BE1002136A5 - Preparation de tetrazoles antihyperchlolesterolemiques et de leurs intermediaires. - Google Patents

Preparation de tetrazoles antihyperchlolesterolemiques et de leurs intermediaires. Download PDF

Info

Publication number
BE1002136A5
BE1002136A5 BE8900162A BE8900162A BE1002136A5 BE 1002136 A5 BE1002136 A5 BE 1002136A5 BE 8900162 A BE8900162 A BE 8900162A BE 8900162 A BE8900162 A BE 8900162A BE 1002136 A5 BE1002136 A5 BE 1002136A5
Authority
BE
Belgium
Prior art keywords
preparation
intermediates
antihyperchlolesterolemic
tetrazoles
radical
Prior art date
Application number
BE8900162A
Other languages
English (en)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of BE1002136A5 publication Critical patent/BE1002136A5/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Liquid Crystal Substances (AREA)

Abstract

Nouveaux intermédiaires de formule sensiblement sous la forme cis ou cis-(4R,6S), où R9 et R10 sont chacun un radical C1-4alcoyle ou bien R9 et R10, pris conjointement avec l'atome de carbone auquel ils sont unis, forment un radical cyclopentyle, cyclohexyle ou cycloheptyle et R12 est un atome d'hydrogène, un radical C1-4alcoyle ou un cation métallique, qui sont utiles pour la préparation d'agents antihypercholestérolémiques.
BE8900162A 1988-02-18 1989-02-17 Preparation de tetrazoles antihyperchlolesterolemiques et de leurs intermediaires. BE1002136A5 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/156,865 US4824959A (en) 1988-02-18 1988-02-18 Intermediates for antihypercholesterolemic tetrazole compounds

Publications (1)

Publication Number Publication Date
BE1002136A5 true BE1002136A5 (fr) 1990-07-24

Family

ID=22561419

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8900162A BE1002136A5 (fr) 1988-02-18 1989-02-17 Preparation de tetrazoles antihyperchlolesterolemiques et de leurs intermediaires.

Country Status (32)

Country Link
US (1) US4824959A (fr)
JP (2) JP2871707B2 (fr)
KR (1) KR970002233B1 (fr)
CN (1) CN1025619C (fr)
AT (1) AT401057B (fr)
AU (1) AU621586B2 (fr)
BE (1) BE1002136A5 (fr)
CA (1) CA1340430C (fr)
CH (1) CH680792A5 (fr)
CY (1) CY1874A (fr)
DD (4) DD285603A5 (fr)
DE (1) DE3904899A1 (fr)
DK (1) DK75289A (fr)
EG (1) EG19217A (fr)
ES (1) ES2017810A6 (fr)
FI (1) FI890725L (fr)
FR (1) FR2630112B1 (fr)
GB (1) GB2216121B (fr)
GR (1) GR1000664B (fr)
HK (3) HK129295A (fr)
HU (2) HU204045B (fr)
IE (1) IE65090B1 (fr)
IT (1) IT1230750B (fr)
LU (1) LU87456A1 (fr)
MY (1) MY106279A (fr)
NL (1) NL8900397A (fr)
NO (1) NO172439C (fr)
NZ (1) NZ227935A (fr)
PT (1) PT89748B (fr)
SE (2) SE503179C2 (fr)
YU (1) YU34189A (fr)
ZA (1) ZA891239B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3741509A1 (de) * 1987-12-08 1989-06-22 Hoechst Ag Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
GB2244706B (en) * 1988-02-18 1992-07-15 Bristol Myers Co Preparation of antihypercholesterolemic tetrazole intermediates
US4870187A (en) * 1988-08-23 1989-09-26 Bristol-Myers Company Antihypercholesterolemic tetrazol-1-yl compounds
US5010205A (en) * 1988-08-23 1991-04-23 Bristol-Myers Company Antihypercholesterolemic tetrazol-1-yl intermediates
DE4128345C1 (en) * 1991-08-27 1993-06-09 Hoechst Ag, 6230 Frankfurt, De 3R,5S 3,5,6-tri:hydroxy-hexanoic acid isopropylidene ketal derivs. prepn. - from 7-benzyl:oxy 4,6-di:hydroxy:heptene by multistage process
US5278313A (en) * 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
US5284957A (en) * 1992-09-03 1994-02-08 Eli Lilly And Company Excitatory amino acid receptor antagonists
CA2137049A1 (fr) * 1993-12-15 1995-06-16 John K. Thottathil Sels d'acides amines de composes antihypercholesterolemiques a base de tetrazole et leur methode de preparation
DE10147030A1 (de) * 2001-09-04 2003-03-27 Forschungszentrum Juelich Gmbh Verfahren zur Trennung diastereomerer 1,3-Diol-Acetale
US20050272808A1 (en) * 2004-05-11 2005-12-08 Nadav Zamir Compositions and methods for the treatment of hypertension
EP1746988A1 (fr) * 2004-05-11 2007-01-31 Darley Pharmaceuticals Ltd. Spiroderives pour le traitement de l'hypertension
CN104303915B (zh) * 2014-08-25 2016-05-25 李世峰 一种机插水稻水浮式育秧技术

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0252476A2 (fr) * 1986-07-07 1988-01-13 Warner-Lambert Company Dérivés de trans-6-[2-(N-hétéroaryl-pyrazol-4-yl-3,5-disubstitués)-éthyl] ou -éthényl]tétrahydro-4-hydroxypyran-2-one, procédé pour leur préparation et leur utilisation
EP0259087A2 (fr) * 1986-09-02 1988-03-09 Merck & Co. Inc. Prodrogues de composés antihypercholestérolémiques
US4751229A (en) * 1987-07-09 1988-06-14 Warner-Lambert Company Treating fungal infections with substituted-(6-(tetrahydro-4-hydroxy-2-oxo-2H-pyran-2-yl)ethyl)- or ethenyl)pyrazoles
FR2612924A1 (fr) * 1987-02-25 1988-09-30 Bristol Myers Co Derives de tetrazole antihypercholesterolemiques

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58225085A (ja) * 1982-06-24 1983-12-27 Nippon Kayaku Co Ltd アセタ−ルグリコ−ルジアクリレ−トおよびその製造法
DE3807929A1 (de) * 1988-03-10 1989-09-28 Basf Ag Verfahren zur herstellung von reliefformen

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0252476A2 (fr) * 1986-07-07 1988-01-13 Warner-Lambert Company Dérivés de trans-6-[2-(N-hétéroaryl-pyrazol-4-yl-3,5-disubstitués)-éthyl] ou -éthényl]tétrahydro-4-hydroxypyran-2-one, procédé pour leur préparation et leur utilisation
EP0259087A2 (fr) * 1986-09-02 1988-03-09 Merck & Co. Inc. Prodrogues de composés antihypercholestérolémiques
FR2612924A1 (fr) * 1987-02-25 1988-09-30 Bristol Myers Co Derives de tetrazole antihypercholesterolemiques
US4751229A (en) * 1987-07-09 1988-06-14 Warner-Lambert Company Treating fungal infections with substituted-(6-(tetrahydro-4-hydroxy-2-oxo-2H-pyran-2-yl)ethyl)- or ethenyl)pyrazoles

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TETRAHEDRON LETTERS, vol. 27, no. 43, 1986, pages 5201-5202, Pergamon Press, GB; B. O'CONNOR et al.: "Syntheses of argentilactone 11 and goniothalamin 15" *

Also Published As

Publication number Publication date
SE8900565D0 (sv) 1989-02-17
ES2017810A6 (es) 1991-03-01
LU87456A1 (fr) 1989-09-20
IT8919474A0 (it) 1989-02-17
NO172439C (no) 1993-07-21
DD285603A5 (de) 1990-12-19
PT89748B (pt) 1994-05-31
GB2216121B (en) 1992-07-15
SE9300595A0 (sv) 1993-02-23
JPH115791A (ja) 1999-01-12
FI890725A0 (fi) 1989-02-15
HU209905B (en) 1994-11-28
NO890661L (no) 1989-08-21
EG19217A (en) 1995-09-30
CN1036013A (zh) 1989-10-04
NO890661D0 (no) 1989-02-16
FI890725A7 (fi) 1989-08-19
JP2922887B2 (ja) 1999-07-26
CA1340430C (fr) 1999-03-09
DD285600A5 (de) 1990-12-19
HK47596A (en) 1996-03-29
FR2630112A1 (fr) 1989-10-20
KR890012992A (ko) 1989-09-20
JP2871707B2 (ja) 1999-03-17
NO172439B (no) 1993-04-13
AT401057B (de) 1996-06-25
GB8903604D0 (en) 1989-04-05
IE890523L (en) 1989-08-18
IT1230750B (it) 1991-10-29
DD285602A5 (de) 1990-12-19
SE503179C2 (sv) 1996-04-15
CH680792A5 (fr) 1992-11-13
DE3904899A1 (de) 1989-08-31
ATA36189A (de) 1995-10-15
NZ227935A (en) 1990-07-26
SE9300595D0 (sv) 1993-02-23
HU204045B (en) 1991-11-28
SE8900565L (sv) 1989-08-19
DK75289A (da) 1989-08-19
MY106279A (en) 1995-04-29
FR2630112B1 (fr) 1994-07-29
HUT50167A (en) 1989-12-28
DD283618A5 (de) 1990-10-17
JPH01249771A (ja) 1989-10-05
DK75289D0 (da) 1989-02-17
NL8900397A (nl) 1989-09-18
HUT50809A (en) 1990-03-28
AU3007589A (en) 1989-08-24
KR970002233B1 (ko) 1997-02-26
ZA891239B (en) 1991-12-24
CY1874A (en) 1996-04-05
US4824959A (en) 1989-04-25
GR1000664B (el) 1992-09-25
AU621586B2 (en) 1992-03-19
YU34189A (en) 1991-02-28
FI890725L (fi) 1989-08-19
GB2216121A (en) 1989-10-04
HK129395A (en) 1995-08-24
PT89748A (pt) 1989-10-04
CN1025619C (zh) 1994-08-10
HK129295A (en) 1995-08-24
IE65090B1 (en) 1995-10-04

Similar Documents

Publication Publication Date Title
BE1002136A5 (fr) Preparation de tetrazoles antihyperchlolesterolemiques et de leurs intermediaires.
ES8603271A1 (es) Un metodo de producir una composicion de interleuquina-2
LU91006I2 (en) Neupopeg-pegfilgrastim et ses dérivés pharmaceutiquement acceptables
EP0156603A3 (en) 3-substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
TW282467B (fr)
GR3034924T3 (en) Novel peptide derivatives
UA11100A (uk) Спосіб одержаhhя феhілалкіламіhів або їх фармакологічhо прийhятhих солей
IE820648L (en) Diazaspiro undecanones
DE3687007D1 (en) 6-thioxanthinderivate.
ES2001049A6 (es) Una aleacion base de aluminio
ZA925093B (en) 6-oxo-azepinoindol compounds as well as a process and intermediate products for the production thereof,and drugs that contain these compounds
EP0207681A3 (en) Pyrrolidone derivatives
IL90533A0 (en) Benzazepine derivatives,their preparation and pharmaceutical compositions containing them
ATE71092T1 (de) Hydroxybutenolid-derivate, ihre herstellung und ihre verwendung.
JPS6440479A (en) Piperidine derivative
ES8606847A1 (es) Procedimiento para la preparacion de derivados de dialquila-mino-etilanilina antihipertensos
HUT45250A (en) Process for producing 5-substituted octahydro-indolysin derivatives and pharmaceutical compositions containing them as active components
EP0187711A3 (en) Octahydroindolizine compounds useful as analgesics
GB8511891D0 (en) Alkenoic acids
DE3560110D1 (en) Derivatives of 2-alkoxyaminosulfonylbenzenesulfonylurea
ES8602676A1 (es) Un procedimiento para la preparacion de nuevos derivados de pirrolo-(2,1-a)isoquilonina.
DE3855751D1 (en) Hypoglycemische peptide
ES8601917A1 (es) Procedimiento para producir 4,5-dihidro-6-vinil-3(2h)-piri- dazinonas y 6-vinil-3(2h)-piridazinonas
ES8608315A1 (es) Procedimiento para la obtencion de un somnifero conteniendo lorazepam
SATAKE An Economic Analysis on Robot