ES2037613A1 - Procedimiento de obtencion de nuevos derivados dipeptidicos. - Google Patents

Procedimiento de obtencion de nuevos derivados dipeptidicos.

Info

Publication number
ES2037613A1
ES2037613A1 ES919102792A ES9102792A ES2037613A1 ES 2037613 A1 ES2037613 A1 ES 2037613A1 ES 919102792 A ES919102792 A ES 919102792A ES 9102792 A ES9102792 A ES 9102792A ES 2037613 A1 ES2037613 A1 ES 2037613A1
Authority
ES
Spain
Prior art keywords
lower alkyl
derivatives
aryl
dipeptidic
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES919102792A
Other languages
English (en)
Other versions
ES2037613B1 (es
Inventor
Coy Francisco Pubill
Llorente Lydia Cabeza
Falco Carlos Malet
Moliner Jose Repolles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lacer SA
Original Assignee
Lacer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lacer SA filed Critical Lacer SA
Publication of ES2037613A1 publication Critical patent/ES2037613A1/es
Application granted granted Critical
Publication of ES2037613B1 publication Critical patent/ES2037613B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE NUEVOS DERIVADOS DIPEPTIDICOS DE LA FORMULA GENERAL (I) FORMULA DONDE: N ES 0 O 1-3; R ES OH, SH, NH2, HALOGENO, ORSI4, SRSI4, NHRSI4 O N(RSI4)SI2, (RSI4 ES UN ALQUILO INFERIOR, ARILO O ACILO); RSI1 ES OH, ALCOXI, ARILALCOXI, ARILOXI O AMINO DISUBSTITUIDO; RSI2 ES UN GRUPO ALQUILO O AMINO ALQUILO; RSI3 ES HALOGENO, NOSI2, ALQUILO, HALOALQUILO, ARILALQUILO O ARILO. ESTA BASADO EN LA REACCION DE UN COMPUESTO DE FORMULA II FORMULA CON UN DIPEPTIDO DE FORMULA III FORMULA DICHOS DERIVADOS SON UTILES, ENTRE OTRAS COSAS, PARA EL TRATAMIENTO DE LA HIPERTENSION.
ES9102792A 1991-02-27 1991-12-16 Procedimiento de obtencion de nuevos derivados dipeptidicos. Expired - Fee Related ES2037613B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91102950A EP0500989B1 (en) 1991-02-27 1991-02-27 N-(alpha-substituted-pyridinyl) carbonyl dipeptide antihypertensive agents

Publications (2)

Publication Number Publication Date
ES2037613A1 true ES2037613A1 (es) 1993-06-16
ES2037613B1 ES2037613B1 (es) 1994-03-16

Family

ID=8206465

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9102792A Expired - Fee Related ES2037613B1 (es) 1991-02-27 1991-12-16 Procedimiento de obtencion de nuevos derivados dipeptidicos.

Country Status (18)

Country Link
US (1) US5432159A (es)
EP (1) EP0500989B1 (es)
JP (1) JPH05507295A (es)
AT (1) ATE174343T1 (es)
AU (1) AU650954B2 (es)
BR (1) BR9204779A (es)
CA (1) CA2081471A1 (es)
CZ (1) CZ280952B6 (es)
DE (1) DE69130605T2 (es)
ES (1) ES2037613B1 (es)
FI (1) FI924850L (es)
HU (1) HUT62313A (es)
NO (1) NO924076L (es)
PL (1) PL167915B1 (es)
PT (1) PT100148B (es)
RO (1) RO111369B1 (es)
RU (1) RU2098424C1 (es)
WO (1) WO1992015608A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995014033A1 (en) * 1993-11-19 1995-05-26 Aktiebolaget Astra Novel dipeptide derivatives
NZ337698A (en) * 1997-04-04 2001-07-27 Pfizer Prod Inc Nicotinamide derivatives for selective inhibition of phosphodiesterase type 4 (PDE4) and the production of tumour necrosis factor (TNF) useful for the treatment of respiratory, rheumatoid and allergic diseases
EP1035131B1 (en) * 1998-09-22 2006-11-22 Kaneka Corporation Process for the preparation of n2 -(1(s)-carboxy-3-phenylpropyl)-l-lysyl-l-proline
ATE305467T1 (de) 2001-01-31 2005-10-15 Pfizer Prod Inc Als inhibitoren von pde4-isozymen geeignete etherderivate
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
IL156413A0 (en) 2001-01-31 2004-01-04 Pfizer Prod Inc Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
WO2002060898A1 (en) 2001-01-31 2002-08-08 Pfizer Products Inc. Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes
WO2003033471A1 (en) * 2001-10-17 2003-04-24 Tobishi Pharmaceutical Co.,Ltd Novel pyridone derivative and remedial agent for circulatory disease containing the same
CN1638790A (zh) * 2002-01-29 2005-07-13 Wyeth公司 用于调节连接蛋白半通道的组合物和方法
SI21507A (sl) * 2003-05-16 2004-12-31 LEK farmacevtska dru�ba d.d. Postopek za pripravo spojin z ace inhibitornim delovanjem
CN101155798A (zh) * 2005-04-14 2008-04-02 默克公司 Vla-4拮抗剂

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0080283A1 (en) * 1981-11-06 1983-06-01 Smithkline Beckman Corporation N-carboxyalkylproline-containing tripeptides
DE3332633A1 (de) * 1983-09-09 1985-04-04 Luitpold-Werk Chemisch-pharmazeutische Fabrik GmbH & Co, 8000 München Substituierte carbonsaeurederivate, verfahren zu ihrer herstellung, und arzneimittel

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU537592B2 (en) * 1979-04-02 1984-07-05 E.R. Squibb & Sons, Inc. Mercaptoacyldipeptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0080283A1 (en) * 1981-11-06 1983-06-01 Smithkline Beckman Corporation N-carboxyalkylproline-containing tripeptides
DE3332633A1 (de) * 1983-09-09 1985-04-04 Luitpold-Werk Chemisch-pharmazeutische Fabrik GmbH & Co, 8000 München Substituierte carbonsaeurederivate, verfahren zu ihrer herstellung, und arzneimittel

Also Published As

Publication number Publication date
RO111369B1 (ro) 1996-09-30
NO924076D0 (no) 1992-10-21
FI924850A0 (fi) 1992-10-26
HUT62313A (en) 1993-04-28
CA2081471A1 (en) 1992-08-28
PL167915B1 (pl) 1995-12-30
ATE174343T1 (de) 1998-12-15
HU9203324D0 (en) 1993-01-28
NO924076L (no) 1992-12-21
EP0500989B1 (en) 1998-12-09
PT100148A (pt) 1993-05-31
CZ280952B6 (cs) 1996-05-15
ES2037613B1 (es) 1994-03-16
US5432159A (en) 1995-07-11
PL296625A1 (en) 1993-08-09
PT100148B (pt) 1999-06-30
AU650954B2 (en) 1994-07-07
CZ322092A3 (en) 1993-02-17
FI924850A7 (fi) 1992-10-26
DE69130605D1 (de) 1999-01-21
RU2098424C1 (ru) 1997-12-10
DE69130605T2 (de) 1999-05-20
FI924850L (fi) 1992-10-26
BR9204779A (pt) 1993-08-17
WO1992015608A1 (en) 1992-09-17
EP0500989A1 (en) 1992-09-02
AU1278392A (en) 1992-10-06
JPH05507295A (ja) 1993-10-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20071217