ATE148704T1 - Imidazo (1,2-a> pyrasin-4-on-derivate welche als ampa und nmda receptor antagonisten dienen - Google Patents

Imidazo (1,2-a> pyrasin-4-on-derivate welche als ampa und nmda receptor antagonisten dienen

Info

Publication number: ATE148704T1
Authority: AT; Austria
Prior art keywords: pct; pyrasine; ampa; imidazo; derivatives
Prior art date: 1993-07-16

Application number

AT94922903T

Other languages

English (en)

Inventor

Jean-Claude Aloup

Serge Mignani

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-16

Filing date

1994-07-11

Publication date

1997-02-15

1994-07-11 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1997-02-15 Application granted granted Critical

1997-02-15 Publication of ATE148704T1 publication Critical patent/ATE148704T1/de

Links

229940127523 NMDA Receptor Antagonists Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
229910006069 SO3H Inorganic materials 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000004442 acylamino group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002883 imidazolyl group Chemical group 0.000 abstract 1
-1 nitro, cyano, phenyl Chemical group 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Anesthesiology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT94922903T 1993-07-16 1994-07-11 Imidazo (1,2-a> pyrasin-4-on-derivate welche als ampa und nmda receptor antagonisten dienen ATE148704T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9308753A FR2707645B1 (fr)	1993-07-16	1993-07-16	Dérivés d'imidazo[1,2-a]pirazine-4-one, leur préparation et les médicaments les contenant.

Publications (1)

Publication Number	Publication Date
ATE148704T1 true ATE148704T1 (de)	1997-02-15

Family

ID=9449311

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94922903T ATE148704T1 (de)	1993-07-16	1994-07-11	Imidazo (1,2-a> pyrasin-4-on-derivate welche als ampa und nmda receptor antagonisten dienen

Country Status (13)

Country	Link
US (1)	US5672705A (de)
EP (1)	EP0708778B1 (de)
JP (1)	JPH09500123A (de)
AT (1)	ATE148704T1 (de)
AU (1)	AU7265194A (de)
DE (1)	DE69401716T2 (de)
DK (1)	DK0708778T3 (de)
ES (1)	ES2098158T3 (de)
FR (1)	FR2707645B1 (de)
GR (1)	GR3022498T3 (de)
IL (1)	IL110328A0 (de)
WO (1)	WO1995002602A1 (de)
ZA (1)	ZA945157B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2717814B1 (fr) *	1994-03-28	1996-04-26	Rhone Poulenc Rorer Sa	Dérivés de 1,2,4-triazolo(4,3-a)pyrazine-4-one, leur préparation et les médicaments les contenant.
FR2717813B1 (fr) *	1994-03-28	1996-05-10	Rhone Poulenc Rorer Sa	Dérivés d'imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant .
FR2717812B1 (fr) *	1994-03-28	1996-05-10	Rhone Poulenc Rorer Sa	Indeno[1,2-e]pyrazine-4-ones, leur préparation et les médicaments les contenant.
FR2717805B1 (fr) *	1994-03-28	1996-05-10	Rhone Poulenc Rorer Sa	Dérivés de 5H-indeno[1,2-b]pyrazine-2,3-dione, leur préparation et les médicaments les contenant .
FR2743365A1 (fr) *	1996-01-10	1997-07-11	Rhone Poulenc Rorer Sa	Derives de 5h,10h-imidazo(1,2-a)indolo(3,2-e)pyrazine-4-one, leur preparation et les medicaments les contenant
GB9908175D0 (en) *	1999-04-09	1999-06-02	Lilly Co Eli	Method of treating neurological disorders
AU2003222106A1 (en) *	2002-04-03	2003-10-20	Bristol-Myers Squibb Company	Thiopene-based tricyclic compounds and pharmaceutical compositions comprising same
US20040152694A1 (en) *	2003-02-04	2004-08-05	Istvan Kurucz	Methods and compositions for treating inflammatory disorders of the airways
US7732162B2 (en)	2003-05-05	2010-06-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
JP5379692B2 (ja)	2006-11-09	2013-12-25	プロビオドルグエージー	潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
EP2091948B1 (de)	2006-11-30	2012-04-18	Probiodrug AG	Neue inhibitoren von glutaminylcyclase
CA2679446C (en)	2007-03-01	2016-05-17	Probiodrug Ag	New use of glutaminyl cyclase inhibitors
US9656991B2 (en)	2007-04-18	2017-05-23	Probiodrug Ag	Inhibitors of glutaminyl cyclase
BR112012008346B1 (pt)	2009-09-11	2021-12-21	Vivoryon Therapeutics N.V.	Derivados heterocíclicos, seu processo de preparação, e composição farmacêutica
EP2338492A1 (de)	2009-12-24	2011-06-29	Universidad del Pais Vasco	Verfahren und Zusammensetzung zur Behandlung von Alzheimer
WO2011107530A2 (en)	2010-03-03	2011-09-09	Probiodrug Ag	Novel inhibitors
DK2545047T3 (da)	2010-03-10	2014-07-28	Probiodrug Ag	Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5)
EP2560953B1 (de)	2010-04-21	2016-01-06	Probiodrug AG	Hemmer der glutaminylzyklase
WO2012123563A1 (en)	2011-03-16	2012-09-20	Probiodrug Ag	Benz imidazole derivatives as inhibitors of glutaminyl cyclase
PL3461819T3 (pl)	2017-09-29	2020-11-30	Probiodrug Ag	Inhibitory cyklazy glutaminylowej

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK101290D0 (da) *	1990-04-24	1990-04-24	Novo Nordisk As	Heterocykliske forbindelser, deres fremstilling og anvendelse

1993
- 1993-07-16 FR FR9308753A patent/FR2707645B1/fr not_active Expired - Fee Related
1994
- 1994-07-11 DE DE69401716T patent/DE69401716T2/de not_active Expired - Fee Related
- 1994-07-11 DK DK94922903.3T patent/DK0708778T3/da active
- 1994-07-11 WO PCT/FR1994/000865 patent/WO1995002602A1/fr not_active Ceased
- 1994-07-11 ES ES94922903T patent/ES2098158T3/es not_active Expired - Lifetime
- 1994-07-11 EP EP94922903A patent/EP0708778B1/de not_active Expired - Lifetime
- 1994-07-11 JP JP7504375A patent/JPH09500123A/ja active Pending
- 1994-07-11 US US08/583,036 patent/US5672705A/en not_active Expired - Fee Related
- 1994-07-11 AU AU72651/94A patent/AU7265194A/en not_active Abandoned
- 1994-07-11 AT AT94922903T patent/ATE148704T1/de not_active IP Right Cessation
- 1994-07-14 ZA ZA945157A patent/ZA945157B/xx unknown
- 1994-07-14 IL IL11032894A patent/IL110328A0/xx unknown
1997
- 1997-02-06 GR GR960402774T patent/GR3022498T3/el unknown

Also Published As

Publication number	Publication date
FR2707645B1 (fr)	1995-08-11
EP0708778A1 (de)	1996-05-01
EP0708778B1 (de)	1997-02-05
ES2098158T3 (es)	1997-04-16
DE69401716T2 (de)	1997-06-05
DK0708778T3 (da)	1997-03-10
DE69401716D1 (de)	1997-03-20
GR3022498T3 (en)	1997-05-31
IL110328A0 (en)	1994-10-21
ZA945157B (en)	1995-02-24
AU7265194A (en)	1995-02-13
WO1995002602A1 (fr)	1995-01-26
US5672705A (en)	1997-09-30
JPH09500123A (ja)	1997-01-07
FR2707645A1 (fr)	1995-01-20

Legal Events

Date	Code	Title	Description
1997-09-15	UEP	Publication of translation of european patent specification
1999-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE148704T1 (de)	1997-02-15	Imidazo (1,2-a> pyrasin-4-on-derivate welche als ampa und nmda receptor antagonisten dienen
DE69032020D1 (de)	1998-03-12	N-Substituierte 4-Pyrimidinamine und -Pyrimidindiamine, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
DE69420579D1 (de)	1999-10-14	9-HYDROXY-PYRIDO [1,2-a] PYRIMIDIN-4-ON-ETHER-DERIVATE
DE69433984D1 (de)	2004-10-14	Arylpiperazinderivate von indol als liganden der rezeptoren 5 ht1-like, 5 ht1b und 5 ht1d
AU681688B2 (en)	1997-09-04	Imidazo(1,2-a)pyrazine-4-one, preparation thereof and drugs containing same
AU2413995A (en)	1996-02-09	Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase
ATE166055T1 (de)	1998-05-15	5h,10h-imidazo(1,2-a>indeno(1,2-e>pyrazin-4-one derivate, ihre herstellung und die sie enthaltenden arzneimittel
TW429253B (en)	2001-04-11	Novel pyrazole compounds
DK0689534T3 (da)	2003-02-03	Amidderivater som 5-HT1A-ligander
GR3033333T3 (en)	2000-09-29	Carbamoyl carboxylic acid amides
DE69732359D1 (de)	2005-03-03	Disubstituierte morpholin-, oxazepin- oder thiazepinderivate, deren herstellung und verwendung als dopamin-d4-rezeptorantagonisten
ATE187441T1 (de)	1999-12-15	4-oxo-azetidin-2-sulfonsäureamide und ihre salze, verfahren zu deren herstellung und ihre verwendung
DE69501810D1 (de)	1998-04-23	Verwendung von 5-Thia-1,4-Diazabicyclo [4.2.0] Octane-3,8-dioxo Verbindungen in der Antitumor-Therapie