1 (en) 1987-07-29
ES2006631A6 (es) 1989-05-01
EP0229829B1 (en) 1995-02-22
EP0229829A4 (en) 1988-07-27
WO1987000533A1 (en) 1987-01-29
DK124087A (da) 1987-03-11
PT82975A (en) 1986-08-01
DE3650242T2 (de) 1995-06-14
ATE118784T1 (de) 1995-03-15
US5700906A (en) 1997-12-23
IL79277A0 (en) 1986-09-30
DK124087D0 (da) 1987-03-11
DE3650242D1 (de) 1995-03-30
NZ216823A (en) 1990-12-21
ZA865235B (en) 1987-03-25
JPS63500591A (ja) 1988-03-03
AU590599B2 (en) 1989-11-09
PT82975B (pt) 1988-07-01
AU6129286A (en) 1987-02-10

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981103