ES2004133A6 - Procedimiento para la preparacion de una nueva proteina. - Google Patents

Procedimiento para la preparacion de una nueva proteina.

Info

Publication number
ES2004133A6
ES2004133A6 ES8700968A ES8700968A ES2004133A6 ES 2004133 A6 ES2004133 A6 ES 2004133A6 ES 8700968 A ES8700968 A ES 8700968A ES 8700968 A ES8700968 A ES 8700968A ES 2004133 A6 ES2004133 A6 ES 2004133A6
Authority
ES
Spain
Prior art keywords
protein
htlv
gag
purification
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8700968A
Other languages
English (en)
Inventor
Robert Mitchell Crowl
Daru Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES2004133A6 publication Critical patent/ES2004133A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/14011—Deltaretrovirus, e.g. bovine leukeamia virus
    • C12N2740/14022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/974—Aids related test
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • AIDS & HIV (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

PROCEDIMIENTO PARA PRODUCIR UNA PROTEINA QUE TIENE UNA SECUENCIA DE AMINOACIDOS CORRESPONDIENTE A POR LO MENOS UN DETERMINANTE ANTIGENETICO DE UNA PROTEINA GAG HTLV©III Y DE UNA ENV PROTEINA HTLV©III. EL PROCEDIMIENTO COMPRENDE CULTIVAR UN ORGANISMO UNICELULAR QUE CONTIENE UN VECTOR RECOMBINANTE QUE COMPRENDE UNA SECUENCIA DE DNA QUE CODIFICA DICHA PROTEINA BAJO CONDICIONES APROPIADAS DE DESARROLLO, DE MODO QUE SE EXPRESA DICHA PROTEINA. SE AISLA DICHA PROTEINA DEL CULTIVO, Y, SI SE DESEA, SE PURIFICA. SE USAN METODOS PROPIOS DE LA TECNOLOGIA DE DNA. LA PROTEINA GAG/ENV OBTENIDA POR ESTE PROCEDIMIENTO PUEDE UTILIZARSE CON LOS METODOS DE ESTE INVENTO PARA UN NUMERO IMPORTANTE DE PROCEDIMIENTOS INMUNOLOGICOS.
ES8700968A 1986-04-04 1987-04-03 Procedimiento para la preparacion de una nueva proteina. Expired ES2004133A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/848,671 US4925784A (en) 1986-04-04 1986-04-04 Expression and purification of an HTLV-III gag/env gene protein

Publications (1)

Publication Number Publication Date
ES2004133A6 true ES2004133A6 (es) 1988-12-01

Family

ID=25303966

Family Applications (3)

Application Number Title Priority Date Filing Date
ES8700968A Expired ES2004133A6 (es) 1986-04-04 1987-04-03 Procedimiento para la preparacion de una nueva proteina.
ES8803113A Expired - Lifetime ES2016426A6 (es) 1986-04-04 1988-10-14 Un procedimiento para detectar la presencia de anticuerpos frente a virus del sida en el suero humano.
ES8803112A Expired ES2009350A6 (es) 1986-04-04 1988-10-14 Procedimiento para la preparacion de vectores de expresion que codifican una nueva proteina.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES8803113A Expired - Lifetime ES2016426A6 (es) 1986-04-04 1988-10-14 Un procedimiento para detectar la presencia de anticuerpos frente a virus del sida en el suero humano.
ES8803112A Expired ES2009350A6 (es) 1986-04-04 1988-10-14 Procedimiento para la preparacion de vectores de expresion que codifican una nueva proteina.

Country Status (23)

Country Link
US (1) US4925784A (es)
JP (1) JP2625118B2 (es)
KR (1) KR930001118B1 (es)
AT (1) AT400442B (es)
AU (1) AU599091B2 (es)
BE (1) BE1001973A5 (es)
BR (1) BR8701528A (es)
CA (1) CA1341249C (es)
CH (1) CH676004A5 (es)
DE (3) DE3744825C2 (es)
DK (1) DK172274B1 (es)
ES (3) ES2004133A6 (es)
FR (1) FR2606422B1 (es)
GB (1) GB2188639B (es)
IL (1) IL82088A (es)
IT (1) IT1203851B (es)
NL (1) NL192275C (es)
NO (1) NO871409L (es)
NZ (1) NZ219837A (es)
SE (1) SE8701413L (es)
SG (1) SG102792G (es)
SU (1) SU1644720A3 (es)
ZA (1) ZA871724B (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9309574B1 (en) 1984-08-22 2016-04-12 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Molecular cloning of HIV-1 from immortalized cell lines
DE3688051T2 (de) * 1985-12-17 1993-06-24 Akzo Nv Immunochemisches reagenz.
AU590382B2 (en) * 1985-12-24 1989-11-02 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Plasmid and phage clones of human t-cell lymphotropic virus type iii
US4925784A (en) * 1986-04-04 1990-05-15 Hoffmann-La Roche Inc. Expression and purification of an HTLV-III gag/env gene protein
US4983387A (en) * 1986-05-19 1991-01-08 Viral Technologies Inc. HIV related peptides, immunogenic antigens, and use therefor as subunit vaccine for AIDS virus
US5142025A (en) * 1986-08-01 1992-08-25 Repligen Corporation Recombinant HTLV-III proteins and uses thereof
NZ221440A (en) * 1986-08-20 1991-11-26 Genetic Systems Corp Composition containing monoclonal antibodies/peptides useful in treating and diagnosing hiv infections
US5166050A (en) * 1986-08-20 1992-11-24 Bristol-Myers Squibb Company Monoclonal antibodies and peptides useful in treating and diagnosing HIV infections
US5041385A (en) * 1986-11-01 1991-08-20 Oxford Gene Systems Limited Vector expressing fusion proteins and particles
FI885441L (fi) * 1987-03-23 1988-11-23 Hiver Ltd Nya vaccin.
JP2634203B2 (ja) * 1987-09-04 1997-07-23 インターナショナル ミュレックス テクノロジーズ コーポレイション イムノアツセイおよびそれに使用される生物学的構築体
EP0311228A3 (en) * 1987-10-09 1990-05-02 Repligen Corporation Recombinant polypeptides and their uses, including assay for aids virus
NO881501L (no) * 1987-10-09 1989-04-10 Repligen Corp Rekombinante htlv-111-proteiner og anvendelser av disse.
DE3879881D1 (de) * 1987-11-16 1993-05-06 Hoffmann La Roche Rekombinante hiv-2 polypeptide.
US5780038A (en) * 1987-11-16 1998-07-14 Roche Diagnostic Systems, Inc. HIV-2 envelope polypeptides
JPH01179687A (ja) * 1987-12-30 1989-07-17 Chemo Sero Therapeut Res Inst Ｈｉｖ融合蛋白質
JP2559482B2 (ja) * 1988-01-12 1996-12-04 ジーンラブズ テクノロジーズ，インコーポレイテッド Ｈｔｌｖーｉペプチド抗原および分析法
US5204259A (en) * 1988-05-06 1993-04-20 Pharmacia Genetic Engineering, Inc. Methods and systems for producing HIV antigens
DE68917520T2 (de) * 1988-05-06 1995-01-05 Ferropas Ag Verfahren und Systeme zur Herstellung von HIV-Antigenen.
FR2632310B1 (fr) * 1988-06-06 1992-04-10 Pasteur Institut Peptides ayant des proprietes protectrices d'un virus pathogene du type hiv dans des cellules sensibles
US6197496B1 (en) 1988-06-09 2001-03-06 Institut Pasteur Immunological reagents and diagnostic methods for the detection of human immunodeficiency virus type 2 utilizing multimeric forms of the envelope proteins gp300, p200, and p90/80
CA2003383A1 (en) 1988-11-23 1990-05-23 Sushil G. Devare Synthetic dna derived recombinant hiv antigens
US5817318A (en) * 1989-05-03 1998-10-06 Connaught Laboratories Limited Synthetic peptides for an HIV-1 vaccine
GB8923123D0 (en) * 1989-10-13 1989-11-29 Connaught Lab A vaccine for human immunodeficiency virus
ATE183235T1 (de) * 1990-03-21 1999-08-15 Wolf Hans Joachim Prof Dr Für abgeänderte retrovirale gag-polypeptide kodierende dna-sequenzen und diese enthaltende impfstoffe oder aggregate davon
US6228608B1 (en) 1991-02-28 2001-05-08 Aquila Biopharmaceuticals, Inc. Recombinant FIV glycoprotein 160 and P24 gag protein
JP3327549B2 (ja) * 1991-08-21 2002-09-24 アボツト・ラボラトリーズ Ｃ１００領域に対する組換え抗原を利用したｃ型肝炎アッセイ
GB9208218D0 (en) * 1992-04-14 1992-05-27 British Bio Technology Hybrid particles
CA2084386C (en) * 1992-06-04 2001-02-20 Atsushi Saito Hiv antigen
US5580773A (en) * 1992-06-17 1996-12-03 Korea Green Cross Corporation Chimeric immunogenic gag-V3 virus-like particles of the human immunodeficiency virus (HIV)
KR0172970B1 (ko) * 1992-06-17 1999-02-01 김영길 Aids백신에 유용한 키메릭 단백 및 그의 제조방법
DK0586076T3 (da) * 1992-08-07 2003-10-20 Wyeth Corp Rekombinant adenovirus-vacciner
CN1111540C (zh) * 1993-06-09 2003-06-18 康诺特实验室有限公司 串联的合成hiv－1肽类
PT638316E (pt) * 1993-08-11 2003-10-31 Wyeth Corp Vacinas de adenoviros recombinante
WO1995016040A2 (en) * 1993-12-10 1995-06-15 The Canadian Red Cross Society Immunofluorescence assay for the detection of antibodies using recombinant antigens in insoluble form
DE4405810A1 (de) 1994-02-23 1995-08-24 Behringwerke Ag Von einem Retrovirus aus der HIV-Gruppe abgeleitete Peptide und deren Verwendung
AU2517895A (en) * 1994-05-20 1995-12-18 Microgenesys, Inc. Hiv polyprotein immunogens
FR2726576B1 (fr) * 1994-11-07 1997-01-31 Pf Medicament Production de peptides analogues de peptides hydrophobes, peptide recombinant, sequence d'adn correspondante
RU2126048C1 (ru) * 1997-01-28 1999-02-10 Институт молекулярной генетики РАН Способ определения генетической устойчивости обследуемых к инфицированию вирусом иммунодефицита человека первого типа (вич-1)
US6846905B2 (en) * 1997-08-15 2005-01-25 Abbott Laboratories Antigen constructs useful in the detection and differentiation of antibodies to HIV
NO311807B1 (no) 1999-03-04 2002-01-28 Bionor Immuno As HIV-peptider, antigener, vaksinepreparater, immunoassay- testsett og en metode for påvisning av antistoffer fremkalt av HIV
DE10106295C1 (de) * 2001-02-02 2002-08-22 Gaifar German American Inst Fo Protein mit mehreren Antigen-Epitop-Sequenzen, welches immobilisiert ist
AU2013273481B2 (en) 2012-06-06 2018-04-05 Bionor Immuno As HIV vaccine
WO2016005508A1 (en) 2014-07-11 2016-01-14 Bionor Immuno As Method for reducing and/or delaying pathological effects of human immunodeficiency virus i (hiv) or for reducing the risk of developing acquired immunodeficiency syndrome (aids)

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4237224A (en) * 1974-11-04 1980-12-02 Board Of Trustees Of The Leland Stanford Jr. University Process for producing biologically functional molecular chimeras
DE2814039C3 (de) * 1978-03-31 1981-02-19 Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig Verfahren zur Herstellung von Hybrid-Bakterien
GB8423659D0 (en) * 1984-09-19 1984-10-24 Pasteur Institut Cloned dna sequences
GB8324800D0 (en) * 1983-09-15 1983-10-19 Pasteur Institut Antigens
IE58321B1 (en) * 1984-04-23 1993-09-08 Us Health Isolation of proteins of HTLV-III, serological detection of antibodies to HTLV-III in sera of patients with aids and pre-aids conditions, and detection of HTLV-III infection bi/immuno-assays using HTLV-III infection by immuno-assays using HTLV-III and its proteins
WO1986000930A1 (en) * 1984-07-20 1986-02-13 Worcester Foundation For Experimental Biology Retroviral vaccines and vectors and methods for their construction
IL76082A (en) * 1984-08-22 1991-07-18 Us Health Molecular clones of the genome of htlv-iii and a process for the preparation thereof
NZ213823A (en) * 1984-10-26 1988-05-30 Us Health Producing human t-cell leukemia retrovirus envelope protein fragments in bacteria
CA1341423C (en) * 1984-10-31 2003-03-04 Paul A. Luciw Recombinant proteins of viruses associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome
DE3588134T2 (de) * 1984-12-24 1997-03-20 Genentech Inc Fusionen von AIDS-verwandten Polypeptiden
US4774175A (en) * 1985-03-01 1988-09-27 Centocor, Inc. Immunochemical methods for the detection of antibody against HTLV-III
US4751180A (en) * 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
ES8706824A1 (es) * 1985-04-08 1987-07-01 Genetic Systems Corp Un metodo para preparar proteinas que son inmunologicamente reactivas con anticuerpos para virus asociados con linfadenopatia.
FI861626A7 (fi) * 1985-04-19 1986-10-20 Hoffmann La Roche Foervaervat immunbristsyndrom (aids) -relaterat viralt rekombinant hoeljeprotein samt ett testfoerfarande foer aids.
EP0220273B2 (en) * 1985-04-29 2007-01-17 Bio-Rad Laboratories, Inc. Synthetic antigens for the detection of aids-related disease
EP0213894A3 (en) * 1985-08-23 1987-10-21 Advanced Genetics Research Institute Defective viral particle vaccines and methods for their use
JP2564268B2 (ja) * 1985-08-28 1996-12-18 協和醗酵工業株式会社 融合抗原ポリペプチド
JP2702911B2 (ja) * 1985-09-11 1998-01-26 ユナイテツド・バイオメデイカル・インコ−ポレ−テツド 合成ペプチド、並びにそれを用いたエイズおよびプリ・エイズの検出方法
NZ217645A (en) * 1985-09-25 1991-11-26 Oncogen Recombinant viruses expressing lav/htlv-iii related epitopes and vaccine formulations
GB8525615D0 (en) * 1985-10-17 1985-11-20 Hoffmann La Roche Polypeptides
ATE108022T1 (de) * 1985-10-24 1994-07-15 Southwest Found Biomed Res Synthetische peptide und deren verwendung zur diagnose und impfung für aids und arc.
AU6713287A (en) * 1986-01-06 1987-07-09 F. Hoffmann-La Roche & Co. Expression of htlv-iii gag-gene
US4753873A (en) * 1986-02-03 1988-06-28 Cambridge Bioscience Corporation Peptides for the diagnosis of HTLV-III antibodies, their preparation and use
US4734362A (en) * 1986-02-03 1988-03-29 Cambridge Bioscience Corporation Process for purifying recombinant proteins, and products thereof
US4808536A (en) * 1986-02-27 1989-02-28 Centocor, Inc. Immunochemical method for detection of antibody against HTLV-III core protein based upon recombinant HTLV-III gag gene encoded protein
US4925784A (en) * 1986-04-04 1990-05-15 Hoffmann-La Roche Inc. Expression and purification of an HTLV-III gag/env gene protein
GB8629116D0 (en) * 1986-12-05 1987-01-14 Hoffmann La Roche Env/gag polypeptides

Also Published As

Publication number Publication date
NZ219837A (en) 1990-09-26
US4925784A (en) 1990-05-15
KR870010189A (ko) 1987-11-30
KR930001118B1 (ko) 1993-02-18
NO871409D0 (no) 1987-04-03
CA1341249C (en) 2001-06-12
FR2606422A1 (fr) 1988-05-13
NO871409L (no) 1987-10-05
IT1203851B (it) 1989-02-23
IL82088A (en) 1991-11-21
NL192275C (nl) 1997-04-03
JPS62244393A (ja) 1987-10-24
FR2606422B1 (fr) 1991-01-04
ATA82487A (de) 1995-05-15
DE3744827C2 (es) 1990-08-09
GB2188639B (en) 1990-09-26
SU1644720A3 (ru) 1991-04-23
DE3711016A1 (de) 1987-10-08
AU7103287A (en) 1987-10-08
AU599091B2 (en) 1990-07-12
DE3744825C2 (es) 1990-10-25
DE3711016C2 (es) 1990-08-02
IT8719973A0 (it) 1987-04-03
AT400442B (de) 1995-12-27
SE8701413D0 (sv) 1987-04-03
CH676004A5 (es) 1990-11-30
IL82088A0 (en) 1987-10-30
ES2009350A6 (es) 1989-09-16
ES2016426A6 (es) 1990-11-01
BE1001973A5 (fr) 1990-05-02
DK172274B1 (da) 1998-02-16
DK166087D0 (da) 1987-04-01
DK166087A (da) 1987-10-05
BR8701528A (pt) 1988-01-19
SG102792G (en) 1993-01-29
NL192275B (nl) 1996-12-02
GB8707971D0 (en) 1987-05-07
SE8701413L (sv) 1987-10-05
NL8700795A (nl) 1987-11-02
ZA871724B (en) 1987-11-25
GB2188639A (en) 1987-10-07
JP2625118B2 (ja) 1997-07-02

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