ES2010736A6 - Procedimiento para preparar nuevos derivados del acido furanuronico. - Google Patents
Procedimiento para preparar nuevos derivados del acido furanuronico.Info
- Publication number
- ES2010736A6 ES2010736A6 ES8703585A ES8703585A ES2010736A6 ES 2010736 A6 ES2010736 A6 ES 2010736A6 ES 8703585 A ES8703585 A ES 8703585A ES 8703585 A ES8703585 A ES 8703585A ES 2010736 A6 ES2010736 A6 ES 2010736A6
- Authority
- ES
- Spain
- Prior art keywords
- acid
- procedure
- new derivatives
- prepare new
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 5
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 ISOPROPYLIDENE GROUP Chemical group 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 230000001603 reducing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR NUEVOS DERIVADOS DEL ACIDO FURANURONICO, DE FORMULA (I). COMPRENDE ESCINDIR EL GRUPO ISOPROPILIDENO PROTECTOR DE UN COMPUESTO DE FORMULA (II) POR REACCION DE ESTE CON ACIDO TRIFLUOROACETICO, A TEMPERATURAS COMPRENDIDAS ENTRE 0GC Y LA TEMPERATURA AMBIENTE, O CON ACIDO CLORHIDRICO, O ACIDO FORMICO ACUOSO, A TEMPERATURAS DE 40 A 60GC. LOS COMPUESTOS (I) TIENEN ACTIVIDAD REDUCTORA DE LA PRESION SANGUINEA Y SE PUEDEN USAR, POR TANTO, COMO MEDICAMENTOS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3642748 | 1986-12-15 | ||
| DE3729768 | 1987-09-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2010736A6 true ES2010736A6 (es) | 1989-12-01 |
Family
ID=25850352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8703585A Expired ES2010736A6 (es) | 1986-12-15 | 1987-12-15 | Procedimiento para preparar nuevos derivados del acido furanuronico. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4855288A (es) |
| KR (1) | KR880007533A (es) |
| AT (1) | AT393506B (es) |
| AU (1) | AU601247B2 (es) |
| BE (1) | BE1001621A3 (es) |
| CA (1) | CA1291752C (es) |
| CH (1) | CH676851A5 (es) |
| DK (1) | DK655487A (es) |
| ES (1) | ES2010736A6 (es) |
| FI (1) | FI86431C (es) |
| FR (1) | FR2608159B1 (es) |
| GB (1) | GB2199036B (es) |
| GR (1) | GR871895B (es) |
| HU (1) | HU198950B (es) |
| IL (1) | IL84808A (es) |
| IT (1) | IT1230116B (es) |
| LU (1) | LU87071A1 (es) |
| MY (1) | MY102270A (es) |
| NL (1) | NL8702926A (es) |
| NZ (1) | NZ222897A (es) |
| PH (1) | PH25421A (es) |
| SE (1) | SE8704979L (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU87181A1 (fr) * | 1987-04-06 | 1988-11-17 | Sandoz Sa | Nouveaux derives de l'acide furannuronique,leur preparation et leur utilisation comme medicaments |
| US5219840A (en) * | 1987-04-06 | 1993-06-15 | Sandoz Ltd. | Antihypertensive 9-(2,N6 -disubstituted adenyl) ribofuranuronic acid derivatives |
| AU654507B2 (en) * | 1990-09-25 | 1994-11-10 | Rhone-Poulenc Rorer International (Holdings) Inc. | Compounds having antihypertensive and anti-ischemic properties |
| US5561134A (en) * | 1990-09-25 | 1996-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
| GB9111580D0 (en) * | 1991-05-30 | 1991-07-24 | Wellcome Found | Nucleoside derivative |
| FR2687678B1 (fr) * | 1992-01-31 | 1995-03-31 | Union Pharma Scient Appl | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant. |
| TW528755B (en) | 1996-12-24 | 2003-04-21 | Glaxo Group Ltd | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives |
| YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
| JP3933870B2 (ja) | 1998-06-23 | 2007-06-20 | グラクソ グループ リミテッド | ２−（プリン−９−イル）−テトラヒドロフラン−３，４−ジオール誘導体 |
| PE20060272A1 (es) | 2004-05-24 | 2006-05-22 | Glaxo Group Ltd | (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a |
| GB0514809D0 (en) * | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6717061A (es) * | 1966-12-21 | 1968-06-24 | ||
| US4029884A (en) * | 1971-03-18 | 1977-06-14 | Abbott Laboratories | Adenosine-5'-carboxylic acid amides |
| CA1082695A (en) * | 1972-04-10 | 1980-07-29 | Francis E. Fischer | Process for preparing adenosine-5'-carboxamides |
| US3966917A (en) * | 1974-07-30 | 1976-06-29 | Abbott Laboratories | Platelet aggregation inhibitors |
| DE2610985A1 (de) * | 1976-03-16 | 1977-09-29 | Byk Gulden Lomberg Chem Fab | Arzneimittel enthaltend beta-d-1 (6-amino-9h-purin-9-yl)-1-deoxyribofuranuronsaeurederivate |
| LU75374A1 (es) * | 1976-07-13 | 1978-02-08 | ||
| US4167565A (en) * | 1976-11-08 | 1979-09-11 | Abbott Laboratories | Adenosine-5'-carboxamides and method of use |
| US5310731A (en) * | 1984-06-28 | 1994-05-10 | Whitby Research, Inc. | N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents |
| LU87181A1 (fr) * | 1987-04-06 | 1988-11-17 | Sandoz Sa | Nouveaux derives de l'acide furannuronique,leur preparation et leur utilisation comme medicaments |
-
1987
- 1987-12-04 HU HU875452A patent/HU198950B/hu not_active IP Right Cessation
- 1987-12-04 NL NL8702926A patent/NL8702926A/nl not_active Application Discontinuation
- 1987-12-07 CH CH4763/87A patent/CH676851A5/de not_active IP Right Cessation
- 1987-12-11 BE BE8701420A patent/BE1001621A3/fr not_active IP Right Cessation
- 1987-12-12 MY MYPI87003187A patent/MY102270A/en unknown
- 1987-12-14 GB GB8729116A patent/GB2199036B/en not_active Expired - Lifetime
- 1987-12-14 LU LU87071A patent/LU87071A1/fr unknown
- 1987-12-14 FI FI875491A patent/FI86431C/fi not_active IP Right Cessation
- 1987-12-14 AU AU82523/87A patent/AU601247B2/en not_active Ceased
- 1987-12-14 GR GR871895A patent/GR871895B/el unknown
- 1987-12-14 KR KR870014412A patent/KR880007533A/ko not_active Ceased
- 1987-12-14 PH PH36210A patent/PH25421A/en unknown
- 1987-12-14 FR FR878717542A patent/FR2608159B1/fr not_active Expired - Lifetime
- 1987-12-14 CA CA000554261A patent/CA1291752C/en not_active Expired - Lifetime
- 1987-12-14 IL IL84808A patent/IL84808A/xx not_active IP Right Cessation
- 1987-12-14 DK DK655487A patent/DK655487A/da not_active Application Discontinuation
- 1987-12-14 AT AT3285/87A patent/AT393506B/de not_active IP Right Cessation
- 1987-12-14 US US07/132,492 patent/US4855288A/en not_active Expired - Fee Related
- 1987-12-14 SE SE8704979A patent/SE8704979L/xx not_active Application Discontinuation
- 1987-12-14 NZ NZ222897A patent/NZ222897A/xx unknown
- 1987-12-15 ES ES8703585A patent/ES2010736A6/es not_active Expired
- 1987-12-15 IT IT8748709A patent/IT1230116B/it active
Also Published As
| Publication number | Publication date |
|---|---|
| GB2199036B (en) | 1990-07-18 |
| NZ222897A (en) | 1990-02-26 |
| IL84808A0 (en) | 1988-06-30 |
| HU198950B (en) | 1989-12-28 |
| AT393506B (de) | 1991-11-11 |
| LU87071A1 (fr) | 1988-07-14 |
| FI875491L (fi) | 1988-06-16 |
| FR2608159A1 (fr) | 1988-06-17 |
| KR880007533A (ko) | 1988-08-27 |
| MY102270A (en) | 1992-05-15 |
| US4855288A (en) | 1989-08-08 |
| FI86431B (fi) | 1992-05-15 |
| FI86431C (fi) | 1992-08-25 |
| PH25421A (en) | 1991-07-01 |
| IT1230116B (it) | 1991-10-07 |
| ATA328587A (de) | 1991-04-15 |
| CH676851A5 (es) | 1991-03-15 |
| SE8704979L (sv) | 1988-06-16 |
| IT8748709A0 (it) | 1987-12-15 |
| SE8704979D0 (sv) | 1987-12-14 |
| AU8252387A (en) | 1988-06-16 |
| BE1001621A3 (fr) | 1989-12-19 |
| HUT47594A (en) | 1989-03-28 |
| FI875491A0 (fi) | 1987-12-14 |
| GB8729116D0 (en) | 1988-01-27 |
| IL84808A (en) | 1991-07-18 |
| CA1291752C (en) | 1991-11-05 |
| AU601247B2 (en) | 1990-09-06 |
| GB2199036A (en) | 1988-06-29 |
| FR2608159B1 (fr) | 1990-06-08 |
| DK655487A (da) | 1988-06-16 |
| GR871895B (en) | 1988-04-04 |
| NL8702926A (nl) | 1988-07-01 |
| DK655487D0 (da) | 1987-12-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8706673A1 (es) | Un procedimiento para la preparacion de derivados de 1,4-dihidro-4-oxonaftiridina y sus sales | |
| ES8702787A1 (es) | Procedimiento para preparar nuevos tetrahidro-benzotiazoles. | |
| ES8400444A1 (es) | Procedimiento para la preparacion de nuevos derivados de carbapenem. | |
| ES2040234T3 (es) | Derivados del tetrahidronaftaleno y medicamentos que los contienen. | |
| ES8406413A1 (es) | Un procedimiento para preparar derivados de fenilciclobutano.(como divisional de la patente numero 511.152) | |
| CU22305A3 (es) | Procedimiento para la preparacion de un derivado de aminoacidos | |
| ES8404184A1 (es) | Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados. | |
| ES8700250A1 (es) | Procedimiento para preparar derivados de acido 4-hidroxifenil-1,3-dioxan-cis-5-ilalquenoico | |
| ES8503669A1 (es) | Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos. | |
| ES8304096A1 (es) | "procedimiento para la preparacion de nuevas piriimidinonas". | |
| ES2010736A6 (es) | Procedimiento para preparar nuevos derivados del acido furanuronico. | |
| ES8602022A1 (es) | Un procedimiento para preparar un derivado de 4'-dimetil-4-epipodofilotoxina | |
| ES8707547A1 (es) | Procedimiento para preparar un oligopeptidil-argininol u-homoargininol o derivado de estos | |
| ES8705442A1 (es) | Un procedimiento para preparar compuestos de carbapenem | |
| ES2038630T3 (es) | Un procedimiento para preparar un compuesto de acido fenoxiacetico. | |
| ES8802015A1 (es) | Procedimiento para preparar alfa-aminoacidos sustituidos | |
| ES8801284A1 (es) | Procedimiento para preparar nuevos compuestos de benzotiofeno y benzofurano | |
| ES8703471A1 (es) | Procedimiento para preparar nuevos derivados imidazo | |
| ES8700246A1 (es) | Procedimiento para la fabricacion de nuevos derivados de la cumarina | |
| ES8605513A1 (es) | Un procedimiento para preparar derivados de piridina | |
| ES2032752T3 (es) | Procedimiento de preparacion de derivados de la 1-bencenosulfonil-2-oxo-5-alcoxi-pirrolidina. | |
| ES8607299A1 (es) | Procedimiento para preparar (2-oxo-1,2,3,5-tetrahidroimida- zo(2,1-b)quinazolinil)-oxialquilamidas | |
| ES8107192A1 (es) | Un procedimiento para la preparacion de un compuesto sele- ccionado entre el grupo formado por una imidazolilurea | |
| ES8303427A1 (es) | "un procedimiento para preparar compuestos de cefem". | |
| ES8704468A1 (es) | Procedimiento para preparar nuevos 1,2,4-triazolo-carbamatos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SA6 | Expiration date (snapshot 920101) |
Free format text: 2007-12-15 |
|
| FD1A | Patent lapsed |
Effective date: 20010402 |