ES2019713A6 - Un procedimiento para preparar derivados clorados de adenosina. - Google Patents
Un procedimiento para preparar derivados clorados de adenosina.Info
- Publication number
- ES2019713A6 ES2019713A6 ES8801398A ES8801398A ES2019713A6 ES 2019713 A6 ES2019713 A6 ES 2019713A6 ES 8801398 A ES8801398 A ES 8801398A ES 8801398 A ES8801398 A ES 8801398A ES 2019713 A6 ES2019713 A6 ES 2019713A6
- Authority
- ES
- Spain
- Prior art keywords
- cyclic phosphate
- chloroadenosine
- aminoadenosine
- preparation
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229910019142 PO4 Inorganic materials 0.000 title abstract 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title abstract 4
- 239000010452 phosphate Substances 0.000 title abstract 4
- DVGWFQILDUEEGX-UUOKFMHZSA-N (2r,3r,4s,5r)-2-(6,8-diaminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound NC1=NC2=C(N)N=CN=C2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O DVGWFQILDUEEGX-UUOKFMHZSA-N 0.000 title abstract 2
- CLLFEJLEDNXZNR-UUOKFMHZSA-N (4ar,6r,7r,7as)-6-(6-amino-8-chloropurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4h-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1Cl CLLFEJLEDNXZNR-UUOKFMHZSA-N 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- MHDPPLULTMGBSI-UUOKFMHZSA-N (2r,3r,4s,5r)-2-(6-amino-8-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound ClC1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O MHDPPLULTMGBSI-UUOKFMHZSA-N 0.000 abstract 1
- VJUPMOPLUQHMLE-UUOKFMHZSA-N 8-Bromoadenosine Chemical compound BrC1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O VJUPMOPLUQHMLE-UUOKFMHZSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DERIVADOS OLORADOS DE ADENOSINA DE FORMULAS:
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/136,407 US4861873A (en) | 1987-12-21 | 1987-12-21 | 8-Chloroadenosine 3', 5'-cyclic monophosphate preparations |
| US18007088A | 1988-04-11 | 1988-04-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2019713A6 true ES2019713A6 (es) | 1991-07-01 |
Family
ID=26834271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8801398A Expired - Fee Related ES2019713A6 (es) | 1987-12-21 | 1988-05-06 | Un procedimiento para preparar derivados clorados de adenosina. |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP0346400A4 (es) |
| JP (1) | JPH02502911A (es) |
| KR (1) | KR900700107A (es) |
| AU (2) | AU1933588A (es) |
| CA (1) | CA1326849C (es) |
| DK (1) | DK406589A (es) |
| ES (1) | ES2019713A6 (es) |
| MX (1) | MX168619B (es) |
| NZ (1) | NZ224307A (es) |
| WO (2) | WO1989005647A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1335572C (en) * | 1988-05-23 | 1995-05-16 | Yoon Sang Cho-Chung | Derivatives of cyclic amp as treatment for cancer |
| US4908441A (en) * | 1988-07-19 | 1990-03-13 | Warner-Lambert Company | Deoxyadenosine compounds and methods of making and using the same |
| WO1991019728A1 (en) * | 1990-06-15 | 1991-12-26 | Nippon Shinyaku Co., Ltd. | Nucleotide derivative |
| CN1037575C (zh) * | 1993-10-15 | 1998-03-04 | 北京市肿瘤防治研究所 | 8-氯腺苷制备抗肿瘤药物 |
| GB201820685D0 (en) * | 2018-12-19 | 2019-01-30 | NuCana plc | Synthesis of 8-chloroadenosine derivatives |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1336441A (en) * | 1969-10-10 | 1973-11-07 | Anvar | Derivatives of cyclo adenosine-3,5-phosphoric acid and their preparation |
| US3849553A (en) * | 1973-09-04 | 1974-11-19 | Nelson Res & Dev | Cyclic nucleotide therapeutic preparation |
| US4369181A (en) * | 1981-08-05 | 1983-01-18 | Sri International | Process for treating proliferative skin diseases using certain 6,8-substituted ribofuranosylpurine-3',5'-cyclic phosphates |
-
1988
- 1988-04-15 WO PCT/US1988/001167 patent/WO1989005647A1/en not_active Ceased
- 1988-04-15 AU AU19335/88A patent/AU1933588A/en not_active Abandoned
- 1988-04-20 WO PCT/US1988/001217 patent/WO1989005648A1/en not_active Ceased
- 1988-04-20 NZ NZ224307A patent/NZ224307A/xx unknown
- 1988-04-20 CA CA000564584A patent/CA1326849C/en not_active Expired - Fee Related
- 1988-04-20 KR KR1019890701558A patent/KR900700107A/ko not_active Ceased
- 1988-04-20 AU AU19328/88A patent/AU1932888A/en not_active Abandoned
- 1988-04-20 JP JP63504764A patent/JPH02502911A/ja active Pending
- 1988-04-20 EP EP19880905052 patent/EP0346400A4/en not_active Withdrawn
- 1988-04-20 EP EP19920106624 patent/EP0499291A1/en not_active Withdrawn
- 1988-05-06 ES ES8801398A patent/ES2019713A6/es not_active Expired - Fee Related
- 1988-12-19 MX MX014239A patent/MX168619B/es unknown
-
1989
- 1989-08-18 DK DK406589A patent/DK406589A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK406589A (da) | 1989-10-12 |
| WO1989005648A1 (en) | 1989-06-29 |
| WO1989005647A1 (en) | 1989-06-29 |
| CA1326849C (en) | 1994-02-08 |
| NZ224307A (en) | 1990-03-27 |
| KR900700107A (ko) | 1990-08-11 |
| EP0499291A1 (en) | 1992-08-19 |
| DK406589D0 (da) | 1989-08-18 |
| AU1933588A (en) | 1989-07-19 |
| MX168619B (es) | 1993-06-01 |
| JPH02502911A (ja) | 1990-09-13 |
| EP0346400A4 (en) | 1990-11-28 |
| EP0346400A1 (en) | 1989-12-20 |
| AU1932888A (en) | 1989-07-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20050507 |