ES2028890T3 - Procedimiento de sintesis estereoespecifica de derivados del indol. - Google Patents

Procedimiento de sintesis estereoespecifica de derivados del indol.

Info

Publication number
ES2028890T3
ES2028890T3 ES198787401563T ES87401563T ES2028890T3 ES 2028890 T3 ES2028890 T3 ES 2028890T3 ES 198787401563 T ES198787401563 T ES 198787401563T ES 87401563 T ES87401563 T ES 87401563T ES 2028890 T3 ES2028890 T3 ES 2028890T3
Authority
ES
Spain
Prior art keywords
stereo
specific synthesis
synthesis procedure
compound
indol derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787401563T
Other languages
English (en)
Inventor
Jean Le Hameau De La Rauze Wagnon
Claude Plouzane
Bernard Tonnerre
Dino Nisato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Application granted granted Critical
Publication of ES2028890T3 publication Critical patent/ES2028890T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

LA PRESENTE INVENCION TIENE COMO FIN UN PROCEDIMIENTO DE SINTESIS ESTEREOESPECIFICA DE DERIVADOS DEL INDOL DE FORMULA (I). DICHO PROCEDIMIENTO CONSISTE EN UTILIZAR EL 3-TOSILOXI-O-1,2-ISOPROPILIDENO 1,2-PROPANODIOL BAJO UNA FORMA OPTICAMENTE PURA PARA INTRODUCIR EN CARBONO ASIMETRICO C* DEL COMPUESTO (I). LA PRESENTE INVENCION TIENE IGUALMENTE COMO FIN LAS OXAZOLIDINONAS INTERMEDIARIAS DE FORMULA (IX) EN LA CUAL R5 ES H O UN GRUPO (II).
ES198787401563T 1986-07-03 1987-07-03 Procedimiento de sintesis estereoespecifica de derivados del indol. Expired - Lifetime ES2028890T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8609680A FR2601008B1 (fr) 1986-07-03 1986-07-03 Procede de synthese stereospecifique de derives de l'indole

Publications (1)

Publication Number Publication Date
ES2028890T3 true ES2028890T3 (es) 1992-07-16

Family

ID=9337041

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787401563T Expired - Lifetime ES2028890T3 (es) 1986-07-03 1987-07-03 Procedimiento de sintesis estereoespecifica de derivados del indol.

Country Status (11)

Country Link
US (1) US4806655A (es)
EP (1) EP0251938B1 (es)
JP (1) JPS6322559A (es)
KR (1) KR880001592A (es)
AT (1) ATE69219T1 (es)
CA (1) CA1298303C (es)
DE (1) DE3774342D1 (es)
DK (1) DK338687A (es)
ES (1) ES2028890T3 (es)
FR (1) FR2601008B1 (es)
GR (1) GR3003562T3 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5030640A (en) * 1989-01-05 1991-07-09 Merck & Co., Inc. Novel β-adrenergic agonists and pharmaceutical compositions thereof
US5747501A (en) * 1992-04-07 1998-05-05 Pfizer, Inc. Indole derivatives
TW456052B (en) * 1995-11-14 2001-09-21 Sumitomo Chemical Co Process for producing group III-V compound semiconductor
JP2003055344A (ja) * 1999-01-29 2003-02-26 Dainippon Pharmaceut Co Ltd ３，７−ジ置換インドール誘導体及びそれを含有する医薬組成物
TWI316511B (en) 2002-11-26 2009-11-01 Smithkline Beecham Corp Calcilytic compounds
JPWO2008120655A1 (ja) * 2007-03-30 2010-07-15 株式会社医薬分子設計研究所 Ｉ型１１βヒドロキシステロイド脱水素酵素阻害活性を有するオキサゾリジノン誘導体
US8927190B2 (en) * 2010-01-25 2015-01-06 Rohm And Haas Electronic Materials Llc Photoresist comprising nitrogen-containing compound

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1116598A (en) * 1977-07-13 1982-01-19 William T. Comer 3-indolyl-tertiary butylaminopropanols
US4234595A (en) * 1977-07-13 1980-11-18 Mead Johnson & Company 3-Indolyl-tertiary butylaminopropanols
FR2463765A1 (fr) * 1979-08-17 1981-02-27 Clin Midy Nouveaux derives de l'indole actifs sur le systeme cardiovasculaire
FR2523964B1 (fr) * 1982-03-23 1985-09-27 Sanofi Sa Nouveaux derives de la tryptamine actifs notamment sur le systeme cardiovasculaire et procede pour leur preparation
NZ208337A (en) * 1983-06-10 1988-10-28 Bristol Myers Co 2-(2-hydroxy-3-((2-(ar-hydroxy-1h-aminopropoxy-yl)ethyl benzonitriles and pharmaceutical compositions

Also Published As

Publication number Publication date
FR2601008A1 (fr) 1988-01-08
DK338687D0 (da) 1987-07-01
EP0251938B1 (fr) 1991-11-06
ATE69219T1 (de) 1991-11-15
DE3774342D1 (de) 1991-12-12
EP0251938A1 (fr) 1988-01-07
CA1298303C (en) 1992-03-31
GR3003562T3 (es) 1993-03-16
FR2601008B1 (fr) 1990-03-30
JPS6322559A (ja) 1988-01-30
US4806655A (en) 1989-02-21
KR880001592A (ko) 1988-04-25
DK338687A (da) 1988-01-04

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