ES2010736A6 - Procedimiento para preparar nuevos derivados del acido furanuronico. - Google Patents
Procedimiento para preparar nuevos derivados del acido furanuronico.Info
- Publication number
- ES2010736A6 ES2010736A6 ES8703585A ES8703585A ES2010736A6 ES 2010736 A6 ES2010736 A6 ES 2010736A6 ES 8703585 A ES8703585 A ES 8703585A ES 8703585 A ES8703585 A ES 8703585A ES 2010736 A6 ES2010736 A6 ES 2010736A6
- Authority
- ES
- Spain
- Prior art keywords
- acid
- procedure
- new derivatives
- prepare new
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 5
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 ISOPROPYLIDENE GROUP Chemical group 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 230000001603 reducing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR NUEVOS DERIVADOS DEL ACIDO FURANURONICO, DE FORMULA (I). COMPRENDE ESCINDIR EL GRUPO ISOPROPILIDENO PROTECTOR DE UN COMPUESTO DE FORMULA (II) POR REACCION DE ESTE CON ACIDO TRIFLUOROACETICO, A TEMPERATURAS COMPRENDIDAS ENTRE 0GC Y LA TEMPERATURA AMBIENTE, O CON ACIDO CLORHIDRICO, O ACIDO FORMICO ACUOSO, A TEMPERATURAS DE 40 A 60GC. LOS COMPUESTOS (I) TIENEN ACTIVIDAD REDUCTORA DE LA PRESION SANGUINEA Y SE PUEDEN USAR, POR TANTO, COMO MEDICAMENTOS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3642748 | 1986-12-15 | ||
| DE3729768 | 1987-09-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2010736A6 true ES2010736A6 (es) | 1989-12-01 |
Family
ID=25850352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8703585A Expired ES2010736A6 (es) | 1986-12-15 | 1987-12-15 | Procedimiento para preparar nuevos derivados del acido furanuronico. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4855288A (es) |
| KR (1) | KR880007533A (es) |
| AT (1) | AT393506B (es) |
| AU (1) | AU601247B2 (es) |
| BE (1) | BE1001621A3 (es) |
| CA (1) | CA1291752C (es) |
| CH (1) | CH676851A5 (es) |
| DK (1) | DK655487A (es) |
| ES (1) | ES2010736A6 (es) |
| FI (1) | FI86431C (es) |
| FR (1) | FR2608159B1 (es) |
| GB (1) | GB2199036B (es) |
| GR (1) | GR871895B (es) |
| HU (1) | HU198950B (es) |
| IL (1) | IL84808A (es) |
| IT (1) | IT1230116B (es) |
| LU (1) | LU87071A1 (es) |
| MY (1) | MY102270A (es) |
| NL (1) | NL8702926A (es) |
| NZ (1) | NZ222897A (es) |
| PH (1) | PH25421A (es) |
| SE (1) | SE8704979L (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5219840A (en) * | 1987-04-06 | 1993-06-15 | Sandoz Ltd. | Antihypertensive 9-(2,N6 -disubstituted adenyl) ribofuranuronic acid derivatives |
| LU87181A1 (fr) * | 1987-04-06 | 1988-11-17 | Sandoz Sa | Nouveaux derives de l'acide furannuronique,leur preparation et leur utilisation comme medicaments |
| SG80526A1 (en) * | 1990-09-25 | 2001-05-22 | Rhone Poulenc Rorer Int | Compounds having antihypertensive and anti- ischemic properies |
| US5561134A (en) * | 1990-09-25 | 1996-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
| GB9111580D0 (en) * | 1991-05-30 | 1991-07-24 | Wellcome Found | Nucleoside derivative |
| FR2687678B1 (fr) * | 1992-01-31 | 1995-03-31 | Union Pharma Scient Appl | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant. |
| TW528755B (en) | 1996-12-24 | 2003-04-21 | Glaxo Group Ltd | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives |
| YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
| AU750462B2 (en) | 1998-06-23 | 2002-07-18 | Glaxo Group Limited | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives |
| AR049384A1 (es) | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | Derivados de purina |
| GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6717061A (es) * | 1966-12-21 | 1968-06-24 | ||
| US4029884A (en) * | 1971-03-18 | 1977-06-14 | Abbott Laboratories | Adenosine-5'-carboxylic acid amides |
| CA1082695A (en) * | 1972-04-10 | 1980-07-29 | Francis E. Fischer | Process for preparing adenosine-5'-carboxamides |
| US3966917A (en) * | 1974-07-30 | 1976-06-29 | Abbott Laboratories | Platelet aggregation inhibitors |
| DE2610985A1 (de) * | 1976-03-16 | 1977-09-29 | Byk Gulden Lomberg Chem Fab | Arzneimittel enthaltend beta-d-1 (6-amino-9h-purin-9-yl)-1-deoxyribofuranuronsaeurederivate |
| LU75374A1 (es) * | 1976-07-13 | 1978-02-08 | ||
| US4167565A (en) * | 1976-11-08 | 1979-09-11 | Abbott Laboratories | Adenosine-5'-carboxamides and method of use |
| US5310731A (en) * | 1984-06-28 | 1994-05-10 | Whitby Research, Inc. | N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents |
| LU87181A1 (fr) * | 1987-04-06 | 1988-11-17 | Sandoz Sa | Nouveaux derives de l'acide furannuronique,leur preparation et leur utilisation comme medicaments |
-
1987
- 1987-12-04 NL NL8702926A patent/NL8702926A/nl not_active Application Discontinuation
- 1987-12-04 HU HU875452A patent/HU198950B/hu not_active IP Right Cessation
- 1987-12-07 CH CH4763/87A patent/CH676851A5/de not_active IP Right Cessation
- 1987-12-11 BE BE8701420A patent/BE1001621A3/fr not_active IP Right Cessation
- 1987-12-12 MY MYPI87003187A patent/MY102270A/en unknown
- 1987-12-14 AU AU82523/87A patent/AU601247B2/en not_active Ceased
- 1987-12-14 FR FR878717542A patent/FR2608159B1/fr not_active Expired - Lifetime
- 1987-12-14 KR KR870014412A patent/KR880007533A/ko not_active Ceased
- 1987-12-14 GB GB8729116A patent/GB2199036B/en not_active Expired - Lifetime
- 1987-12-14 FI FI875491A patent/FI86431C/fi not_active IP Right Cessation
- 1987-12-14 LU LU87071A patent/LU87071A1/fr unknown
- 1987-12-14 IL IL84808A patent/IL84808A/xx not_active IP Right Cessation
- 1987-12-14 SE SE8704979A patent/SE8704979L/xx not_active Application Discontinuation
- 1987-12-14 GR GR871895A patent/GR871895B/el unknown
- 1987-12-14 PH PH36210A patent/PH25421A/en unknown
- 1987-12-14 US US07/132,492 patent/US4855288A/en not_active Expired - Fee Related
- 1987-12-14 AT AT3285/87A patent/AT393506B/de not_active IP Right Cessation
- 1987-12-14 NZ NZ222897A patent/NZ222897A/xx unknown
- 1987-12-14 DK DK655487A patent/DK655487A/da not_active Application Discontinuation
- 1987-12-14 CA CA000554261A patent/CA1291752C/en not_active Expired - Lifetime
- 1987-12-15 IT IT8748709A patent/IT1230116B/it active
- 1987-12-15 ES ES8703585A patent/ES2010736A6/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK655487A (da) | 1988-06-16 |
| US4855288A (en) | 1989-08-08 |
| HUT47594A (en) | 1989-03-28 |
| PH25421A (en) | 1991-07-01 |
| SE8704979L (sv) | 1988-06-16 |
| NZ222897A (en) | 1990-02-26 |
| SE8704979D0 (sv) | 1987-12-14 |
| FR2608159B1 (fr) | 1990-06-08 |
| AU8252387A (en) | 1988-06-16 |
| IT8748709A0 (it) | 1987-12-15 |
| FI86431B (fi) | 1992-05-15 |
| IL84808A0 (en) | 1988-06-30 |
| FI875491L (fi) | 1988-06-16 |
| MY102270A (en) | 1992-05-15 |
| GB2199036B (en) | 1990-07-18 |
| CA1291752C (en) | 1991-11-05 |
| IT1230116B (it) | 1991-10-07 |
| HU198950B (en) | 1989-12-28 |
| ATA328587A (de) | 1991-04-15 |
| LU87071A1 (fr) | 1988-07-14 |
| GB2199036A (en) | 1988-06-29 |
| FR2608159A1 (fr) | 1988-06-17 |
| AT393506B (de) | 1991-11-11 |
| FI875491A0 (fi) | 1987-12-14 |
| AU601247B2 (en) | 1990-09-06 |
| KR880007533A (ko) | 1988-08-27 |
| BE1001621A3 (fr) | 1989-12-19 |
| GB8729116D0 (en) | 1988-01-27 |
| IL84808A (en) | 1991-07-18 |
| DK655487D0 (da) | 1987-12-14 |
| NL8702926A (nl) | 1988-07-01 |
| FI86431C (fi) | 1992-08-25 |
| CH676851A5 (es) | 1991-03-15 |
| GR871895B (en) | 1988-04-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SA6 | Expiration date (snapshot 920101) |
Free format text: 2007-12-15 |
|
| FD1A | Patent lapsed |
Effective date: 20010402 |