ES2031959T3 - Procedimiento para preparar acidos 3,5-dihidroxicarboxilicos y sus derivados. - Google Patents

Procedimiento para preparar acidos 3,5-dihidroxicarboxilicos y sus derivados.

Info

Publication number
ES2031959T3
ES2031959T3 ES198888110833T ES88110833T ES2031959T3 ES 2031959 T3 ES2031959 T3 ES 2031959T3 ES 198888110833 T ES198888110833 T ES 198888110833T ES 88110833 T ES88110833 T ES 88110833T ES 2031959 T3 ES2031959 T3 ES 2031959T3
Authority
ES
Spain
Prior art keywords
derivatives
acids
dihidroxicarboxilic
preparing
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888110833T
Other languages
English (en)
Inventor
Gunther Dr. Wess
Wilhelm Prof. Dr. Bartmann
Gerhard Dr. Beck
Ernold Dr. Dr. Granzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2031959T3 publication Critical patent/ES2031959T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/486—Polycyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)

Abstract

SE DESCRIBEN ACIDOS 3,5-DIHIDROXICARBONO Y SUS DERIVADOS DE LA FORMULA(I), Y LAS LACTONAS CORRESPONDIENTES DE LA FORMULA(II), DONDE R1, R2, R3, R4, A-B Y X-Y TIENEN LAS SIGNIFICACIONES DADAS, PROCESO PARA LA FABRICACION DE ESTOS COMPUESTOS, SU USO COMO MEDICAMENTO Y PREPARADOS FARMACEUTICOS.
ES198888110833T 1987-07-10 1988-07-07 Procedimiento para preparar acidos 3,5-dihidroxicarboxilicos y sus derivados. Expired - Lifetime ES2031959T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873722807 DE3722807A1 (de) 1987-07-10 1987-07-10 Neue 3,5-dihydroxycarbonsaeuren und deren derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte

Publications (1)

Publication Number Publication Date
ES2031959T3 true ES2031959T3 (es) 1993-01-01

Family

ID=6331292

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888110833T Expired - Lifetime ES2031959T3 (es) 1987-07-10 1988-07-07 Procedimiento para preparar acidos 3,5-dihidroxicarboxilicos y sus derivados.

Country Status (17)

Country Link
EP (1) EP0306649B1 (es)
JP (1) JPS6445337A (es)
KR (1) KR890001941A (es)
AT (1) ATE73123T1 (es)
AU (1) AU606712B2 (es)
DE (2) DE3722807A1 (es)
DK (1) DK383988A (es)
ES (1) ES2031959T3 (es)
FI (1) FI90412C (es)
GR (1) GR3004588T3 (es)
HU (1) HU199768B (es)
IL (1) IL87035A0 (es)
NO (1) NO167795C (es)
NZ (1) NZ225343A (es)
PH (1) PH27496A (es)
PT (1) PT87928B (es)
ZA (1) ZA884920B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989003212A1 (en) * 1987-10-13 1989-04-20 Pfizer Inc. 3,5-dihydroxy-6,8-nonadienoic acids and derivatives as hypocholesterolemic agents
DE3826814A1 (de) * 1988-08-06 1990-02-08 Hoechst Ag Neue 6-fluor-3,5-dihydroxycarbonsaeuren und deren derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
DE3832570A1 (de) * 1988-09-24 1990-03-29 Hoechst Ag 7-substituierte derivate der 3,5-dihydroxyhept-6-insaeure, verfahren zur ihrer herstellung, ihre verwendung als arzneimittel, sowie zwischenprodukte
EP0430129A3 (en) * 1989-11-30 1992-02-26 Tanabe Seiyaku Co., Ltd. Novel phenylethylene derivatives, processes for preparing the same and intermediates therefor
WO1992022560A1 (fr) * 1991-06-19 1992-12-23 Shionogi Seiyaku Kabushiki Kaisha Intermediaire optiquement actif et production de celui-ci
BRPI0408005A (pt) * 2003-03-05 2006-02-14 Celgene Corp composto, composição farmacêutica, métodos para inibir angiogênese, atividade de pde4 em uma célula e proliferação de célula de cáncer, para inibir ou reduzir polimerização de tubulina ou estabilidade de tubulina em uma célula, para tratar ou melhorar um distúrbio inflamatório, um cáncer e um distúrbio do sistema nervoso central e para visar, bloquear ou destruir a função de vasculatura de tumor e o endotélio de vasos de tumor
EP2072729B1 (en) * 2007-12-21 2013-06-26 IVECO S.p.A. Hinge for vehicle door, in particular of a van

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL102791C (es) * 1957-08-01
BE634738A (es) * 1962-07-11 1900-01-01
US3919304A (en) * 1968-10-25 1975-11-11 Ciba Geigy Corp {62 -Hydroxy-{62 -(cycloalkenylphenyl)alkanoic acids, esters and salts
BE793686A (fr) * 1972-01-07 1973-07-04 Beecham Group Ltd Composes di-aryliques biologiquement actifs
DE2212948A1 (de) * 1972-03-17 1973-09-20 Basf Ag Verfahren zur herstellung von in alpha-stellung verzweigten alpha,betaungesaettigten aldehyden
JPS5559140A (en) * 1978-10-30 1980-05-02 Sankyo Co Ltd 3,5-dihydroxypentanoic alkyl ester derivative, its preparation and remedy for hyperlipemia containing the same as the effective component
US4341910A (en) * 1979-01-25 1982-07-27 Texas Alkyls, Inc. Preparation of unsaturated alcohols
US4459422A (en) * 1979-08-17 1984-07-10 Merck & Co., Inc. Substituted pyranone inhibitors of cholesterol synthesis
US4567289A (en) * 1979-08-17 1986-01-28 Merck & Co., Inc. Substituted pyranone inhibitors of cholesterol synthesis
DE2934251A1 (de) * 1979-08-24 1981-03-26 Basf Ag, 67063 Ludwigshafen Verfahren zur herstellung von ungesaettigten alkoholen.
DE3160641D1 (en) * 1980-05-13 1983-08-25 Ciba Geigy Ag Process for the preparation of benzene or naphthalene alkenyl carboxylic acid derivatives
FI77839C (fi) * 1982-05-27 1989-05-10 Farmos Oy Foerfarande foer framstaellning av nya terapeutiskt effektiva trifenylalkan- och alkenderivat.
JPS59163336A (ja) * 1983-03-09 1984-09-14 Nippon Petrochem Co Ltd アルデヒドの製造法
HUT39142A (en) * 1984-07-24 1986-08-28 Sandoz Ag Process for producing naphtyl-analogues of mevalolactone and derivatives and pharmaceutical compositions containing them
DE3523181A1 (de) * 1985-06-28 1987-01-08 Basf Ag Verfahren zur herstellung von 2-methyl-2-alkenalen
US4611081A (en) * 1985-07-05 1986-09-09 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors intermediates
US4745229A (en) * 1986-02-28 1988-05-17 Kuraray Company Ltd. Process for preparing α, β-unsaturated aldehydes

Also Published As

Publication number Publication date
IL87035A0 (en) 1988-12-30
HU199768B (en) 1990-03-28
ZA884920B (en) 1989-01-17
FI90412B (fi) 1993-10-29
PT87928A (pt) 1989-06-30
GR3004588T3 (es) 1993-04-28
DK383988D0 (da) 1988-07-08
NO883071L (no) 1989-01-11
JPS6445337A (en) 1989-02-17
PH27496A (en) 1993-07-23
NO883071D0 (no) 1988-07-08
KR890001941A (ko) 1989-04-06
NZ225343A (en) 1991-02-26
NO167795B (no) 1991-09-02
DE3722807A1 (de) 1989-01-19
EP0306649A1 (de) 1989-03-15
HUT47237A (en) 1989-02-28
ATE73123T1 (de) 1992-03-15
DE3868794D1 (de) 1992-04-09
EP0306649B1 (de) 1992-03-04
FI883248A7 (fi) 1989-01-11
DK383988A (da) 1989-01-11
AU1888188A (en) 1989-01-12
FI883248A0 (fi) 1988-07-07
AU606712B2 (en) 1991-02-14
PT87928B (pt) 1995-05-04
FI90412C (fi) 1994-02-10
NO167795C (no) 1991-12-11

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