ES2009590A6 - Metodo de preparacion de proteina de cadena pesada del factor tisular humano. - Google Patents

Metodo de preparacion de proteina de cadena pesada del factor tisular humano.

Info

Publication number
ES2009590A6
ES2009590A6 ES8801019A ES8801019A ES2009590A6 ES 2009590 A6 ES2009590 A6 ES 2009590A6 ES 8801019 A ES8801019 A ES 8801019A ES 8801019 A ES8801019 A ES 8801019A ES 2009590 A6 ES2009590 A6 ES 2009590A6
Authority
ES
Spain
Prior art keywords
tissue factor
protein
human tissue
heavy chain
chain protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8801019A
Other languages
English (en)
Inventor
Thomas S Edgington
James H Morrisey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Clinic and Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27364291&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2009590(A6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/067,103 external-priority patent/US5110730A/en
Application filed by Scripps Clinic and Research Foundation filed Critical Scripps Clinic and Research Foundation
Publication of ES2009590A6 publication Critical patent/ES2009590A6/es
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

METODO DE PREPARACION DE PROTEINA DE CADENA PESADA DEL FACTOR TISULAR HUMANO. EL METODO COMPRENDE: A) CULTIVARCELULAS DE MAMIFEROS TRANSFORMADOS CON UNA MOLECULA DE ADN RECOMBINANTE QUE COMPRENDE UN VECTOR DE EXPRESION COMPATIBLE, OPERATIVAMENTE ENLAZADO A UN PRIMER SEGMENTO DE ADN CODIFICANTE DE LA PROTEINA DE CADENA PESADA DEL FACTOR TISULAR (FT) HUMANO, Y UN SEGUNDO SEGMENTO DE ADN CONTIGUO AL PRIMERO, CODIFICANTE DE UNA SECUENCIA LIDER, DEFINIENDO CONJUNTAMENTE DICHOS SEGMENTOS UN GEN ESTRUCTURAL QUE CODIFICA A UNA FORMA PRECURSORA DE DICHA PROTEINA; B) MANTENER EL CULTIVO HASTA LA EXPRESION DE LA PROTEINA; Y C) RECUPERAR LA PROTEINA. LA SECUENCIA DE AMINOACIDOS DE LA PROTEINA CODIFICADA POR EL GEN ESTRUCTURAL SE REPRESENTA EN LA FORMULA (I). SE PROPORCIONAN ADEMAS ANALOGOS POLIPEPTIDOS DEL SITIO DE UNION DEL FACTOR TISULAR HUMANO ADECUADOS PARA INHIBIR O NEUTRALIZAR LA UNION DEL FACTOR TISULAR ALFACTOR DE COAGULACION VII/VIIA EVITANDO ASI LA COAGULACION.
ES8801019A 1987-03-31 1988-03-30 Metodo de preparacion de proteina de cadena pesada del factor tisular humano. Expired ES2009590A6 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3304787A 1987-03-31 1987-03-31
US07/067,103 US5110730A (en) 1987-03-31 1987-06-25 Human tissue factor related DNA segments
US07/165,939 US5223427A (en) 1987-03-31 1988-03-09 Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain

Publications (1)

Publication Number Publication Date
ES2009590A6 true ES2009590A6 (es) 1989-10-01

Family

ID=27364291

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8801019A Expired ES2009590A6 (es) 1987-03-31 1988-03-30 Metodo de preparacion de proteina de cadena pesada del factor tisular humano.

Country Status (13)

Country Link
US (2) US5223427A (es)
EP (2) EP1364969A3 (es)
JP (1) JP2809415B2 (es)
AT (1) ATE246200T1 (es)
AU (1) AU605864B2 (es)
CA (1) CA1340544C (es)
DE (1) DE3856560T2 (es)
DK (1) DK175703B1 (es)
ES (1) ES2009590A6 (es)
FI (2) FI100184B (es)
NO (1) NO305211B1 (es)
PT (1) PT87138B (es)
WO (1) WO1988007543A1 (es)

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US5504064A (en) * 1991-04-10 1996-04-02 Oklahoma Medical Research Foundation Treatment of bleeding with modified tissue factor in combination with an activator of FVII
US5374617A (en) * 1992-05-13 1994-12-20 Oklahoma Medical Research Foundation Treatment of bleeding with modified tissue factor in combination with FVIIa
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Also Published As

Publication number Publication date
DK175703B1 (da) 2005-01-24
WO1988007543A1 (en) 1988-10-06
DE3856560T2 (de) 2004-08-05
EP0309548B1 (en) 2003-07-30
DE3856560D1 (de) 2003-09-04
ATE246200T1 (de) 2003-08-15
FI954347A0 (fi) 1995-09-15
AU1627488A (en) 1988-11-02
AU605864B2 (en) 1991-01-24
EP0309548A4 (en) 1991-08-07
US5622931A (en) 1997-04-22
CA1340544C (en) 1999-05-18
DK666888D0 (da) 1988-11-29
EP1364969A3 (en) 2004-12-29
FI885543L (fi) 1988-11-29
NO885326L (no) 1989-01-30
FI100184B (fi) 1997-10-15
NO885326D0 (no) 1988-11-29
DK666888A (da) 1989-01-31
NO305211B1 (no) 1999-04-19
PT87138B (pt) 1992-07-31
FI97813B (fi) 1996-11-15
US5223427A (en) 1993-06-29
FI885543A0 (fi) 1988-11-29
FI954347L (fi) 1995-09-15
PT87138A (pt) 1988-04-01
JP2809415B2 (ja) 1998-10-08
EP1364969A2 (en) 2003-11-26
JPH01503438A (ja) 1989-11-22
FI97813C (fi) 1997-02-25
EP0309548A1 (en) 1989-04-05

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