ES2015665A6 - Procedimiento para preparar nuevos compuestos de tiofosforamidito y fosforoditioato de nucleosidos y polinucleotidos. - Google Patents

Procedimiento para preparar nuevos compuestos de tiofosforamidito y fosforoditioato de nucleosidos y polinucleotidos.

Info

Publication number
ES2015665A6
ES2015665A6 ES8901786A ES8901786A ES2015665A6 ES 2015665 A6 ES2015665 A6 ES 2015665A6 ES 8901786 A ES8901786 A ES 8901786A ES 8901786 A ES8901786 A ES 8901786A ES 2015665 A6 ES2015665 A6 ES 2015665A6
Authority
ES
Spain
Prior art keywords
polynucleotide
processes
thiophosphoramidite
nucleoside
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES8901786A
Other languages
English (en)
Inventor
Marvin Caruthers
Wolfgang Brill
John Nielsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University Patents Inc
Original Assignee
University Patents Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Patents Inc filed Critical University Patents Inc
Publication of ES2015665A6 publication Critical patent/ES2015665A6/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVOS COMPUESTOS DE TIOFOSFORAMIDITO Y FOSFORODITIOATO DE NUCLEOSIDOS Y POLINUCLEOTIDOS. COMPRENDE CONDENSAR EL GRUPO 3''-OH O 5''-OH DE UN NUCLEOSIDO U OLIGONUCLEOTIDO, MEDIANTE UN AGENTE DE ACOPLAMIENTO A TRAVES DEL 5''-O- O 3''-O-, RESPECTIVAMENTE, DE DICHO NUCLEOSIDO U OLIGONUCLEOTIDO, CON UN COMPUESTO DE FORMULA: EN DONDE LOS DISTINTOS RADICALES TIENEN LOS SIGNIFICADOS INDICADOS EN LA DESCRIPCION. LOS NUEVOS COMPUESTOS TIENEN APLICACION BIOLOGICA, TERAPEUTICA Y DIAGNOSTICA.
ES8901786A 1988-05-26 1989-05-26 Procedimiento para preparar nuevos compuestos de tiofosforamidito y fosforoditioato de nucleosidos y polinucleotidos. Expired - Fee Related ES2015665A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19888688A 1988-05-26 1988-05-26
US31401189A 1989-02-22 1989-02-22

Publications (1)

Publication Number Publication Date
ES2015665A6 true ES2015665A6 (es) 1990-09-01

Family

ID=26894243

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8901786A Expired - Fee Related ES2015665A6 (es) 1988-05-26 1989-05-26 Procedimiento para preparar nuevos compuestos de tiofosforamidito y fosforoditioato de nucleosidos y polinucleotidos.

Country Status (7)

Country Link
EP (1) EP0378615A4 (es)
JP (1) JPH03501128A (es)
KR (1) KR900701813A (es)
AU (1) AU626305B2 (es)
ES (1) ES2015665A6 (es)
IL (1) IL90359A0 (es)
WO (1) WO1989011486A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756496B1 (en) 1988-09-23 2004-06-29 Isis Pharmaceuticals, Inc. Nucleoside hydrogen phosphonodithioate diesters and activated phosphonodithioate analogues
US5194599A (en) * 1988-09-23 1993-03-16 Gilead Sciences, Inc. Hydrogen phosphonodithioate compositions
US5470967A (en) * 1990-04-10 1995-11-28 The Dupont Merck Pharmaceutical Company Oligonucleotide analogs with sulfamate linkages
US5151510A (en) * 1990-04-20 1992-09-29 Applied Biosystems, Inc. Method of synethesizing sulfurized oligonucleotide analogs
EP0463712A3 (en) 1990-06-27 1992-04-08 University Patents, Inc. Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections
US5378825A (en) * 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
US5610289A (en) * 1990-07-27 1997-03-11 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogues
US5623070A (en) * 1990-07-27 1997-04-22 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
US5602240A (en) * 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
JPH06505704A (ja) * 1990-09-20 1994-06-30 ギリアド　サイエンシズ，インコーポレイテッド 改変ヌクレオシド間結合
US5965722A (en) * 1991-05-21 1999-10-12 Isis Pharmaceuticals, Inc. Antisense inhibition of ras gene with chimeric and alternating oligonucleotides
ATE161586T1 (de) 1991-10-11 1998-01-15 Behringwerke Ag Verfahren zur herstellung eines polynukleotids zum gebrauch in ''single-primer'' amplifizierung und phosphorothioat-enthaltende oligonukleotide als primer in nukleinsäureamplifizierung
AU3920293A (en) * 1993-03-16 1994-10-11 Board Of Regents Of The University Of Nebraska, The Novel metal binding agents, and methods and compositions for their use to treat metal toxicity
US6001982A (en) 1993-07-29 1999-12-14 Isis Pharmaceuticals, Inc. Synthesis of oligonucleotides
US5571902A (en) * 1993-07-29 1996-11-05 Isis Pharmaceuticals, Inc. Synthesis of oligonucleotides
EP0932698A1 (en) * 1996-03-26 1999-08-04 Lynx Therapeutics, Inc. Oligonucleotide treatments and compositions for human melanoma
US7255874B1 (en) 2001-12-21 2007-08-14 Closure Medical Corporation Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto
JP6358955B2 (ja) 2012-10-31 2018-07-18 武田薬品工業株式会社 新規修飾核酸
PE20210255A1 (es) 2016-12-01 2021-02-10 Takeda Pharmaceuticals Co Dinucleotido ciclico como agonistas de sting (estimulador de genes de interferon)
CN110678447B (zh) 2017-06-16 2023-12-12 卫材R&D管理有限公司 经修饰的核酸单体化合物及寡核酸类似物
WO2019122279A1 (en) * 2017-12-22 2019-06-27 Roche Innovation Center Copenhagen A/S Oligonucleotides comprising a phosphorodithioate internucleoside linkage
CA3084170A1 (en) * 2017-12-22 2019-06-27 Roche Innovation Center Copenhagen A/S Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage
CN111039977B (zh) * 2019-12-31 2022-11-08 广州同隽医药科技有限公司 一种亚磷酰化试剂及其在寡核苷酸合成中的应用
WO2022122613A1 (en) * 2020-12-08 2022-06-16 F. Hoffmann-La Roche Ag Novel synthesis of phosphorodithioate oligonucleotides

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US808708A (en) * 1905-09-20 1906-01-02 Earnest R Wingate Clamp.
US3451997A (en) * 1965-11-30 1969-06-24 Kyowa Hakko Kogyo Kk Monothio-phosphate ester catalysis for preparation of ribonucleoside derivatives
DE2122529A1 (de) * 1971-05-06 1972-12-14 Max Planck Gesellschaft zur Förde rung der Wissenschaften e V , 3400 Gottin gen Thiophosphatanaloge der Nucleosid di und tnphosphate sowie Verfahren zu ihrer Herstellung
US3853844A (en) * 1972-08-04 1974-12-10 R Robins Nucleoside 3{40 ,5{40 ,-cyclic phosphorothioates
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
US4668777A (en) * 1981-03-27 1987-05-26 University Patents, Inc. Phosphoramidite nucleoside compounds
US4373071A (en) * 1981-04-30 1983-02-08 City Of Hope Research Institute Solid-phase synthesis of polynucleotides
US4728730A (en) * 1984-09-12 1988-03-01 Wisconsin Alumini Research Foundation Synthesis of nucleoside thiophosphoanhydrides
JPS6251695A (ja) * 1985-08-29 1987-03-06 Yuki Gosei Yakuhin Kogyo Kk ホスホロアミダイト類の合成法
WO1990012022A1 (en) * 1989-03-31 1990-10-18 University Patents, Inc. Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections
AU6603690A (en) * 1989-10-05 1991-04-28 University Patents Inc. Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and processes

Also Published As

Publication number Publication date
KR900701813A (ko) 1990-12-04
WO1989011486A1 (en) 1989-11-30
AU626305B2 (en) 1992-07-30
EP0378615A1 (en) 1990-07-25
JPH03501128A (ja) 1991-03-14
AU3739289A (en) 1989-12-12
IL90359A0 (en) 1989-12-15
EP0378615A4 (en) 1992-04-08

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FD1A Patent lapsed

Effective date: 20000201