ES2040478T3 - Aparato y procedimiento de deteccion y de recuento de particulas fluorescentes, soportadas por un soporte solido. - Google Patents

Aparato y procedimiento de deteccion y de recuento de particulas fluorescentes, soportadas por un soporte solido.

Info

Publication number
ES2040478T3
ES2040478T3 ES198989400656T ES89400656T ES2040478T3 ES 2040478 T3 ES2040478 T3 ES 2040478T3 ES 198989400656 T ES198989400656 T ES 198989400656T ES 89400656 T ES89400656 T ES 89400656T ES 2040478 T3 ES2040478 T3 ES 2040478T3
Authority
ES
Spain
Prior art keywords
fluorescent
detection
counting
particles
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198989400656T
Other languages
English (en)
Inventor
Michel Van Hoegaerden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemunex SA
Original Assignee
Chemunex SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9364021&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2040478(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chemunex SA filed Critical Chemunex SA
Application granted granted Critical
Publication of ES2040478T3 publication Critical patent/ES2040478T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N2021/0162—Arrangements or apparatus for facilitating the optical investigation using microprocessors for control of a sequence of operations, e.g. test, powering, switching, processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/10—Scanning
    • G01N2201/105—Purely optical scan
    • G01N2201/1053—System of scan mirrors for composite motion of beam
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/10—Scanning
    • G01N2201/108—Miscellaneous
    • G01N2201/1087—Focussed scan beam, e.g. laser

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Signal Processing (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Luminescent Compositions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN APARATO DE DETECCION Y DE RECUENTO DE PARTICULAS FLUORESCENTES O HECHAS FLUORESCENTES, PORTADAS POR UN SOPORTE SOLIDO, Y A UN PROCEDIMIENTO DE DETECCION DE DICHAS PARTICULAS, CON AYUDA DE DICHO APARATO. EL APARATO DE DETECCION Y RECUENTO DE PARTICULAS, PRESENTES NORMALMENTE, O EVENTUALMENTE CONTENIDAS COMO CONTAMINANTES, EN UN FLUIDO LIQUIDO O GASEOSO, O EN UN PRODUCTO EN PARTICULAR ALIMENTICEO O DE HIGIENE, POR FLUORIMETRIA, COMPRENDE UNA FUENTE LUMINOSA (10), MEDIOS DE FOCALIZACION (12) DEL HAZ SALIDO DE DICHA FUENTE LUMINOSA Y POR LO MENOS UN MEDIO DE DETECCION (40) DE LUZ FLUORESCENTE EMITIDA POR LAS PARTICULAS (60) PRESENTES, Y COMPRENDE ADEMAS: UN SOPORTE (50) APROPIADO PARA RECOGER LAS PARTICULAS NATURALMENTE FLUORESCENTES O HECHAS FLUORESCENTES CON AYUDA DE POR LO MENOS UN COLORANTE ADECUADO ELEGIDO DEL GRUPO QUE COMPRENDE LOS COLORANTES VITALES, LOS COLORANTES DE VIABILIDAD POSITIVA Y SUSTANCIAS FLUORESCENTES LLEVADAS POR ANTICUERPOS Y/O SONDASNUCLEICAS; MEDIOS DE EXPLORACION (21, 31, 35) DE LA TOTALIDAD DE LA SUPERFICIE DEL SOPORTE A ANALIZAR POR DICHO HAZ LUMINOSO; Y UN MICROPROCESADOR (45) DE TRATAMIENTO, PROVISTO DE POR LO MENOS UN MEDIO DE REGISTRO Y DE CONTEO SIMULTANEO DE LAS SEÑALES ELECTRICAS TRANSMITIDAS POR EL O LOS DISPOSITIVOS DE DETECCION (40) Y EL SISTEMA DE EXPLORACION (21, 31, 35).
ES198989400656T 1988-03-08 1989-03-08 Aparato y procedimiento de deteccion y de recuento de particulas fluorescentes, soportadas por un soporte solido. Expired - Lifetime ES2040478T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8802936A FR2628530B1 (fr) 1988-03-08 1988-03-08 Appareil et procede de detection et de numeration de particules fluorescentes, portees par un support solide

Publications (1)

Publication Number Publication Date
ES2040478T3 true ES2040478T3 (es) 1993-10-16

Family

ID=9364021

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198989400656T Expired - Lifetime ES2040478T3 (es) 1988-03-08 1989-03-08 Aparato y procedimiento de deteccion y de recuento de particulas fluorescentes, soportadas por un soporte solido.

Country Status (7)

Country Link
EP (1) EP0333561B1 (es)
JP (1) JP2648376B2 (es)
AT (1) ATE89416T1 (es)
DE (1) DE68906443T2 (es)
ES (1) ES2040478T3 (es)
FR (1) FR2628530B1 (es)
WO (1) WO1989008834A1 (es)

Families Citing this family (23)

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Publication number Priority date Publication date Assignee Title
US4979824A (en) * 1989-05-26 1990-12-25 Board Of Trustees Of The Leland Stanford Junior University High sensitivity fluorescent single particle and single molecule detection apparatus and method
US6955915B2 (en) 1989-06-07 2005-10-18 Affymetrix, Inc. Apparatus comprising polymers
US6919211B1 (en) 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6406844B1 (en) 1989-06-07 2002-06-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
EP0405480A3 (en) * 1989-06-28 1991-05-08 Kirin Beer Kabushiki Kaisha Method of and apparatus for detecting microorganisms
DE69223980T2 (de) * 1991-10-15 1998-05-28 Multilyte Ltd Bindungstest unter benutzung eines markierten reagens
JP3067347B2 (ja) * 1991-10-30 2000-07-17 株式会社島津製作所 ゲル状ビーズの選別装置
DE4326181A1 (de) * 1993-08-04 1995-02-09 Europ Lab Molekularbiolog Verfahren und Vorrichtung zur Lumineszenzspektroskopie und Materialmikrobearbeitung von fixierten und bewegten Molekülen, Partikeln und Objekten
EP0750045A1 (en) 1995-06-22 1996-12-27 Chemunex Method for rapid diagnostic of urinary tract infections
DE19629141A1 (de) * 1996-07-19 1998-04-16 Bayer Ag Verfahren und Vorrichtung zum Screening von Molekülen bezüglich ihres individuellen Bindungsverhaltens zu mindestens einem vorgegebenen Ligand
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
DE19814715A1 (de) * 1998-04-02 1999-10-07 Sartorius Gmbh Gelatinemembranfilter, Verfahren zu ihrer Herstellung und ihre Verwendung
FR2801660B1 (fr) 1999-11-29 2002-01-18 Chemunex Dispositif de manipulation d'un porte-support solide pour contaminants
USD463027S1 (en) 2000-07-24 2002-09-17 Chemunex Filtering system for fluid
NL1021800C2 (nl) * 2002-10-31 2004-05-06 Plant Res Int Bv Werkwijze en inrichting voor het maken van beelden van de kwantumefficientie van het fotosynthesesysteem met tot doel het bepalen van de kwaliteit van plantaardig materiaal en werkwijze en inrichting voor het meten, classificeren en sorteren van plantaardig materiaal.
JP2007286041A (ja) * 2006-03-24 2007-11-01 Nippon Suisan Kaisha Ltd 異物の検出方法
DE102008029700A1 (de) * 2008-06-24 2010-01-14 Palas Gmbh Partikel- Und Lasermesstechnik Verfahren zum Bestimmen des Eindringens von Prüfpartikeln in einen Messbereich
DE102009023279A1 (de) * 2009-05-29 2010-12-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur Bestimmung von einer Keimverteilung abhängigen Information auf einem Trägersubstrat und Verfahren zum Bestimmen derselben
DE102012005381A1 (de) * 2012-03-16 2013-09-19 Daimler Ag Vorrichtung und Verfahren zur Ermittlung eines Verschmutzungsgrades eines Luftfilters eines Fahrzeugs
KR102237035B1 (ko) * 2019-10-14 2021-04-06 성균관대학교산학협력단 여과액을 이용한 곰팡이 검출용 전기화학센서
CN115615933A (zh) * 2021-07-13 2023-01-17 国家能源投资集团有限责任公司 一种污物吸附量的检测方法、检测系统和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3551295A (en) * 1967-11-29 1970-12-29 Northrop Corp Microbiological detection and identification system
JPS5113298A (en) * 1974-07-23 1976-02-02 Joko Sangyo Kk Reezaaokogentosuru takentainodosokuteihohoto sochi
JPS53135660A (en) * 1977-04-30 1978-11-27 Olympus Optical Co Ltd Fluorescent photometric microscope using laser light
GB1587172A (en) * 1977-05-19 1981-04-01 Northern Eng Ind Detecting and analysis of particulate material in fluid streams
US4162405A (en) * 1978-05-23 1979-07-24 Britton Chance Flying spot fluoro-meter for oxidized flavoprotein and reduced pyridine nucleotide
JPS5749888A (en) * 1980-09-10 1982-03-24 Hitachi Ltd Pool gate washer making method
JPS6080745A (ja) * 1983-10-11 1985-05-08 Hitachi Ltd 異物自動検出装置
JPS6120839A (ja) * 1984-07-10 1986-01-29 Fuji Photo Film Co Ltd バクテリアカウンタ
JPS6281567A (ja) * 1985-10-07 1987-04-15 Showa Denko Kk 粒子凝集反応を用いる定量方法
FR2668867B1 (fr) * 1990-11-02 1993-01-29 Burger Jacques Procede de codage binaire a taux de basculement des elements binaires sensiblement uniforme, et procedes d'incrementation et de decrementation correspondants.
JPH0680745A (ja) * 1992-08-07 1994-03-22 Unie Chem Kk ビニル系ないしアクリル系新規重合体及びその製造方法

Also Published As

Publication number Publication date
JPH02504076A (ja) 1990-11-22
ATE89416T1 (de) 1993-05-15
EP0333561B1 (fr) 1993-05-12
FR2628530B1 (fr) 1994-01-28
FR2628530A1 (fr) 1989-09-15
EP0333561A1 (fr) 1989-09-20
WO1989008834A1 (fr) 1989-09-21
JP2648376B2 (ja) 1997-08-27
DE68906443T2 (de) 1993-09-02
DE68906443D1 (de) 1993-06-17

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