ES2008632A6 - Thiophene-carboxamide deriv. prepn. - Google Patents

Thiophene-carboxamide deriv. prepn.

Info

Publication number
ES2008632A6
ES2008632A6 ES8803046A ES8803046A ES2008632A6 ES 2008632 A6 ES2008632 A6 ES 2008632A6 ES 8803046 A ES8803046 A ES 8803046A ES 8803046 A ES8803046 A ES 8803046A ES 2008632 A6 ES2008632 A6 ES 2008632A6
Authority
ES
Spain
Prior art keywords
alkyl
deriv
prepn
carboxamide
thiophene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8803046A
Other languages
Spanish (es)
Inventor
Fernandez M Isabel Fernandez
Terrence M Hotten
David Edward Tupper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lilly SA
Lilly Industries Ltd
Original Assignee
Lilly SA
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly SA, Lilly Industries Ltd filed Critical Lilly SA
Priority to ES8803046A priority Critical patent/ES2008632A6/en
Publication of ES2008632A6 publication Critical patent/ES2008632A6/en
Expired legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The derivs. are of formula (I) in which R1, R2 and R3 are H, OH, halogen, NO2, NH2, 2-5C acylamino, 1-4C alkyl, CHO, CH2OH, CH2O-1-4C alkyl, COOH, CO-1-3C alkyl, CH(OH)-1-3C alkyl, 1-4C alkoxy, 2-4C alkenyloxy, 1-4C alkylthio, alkylsulphinyl or alkylsulphonyl, N-substd. heterocycle, opt. substd. phenyl, phenylthio, phenylsulphinyl, phenylsulphonyl or phenylsulphonamido, or R1 and R2 together form a 3-5C alkylene bridge, one of R2 and R3 being 1-4C alkoxy or 2-4C alkenyl-oxy, and X is a 5-8C alicyclic gp. contg. amidic N or linked by a 1-3C alkylene gp. - They act on the central nervous system in treatment of vomiting, depression, anxiety or certain psychotic states, and are made by reaction of a cpd. (II), in which Z is halogen, OH or OR, R is an active gp., with an amine X-NH2.
ES8803046A 1988-10-06 1988-10-06 Thiophene-carboxamide deriv. prepn. Expired ES2008632A6 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES8803046A ES2008632A6 (en) 1988-10-06 1988-10-06 Thiophene-carboxamide deriv. prepn.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8803046A ES2008632A6 (en) 1988-10-06 1988-10-06 Thiophene-carboxamide deriv. prepn.

Publications (1)

Publication Number Publication Date
ES2008632A6 true ES2008632A6 (en) 1989-07-16

Family

ID=8258376

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8803046A Expired ES2008632A6 (en) 1988-10-06 1988-10-06 Thiophene-carboxamide deriv. prepn.

Country Status (1)

Country Link
ES (1) ES2008632A6 (en)

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2008-10-06

FD1A Patent lapsed

Effective date: 20100528