ES2038676T3 - Nuevos mejoradores de absorcion percutanea, composiciones que los contienen y metodo de uso. - Google Patents

Nuevos mejoradores de absorcion percutanea, composiciones que los contienen y metodo de uso.

Info

Publication number
ES2038676T3
ES2038676T3 ES198787310141T ES87310141T ES2038676T3 ES 2038676 T3 ES2038676 T3 ES 2038676T3 ES 198787310141 T ES198787310141 T ES 198787310141T ES 87310141 T ES87310141 T ES 87310141T ES 2038676 T3 ES2038676 T3 ES 2038676T3
Authority
ES
Spain
Prior art keywords
dioxacycloalkanes
compositions
new
improvers
contain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787310141T
Other languages
English (en)
Inventor
Carlos M. Samour
Stefanos Daskalakis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Macrochem Corp
Original Assignee
Macrochem Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macrochem Corp filed Critical Macrochem Corp
Application granted granted Critical
Publication of ES2038676T3 publication Critical patent/ES2038676T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20—Free hydroxyl or mercaptan

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE PROPORCIONAN NUEVOS 1,3-DIOXACICLOALCANOS JUNTO CON NUEVAS COMPOSICIONES DE 1,3-DIOXACICLOALCANO, QUE SON UTILES PARA MEJORAR LA ABSORCION DE AGENTES TERAPEUTICOS A TRAVES DE LA PIEL DE HUMANOS Y ANIMALES. TAMBIEN SE DESCRIBE EL METODO PARA MEJORAR LA PENETRACION EN LA PIEL DE AGENTES TERAPEUTICOS UTILIZANDO 1,3-DIOXAXICLOALCANOS. LOS COMPUESTOS PREFERIDOS SON 1,3-DIOXACICLOALCANOS Y 1,3-DIOXANOS (1,3-DIOXACICLOHEXANOS). LOS COMPUESTOS PREFERIDOS TIENEN LA FORMULA:(I) EN LA QUE R, RO, R1, R2, R3, R4, R5 Y R6 SE ELIGEN CADA UNO INDEPENDIENTEMENTE DE HIDROGENO Y GRUPOS ALIFATICOS C1-C18, PREFERIBLEMENTE ALQUIL, ALQUENIL, HALO, HIDROXI, CARBOXI, CARBOXAMIDA Y SUS FORMAS DE CARBOALCOXI SUSTITUIDAS, CON POR LO MENOS UNO DE DICHOS R'', UN GRUPO ALQUILO O ALQUENILO C4-C8; Y N ES 0 O 1; SIENDO EL NUMERO TOTAL DE ATOMOS DE CARBONO EN TODOS LOS GRUPOS R NO MAS QUE 40, Y PREFERIBLEMENTE MENOS QUE 20, Y NO MAS QUE UNO DE ELLOS CONTIENE 18 O MAS ATOMOS DE CARBONO.
ES198787310141T 1986-11-17 1987-11-17 Nuevos mejoradores de absorcion percutanea, composiciones que los contienen y metodo de uso. Expired - Lifetime ES2038676T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/931,653 US4861764A (en) 1986-11-17 1986-11-17 Percutaneous absorption enhancers, compositions containing same and method of use

Publications (1)

Publication Number Publication Date
ES2038676T3 true ES2038676T3 (es) 1993-08-01

Family

ID=25461144

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787310141T Expired - Lifetime ES2038676T3 (es) 1986-11-17 1987-11-17 Nuevos mejoradores de absorcion percutanea, composiciones que los contienen y metodo de uso.

Country Status (7)

Country Link
US (1) US4861764A (es)
EP (1) EP0268460B1 (es)
AT (1) ATE69168T1 (es)
CA (1) CA1313619C (es)
DE (1) DE3774398D1 (es)
ES (1) ES2038676T3 (es)
GR (1) GR3003238T3 (es)

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WO1992016236A1 (en) * 1991-03-19 1992-10-01 Rajadhyaksha Vithal J Compositions and method comprising aminoalcohol derivatives as membrane penetration enhancers
ES2120477T3 (es) * 1992-01-21 1998-11-01 Macrochem Corp Administracion iontoforetica de medicamentos perfeccionada.
EP0656356A1 (en) * 1992-08-21 1995-06-07 Japan Tobacco Inc. Dioxacycloalkane compound with renin-inhibiting activity
US5334615A (en) * 1992-12-17 1994-08-02 Walles Wilhelm E Oil with bactericidal and virucidal properties
US5637616A (en) * 1993-06-18 1997-06-10 Arcturus Pharmaceutical Corporation Method for treating diseases mediated by proteases
US5620980A (en) 1995-02-22 1997-04-15 Macrochem Corporation Method for treating hair loss
AUPN814496A0 (en) 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
US6124479A (en) * 1996-09-10 2000-09-26 Daiso Co., Ltd. Process for the preparation of 1,3-dioxolane-4-methanols
AU4136597A (en) * 1996-09-10 1998-04-02 Daiso Co. Ltd. Process for preparing 1,3-dioxolane-4-methanol compounds
DE19711758C2 (de) * 1997-03-21 2003-06-18 Degussa Verfahren zur Herstellung von 1,3-Dioxanverbindungen
US5976566A (en) * 1997-08-29 1999-11-02 Macrochem Corporation Non-steroidal antiinflammtory drug formulations for topical application to the skin
US5968919A (en) * 1997-10-16 1999-10-19 Macrochem Corporation Hormone replacement therapy drug formulations for topical application to the skin
US6153769A (en) * 1997-11-27 2000-11-28 Roche Vitamins Inc. Manufacture of polyene aldehydes
BR9904780A (pt) * 1998-02-09 2000-03-08 Macrochem Corp Esmalte fungicida para unhas e método de uso do mesmo
US5942545A (en) * 1998-06-15 1999-08-24 Macrochem Corporation Composition and method for treating penile erectile dysfunction
ATE343379T1 (de) * 1998-08-20 2006-11-15 3M Innovative Properties Co Sprühverband und wirkstoffabgabesystem
US7537773B1 (en) * 1998-08-25 2009-05-26 Botulinum Toxin Research Associates, Inc. Chemodenervating pharmaceutical as anti-inflammatory agent
US6825234B2 (en) 1998-12-10 2004-11-30 Nexmed (Holdings) , Inc. Compositions and methods for amelioration of human female sexual dysfunction
US6486207B2 (en) 1998-12-10 2002-11-26 Nexmed (Holdings), Inc. Compositions and methods for amelioration of human female sexual dysfunction
US20070191320A1 (en) * 1998-12-10 2007-08-16 Nexmed Holdings, Inc. Methods of treatment for female sexual arousal disorder
US6596266B2 (en) 2000-02-18 2003-07-22 Natural Science, Inc. Compositions containing minoxidil and saw palmetto for treating baldness
US20050008602A1 (en) * 2000-06-05 2005-01-13 Sumitomo Electric Industries, Ltd. Oligopeptides for promoting hair growth
US7241731B2 (en) 2000-06-05 2007-07-10 Sumitomo Electric Industries, Ltd. Oligopeptides for promoting hair growth
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
US20030139384A1 (en) * 2000-08-30 2003-07-24 Dudley Robert E. Method for treating erectile dysfunction and increasing libido in men
JP2005514346A (ja) * 2001-11-09 2005-05-19 キュー エル ティー インク． 光感作剤及び皮膚浸透エンハンサーを含有する組成物並びに光力学療法におけるそれらの使用
TWI339122B (en) * 2002-03-15 2011-03-21 Lab Besins Iscovesco Androgen pharmaceutical composition,kit containing the same and method for using the same
HRP20050918A2 (en) 2003-03-21 2006-12-31 Nexmed Holdings Antifungal nail coat and method of use
MXPA05010069A (es) * 2003-03-21 2005-11-23 Nexmed Holdings Inc Composiciones de prostaglandina para el tratamiento de la disfuncion erectil.
DE10314976A1 (de) * 2003-04-02 2004-10-14 Bayer Healthcare Ag Verbesserte Penetration von Wirkstoffen in Zellen und Organe
KR20050041815A (ko) * 2003-10-31 2005-05-04 싸이토팜(주) 자외선에 의한 피부손상을 경감시키는 항산화 조성물
CA2457214A1 (en) 2004-02-06 2005-08-06 Qlt Inc. Photodynamic therapy for the treatment of acne
FR2869232B1 (fr) * 2004-04-21 2007-09-21 Gattefosse Sas Soc Par Actions Nouveaux excipients pharmaceutiques ou cosmetiques a base d'acetals cyliques
KR20070121746A (ko) * 2005-03-14 2007-12-27 매크로켐 코포레이션 사람 피부를 통한 마크롤라이드 침투의 개선
AU2006247934A1 (en) * 2005-05-11 2006-11-23 Macrochem Corporation Low dose administration of a topical composition
GT200600396A (es) * 2005-09-07 2007-04-23 Dispositivos para la aplicacion de medicamentos transdermicos conteniendo o-desmetil venlafaxina (odv) o sus sales
GT200600397A (es) * 2005-09-07 2007-08-28 Formulas topicas conteniendo o-desmetil venlafaxina (odv) o sus sales
CN101316602B (zh) 2005-09-27 2015-06-03 组织技术公司 羊膜制品和纯化的组合物及其使用方法
US8187639B2 (en) 2005-09-27 2012-05-29 Tissue Tech, Inc. Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
SI1937276T1 (sl) 2005-10-12 2013-04-30 Unimed Pharmaceuticals, Llc C/O Abbott Laboratoires 100 Abbott Park Road Izboljšani testosteronski gel in postopek uporabe
DE112006002834T5 (de) 2005-11-04 2008-10-30 Acrux DDS Pty. Ltd., West Melbourne Verfahren und System für eine transdermale Arzneimittelzufuhr
CA2740200C (en) 2007-10-10 2015-01-13 Therametics, Llc Methods and compositions for treating dermatological diseases and conditions
EP2579847A1 (en) * 2010-06-11 2013-04-17 Pola Pharma Inc. Antimycotic pharmaceutical composition
EP2717888B1 (en) 2011-06-10 2020-09-09 Tissuetech, Inc. Methods of processing fetal support tissues
CN103874762A (zh) 2011-08-26 2014-06-18 组织技术公司 胎儿支持组织的灭菌方法
MX370929B (es) 2012-10-28 2020-01-08 Revance Therapeutics Inc Composiciones y usos de las mismas para el tratamiento seguro de la rinitis.
JP2018500388A (ja) 2014-11-18 2018-01-11 ラットガーズ、ザ ステート ユニバーシティ オブ ニュージャージー 代謝疾患及び癌の治療のための、新規ミトコンドリアアンカップラー
US12551509B2 (en) 2015-11-18 2026-02-17 Lucina Patent Holdco, Llc Acellular regenerative products and methods of their manufacture
CN109415363B (zh) 2016-05-18 2021-07-20 罗格斯，新泽西州立大学 用于治疗代谢疾病和癌症的新的线粒体解偶联剂
EP4740733A1 (en) 2024-11-12 2026-05-13 Uniwersystet Slaski w Katowicach Compositions of adjuvants and cosolvents for improving penetration of herbicides and/or fertilisers through surfaces of aboveground parts of plant organs.

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US4012520A (en) * 1973-08-08 1977-03-15 The Upjohn Company Composition and method of producing infertility in male rodents
GB1448458A (en) * 1973-11-21 1976-09-08 Allen & Hanburys Ltd 1,3-dioxan derivatives and pharmaceutical compositions thereof
IT1037122B (it) * 1975-04-01 1979-11-10 Maggioni E C S P A Derivati alogenati dell 1 3 dios solano ad attivita mucolitica
ATE3292T1 (de) * 1978-11-30 1983-05-15 Imperial Chemical Industries Plc Zusammensetzungen, die 1,3 dioxolane als aufweichmittel enthalten.
CA1225594A (en) * 1983-05-20 1987-08-18 Jourge Heller Method for percutaneously administering physiologically active agents
US4557934A (en) * 1983-06-21 1985-12-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one

Also Published As

Publication number Publication date
US4861764A (en) 1989-08-29
GR3003238T3 (en) 1993-02-17
ATE69168T1 (de) 1991-11-15
DE3774398D1 (de) 1991-12-12
EP0268460B1 (en) 1991-11-06
CA1313619C (en) 1993-02-16
EP0268460A1 (en) 1988-05-25

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