ATE85614T1 - Psychotropische bizyklische imide. - Google Patents

Psychotropische bizyklische imide.

Info

Publication number: ATE85614T1
Authority: AT; Austria
Prior art keywords: carbon atoms; integers; psychotropic; imides; bicyclic imides
Prior art date: 1987-04-03

Application number

AT88903638T

Other languages

English (en)

Inventor

Gary Paul Stack

Magid Abdel-Megid Abou-Gharbia

Edward James Podlesny

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-03

Filing date

1988-03-31

Publication date

1993-02-15

1988-03-31 Application filed by American Home Prod filed Critical American Home Prod

1993-02-15 Application granted granted Critical

1993-02-15 Publication of ATE85614T1 publication Critical patent/ATE85614T1/de

Links

150000003949 imides Chemical class 0.000 title abstract 2
230000000506 psychotropic effect Effects 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 6
-1 trifluoromethylphenyl Chemical group 0.000 abstract 6
125000004450 alkenylene group Chemical group 0.000 abstract 1
125000005036 alkoxyphenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
230000000561 anti-psychotic effect Effects 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000005059 halophenyl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004307 pyrazin-2-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 abstract 1
125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 abstract 1
125000005493 quinolyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/24—Camphidines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Pyrane Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)

AT88903638T 1987-04-03 1988-03-31 Psychotropische bizyklische imide. ATE85614T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US07/034,525 US4748240A (en)	1987-04-03	1987-04-03	Psychotropic bicyclic imides
EP88903638A EP0309544B1 (de)	1987-04-03	1988-03-31	Psychotropische bizyklische imide
PCT/US1988/000974 WO1988007530A1 (en)	1987-04-03	1988-03-31	Psychotropic bicyclic imides

Publications (1)

Publication Number	Publication Date
ATE85614T1 true ATE85614T1 (de)	1993-02-15

Family

ID=21876959

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88903638T ATE85614T1 (de)	1987-04-03	1988-03-31	Psychotropische bizyklische imide.

Country Status (12)

Country	Link
US (1)	US4748240A (de)
EP (1)	EP0309544B1 (de)
JP (1)	JPH01502757A (de)
AT (1)	ATE85614T1 (de)
AU (1)	AU616656B2 (de)
CA (1)	CA1335502C (de)
DE (1)	DE3878371T2 (de)
ES (1)	ES2009257A6 (de)
GB (1)	GB2203431B (de)
GR (1)	GR1000245B (de)
PT (1)	PT87034B (de)
WO (1)	WO1988007530A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2601364B1 (fr) *	1986-07-09	1988-10-21	Adir	Nouveaux derives de la piperazine dione-2,6, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US4797488A (en) *	1987-04-03	1989-01-10	American Home Products Corporation	Psychotropic polycyclic imides
US4804751A (en) *	1987-06-30	1989-02-14	American Home Products Corporation	Polycyclic hydrocarbon succinimides with psychotropic activity
EP0350145A3 (de) *	1988-04-28	1990-07-04	Yamanouchi Pharmaceutical Co. Ltd.	Pyridylthiazolidine carboxamide Derivative und ihreZwischenprodukte und deren Herstellung
US5242911A (en) *	1988-06-17	1993-09-07	Pfizer Inc.	Bridged bicyclic imides as anxiolytics and antidepressants
FI911285A7 (fi) *	1988-09-16	1991-03-15	Pfizer	Antipsykoottisia bisyklisiä 4-/4-(3-bentsisotiatsolyyli)-1-piperatsiny yli/butyylisiltaimidejä
SE8803429D0 (sv) *	1988-09-28	1988-09-28	Pharmacia Ab	Novel pyridyl- and pyrimidyl derivatives
EP0376633B1 (de) *	1988-12-28	1994-10-12	Suntory Limited	Benzoxazepinderivate
US5053508A (en) *	1990-03-09	1991-10-01	American Home Products Corporation	Fused heterotricyclic imides with psychotropic activity and intermedrates thereof
SU1825501A3 (ru) *	1990-10-29	1995-12-10	И.В. Комиссаров	Dl-3-[(4-[4- (2-пиридил)-1- пиперазинил]бутил)] -1,8,8-триметил -3-азабицикло[3,2,1] октан-2,4-диона дигидрохлорид, проявляющий противотревожную, нейролептическую и противорвотную активность
IE914218A1 (en) *	1991-09-11	1993-03-24	Mcneilab Inc	Novel 4-arylpiperazines and 4-arylpiperidines
JPH05345764A (ja) *	1991-11-26	1993-12-27	Asahi Chem Ind Co Ltd	新規アゼピン誘導体、その製造法およびその用途
US5484788A (en) *	1993-03-26	1996-01-16	Beth Israel Hospital Association	Buspirone as a systemic immunosuppressant
US5631017A (en) *	1993-03-26	1997-05-20	Beth Israel Deaconess Medical Center, Inc.	Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5637314A (en) *	1995-06-07	1997-06-10	Beth Israel Deaconess Medical Center, Inc.	Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
WO2003084928A1 (en) *	2002-04-08	2003-10-16	Ranbaxy Laboratories Limited	Alpha, omega-dicarboximide derivatives as useful uro-selective α1α adrenoceptor blockers
US20060247249A1 (en) *	2005-11-16	2006-11-02	Mohammad Salman	Carboximide derivatives as useful uro-selective alpha-1a adrenoceptor blockers
CN116813547A (zh) *	2023-06-29	2023-09-29	爱斯特（成都）生物制药股份有限公司	一种制备3-氮杂双环[3，2，1]辛烷盐酸盐的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE759371A (fr) *	1969-11-24	1971-05-24	Bristol Myers Co	Azaspirodecanediones heterocycliques et procedes pour leur preparation
US4305944A (en) *	1980-09-08	1981-12-15	Mead Johnson & Company	N-[(4-[3-cyano substituted pyridyl]piperazino)alkyl]-azaspirodecanediones
FR2540499B1 (fr) *	1983-02-07	1986-09-26	Bristol Myers Co	Derive de 5-fluoro-pyrimidine-2-yl piperazine antipsychotique
JPS6087284A (ja) *	1983-10-19	1985-05-16	Sumitomo Chem Co Ltd	コハク酸イミド誘導体及びその酸付加塩
US4619930A (en) *	1985-01-16	1986-10-28	Bristol-Myers Company	Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use
DD263531A5 (de) *	1986-10-21	1989-01-04	��@��Kk��	Verfahren zur herstellung von verbrueckten bicyclischen imidverbindungen

1987
- 1987-04-03 US US07/034,525 patent/US4748240A/en not_active Expired - Lifetime
1988
- 1988-03-22 PT PT87034A patent/PT87034B/pt active IP Right Grant
- 1988-03-23 CA CA000562257A patent/CA1335502C/en not_active Expired - Fee Related
- 1988-03-30 ES ES8800978A patent/ES2009257A6/es not_active Expired
- 1988-03-31 AU AU15949/88A patent/AU616656B2/en not_active Ceased
- 1988-03-31 DE DE8888903638T patent/DE3878371T2/de not_active Expired - Fee Related
- 1988-03-31 EP EP88903638A patent/EP0309544B1/de not_active Expired - Lifetime
- 1988-03-31 AT AT88903638T patent/ATE85614T1/de not_active IP Right Cessation
- 1988-03-31 JP JP63503415A patent/JPH01502757A/ja active Pending
- 1988-03-31 WO PCT/US1988/000974 patent/WO1988007530A1/en not_active Ceased
- 1988-04-01 GR GR880100215A patent/GR1000245B/el unknown
- 1988-04-05 GB GB8807934A patent/GB2203431B/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0309544A1 (de)	1989-04-05
AU1594988A (en)	1988-11-02
US4748240A (en)	1988-05-31
PT87034A (pt)	1988-04-01
GB2203431A (en)	1988-10-19
AU616656B2 (en)	1991-11-07
PT87034B (pt)	1992-07-31
CA1335502C (en)	1995-05-09
DE3878371T2 (de)	1993-07-08
GR1000245B (el)	1992-05-12
JPH01502757A (ja)	1989-09-21
WO1988007530A1 (en)	1988-10-06
GR880100215A (en)	1989-01-31
GB2203431B (en)	1991-10-16
DE3878371D1 (de)	1993-03-25
EP0309544B1 (de)	1993-02-10
GB8807934D0 (en)	1988-05-05
ES2009257A6 (es)	1989-09-16

Legal Events

Date	Code	Title	Description
1993-07-15	UEP	Publication of translation of european patent specification
1995-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE85614T1 (de)	1993-02-15	Psychotropische bizyklische imide.
FI894066A0 (fi)	1989-08-30	Depressionshaemmande n-substituerade nikotinamidfoereningar.
ATE63551T1 (de)	1991-06-15	Psychotropische polycyclische imide.
ES8303411A1 (es)	1983-02-01	Un procedimiento para la preparacion de derivados de tiofilina o teobromina.
NO173867C (no)	1994-02-16	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzamider
MX9800718A (es)	1998-04-30	Derivados de 2-(4-substituidos)-bencilamino-2-metil- propanamida.
MY129935A (en)	2007-05-31	Dihydropyridine derivatives useful in antitumor therapy
CA2085796A1 (en)	1993-06-21	3(2h)-pyridazinone derivatives and process for the preparation thereof
NZ332840A (en)	2000-05-26	1-[2-(pyridin-2-ylmethoxy)pyridin-5ylcarbamoyl]-indoline derivatives
MX9303990A (es)	1994-01-31	Tetrazolil (fenoxi y fenoxialquil) piperidinil piridazinas como agentes antivirales.
SE8203877L (sv)	1982-12-23	Aminosulfonylbensoesyraderivat
DE69402703D1 (de)	1997-05-22	3-(INDOL-3-YL) PROPENSäURDERIVATE, DIE ALS NMDA- ANTAGONISTEN NÜTZLICH SIND
DK0442424T3 (da)	1995-02-20	Behandling af søvnapnøer med azapironderivater
ATE123025T1 (de)	1995-06-15	2-amino-n-(((4-(aminocarbonyl)pyrimidin-2- yl>amino>alkyl>-pyrimidin-4- carbonsäureamidderivate, ihre herstellung und ihre anwendung in der therapeutica.
IL93063A0 (en)	1990-11-05	Benzo(1,8)naphthyridine derivatives and their preparation
MY103515A (en)	1993-07-31	Ergolinyl heterocycles
FR2543139B1 (fr)	1985-08-16	Derives de (1-alcoxy 2-amino) ethyl pyridine ou pyrazine, leur preparation et leur application en therapeutique
IL86665A0 (en)	1988-11-30	Mitomycin analogs
AU6312694A (en)	1994-11-24	2-aminopyrazine-5-carboxamide derivatives, their preparation and their application in therapeutics
FI921298A7 (fi)	1992-03-25	Menetelmä lääkeaineena käyttökelpoisen 5-(6-imidatso/1,2-a/pyridyyli)pyridiini-johdannaisen valmistamiseksi