ES2003643A6 - Procedimiento de preparacion de los nuevos derivados pirimido (5,4-b) (1,4) oxazinos, asi como sus tautomeros y mezclas tautomeras y sales de adicion acidas de estos compuestos - Google Patents
Procedimiento de preparacion de los nuevos derivados pirimido (5,4-b) (1,4) oxazinos, asi como sus tautomeros y mezclas tautomeras y sales de adicion acidas de estos compuestosInfo
- Publication number
- ES2003643A6 ES2003643A6 ES8603622A ES8603622A ES2003643A6 ES 2003643 A6 ES2003643 A6 ES 2003643A6 ES 8603622 A ES8603622 A ES 8603622A ES 8603622 A ES8603622 A ES 8603622A ES 2003643 A6 ES2003643 A6 ES 2003643A6
- Authority
- ES
- Spain
- Prior art keywords
- group
- stands
- hydrogen
- alkyl
- pyrimido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Indole Compounds (AREA)
Abstract
LA PRESENTE PATENTE REIVINDICA UN PROCEDIMIENTO DE PREPARACION DE NUEVOS DERIVADOS PIRIMIDO 5,4, B 1,4 OXAZINOS DE FORMULA GENERAL (I) EN LA QUE R1, R2, R3, R4, R6 Y R9 TIENEN SIGNIFICADOS DIVERSOS, SEGUN SE DESCRIBE EN LA MEMORIA, CARACTERIZADO POR LA REACCION DE UN COMPUESTO DE FORMULA GENERAL (II) CON UNA AMINA DE FORMULA GENERAL HNR5R6 EN LA QUE R5 Y R6 PUEDEN TENER SIGNIFICADOS DIVERSOS, SEGUIDA EN SU CASO POR LA DIAZOTACION DEL COMPUESTO OBTENIDO ANTERIORMENTE, CON 2,3-EPOXIPROPANOL Y SI SE DESEA LA REACCION DEL COMPUESTO ANTERIORMENTE OBTENIDO, CON UN COMPUESTO DE FORMULA GENERAL XR9 DONDE X REPRESENTA UN GRUPO RESIDUAL. Y TAMBIEN SI SE DESEA, LA TRANSFORMACION DE LOS COMPUESTOS ANTERIORMENTE MENCIONADOS EN SUS SALES DE ADICION. LOS COMPUESTOS OBTENIDOS SEGUN LA PRESENTE INVENCION TIENEN VALIOSAS PROPIEDADES FARMACODINAMICAS CARDIOVASCULARES COMO AGENTES CARDIOTONICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU855042A HU195822B (en) | 1985-12-30 | 1985-12-30 | Process for producing new pyrimido/5,4-b//1,h/oxazine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2003643A6 true ES2003643A6 (es) | 1988-11-01 |
Family
ID=10969567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8603622A Expired ES2003643A6 (es) | 1985-12-30 | 1986-12-30 | Procedimiento de preparacion de los nuevos derivados pirimido (5,4-b) (1,4) oxazinos, asi como sus tautomeros y mezclas tautomeras y sales de adicion acidas de estos compuestos |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4748175A (es) |
| EP (1) | EP0228094B1 (es) |
| JP (1) | JPS62228082A (es) |
| CN (1) | CN1021734C (es) |
| AT (1) | ATE66232T1 (es) |
| AU (1) | AU586380B2 (es) |
| CA (1) | CA1287052C (es) |
| CS (1) | CS268822B2 (es) |
| DD (1) | DD256701A5 (es) |
| DE (1) | DE3680893D1 (es) |
| DK (1) | DK630186A (es) |
| ES (1) | ES2003643A6 (es) |
| FI (1) | FI82469C (es) |
| GR (1) | GR862962B (es) |
| HU (1) | HU195822B (es) |
| IL (1) | IL81117A (es) |
| NO (1) | NO170935C (es) |
| NZ (1) | NZ218795A (es) |
| SU (2) | SU1567122A3 (es) |
| YU (1) | YU46039B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5067754A (en) | 1980-10-29 | 1991-11-26 | Propietary Technology, Inc. | Swivelable quick connector assembly |
| CA1331178C (en) * | 1988-02-05 | 1994-08-02 | James J. Wade | Triazolo ¬1,5-c| pyrimido ¬1,4| azines as bronchodilators |
| GB2359551A (en) * | 2000-02-23 | 2001-08-29 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4215216A (en) * | 1979-04-18 | 1980-07-29 | American Home Products Corporation | 7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives |
-
1985
- 1985-12-30 HU HU855042A patent/HU195822B/hu not_active IP Right Cessation
-
1986
- 1986-12-23 NZ NZ218795A patent/NZ218795A/xx unknown
- 1986-12-29 DK DK630186A patent/DK630186A/da not_active Application Discontinuation
- 1986-12-30 CA CA000526548A patent/CA1287052C/en not_active Expired - Lifetime
- 1986-12-30 ES ES8603622A patent/ES2003643A6/es not_active Expired
- 1986-12-30 SU SU864028913A patent/SU1567122A3/ru active
- 1986-12-30 DE DE8686118122T patent/DE3680893D1/de not_active Expired - Lifetime
- 1986-12-30 AT AT86118122T patent/ATE66232T1/de not_active IP Right Cessation
- 1986-12-30 US US06/947,700 patent/US4748175A/en not_active Expired - Fee Related
- 1986-12-30 DD DD86298832A patent/DD256701A5/de not_active IP Right Cessation
- 1986-12-30 FI FI865344A patent/FI82469C/fi not_active IP Right Cessation
- 1986-12-30 YU YU227986A patent/YU46039B/sh unknown
- 1986-12-30 CS CS8610262A patent/CS268822B2/cs unknown
- 1986-12-30 CN CN86108914A patent/CN1021734C/zh not_active Expired - Fee Related
- 1986-12-30 GR GR862962A patent/GR862962B/el unknown
- 1986-12-30 AU AU67043/86A patent/AU586380B2/en not_active Ceased
- 1986-12-30 IL IL81117A patent/IL81117A/xx not_active IP Right Cessation
- 1986-12-30 NO NO865347A patent/NO170935C/no unknown
- 1986-12-30 EP EP86118122A patent/EP0228094B1/de not_active Expired - Lifetime
-
1987
- 1987-01-05 JP JP62000083A patent/JPS62228082A/ja active Pending
-
1988
- 1988-06-14 SU SU884355907A patent/SU1567123A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| FI82469B (fi) | 1990-11-30 |
| EP0228094A3 (en) | 1988-10-12 |
| YU46039B (sh) | 1992-12-21 |
| NO170935C (no) | 1992-12-30 |
| FI865344A7 (fi) | 1987-07-01 |
| NO170935B (no) | 1992-09-21 |
| FI82469C (fi) | 1991-03-11 |
| HU195822B (en) | 1988-07-28 |
| HUT44032A (en) | 1988-01-28 |
| CN1021734C (zh) | 1993-08-04 |
| SU1567123A3 (ru) | 1990-05-23 |
| IL81117A (en) | 1990-07-12 |
| CS1026286A2 (en) | 1989-08-14 |
| JPS62228082A (ja) | 1987-10-06 |
| AU586380B2 (en) | 1989-07-06 |
| FI865344A0 (fi) | 1986-12-30 |
| CN86108914A (zh) | 1987-09-30 |
| US4748175A (en) | 1988-05-31 |
| NO865347L (no) | 1987-07-01 |
| DD256701A5 (de) | 1988-05-18 |
| DK630186A (da) | 1987-07-01 |
| EP0228094B1 (de) | 1991-08-14 |
| AU6704386A (en) | 1987-07-02 |
| CA1287052C (en) | 1991-07-30 |
| SU1567122A3 (ru) | 1990-05-23 |
| GR862962B (en) | 1987-05-05 |
| IL81117A0 (en) | 1987-03-31 |
| CS268822B2 (en) | 1990-04-11 |
| NZ218795A (es) | 1989-02-24 |
| DE3680893D1 (de) | 1991-09-19 |
| DK630186D0 (da) | 1986-12-29 |
| YU227986A (en) | 1988-02-29 |
| EP0228094A2 (de) | 1987-07-08 |
| ATE66232T1 (de) | 1991-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SA6 | Expiration date (snapshot 920101) |
Free format text: 2006-12-30 |
|
| FD1A | Patent lapsed |
Effective date: 20010402 |