ES2017810A6 - Preparacion de compuestos tetrazolicos antihipercolesterolemicos e intermedios para los mismos. - Google Patents

Preparacion de compuestos tetrazolicos antihipercolesterolemicos e intermedios para los mismos.

Info

Publication number
ES2017810A6
ES2017810A6 ES8900538A ES8900538A ES2017810A6 ES 2017810 A6 ES2017810 A6 ES 2017810A6 ES 8900538 A ES8900538 A ES 8900538A ES 8900538 A ES8900538 A ES 8900538A ES 2017810 A6 ES2017810 A6 ES 2017810A6
Authority
ES
Spain
Prior art keywords
compound
hypercholesterolemic
compounds
tetrazolic
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES8900538A
Other languages
English (en)
Inventor
William Teh-Wei Han
John J Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES2017810A6 publication Critical patent/ES2017810A6/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Liquid Crystal Substances (AREA)

Abstract

PREPARACION DE COMPUESTOS TETRAZOLICOS ANTIHIPERCOLESTEROLEMICOS E INTERMEDIOS PARA LOS MISMOS. SE DESCRIBE UN PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS INTERMEDDIOS DE FORMULAS IX, IIIB Y XII DADAS EN LA MEMORIA Y DEL AGENTE ANTIHIPERCOLESTEROLEMICO DE FORMULA III TAMBIEN DADA EN LA MEMORIA EN FORMA SUSTANCIALMENTE CIS O CIS-(4R,6SS), QUE CONSISTE EN HIDROLIZAR UN ESTER VIII, RESOLVER EL ACIDO VIII OBTENIDO Y OXIDAR EL ACIDO DE IX OBTENIDO PARA OBTENER UN COMPUESTO IIIB Y DESPUES HACER REACCIONAR EL COMPUESTO IIIB CON UN COMPUESTO X PARA OBTENER UN COMPUESTO XII QUE SE HACE REACCIONAR CON UN ACIDO PARA DAR EL COMPUESTO I Y FINALMENTE CICLAR EL COMPUESTO I PARA FORMAR EL COMPUESTO II.
ES8900538A 1988-02-18 1989-02-15 Preparacion de compuestos tetrazolicos antihipercolesterolemicos e intermedios para los mismos. Expired - Fee Related ES2017810A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/156,865 US4824959A (en) 1988-02-18 1988-02-18 Intermediates for antihypercholesterolemic tetrazole compounds

Publications (1)

Publication Number Publication Date
ES2017810A6 true ES2017810A6 (es) 1991-03-01

Family

ID=22561419

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8900538A Expired - Fee Related ES2017810A6 (es) 1988-02-18 1989-02-15 Preparacion de compuestos tetrazolicos antihipercolesterolemicos e intermedios para los mismos.

Country Status (32)

Country Link
US (1) US4824959A (es)
JP (2) JP2871707B2 (es)
KR (1) KR970002233B1 (es)
CN (1) CN1025619C (es)
AT (1) AT401057B (es)
AU (1) AU621586B2 (es)
BE (1) BE1002136A5 (es)
CA (1) CA1340430C (es)
CH (1) CH680792A5 (es)
CY (1) CY1874A (es)
DD (4) DD283618A5 (es)
DE (1) DE3904899A1 (es)
DK (1) DK75289A (es)
EG (1) EG19217A (es)
ES (1) ES2017810A6 (es)
FI (1) FI890725L (es)
FR (1) FR2630112B1 (es)
GB (1) GB2216121B (es)
GR (1) GR1000664B (es)
HK (3) HK129395A (es)
HU (2) HU204045B (es)
IE (1) IE65090B1 (es)
IT (1) IT1230750B (es)
LU (1) LU87456A1 (es)
MY (1) MY106279A (es)
NL (1) NL8900397A (es)
NO (1) NO172439C (es)
NZ (1) NZ227935A (es)
PT (1) PT89748B (es)
SE (2) SE503179C2 (es)
YU (1) YU34189A (es)
ZA (1) ZA891239B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3741509A1 (de) * 1987-12-08 1989-06-22 Hoechst Ag Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
GB2244705B (en) * 1988-02-18 1992-07-15 Bristol Myers Co Preparation of antihypercholesterolemic tetrazole compounds and intermediates thereof
US5010205A (en) * 1988-08-23 1991-04-23 Bristol-Myers Company Antihypercholesterolemic tetrazol-1-yl intermediates
US4870187A (en) * 1988-08-23 1989-09-26 Bristol-Myers Company Antihypercholesterolemic tetrazol-1-yl compounds
DE4128345C1 (en) * 1991-08-27 1993-06-09 Hoechst Ag, 6230 Frankfurt, De 3R,5S 3,5,6-tri:hydroxy-hexanoic acid isopropylidene ketal derivs. prepn. - from 7-benzyl:oxy 4,6-di:hydroxy:heptene by multistage process
US5278313A (en) * 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
US5284957A (en) * 1992-09-03 1994-02-08 Eli Lilly And Company Excitatory amino acid receptor antagonists
CA2137049A1 (en) * 1993-12-15 1995-06-16 John K. Thottathil Amino acid salts of and methods for preparing antihypercholesterolemic tetrazole compounds
DE10147030A1 (de) * 2001-09-04 2003-03-27 Forschungszentrum Juelich Gmbh Verfahren zur Trennung diastereomerer 1,3-Diol-Acetale
WO2005107739A1 (en) * 2004-05-11 2005-11-17 Darley Pharmaceuticals Ltd. Spiroderivatives for the treatment of hypertension
US20050272808A1 (en) * 2004-05-11 2005-12-08 Nadav Zamir Compositions and methods for the treatment of hypertension
CN104303915B (zh) * 2014-08-25 2016-05-25 李世峰 一种机插水稻水浮式育秧技术

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58225085A (ja) * 1982-06-24 1983-12-27 Nippon Kayaku Co Ltd アセタ−ルグリコ−ルジアクリレ−トおよびその製造法
US4808621A (en) * 1986-07-07 1989-02-28 Warner-Lambert Company Trans-6-[2-(N-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl]- or ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
US4837205A (en) * 1986-09-02 1989-06-06 Merck & Co., Inc. Prodrugs of antihypercholesterolemic compounds
US4897490A (en) * 1987-02-25 1990-01-30 Bristol-Meyers Company Antihypercholesterolemic tetrazole compounds
US4751229A (en) * 1987-07-09 1988-06-14 Warner-Lambert Company Treating fungal infections with substituted-(6-(tetrahydro-4-hydroxy-2-oxo-2H-pyran-2-yl)ethyl)- or ethenyl)pyrazoles
DE3807929A1 (de) * 1988-03-10 1989-09-28 Basf Ag Verfahren zur herstellung von reliefformen

Also Published As

Publication number Publication date
AU621586B2 (en) 1992-03-19
SE503179C2 (sv) 1996-04-15
SE8900565D0 (sv) 1989-02-17
HK129295A (en) 1995-08-24
NO172439B (no) 1993-04-13
YU34189A (en) 1991-02-28
PT89748A (pt) 1989-10-04
ATA36189A (de) 1995-10-15
KR890012992A (ko) 1989-09-20
NO890661L (no) 1989-08-21
EG19217A (en) 1995-09-30
GB2216121A (en) 1989-10-04
IE890523L (en) 1989-08-18
DD285602A5 (de) 1990-12-19
HU209905B (en) 1994-11-28
FR2630112A1 (fr) 1989-10-20
DE3904899A1 (de) 1989-08-31
JP2922887B2 (ja) 1999-07-26
DD285603A5 (de) 1990-12-19
SE8900565L (sv) 1989-08-19
CN1036013A (zh) 1989-10-04
KR970002233B1 (ko) 1997-02-26
NO172439C (no) 1993-07-21
US4824959A (en) 1989-04-25
HUT50809A (en) 1990-03-28
DD285600A5 (de) 1990-12-19
CH680792A5 (es) 1992-11-13
JPH115791A (ja) 1999-01-12
AT401057B (de) 1996-06-25
CN1025619C (zh) 1994-08-10
HU204045B (en) 1991-11-28
ZA891239B (en) 1991-12-24
MY106279A (en) 1995-04-29
GB8903604D0 (en) 1989-04-05
GB2216121B (en) 1992-07-15
JPH01249771A (ja) 1989-10-05
HK47596A (en) 1996-03-29
CY1874A (en) 1996-04-05
CA1340430C (en) 1999-03-09
IT8919474A0 (it) 1989-02-17
AU3007589A (en) 1989-08-24
FR2630112B1 (fr) 1994-07-29
LU87456A1 (fr) 1989-09-20
NZ227935A (en) 1990-07-26
SE9300595D0 (sv) 1993-02-23
NL8900397A (nl) 1989-09-18
PT89748B (pt) 1994-05-31
SE9300595A0 (sv) 1993-02-23
NO890661D0 (no) 1989-02-16
DK75289D0 (da) 1989-02-17
FI890725A7 (fi) 1989-08-19
DD283618A5 (de) 1990-10-17
IT1230750B (it) 1991-10-29
FI890725L (fi) 1989-08-19
JP2871707B2 (ja) 1999-03-17
GR1000664B (el) 1992-09-25
DK75289A (da) 1989-08-19
FI890725A0 (fi) 1989-02-15
HUT50167A (en) 1989-12-28
HK129395A (en) 1995-08-24
BE1002136A5 (fr) 1990-07-24
IE65090B1 (en) 1995-10-04

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Legal Events

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Effective date: 20110225