ES2044052T3 - Un metodo para la determinacion simultanea de variaciones de secuencias de dna en un gran numero de sitios, y un estuche de materiales para dicho metodo. - Google Patents

Un metodo para la determinacion simultanea de variaciones de secuencias de dna en un gran numero de sitios, y un estuche de materiales para dicho metodo.

Info

Publication number
ES2044052T3
ES2044052T3 ES89201095T ES89201095T ES2044052T3 ES 2044052 T3 ES2044052 T3 ES 2044052T3 ES 89201095 T ES89201095 T ES 89201095T ES 89201095 T ES89201095 T ES 89201095T ES 2044052 T3 ES2044052 T3 ES 2044052T3
Authority
ES
Spain
Prior art keywords
sites
large number
variations
materials
case
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89201095T
Other languages
English (en)
Inventor
Jan Vijg
Andreas Gerardus Uitterlinden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Original Assignee
Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO filed Critical Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Application granted granted Critical
Publication of ES2044052T3 publication Critical patent/ES2044052T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

LA INVENCION RELATA UN METODO DE DETERMINACION SIMULTANEA DE VARIACIONES DE SECUENCIA DE ADN EN UN LARGO NUMERO DE EMPLAZAMIENTOS Y UN KIT RECOMENDABLE PARA EL MISMO. EL METODO COMPRENDE UNA SEPARACION ELECTROFORETICA DE FRAGMENTOS DE RESTRUICCION EN DOS DIMENSIONES DE LAS BASES DE DOS CRITERIONES INDEPENDIENTES NOMINALMENTE, DE SECUENCIA DE LONGITUD Y BASE, Y DETECCION DE FRAGMENTOS SEPARADOS POR MEDIO DE UNA SONDA MARCADA QUE COMPRENDE UNA O MAS MUESTRAS DE SONDEO DE LAS SECUENCIAS REPETIDAS. SONDAS PREFERIDAS SON MINISATETLITES GC-VICH O SIMPLE SECUENCIA DE SONDAS DE FRECUENCIA.
ES89201095T 1988-05-02 1989-04-28 Un metodo para la determinacion simultanea de variaciones de secuencias de dna en un gran numero de sitios, y un estuche de materiales para dicho metodo. Expired - Lifetime ES2044052T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8801147A NL8801147A (nl) 1988-05-02 1988-05-02 Werkwijze voor het detecteren van genetische variatie, en daarvoor geschikte kit.

Publications (1)

Publication Number Publication Date
ES2044052T3 true ES2044052T3 (es) 1994-01-01

Family

ID=19852240

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89201095T Expired - Lifetime ES2044052T3 (es) 1988-05-02 1989-04-28 Un metodo para la determinacion simultanea de variaciones de secuencias de dna en un gran numero de sitios, y un estuche de materiales para dicho metodo.

Country Status (7)

Country Link
US (1) US5068176A (es)
EP (1) EP0349024B1 (es)
JP (1) JPH078240B2 (es)
AT (1) ATE95247T1 (es)
DE (1) DE68909514T2 (es)
ES (1) ES2044052T3 (es)
NL (1) NL8801147A (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL9100132A (nl) * 1991-01-25 1992-08-17 Ingeny Bv Werkwijze voor het detecteren van dna sequentievariatie.
WO1992013971A1 (en) * 1991-02-05 1992-08-20 Lifecodes Corporation Molecular genetic identification using probes that recognize polymorphic loci
US5213669A (en) * 1992-01-31 1993-05-25 Beckman Instruments, Inc. Capillary column containing a dynamically cross-linked composition and method of use
US5354442A (en) * 1992-05-21 1994-10-11 The United States Of America As Represented By The Secretary Of The Commerce Matrix modification in the electrophoretic separation of nucleic acids
US5503980A (en) * 1992-11-06 1996-04-02 Trustees Of Boston University Positional sequencing by hybridization
US5795714A (en) * 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
US6436635B1 (en) 1992-11-06 2002-08-20 Boston University Solid phase sequencing of double-stranded nucleic acids
US6007987A (en) * 1993-08-23 1999-12-28 The Trustees Of Boston University Positional sequencing by hybridization
US5495432A (en) * 1994-01-03 1996-02-27 Industrial Technology Research Institute Apparatus and method for sampling rate conversion
US5736025A (en) * 1994-04-04 1998-04-07 Genomyx Inc. Control of temperature gradients during gel electrophoresis using turbulent gas flow
NL9401082A (nl) * 1994-06-28 1996-02-01 Ingeny Bv Werkwijze voor het detecteren van mutaties.
US7803529B1 (en) 1995-04-11 2010-09-28 Sequenom, Inc. Solid phase sequencing of biopolymers
CA2223061C (en) * 1995-06-06 2008-04-22 Jan Vijg Method of and apparatus for diagnostic dna testing
US6048691A (en) * 1996-05-13 2000-04-11 Motorola, Inc. Method and system for performing a binding assay
AU7019498A (en) 1997-04-10 1998-10-30 Diagnocure Inc. Pca3, pca3 genes, and methods of use
ES2260059T3 (es) 1999-09-29 2006-11-01 Diagnocure Inc. Rna mensajero del pca3 en tejidos benignos y malignos de prostata.
DE60045932D1 (de) 2000-09-01 2011-06-16 Gen Probe Inc HIV-1-Sequenzverstärkung zur Erkennung von Sequenzen in Zusammenhang mit Wirkstoffresistenz-Mutationen
EP1320745A4 (en) * 2000-09-01 2008-10-01 Applera Corp SYSTEM AND METHOD FOR TEMPERATURE GRADIENT CAPILLARY ELECTROPHORESIS
AU2002214569A1 (en) * 2000-10-11 2002-04-22 Spectrumedix Corporation System and method for determining the presence of methylated cytosines in polynucleotides
EP1202211A3 (en) * 2000-10-26 2004-12-22 Riken Genomic DNA analysis computer program
WO2003033743A1 (en) * 2001-10-18 2003-04-24 Spectrumedix Corporation System and method for temperature gradient capillary electrophoresis
US6872530B2 (en) * 2002-04-24 2005-03-29 Spectrumedix, Llc Method for determining the presence of DNA variants using peptide nucleic acid probes
AU2003256579A1 (en) * 2002-07-16 2004-02-02 Spectrumedix Llc Method and system for comparative genomics for organisms using temperature gradient electrophoresis
AU2004209578A1 (en) 2003-02-07 2004-08-19 Diagnocure Inc. Method to detect prostate cancer in a sample
US7303879B2 (en) * 2003-07-31 2007-12-04 Applera Corporation Determination of SNP allelic frequencies using temperature gradient electrophoresis
ATE498682T1 (de) * 2004-09-02 2011-03-15 Lifeind Ehf Zweidimensionale strangform- und längenabhängige trennung von nukleinsäurefragmenten
DE102004048334A1 (de) * 2004-10-01 2006-04-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verbessertes elektrophoretisches Trennverfahren für die Analyse der Genexpression
CA2491067A1 (en) 2004-12-24 2006-06-24 Stichting Katholieke Universiteit Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer
WO2006122401A1 (en) * 2005-05-16 2006-11-23 Institut De Recherches Cliniques De Montreal/I.R.C.M. Negative regulation of nk cell functions by eat-2, a sap-related adaptor expressed in innate immune cells
WO2007056394A2 (en) * 2005-11-08 2007-05-18 The Trustees Of Columbia University In The City Of New York Genetic markers of true low birth weight
JP5716217B2 (ja) * 2009-12-15 2015-05-13 公益財団法人ヒューマンサイエンス振興財団 長鎖繰返し配列を含有する遺伝子又は遺伝子産物の選択又は優先的回収方法
WO2014140167A1 (en) 2013-03-14 2014-09-18 Dsm Ip Assets B.V. Cell wall deconstruction enzymes of malbranchea cinnamomea and uses thereof
WO2014140165A1 (en) 2013-03-14 2014-09-18 Dsm Ip Assets B.V. Cell wall deconstruction enzymes of paecilomyces byssochlamydoides and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3503978A1 (de) * 1984-08-01 1986-02-06 Detlev Prof.Dr. 4000 Düsseldorf Riesner Verfahren zur frueherkennung von pflanzenkrankheiten
EP0219842A1 (en) * 1985-10-23 1987-04-29 Allied Corporation Nucleic acid assay employing pair segment inhibition or competition

Also Published As

Publication number Publication date
EP0349024A1 (en) 1990-01-03
DE68909514D1 (de) 1993-11-04
NL8801147A (nl) 1989-12-01
EP0349024B1 (en) 1993-09-29
ATE95247T1 (de) 1993-10-15
US5068176A (en) 1991-11-26
JPH078240B2 (ja) 1995-02-01
JPH02104299A (ja) 1990-04-17
DE68909514T2 (de) 1994-01-20

Similar Documents

Publication Publication Date Title
DE68909514D1 (de) Verfahren zur gleichzeitigen bestimmung von dns-sequenzvariationen von zahlreichen stellen und ein satz dafuer.
FI911536A7 (fi) Nukleiinihappokoettimet, jotka sisältävät parannetun molekyylikytkimen , sekä niitä sisältävät määritysmenetelmät ja testipakkaukset
DE3684194D1 (de) Messfuehler und verfahren zum nachweis und zur quantitativen bestimmung von kraft- und drehmomentkomponenten.
KR880700935A (ko) 비파괴재료시험 및 자기구조적 재료조사 방법 그 장치
DE68917399D1 (de) Testvorrichtung und Verfahren zur Protein-Untersuchung.
KR880700258A (ko) 중합체 경도 비파괴 측정 방법
ES555428A0 (es) Un metodo para ensayar cuantitativamente la proteina c en un medio que la contiene.
DK129588A (da) Fremgangsmaade til bestemmelse af nukleinsyrer samt reagenskombination og reagenssaet dertil
DK235887A (da) Immunoassaymetode og proevesaet til paavisning af et med human carcinoma forbundet antigen
DE3780301D1 (de) Geraet zur sequenzanalyse von basen.
DE3784109D1 (de) Selektiver zufuhrapparat von pruefsaetzen fuer biochemischen analysierenden apparat.
DE69010143D1 (de) Testeinrichtung und Verfahren zur Bestimmung von Fructoasminen.
DE3851587D1 (de) Verfahren und Apparatur zur Widerstandsmessung.
NO882300D0 (no) Fremgangsmaate og testanordning for separering av merket reagens i en immunometrisk-analyse.
DE3676977D1 (de) Vorrichtung und verfahren zum pruefen von explosivstoffen.
DE69024955D1 (de) Ermittlung und quantifizierung mehrerer analyten unter verwendung von markierungstechniken
MX159990A (es) Metodo y aparato para transportar,probar,medir y realizar otras operaciones en un objeto en un orden seleccionado
DK440577A (da) Fremgangsmaade til idenfificering af overfladeproteiner paa cancerceller klinisk proevemetode til paavisning af immunitet og fremgangsmaade til immunisering
DK0782706T3 (da) Testmetode
DE68917273D1 (de) Testmethode und Gerät zur Bestimmung des gesamten Proteins.
NO901612L (no) Fremgangsmaate og apparat for maaling av flerfasestroemninger, saerlig i hydrokarbonbroenner.
FI881608A7 (fi) Analyysimenetelmä ja -laite lateksien karakterisoimiseksi.
DE3874605D1 (de) Mikrosonde in integrierter schalttechnik zur feststellung bestimmter gase.
DE3667855D1 (de) Pruefanordnung zur beruehrungslosen ermittlung von defekten in nicht strukturierten flaechen.
DE3883808D1 (de) Testsatz, Extraktionsvorrichtung und Verfahren zur Bestimmung von Streptococcus-A-Antigen.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 349024

Country of ref document: ES