ES2034909A6 - Metodo para la obtencion de derivados de 1h-azol-(w-(4-(2-pirimidinil)-1-piperazinil)-alquilo. - Google Patents

Metodo para la obtencion de derivados de 1h-azol-(w-(4-(2-pirimidinil)-1-piperazinil)-alquilo.

Info

Publication number
ES2034909A6
ES2034909A6 ES9002951A ES9002951A ES2034909A6 ES 2034909 A6 ES2034909 A6 ES 2034909A6 ES 9002951 A ES9002951 A ES 9002951A ES 9002951 A ES9002951 A ES 9002951A ES 2034909 A6 ES2034909 A6 ES 2034909A6
Authority
ES
Spain
Prior art keywords
temperature
diox
compound
mixture
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9002951A
Other languages
English (en)
Inventor
Constansa Jordi Frigola
Corominas Juan Pares
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of ES2034909A6 publication Critical patent/ES2034909A6/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Flanged Joints, Insulating Joints, And Other Joints (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Lubricants (AREA)
  • Ceramic Products (AREA)
  • Surgical Instruments (AREA)
  • Paper (AREA)
  • Saccharide Compounds (AREA)

Abstract

METODOS PARA LA OBTENCION DE DERIVADOS DE 1H-AZOL-(W-(4-(2-PIRIMIDINIL)-1-PIPERAZINIL)-ALQUILO. UN METODO PREFERIDO PARA LA OBTENCION DE DERIVADOS DE FORMULA GENERAL I COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA GENERAL II CON UN COMPUESTO DE FORMULA GENERAL III, EFECTUANDOSE LA REACCION EN PRESENCIA DE UN SOLVENTE ADECUADO, POR EJEMPLO EL DIMETILSULFOXIDO, LA DIMETILFORMAMIDA, UN ALCOHOL, UN HIDROCARBURO, AROMATICO O NO, UN ETER, TAL COMO EL DIOXANO O EL ETER DIFENILICO, O UNA MEZCLA DE ESTOS SOLVENTES, VENTAJOSAMENTE EN PRESENCIA DE UNA BASE TAL COMO LOS HIDROXIDOS, LOS CRBONATOS O LOS BICARBONATOS DE METALES ALCALINOS, O BIEN DE UNA MEZCLA DE ESTAS BASES, VARIANDO LAS TEMPERATURAS MAS ADECUADAS ENTRE LA TEMPERATURA AMBIENTE Y LA TEMPERATURA DE REFLUJO DEL SOLVENTE, Y ESTANDO COMPRENDIDO EL TIEMJPO DE REACCION ENTRE 1 HORA Y 24 HORAS. SE UTILIZA PARA LA FABRICACION DE MEDICAMENTOS DESTINADOS ALTRATAMIENTO DE PROBLEMAS ASOCIADOS AL SINDROME DE ABSTINENCIA.
ES9002951A 1989-11-22 1990-11-21 Metodo para la obtencion de derivados de 1h-azol-(w-(4-(2-pirimidinil)-1-piperazinil)-alquilo. Expired - Fee Related ES2034909A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8915316A FR2654621B1 (fr) 1989-11-22 1989-11-22 Inhibition du syndrome d'abstinence.

Publications (1)

Publication Number Publication Date
ES2034909A6 true ES2034909A6 (es) 1993-04-01

Family

ID=9387643

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9002951A Expired - Fee Related ES2034909A6 (es) 1989-11-22 1990-11-21 Metodo para la obtencion de derivados de 1h-azol-(w-(4-(2-pirimidinil)-1-piperazinil)-alquilo.

Country Status (16)

Country Link
US (1) US5162323A (es)
EP (1) EP0429360B1 (es)
JP (1) JPH0699309B2 (es)
KR (1) KR950007230B1 (es)
AT (1) ATE95698T1 (es)
AU (1) AU628237B2 (es)
CA (1) CA2030401C (es)
DE (1) DE69003924T2 (es)
DK (1) DK0429360T3 (es)
ES (1) ES2034909A6 (es)
FR (1) FR2654621B1 (es)
HU (1) HU207797B (es)
NO (1) NO905028L (es)
PT (1) PT95949B (es)
RU (1) RU2042674C1 (es)
ZA (1) ZA909256B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002032880A1 (es) * 2000-10-20 2002-04-25 Laboratorios Del Dr. Esteve, S.A. Nuevos derivados de cianoaril (o cianoheteroaril)-carbonil-piperazinil-pirimidinas, su preparación y su aplicación como medicamentos

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681956A (en) * 1990-12-28 1997-10-28 Neurogen Corporation 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
US5633377A (en) * 1990-12-28 1997-05-27 Neurogen Corporation 4-piperidino- and piperazinomethyl-2-cyclohexyl imidazole derivatives; dopamine receptor subtype specific ligands
FR2671972B1 (fr) * 1991-01-25 1995-03-03 Esteve Labor Dr Utilisation de derives 1-h-azole-(omega-(4-(2-pyrimidinyl)-1-piperazinyl)-alkyl) pour la preparation de medicaments destines au traitement des troubles des fonctions cognitives.
FR2701260B1 (fr) * 1993-02-05 1995-05-05 Esteve Labor Dr Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments.
FR2705098B1 (fr) * 1993-05-10 1995-08-04 Esteve Labor Dr Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) .
ES2099031B1 (es) * 1995-05-31 1997-12-01 Esteve Labor Dr Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimientos de preparacion y composiciones que los contienen.
US6166205A (en) * 1998-09-02 2000-12-26 Neurogen Corporation 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands
FR2797399B1 (fr) * 1999-08-13 2002-10-18 Aventis Pharma Sa Utilisation de la cyamemazine dans le traitement du sevrage aux benzodiazepines
ES2319074B1 (es) * 2005-07-15 2009-12-03 Laboratorios Del Dr. Esteve, S.A. Combinacion de principios activos.
EP1749525A1 (en) * 2005-07-15 2007-02-07 Laboratorios Del Dr. Esteve, S.A. Combination of substituted pyrazolines and anti-addictive agent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4777173A (en) * 1987-03-25 1988-10-11 Bristol-Myers Company Method for treatment of alcohol abuse
FR2642759B1 (fr) * 1989-02-09 1991-05-17 Laboratorios Esteve Sa Derives de pyrimidyl-piperazinyl-alkyl azoles avec activite anxiolytique et/ou tranquillisante

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002032880A1 (es) * 2000-10-20 2002-04-25 Laboratorios Del Dr. Esteve, S.A. Nuevos derivados de cianoaril (o cianoheteroaril)-carbonil-piperazinil-pirimidinas, su preparación y su aplicación como medicamentos
ES2167276A1 (es) * 2000-10-20 2002-05-01 Esteve Labor Dr Nuevos derivados de cianoaril (o cianoheteroaril)-carbonil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos.
US7300937B2 (en) 2000-10-20 2007-11-27 Laboratorios Del Dr. Esteve, S.A. Derivatives of cyano-aryl (or cyanoheteroaryl)-carbonyl-piperazinyl-pyrimidines, their preparation and application as medication

Also Published As

Publication number Publication date
FR2654621B1 (fr) 1994-09-23
PT95949A (pt) 1991-09-13
US5162323A (en) 1992-11-10
EP0429360B1 (fr) 1993-10-13
FR2654621A1 (fr) 1991-05-24
ZA909256B (en) 1991-10-30
KR910009268A (ko) 1991-06-28
EP0429360A2 (fr) 1991-05-29
AU6676790A (en) 1991-05-30
AU628237B2 (en) 1992-09-10
ATE95698T1 (de) 1993-10-15
EP0429360A3 (en) 1991-09-25
RU2042674C1 (ru) 1995-08-27
JPH0699309B2 (ja) 1994-12-07
HU907230D0 (en) 1991-05-28
DE69003924D1 (de) 1993-11-18
JPH03176422A (ja) 1991-07-31
DE69003924T2 (de) 1994-02-24
DK0429360T3 (da) 1993-12-13
CA2030401C (fr) 2000-03-07
CA2030401A1 (fr) 1991-05-23
HU207797B (en) 1993-06-28
NO905028L (no) 1991-05-23
HUT56093A (en) 1991-07-29
PT95949B (pt) 1998-01-30
KR950007230B1 (ko) 1995-07-07
NO905028D0 (no) 1990-11-20

Similar Documents

Publication Publication Date Title
ES2021941A6 (es) Procedimiento para la preparacion de nuevos derivados de pirimidinil-piperacinil-alquil azoles.
ES8304095A1 (es) Un procedimiento para la preparacion de derivados de quinazolina.
ES472641A1 (es) Procedimiento para la obtencion de propenil-aminas
ES2038188T3 (es) Un procedimiento para preparar nuevas tienopiridinonas.
ES2059416T3 (es) 1,4-dihidropiridina-enantiomeros.
ES8606879A1 (es) Un procedimiento para la preparacion de derivados esteroida-les
ES8601992A1 (es) Procedimiento para preparar 2-fenil-imidazoles
ES8403453A1 (es) Un procedimiento para preparar amidas del acido 1-metil-5-p-toluoilpirrol-2-acetico.
ES8800678A1 (es) Un procedimiento para la preparacion de nuevos benzotiofenos
ES8301980A1 (es) Procedimiento para la preparacion de 8-arilalcohil-3-fenil-3-nortropanoles .
ES8103745A1 (es) Procedimiento para la preparacion de derivados de pirido (2,1-b) quinazolinona
ES8707731A1 (es) Un procedimiento para la preparacion de derivados de oxindol
PT96381A (pt) Processo para a preparacao de derivados de 2-aminopirimidina-4-carboxamida e de composicoes farmaceuticas que os contem
ES8201583A1 (es) Un procedimiento para la preparacion de derivados de triazo-lopiridazina
ES8704468A1 (es) Procedimiento para preparar nuevos 1,2,4-triazolo-carbamatos
ES2022006A6 (es) Procedimiento para la preparacion de compuestos de acidos piridona carboxilicos azetidinil substituidos.
MX9102686A (es) Carboxamidas de dihidrobenzofurano y proceso para su preparacion.
ES8609246A1 (es) Un procedimiento para preparar un derivado de 3-carbonil-1- aminoalquil-1h-indol
ES8609323A1 (es) Un procedimiento para la preparacion de hexahidro-arilquinolizinas sustituidas.
ES8504192A1 (es) Procedimiento para la preparacion de cis yno trans hidroxiiminooctahidroindolo(2,3-a)-quinolizina racemicos (como divisional de la solicitud de patente de invencion num. 513.016, presentada el 11 de junio de 1982)
ES2010736A6 (es) Procedimiento para preparar nuevos derivados del acido furanuronico.
ES8801834A1 (es) Procedimiento para preparar 1,2-dihidronaftalenos y derivados 1-oxa, 1-tia 1-sulfinilo y 1-sulfonilo de los mismos
ES8800193A1 (es) Procedimiento para preparar 2,4-difenil-1,3-dioxanos
ES8305750A1 (es) "procedimiento de preparacion de nuevas 2-(4-(difenilmetilen)-1-piperidinil)-acetamidas".
ES438138A1 (es) Un procedimiento para preparar acidos tioxantion-2-carboxi- licos.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20021122