ES2033666T1 - Aparato y metodo para realizar la amplificacion automatizada de secuencias de acidos nucleicos y ensayos que emplean etapas de calentamiento y enfriamiento. - Google Patents

Aparato y metodo para realizar la amplificacion automatizada de secuencias de acidos nucleicos y ensayos que emplean etapas de calentamiento y enfriamiento.

Info

Publication number
ES2033666T1
ES2033666T1 ES198787301669T ES87301669T ES2033666T1 ES 2033666 T1 ES2033666 T1 ES 2033666T1 ES 198787301669 T ES198787301669 T ES 198787301669T ES 87301669 T ES87301669 T ES 87301669T ES 2033666 T1 ES2033666 T1 ES 2033666T1
Authority
ES
Spain
Prior art keywords
tests
perform
nucleic acid
acid sequences
cooling stages
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES198787301669T
Other languages
English (en)
Inventor
Larry James Johnson
Richard Alan Leath
Louis Michael Mezei
Joseph Thomas Widunas
Timothy J. Wennberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cetus Oncology Corp
Original Assignee
Cetus Oncology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27125619&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2033666(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cetus Oncology Corp filed Critical Cetus Oncology Corp
Publication of ES2033666T1 publication Critical patent/ES2033666T1/es
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/36—Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Medicinal Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Saccharide Compounds (AREA)
  • Heat-Exchange Devices With Radiators And Conduit Assemblies (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Compression-Type Refrigeration Machines With Reversible Cycles (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

SE PRESENTA UNA MAQUINA PARA LA MEJORA DE LA AMPLIFICACION DE ACIDO NUCLEICO BAJO CONTROL COMPUTERIZADO. LA MAQUINA UTILIZA CUALQUIER NUMERO DE SISTEMAS DE CALENTADO Y ENFRIADO BAJO CONTROL DE UN COMPUTADOR RESIDENTE QUE DIRIGE LOS SISTEMAS DE CALENTADO Y ENFRIADO PARA CALENTAR Y ENFRIAR UNA CAMARA DE REACCION QUE CONTIENE INTERCAMBIADORES DE CALOR EN EL MOMENTO APROPIADO DEL PROCESO. LAS CAMARAS DE REACCION SON PRECARGADAS CON LOS ACIDOS NUCLEICOS QUE SERAN AMPLIFICADOS, UNA ENZIMA TERMOESTABLE PARA CATALIZAR LA POLIMERIZACION, PRIMARIOS OLIGONUCLEOTIDOS ESPECIFICOS, Y CUATRO DIFERENTES TRIFOSFATOS NUCLEOTIDOS. TAMBIEN SE HA DESCUBIERTO EL PROCESO PARA LA REACCION DE CADENA DE AMPLIFICACION IMPLEMENTADA POR LA MAQUINA, EL CUAL UTILIZA UNA ENZIMA TERMOESTABLE.
ES198787301669T 1986-02-25 1987-02-25 Aparato y metodo para realizar la amplificacion automatizada de secuencias de acidos nucleicos y ensayos que emplean etapas de calentamiento y enfriamiento. Pending ES2033666T1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83336886A 1986-02-25 1986-02-25
US89906186A 1986-08-22 1986-08-22

Publications (1)

Publication Number Publication Date
ES2033666T1 true ES2033666T1 (es) 1993-04-01

Family

ID=27125619

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787301669T Pending ES2033666T1 (es) 1986-02-25 1987-02-25 Aparato y metodo para realizar la amplificacion automatizada de secuencias de acidos nucleicos y ensayos que emplean etapas de calentamiento y enfriamiento.

Country Status (13)

Country Link
EP (2) EP0236069B1 (es)
JP (2) JP2613877B2 (es)
KR (1) KR910006599B1 (es)
AT (1) ATE152529T1 (es)
AU (2) AU612316B2 (es)
CA (1) CA1339653C (es)
DE (3) DE776967T1 (es)
DK (1) DK97887A (es)
ES (1) ES2033666T1 (es)
GR (1) GR920300087T1 (es)
IE (1) IE81124B1 (es)
IL (1) IL81663A (es)
NZ (1) NZ219388A (es)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1339653C (en) * 1986-02-25 1998-02-03 Larry J. Johnson Appartus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
IL86724A (en) * 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
AU622426B2 (en) * 1987-12-11 1992-04-09 Abbott Laboratories Assay using template-dependent nucleic acid probe reorganization
FI79342C (fi) * 1987-12-23 1989-12-11 Orion Yhtymae Oy Apparat, del av en apparat och foerfarande foer maongfaldigande av nukleinsyror.
JP2846018B2 (ja) * 1988-01-21 1999-01-13 ジェネンテク，インコーポレイテッド 核酸配列の増幅および検出
US5024934A (en) * 1988-03-14 1991-06-18 The Board Of Regents, The University Of Texas System Detection of minimal numbers of neoplastic cells carrying DNA translocations by DNA sequence amplification
DE3808942A1 (de) * 1988-03-17 1989-09-28 Bio Med Gmbh Ges Fuer Biotechn Inkubator, insbes. fuer die polymerase-ketten-methode
GB8807297D0 (en) * 1988-03-26 1988-04-27 Dean P D G Intelligent heating block
GB2233476B (en) * 1988-03-26 1992-01-29 Peter Duncan Goodearl Dean Reaction temperature control
GB8814962D0 (en) * 1988-06-23 1988-07-27 Lep Scient Ltd Biochemical reaction machine
ATE144556T1 (de) * 1988-06-24 1996-11-15 Amgen Inc Verfahren und mittel zum nachweis von nukleinsäuresequenzen
US5066584A (en) * 1988-09-23 1991-11-19 Cetus Corporation Methods for generating single stranded dna by the polymerase chain reaction
US5075216A (en) * 1988-09-23 1991-12-24 Cetus Corporation Methods for dna sequencing with thermus aquaticus dna polymerase
US4865986A (en) * 1988-10-06 1989-09-12 Coy Corporation Temperature control apparatus
GB8826364D0 (en) * 1988-11-10 1988-12-14 Sykes B C Improvements in/relating to temperature sequencing
CA1338505C (en) * 1989-02-03 1996-08-06 John Bruce Findlay Containment cuvette for pcr and method of use
GB8917963D0 (en) * 1989-08-05 1989-09-20 Scras Apparatus for repeated automatic execution of a thermal cycle for treatment of biological samples
WO1991007504A1 (en) * 1989-11-21 1991-05-30 Kindconi Pty. Ltd. Improved dna polymerisation device
US5935522A (en) * 1990-06-04 1999-08-10 University Of Utah Research Foundation On-line DNA analysis system with rapid thermal cycling
US7081226B1 (en) 1996-06-04 2006-07-25 University Of Utah Research Foundation System and method for fluorescence monitoring
US7273749B1 (en) 1990-06-04 2007-09-25 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US6716580B2 (en) 1990-06-11 2004-04-06 Somalogic, Inc. Method for the automated generation of nucleic acid ligands
AT394911B (de) * 1990-09-12 1992-07-27 Vaillant Gmbh Elektronischer raumtemperatur-regler
KR100236506B1 (ko) * 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
US6703236B2 (en) 1990-11-29 2004-03-09 Applera Corporation Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
FR2672301A1 (fr) * 1991-02-01 1992-08-07 Larzul Daniel Procede et dispositif pour amplifier le nombre d'une sequence definie d'acide nucleique dans un echantillon biologique.
US5270183A (en) * 1991-02-08 1993-12-14 Beckman Research Institute Of The City Of Hope Device and method for the automated cycling of solutions between two or more temperatures
CA2065719A1 (en) 1991-04-30 1992-10-31 John B. Findlay Nucleic acid amplification and detection methods using rapid polymerase chain reaction cycle
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
WO1992020795A1 (en) * 1991-05-17 1992-11-26 Cetus Oncology Corporation INHIBITOR OF NF-λB TRANSCRIPTIONAL ACTIVATOR AND USES THEREOF
WO1992020778A1 (en) * 1991-05-24 1992-11-26 Kindconi Pty Limited Biochemical reaction control
ES2091976T3 (es) 1991-06-20 1996-11-16 Hoffmann La Roche Metodos perfeccionados para la amplificacion del acido nucleico.
AU645915B2 (en) * 1991-07-23 1994-01-27 F. Hoffmann-La Roche Ag Improvements in the in situ PCR
FI915731A0 (fi) * 1991-12-05 1991-12-05 Derek Henry Potter Foerfarande och anordning foer reglering av temperaturen i ett flertal prov.
US6033854A (en) * 1991-12-16 2000-03-07 Biotronics Corporation Quantitative PCR using blocking oligonucleotides
US5348853A (en) * 1991-12-16 1994-09-20 Biotronics Corporation Method for reducing non-specific priming in DNA amplification
US5567583A (en) * 1991-12-16 1996-10-22 Biotronics Corporation Methods for reducing non-specific priming in DNA detection
DE69429038T2 (de) * 1993-07-28 2002-03-21 Pe Corporation (Ny), Norwalk Vorrichtung und Verfahren zur Nukleinsäurevervielfältigung
CA2130517C (en) * 1993-09-10 1999-10-05 Walter Fassbind Array of reaction containers for an apparatus for automatic performance of temperature cycles
CA2130013C (en) * 1993-09-10 1999-03-30 Rolf Moser Apparatus for automatic performance of temperature cycles
US5597694A (en) * 1993-10-07 1997-01-28 Massachusetts Institute Of Technology Interspersed repetitive element-bubble amplification of nucleic acids
US5622822A (en) 1994-09-13 1997-04-22 Johnson & Johnson Clinical Diagnostics, Inc. Methods for capture and selective release of nucleic acids using polyethyleneimine and an anionic phosphate ester surfactant and amplification of same
US5582988A (en) 1994-09-15 1996-12-10 Johnson & Johnson Clinical Diagnostics, Inc. Methods for capture and selective release of nucleic acids using weakly basic polymer and amplification of same
US5705366A (en) 1994-09-15 1998-01-06 Johnson & Johnson Clinical Diagnostics, Inc. Coamplification of target nucleic acids using volume exclusion agent in reaction composition, test kit and test device useful therefor
GB9501234D0 (en) * 1995-01-23 1995-03-15 Marshall Biotech Ltd Thermoregulator
ATE428801T1 (de) 1996-06-04 2009-05-15 Univ Utah Res Found Überwachung der hybridisierung während pcr
AU736484B2 (en) * 1997-03-28 2001-07-26 Applied Biosystems, Llc Improvements in thermal cycler for PCR
US7133726B1 (en) 1997-03-28 2006-11-07 Applera Corporation Thermal cycler for PCR
US6893877B2 (en) 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
KR100678978B1 (ko) * 1998-02-10 2007-02-06 도요 고한 가부시키가이샤 유전자를 계통적으로 비교하는 방법
JP2002534985A (ja) * 1999-01-19 2002-10-22 ソマロジック・インコーポレーテッド 核酸リガンドの自動化生成のための方法および装置
NZ513390A (en) 1999-03-19 2003-01-31 Genencor Int Multi-through hole testing plate for high throughput screening
US7014994B1 (en) 1999-03-19 2006-03-21 Cornell Research Foundation,Inc. Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
JP2001136954A (ja) * 1999-08-31 2001-05-22 Toshiba Corp 核酸処理器及び核酸処理方法
DE19946427C2 (de) * 1999-09-28 2002-07-04 Lange Gmbh Dr Bruno Verfahren und Vorrichtung zum definierten gleichzeitigen Wärmebehandeln von mehreren Probenbehältern
DE29917313U1 (de) * 1999-10-01 2001-02-15 MWG-BIOTECH AG, 85560 Ebersberg Vorrichtung zur Durchführung chemischer oder biologischer Reaktionen
US20020151040A1 (en) 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
WO2001061054A2 (en) 2000-02-18 2001-08-23 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US7727479B2 (en) 2000-09-29 2010-06-01 Applied Biosystems, Llc Device for the carrying out of chemical or biological reactions
EP1441853A2 (en) * 2001-06-21 2004-08-04 Hybaid Limited Sample well plate
KR100459896B1 (ko) * 2002-03-06 2004-12-04 삼성전자주식회사 Ｐｃｒ 칩을 구동하기 위한 온도 제어 방법 및 그 장치
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
WO2004074818A2 (en) 2002-12-20 2004-09-02 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
US8676383B2 (en) 2002-12-23 2014-03-18 Applied Biosystems, Llc Device for carrying out chemical or biological reactions
RU2309407C2 (ru) * 2003-03-31 2007-10-27 Каунсил Оф Сайентифик Энд Индастриал Рисерч Быстрый, опосредованный нагреванием способ выполнения сорбционного иммуноферментного анализа
AU2003223108A1 (en) * 2003-03-31 2004-10-25 Council Of Scientific And Industrial Research Rapid heat-mediated method for enzyme-linked immunosorbent assay procedure
RU2234119C1 (ru) * 2003-09-23 2004-08-10 ЗАО "Удел" Термоциклер
CA2559171A1 (en) 2004-03-12 2005-09-29 Biotrove, Inc. Nanoliter array loading
EP1710016A3 (en) 2005-03-30 2011-03-30 Roche Diagnostics GmbH Device having a self sealing fluid port
EP1760465B1 (en) 2005-09-06 2010-06-23 Roche Diagnostics GmbH Device with a compressible matrix having a homogeneous flow profile
US8232091B2 (en) 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
JP2009540299A (ja) 2006-06-05 2009-11-19 カリフォルニア インスティテュート オブ テクノロジー リアルタイムマイクロアレイ
EP1886727A1 (en) 2006-07-14 2008-02-13 Roche Diagnostics GmbH Analytical device
JP4918409B2 (ja) 2006-07-26 2012-04-18 西川ゴム工業株式会社 核酸配列の増幅方法
US8048626B2 (en) 2006-07-28 2011-11-01 California Institute Of Technology Multiplex Q-PCR arrays
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
EP1962084A1 (en) 2007-02-21 2008-08-27 Roche Diagnostics GmbH Apparatus for emitting and detecting beams of light
EP2127751B1 (en) 2008-05-19 2012-05-16 Roche Diagnostics GmbH Improved cooler / heater arrangement with solid film lubricant
JP5372418B2 (ja) 2008-06-23 2013-12-18 株式会社日立ハイテクノロジーズ 核酸分析装置，自動分析装置、及び分析方法
CN102164674B (zh) * 2008-09-23 2014-07-16 皇家飞利浦电子股份有限公司 热循环设备
CN201837588U (zh) 2009-09-09 2011-05-18 海利克斯公司 用于多个反应的光学系统
JP6117694B2 (ja) 2010-04-09 2017-04-19 ライフ テクノロジーズ コーポレーション 動的制御を用いた熱サイクラ器具に対する熱均一性改良
WO2012018639A2 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
WO2012018638A2 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
EP3249054A1 (en) 2012-12-20 2017-11-29 Biomatrica, INC. Formulations and methods for stabilizing pcr reagents
SG11201601275UA (en) 2013-09-16 2016-04-28 Life Technologies Corp Apparatuses, systems and methods for providing thermocycler thermal uniformity
JP5820459B2 (ja) * 2013-12-18 2015-11-24 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． サーモサイクルデバイス
WO2015126621A1 (en) 2014-02-18 2015-08-27 Life Technologies Corporation Apparatuses, systems and methods for providing scalable thermal cyclers and isolating thermoelectric devices
WO2015191632A1 (en) 2014-06-10 2015-12-17 Biomatrica, Inc. Stabilization of thrombocytes at ambient temperatures
EP2985603A1 (en) 2014-08-13 2016-02-17 Yantai AusBio Laboratories Co., Ltd. Method for carrying out a ligand binding assay and device for carrying out such a method
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
KR102589056B1 (ko) 2015-12-08 2023-10-12 바이오매트리카 인코포레이티드 적혈구 침강 속도의 감소
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
JP7687957B2 (ja) 2019-03-14 2025-06-03 インシリクサ， インコーポレイテッド 時間ゲート蛍光ベースの検出のための方法およびシステム
CN113467539B (zh) * 2021-06-09 2023-03-14 上海闻泰信息技术有限公司 基于余热回收的温控系统、控温方法和电子设备

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3505023A (en) * 1967-11-13 1970-04-07 Research Corp Thermally conditioned spot plate
US3847200A (en) * 1972-05-01 1974-11-12 Brinkmann Instr Inc Apparatus for concentrating laboratory specimens by evaporation
FR2360846A1 (fr) * 1976-06-21 1978-03-03 Luce Joseph Etuve-refrigerateur a organe unique de chauffe et de refrigeration
FR2413708A1 (fr) * 1977-12-30 1979-07-27 Poudres & Explosifs Ste Nale Procede et installation de regulation de la temperature d'un corps a partir d'un fluide
JPS5526435A (en) * 1978-08-16 1980-02-25 Hitachi Ltd Programmer
DD157983A3 (de) 1980-08-19 1982-12-22 Dieter Baumert Anordnung zur aufschaltung einer stoergroesse fuer die regelung der heiz-u.kuehlleistung einer peltierbatterie eines thermostaten
EP0058428B1 (en) * 1981-02-18 1985-10-09 Eisai Co., Ltd. An enzyme immuno-assay for simultaneously measuring a plurality of samples and test vessel for carrying out this method
JPS5875064A (ja) * 1981-10-30 1983-05-06 Eisai Co Ltd 生化学的検査や免疫反応に用いられる測定装置
DE3149624A1 (de) * 1981-12-15 1983-06-23 Georg 6050 Offenbach May Vorrichtung zur regelung der temperatur von stoffen
DE3238535A1 (de) * 1982-10-18 1984-04-19 Planer Products Ltd., Sunbury-on-Thames, Middlesex Verfahren und apparat zum gesteuerten kuehlen eines produktes
JPS59100905A (ja) * 1982-12-01 1984-06-11 Omron Tateisi Electronics Co プログラム制御装置
JPS59112254A (ja) * 1982-12-20 1984-06-28 Komatsu Electron Kk 試料の加熱冷却装置
US4683194A (en) * 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
JPS6130597A (ja) * 1984-07-20 1986-02-12 Nippon Zeon Co Ltd ポリヌクレオチド合成装置
ES8706823A1 (es) * 1985-03-28 1987-06-16 Cetus Corp Un procedimiento para detectar la presencia o ausencia de al menos una secuencia especifica de acidos nucleicos en una muestra
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
CA1339653C (en) * 1986-02-25 1998-02-03 Larry J. Johnson Appartus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
JPH0467957A (ja) * 1990-07-09 1992-03-03 Fujitsu Ltd プリンタのインパクトドット印字ヘッド

Also Published As

Publication number Publication date
JPS62240862A (ja) 1987-10-21
IL81663A0 (en) 1987-09-16
AU653932B2 (en) 1994-10-20
ATE152529T1 (de) 1997-05-15
NZ219388A (en) 1989-02-24
DE3752057D1 (de) 1997-06-05
EP0776967A3 (en) 1997-09-10
KR870007945A (ko) 1987-09-23
AU6918087A (en) 1987-08-27
IE81124B1 (en) 2000-03-22
DK97887A (da) 1987-08-26
JP2613877B2 (ja) 1997-05-28
CA1339653C (en) 1998-02-03
KR910006599B1 (ko) 1991-08-29
EP0236069B1 (en) 1997-05-02
DE3752057T2 (de) 1997-09-25
EP0236069A3 (en) 1990-10-03
GR920300087T1 (en) 1992-12-30
AU612316B2 (en) 1991-07-11
DK97887D0 (da) 1987-02-25
IL81663A (en) 1991-05-12
DE776967T1 (de) 1997-11-20
DE236069T1 (de) 1993-02-04
EP0236069A2 (en) 1987-09-09
JPH07303468A (ja) 1995-11-21
EP0776967A2 (en) 1997-06-04
AU7609291A (en) 1991-09-12

Similar Documents

Publication Publication Date Title
GR920300087T1 (en) Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
JP4103964B2 (ja) 温度勾配ブロックを含む熱サイクル装置
DE69429038D1 (de) Vorrichtung und Verfahren zur Nukleinsäurevervielfältigung
Nagai et al. High-throughput PCR in silicon based microchamber array
DK1510823T3 (da) Udförelse af en polymerease kædereaktion
DE69818869D1 (de) Einrichtung für Thermozyklier-Geräten für PCR
US5333675C1 (en) Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
ATE350491T1 (de) Verfahren und vorrichtung zur amplifikation von nukleinsäuresequenzen mittels thermischer konvektion
AU2001221136A1 (en) Rapid thermal recycling device
DE50003023D1 (de) Vorrichtung zur durchführung chemischer oder biologischer reaktionen
ES2143680T3 (es) Metodo para caracterizar dna genomico.
EP1704922A3 (en) System and methods for monitoring PCR processes
BR9403338A (pt) Aparelho para monitorar simultaneamente ampliações múltiplas de ácido nucléico e processo para determinar a quantidade de uma sequência de ácido nucléico específica em uma amostra
DE60334465D1 (de) Probenblockvorrichtung und verfahren zur unterhaltung einer mikrokarte auf einem probenblock
ATE103062T1 (de) Verfahren und vorrichtung zur schnellregulierung einer wandtemperatur.
RU99114775A (ru) Реакторы
DE69224548D1 (de) Verfahren zur Amplifizierung und zum Nachweis von Nukleinsäuren,die einen schnellen PCR-Zyklus verwenden
NO874164D0 (no) Masseundersoekelsesmetode for deteksjon av enkeltbasemutasjoner i multiple loci i genomisk dna ved bruk av denatureringsgradient-gelelektroforese fulgt av effektiv overfoering og hybredisering til forskjellige prober.
DE50110234D1 (de) Verfahren zur Temperierung von Proben auf unterschiedliche Temperaturen in einer Labortemperiereinrichtung
FI121164B (fi) Lämpösyklilaite optimoidulla näytteenpidingeometrialla
Limque et al. Furnace for the Heat Treatment of Drills