ES2018106A6 - Un procedimiento para producir 2,3,5,6-tetrahidron1,3,6ntriazocinon1,2-anbencimidazoles 1,4-sustituidos y sus intermediarios. - Google Patents
Un procedimiento para producir 2,3,5,6-tetrahidron1,3,6ntriazocinon1,2-anbencimidazoles 1,4-sustituidos y sus intermediarios.Info
- Publication number
- ES2018106A6 ES2018106A6 ES8900647A ES8900647A ES2018106A6 ES 2018106 A6 ES2018106 A6 ES 2018106A6 ES 8900647 A ES8900647 A ES 8900647A ES 8900647 A ES8900647 A ES 8900647A ES 2018106 A6 ES2018106 A6 ES 2018106A6
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- phenyl
- alkyl
- formulas
- alkanoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000543 intermediate Substances 0.000 title abstract 3
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- -1 p-methylsulfonylaminophenyl Chemical group 0.000 abstract 8
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 7
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 239000000460 chlorine Substances 0.000 abstract 3
- 125000001624 naphthyl group Chemical group 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 1
- LSGSCAYFTVYWMF-UHFFFAOYSA-N [1,3,6]triazocino[1,2-a]benzimidazole Chemical compound C1=CN=CC=NC2=NC3=CC=CC=C3N21 LSGSCAYFTVYWMF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000005037 alkyl phenyl group Chemical group 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 230000002253 anti-ischaemic effect Effects 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000005186 naphthyloxy group Chemical group C1(=CC=CC2=CC=CC=C12)O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 abstract 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
UN PROCEDIMIENTO PARA PRODUCIR 2,3,5,6-TETRAHIDRO/1,2,6/TRIAZOCINO/1,2-A/BENZIMIDAZOLES 1,4-SUSTITUIDOS Y SUS INTERMEDIARIOS, DE FORMULAS I Y II. EL PROCEDIMIENTO COMPRENDE HACER REACCIONAR UN 1-O 4-RBS2 -SUSTITUIDO-1,2,3,4,5,6-HEXAHIDRO/1,3,6/TRIAZOCINO/1,2-A/BENCIMIDAZOL DE FORMULAS VI O VI, CON UN HALURO DE SULFONILO RBS1-SOSI2-X. LA REACCION SE LLEVA A CABO EN UNA MEZCLA DE AGUA Y ACETATO, FORMIATO O PROPIONATO DE ETILO, EN PRESENCIA DE CARBONATO SODICO O POTASICO, DURANTE 1-18 HORAS A 20-35GC, O BIEN EN AUSENCIA DE AGUA, EN PRESENCIA DE PIRIDINA. LOS COMPUESTOS DESCRITOS PUEDEN SER USADOS COMO AGENTES ANTIARRITMICOS O ANTIISQUEMICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/159,623 US4882323A (en) | 1988-02-23 | 1988-02-23 | 1,2,3,4,5,6-hexahydro[1,3,6]triazocino[1,1-a]benzimidazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2018106A6 true ES2018106A6 (es) | 1991-03-16 |
Family
ID=22573305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8900647A Expired - Fee Related ES2018106A6 (es) | 1988-02-23 | 1989-02-22 | Un procedimiento para producir 2,3,5,6-tetrahidron1,3,6ntriazocinon1,2-anbencimidazoles 1,4-sustituidos y sus intermediarios. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4882323A (es) |
| EP (1) | EP0358749A1 (es) |
| JP (1) | JPH02503321A (es) |
| KR (1) | KR900700481A (es) |
| AU (1) | AU3349989A (es) |
| DK (1) | DK523289A (es) |
| ES (1) | ES2018106A6 (es) |
| PT (1) | PT89783A (es) |
| WO (1) | WO1989008111A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5149700A (en) * | 1990-05-30 | 1992-09-22 | American Home Products Corporation | Substituted arylsulfonamides and benzamides |
| GB9526182D0 (en) * | 1995-12-21 | 1996-02-21 | Unilever Plc | Fabric softening composition |
| EP2181994B1 (en) | 2006-03-31 | 2014-05-28 | Research Foundation Itsuu Laboratory | Antimicrobial compounds |
| US8530646B2 (en) * | 2007-10-02 | 2013-09-10 | Research Foundation Itsuu Laboratory | Oxazolidinone derivative having 7-membered hetero ring |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3873565A (en) * | 1973-05-16 | 1975-03-25 | Parke Davis & Co | Pyrazolodiazocine compounds |
| FR2503165A1 (fr) * | 1981-04-03 | 1982-10-08 | Pharmindustrie | Nouveaux derives de n,n-dimethyl(aza-1 bicyclo(2,2,2)octyl-3)-10 10h phenothiazinesulfonamide-2, procede pour leur preparation et utilisation comme medicaments |
| DE3151597A1 (de) * | 1981-12-28 | 1983-07-07 | Kali-Chemie Pharma Gmbh, 3000 Hannover | (1,2)-anellierte 1,4-benzodiazepin-verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US4720580A (en) * | 1984-09-21 | 1988-01-19 | American Home Products Corporation | N-(aminoalkylene)benzenesulfonamides |
-
1988
- 1988-02-23 US US07/159,623 patent/US4882323A/en not_active Expired - Lifetime
-
1989
- 1989-02-17 AU AU33499/89A patent/AU3349989A/en not_active Abandoned
- 1989-02-17 JP JP1503095A patent/JPH02503321A/ja active Pending
- 1989-02-17 EP EP89903345A patent/EP0358749A1/en not_active Withdrawn
- 1989-02-17 WO PCT/US1989/000646 patent/WO1989008111A1/en not_active Ceased
- 1989-02-22 ES ES8900647A patent/ES2018106A6/es not_active Expired - Fee Related
- 1989-02-22 PT PT89783A patent/PT89783A/pt not_active Application Discontinuation
- 1989-10-20 DK DK523289A patent/DK523289A/da not_active Application Discontinuation
- 1989-10-21 KR KR1019890701933A patent/KR900700481A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO1989008111A1 (en) | 1989-09-08 |
| JPH02503321A (ja) | 1990-10-11 |
| US4882323A (en) | 1989-11-21 |
| AU3349989A (en) | 1989-09-22 |
| DK523289D0 (da) | 1989-10-20 |
| KR900700481A (ko) | 1990-08-13 |
| DK523289A (da) | 1989-12-20 |
| EP0358749A1 (en) | 1990-03-21 |
| PT89783A (pt) | 1989-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SA6 | Expiration date (snapshot 920101) |
Free format text: 2009-02-22 |
|
| FD1A | Patent lapsed |
Effective date: 20041004 |