ES2033666T1 - Aparato y metodo para realizar la amplificacion automatizada de secuencias de acidos nucleicos y ensayos que emplean etapas de calentamiento y enfriamiento. - Google Patents

Aparato y metodo para realizar la amplificacion automatizada de secuencias de acidos nucleicos y ensayos que emplean etapas de calentamiento y enfriamiento.

Info

Publication number
ES2033666T1
ES2033666T1 ES198787301669T ES87301669T ES2033666T1 ES 2033666 T1 ES2033666 T1 ES 2033666T1 ES 198787301669 T ES198787301669 T ES 198787301669T ES 87301669 T ES87301669 T ES 87301669T ES 2033666 T1 ES2033666 T1 ES 2033666T1
Authority
ES
Spain
Prior art keywords
tests
perform
nucleic acid
acid sequences
cooling stages
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES198787301669T
Other languages
English (en)
Inventor
Larry James Johnson
Richard Alan Leath
Louis Michael Mezei
Joseph Thomas Widunas
Timothy J. Wennberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cetus Oncology Corp
Original Assignee
Cetus Oncology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27125619&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2033666(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cetus Oncology Corp filed Critical Cetus Oncology Corp
Publication of ES2033666T1 publication Critical patent/ES2033666T1/es
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/36—Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Medicinal Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Saccharide Compounds (AREA)
  • Heat-Exchange Devices With Radiators And Conduit Assemblies (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Compression-Type Refrigeration Machines With Reversible Cycles (AREA)

Abstract

SE PRESENTA UNA MAQUINA PARA LA MEJORA DE LA AMPLIFICACION DE ACIDO NUCLEICO BAJO CONTROL COMPUTERIZADO. LA MAQUINA UTILIZA CUALQUIER NUMERO DE SISTEMAS DE CALENTADO Y ENFRIADO BAJO CONTROL DE UN COMPUTADOR RESIDENTE QUE DIRIGE LOS SISTEMAS DE CALENTADO Y ENFRIADO PARA CALENTAR Y ENFRIAR UNA CAMARA DE REACCION QUE CONTIENE INTERCAMBIADORES DE CALOR EN EL MOMENTO APROPIADO DEL PROCESO. LAS CAMARAS DE REACCION SON PRECARGADAS CON LOS ACIDOS NUCLEICOS QUE SERAN AMPLIFICADOS, UNA ENZIMA TERMOESTABLE PARA CATALIZAR LA POLIMERIZACION, PRIMARIOS OLIGONUCLEOTIDOS ESPECIFICOS, Y CUATRO DIFERENTES TRIFOSFATOS NUCLEOTIDOS. TAMBIEN SE HA DESCUBIERTO EL PROCESO PARA LA REACCION DE CADENA DE AMPLIFICACION IMPLEMENTADA POR LA MAQUINA, EL CUAL UTILIZA UNA ENZIMA TERMOESTABLE.
ES198787301669T 1986-02-25 1987-02-25 Aparato y metodo para realizar la amplificacion automatizada de secuencias de acidos nucleicos y ensayos que emplean etapas de calentamiento y enfriamiento. Pending ES2033666T1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83336886A 1986-02-25 1986-02-25
US89906186A 1986-08-22 1986-08-22

Publications (1)

Publication Number Publication Date
ES2033666T1 true ES2033666T1 (es) 1993-04-01

Family

ID=27125619

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787301669T Pending ES2033666T1 (es) 1986-02-25 1987-02-25 Aparato y metodo para realizar la amplificacion automatizada de secuencias de acidos nucleicos y ensayos que emplean etapas de calentamiento y enfriamiento.

Country Status (13)

Country Link
EP (2) EP0776967A3 (es)
JP (2) JP2613877B2 (es)
KR (1) KR910006599B1 (es)
AT (1) ATE152529T1 (es)
AU (2) AU612316B2 (es)
CA (1) CA1339653C (es)
DE (3) DE776967T1 (es)
DK (1) DK97887A (es)
ES (1) ES2033666T1 (es)
GR (1) GR920300087T1 (es)
IE (1) IE81124B1 (es)
IL (1) IL81663A (es)
NZ (1) NZ219388A (es)

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DE776967T1 (de) 1997-11-20
JPS62240862A (ja) 1987-10-21
JPH07303468A (ja) 1995-11-21
KR870007945A (ko) 1987-09-23
AU612316B2 (en) 1991-07-11
AU653932B2 (en) 1994-10-20
AU7609291A (en) 1991-09-12
JP2613877B2 (ja) 1997-05-28
ATE152529T1 (de) 1997-05-15
CA1339653C (en) 1998-02-03
GR920300087T1 (en) 1992-12-30
EP0776967A3 (en) 1997-09-10
KR910006599B1 (ko) 1991-08-29
IL81663A (en) 1991-05-12
DE3752057T2 (de) 1997-09-25
EP0236069A2 (en) 1987-09-09
EP0236069B1 (en) 1997-05-02
AU6918087A (en) 1987-08-27
IL81663A0 (en) 1987-09-16
DE236069T1 (de) 1993-02-04
EP0236069A3 (en) 1990-10-03
IE81124B1 (en) 2000-03-22
DE3752057D1 (de) 1997-06-05
DK97887A (da) 1987-08-26
EP0776967A2 (en) 1997-06-04
NZ219388A (en) 1989-02-24
DK97887D0 (da) 1987-02-25

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