ES2044835T5 - Deteccion de microbios en una muestra. - Google Patents
Deteccion de microbios en una muestra.Info
- Publication number
- ES2044835T5 ES2044835T5 ES86117754T ES86117754T ES2044835T5 ES 2044835 T5 ES2044835 T5 ES 2044835T5 ES 86117754 T ES86117754 T ES 86117754T ES 86117754 T ES86117754 T ES 86117754T ES 2044835 T5 ES2044835 T5 ES 2044835T5
- Authority
- ES
- Spain
- Prior art keywords
- sample
- nutrient
- microbe
- test media
- altering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000001514 detection method Methods 0.000 title 1
- 235000015097 nutrients Nutrition 0.000 abstract 5
- 239000001963 growth medium Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000010998 test method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
- C12Q1/10—Enterobacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
LA PRESENCIA O AUSENCIA DE UN MICROBIO OBJETIVO PREDETERMINADO EN UNA MUESTRA SE DETERMINA POR ADICION DE UN MEDIO DE ENSAYO A LA MUESTRA, O VICEVERSA. EL MEDIO DE ENSAYO PROPORCIONA UN MEDIO DE CRECIMIENTO SELECTIVO PARA EL MICROBIO BLANCO O DIANA, E INCLUYE UN NUTRIENTE ESPECIFICO QUE SOLO PUEDE METABOLIZAR EL MICROBIO DIANA. ESTE NUTRIENTE ESPECIFICO SE MODIFICA UNIENDOLE UNA MITAD ALTERADORA DE LA MUESTRA, CON LO QUE EL NUTRIENTE SE CONVIERTE EN INDICADOR NUTRIENTE. LA MITAD ALTERADORA DE LA MUESTRA SE ACTIVA PARA ALTERAR LA MUESTRA SOLO SI EL NUTRIENTE ESPECIFICO SE METABOLIZA POR EL MICROBIO DIANA. LA MITAD ALTERADORA DE LA MUESTRA PUEDE SER UN MATERIAL QUE CAMBIA EL COLOR DE LA MUESTRA (VISIBLE O NO VISIBLE) O CAMBIA UNA CARACTERISTICA ELECTRICA DE LA MUESTRA, O ALTERA ALGUNA OTRA CARACTERISTICA DETECTABLE DE LA MUESTRA. EL MEDIO DE ENSAYO NO TIENE QUE MANTENERSE ESTERIL, Y EL PROCEDIMIENTO DE ENSAYO NO TIENE QUE LLEVARSE A CABO EN AMBIENTE ESTERIL.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/880,305 US4925789A (en) | 1986-06-30 | 1986-06-30 | Method and medium for use in detecting target microbes in situ in a specimen sample of a possibly contaminated material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2044835T3 ES2044835T3 (es) | 1994-01-16 |
| ES2044835T5 true ES2044835T5 (es) | 2000-07-16 |
Family
ID=25375995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES86117754T Expired - Lifetime ES2044835T5 (es) | 1986-06-30 | 1986-12-19 | Deteccion de microbios en una muestra. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4925789A (es) |
| EP (1) | EP0254771B2 (es) |
| JP (1) | JPH074272B2 (es) |
| AT (1) | ATE83010T1 (es) |
| AU (1) | AU597675B2 (es) |
| BR (1) | BR8703173A (es) |
| CA (1) | CA1288322C (es) |
| DE (1) | DE3687232T3 (es) |
| DK (1) | DK175229B1 (es) |
| ES (1) | ES2044835T5 (es) |
| GR (2) | GR3006553T3 (es) |
| IE (1) | IE60884B1 (es) |
| NZ (1) | NZ219147A (es) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5429933A (en) * | 1986-06-30 | 1995-07-04 | Edberg; Stephen C. | Detection of first generation environmental sourced microbes in an environmentally-derived sample |
| CA1317534C (en) * | 1987-03-17 | 1993-05-11 | Arthur Newton Ley | Method of enumerating escherichia coli |
| US5518894A (en) * | 1987-11-05 | 1996-05-21 | Berg; James D. | Rapid coliform detection system |
| DE69102081T2 (de) * | 1990-02-13 | 1995-01-05 | Canon Kk | Tintenstrahlaufzeichnungsvorrichtung. |
| CA2038406C (en) * | 1990-04-12 | 1995-11-21 | Mark L. Sussman | Identifying microorganisms by measuring enzymatic activity in the presence of enzyme activity affecting agents |
| US5210022A (en) * | 1990-04-20 | 1993-05-11 | Rcr Scientific, Inc. | Method test media and chromogenic compounds for identifying and differentiating general coliforms and Escherichia coli bacteria |
| US6699685B1 (en) * | 1990-04-20 | 2004-03-02 | Rcr Scientific, Inc. | Method, test media and chromogenic compounds for identifying and differentiating general coliforms and escherichia coli bacteria |
| US5633144A (en) * | 1990-05-03 | 1997-05-27 | University Of Florida Research Foundation, Inc. | Assay pad and method for determination of the presence of total coliforms |
| US5411867A (en) * | 1990-05-14 | 1995-05-02 | The Regents Of The University Of California | Method for determination of E. coli in water |
| CA2027536C (en) * | 1990-05-14 | 1993-02-16 | George Chang | Method for determination of e.coli in water |
| US5223402A (en) * | 1990-08-30 | 1993-06-29 | Difco Laboratories | Method of detecting microbes utilizing chemiluminescent compound |
| FR2671100B1 (fr) * | 1990-12-28 | 1993-03-05 | Bio Merieux | Procede d'analyse bacteriologique, et milieu de detection des bacteries genre salmonella. |
| US6306621B1 (en) * | 1991-11-18 | 2001-10-23 | The United States Of America As Represented By The Administrator Of The U.S. Environmental Protection Agency | Membrane filter agar medium for simultaneous detection of total coliforms and E. coli |
| US6063590A (en) * | 1991-11-18 | 2000-05-16 | The United States Of America As Represented By The Administrator Of The U.S. Environmental Protection Agency | Membrane filter agar medium containing two enzyme substrates used for the simultaneous detection of total coliforms and E. coli. |
| US5518892A (en) * | 1994-02-23 | 1996-05-21 | Idexx Laboratories, Inc. | Apparatus and method for quantification of biological material in a liquid sample |
| US5849515A (en) * | 1994-04-01 | 1998-12-15 | Hach Company | Method and medium for use in detecting E. coli and total coliforms |
| US5650290A (en) * | 1994-04-01 | 1997-07-22 | Hach Company | Method & Medium for use in detecting E. coli and total coliforms |
| US6146840A (en) * | 1994-04-29 | 2000-11-14 | The Regents Of The University Of California | Simultaneous enumeration of E. coli and total coliforms |
| FR2719905B1 (fr) * | 1994-05-10 | 1996-07-26 | Anjou Rech | Appareil de mesure pour le contrôle de la qualité bactériologique de l'eau. |
| AU2636995A (en) * | 1994-05-18 | 1995-12-05 | Research And Development Institute, Inc. | Simple, rapid method for the detection, identification and enumeration of specific viable microorganisms |
| US5550032A (en) * | 1994-05-27 | 1996-08-27 | George Mason University | Biological assay for microbial contamination |
| US5510243A (en) * | 1994-06-21 | 1996-04-23 | Gelman Sciences, Inc. | Multiple chromogen enzyme targeting (MCET) for use in bacterial contamination monitoring |
| US5610029A (en) * | 1994-11-04 | 1997-03-11 | Idexx Laboratories, Inc. | Medium for detecting target microbes in a sample |
| ES2298457T3 (es) * | 1994-11-04 | 2008-05-16 | Idexx Laboratories, Inc. | Medio para detectar microbios objetivo en una muestra. |
| US5620865A (en) * | 1994-11-04 | 1997-04-15 | Idexx Laboratories, Inc. | Medium for detecting Enterococci in a sample |
| US5605812A (en) * | 1995-05-19 | 1997-02-25 | Charm Sciences, Inc. | Test kit and method for the quantitative determination of coliform bacteria and E. coli |
| US6387650B1 (en) * | 1995-06-07 | 2002-05-14 | Biocontrol Systems, Inc. | Method and composition for detecting bacterial contamination in food products |
| US7560246B2 (en) | 1995-06-07 | 2009-07-14 | Biocontrol Systems, Inc. | Compositions and methods for detecting target microorganisms in a sample |
| US5985594A (en) | 1995-11-14 | 1999-11-16 | Idexx Laboratories, Inc. | Method for quantification of biological material in a sample |
| US5700655A (en) * | 1995-11-14 | 1997-12-23 | Idexx Laboratories, Inc. | Method for quantification of biological material in a sample |
| US7122338B2 (en) * | 1995-11-14 | 2006-10-17 | Biocontrol Systems, Inc. | Method for quantification of biological material in a sample |
| US5726031A (en) * | 1996-03-26 | 1998-03-10 | Rcr Scientific, Inc. | Test media and quantitative method for identification and differentiation of biological materials in a test sample |
| ATE226630T1 (de) | 1996-07-26 | 2002-11-15 | Idexx Lab Inc | Verfahren und medium zum nachweis von vancomycin- resistenten enterococcus |
| US6051394A (en) * | 1996-09-13 | 2000-04-18 | Simmons; Maxine Helen | Detection of microorganisms |
| AU5594601A (en) * | 1996-09-13 | 2001-09-13 | Sbm Limited | Detection of microorganisms |
| US5843699A (en) * | 1997-04-08 | 1998-12-01 | Difco Laboratories, Inc. | Rapid microorganism detection method |
| US6984499B2 (en) * | 1997-10-02 | 2006-01-10 | Idexx Laboratories, Inc. | Method and apparatus for concurrently detecting pathogenic organisms and antimicrobial susceptibility |
| WO1999019510A1 (en) | 1997-10-10 | 1999-04-22 | President And Fellows Of Harvard College | Surface-bound, double-stranded dna protein arrays |
| AU736154B2 (en) | 1997-10-27 | 2001-07-26 | Idexx Laboratories, Inc. | Device and methods for determination of analyte in a solution |
| FR2774097B1 (fr) * | 1998-01-28 | 2000-09-29 | Bio Merieux | Utilisation de derives d'indolamine dans la detection d'une activite de peptidase ou dans la detection de micro-organismes |
| US5968762A (en) * | 1998-03-19 | 1999-10-19 | The University Of Connecticut | Method for detecting bacteria in a sample |
| US5972641A (en) * | 1998-08-28 | 1999-10-26 | Colifast Systems Asa | Rapid coliform detection system |
| US6511819B2 (en) | 1998-08-28 | 2003-01-28 | Nye Colifast As | Rapid coliform detection system |
| FR2816956B1 (fr) * | 2000-11-17 | 2004-08-20 | Bio Merieux | Procede et milieu de detection/identification de bacteries a activite esterasique |
| US6509166B1 (en) * | 2000-11-28 | 2003-01-21 | Robert A. Levine | Detection and quantification of one or more target analytes in a sample using spatially localized analyte reproduction |
| US20030138906A1 (en) * | 2001-11-05 | 2003-07-24 | Ingun Tryland | Fluorescence test for measuring heterotrophic bacteria in water |
| US7384778B2 (en) * | 2002-01-10 | 2008-06-10 | Idexx Laboratories, Inc. | Methods and devices for the detection of pathogenic microorganisms and their antimicrobial susceptibility |
| DE10213361B3 (de) * | 2002-03-26 | 2004-01-08 | Dunkelberg, Hartmut, Prof., Dr. | Verfahren zur Prüfung einer Sterilisierverpackungseinheit auf Wirksamkeit gegen Rekontamination |
| US7874128B2 (en) * | 2003-05-15 | 2011-01-25 | Hartmut Dunkelberg | Test unit and method for testing whether a sterilizing packaging unit is effective against recontamination, and container packaging suitable for applying said method |
| ITTR20030002A1 (it) * | 2003-07-31 | 2005-02-01 | Isrim Societa Consortile A Respon Sabilita Limit | Metodo per la rilevazione di coliformi ed in particolare |
| US20050067300A1 (en) * | 2003-09-25 | 2005-03-31 | The Procter & Gamble Company | Electrolysis device for treating a reservoir of water |
| CN101061232A (zh) | 2004-06-23 | 2007-10-24 | 罗斯玛丽·凯瑟琳·卡梅伦·莎平 | 微生物检测仪器的改进及其使用方法 |
| US7527995B2 (en) * | 2004-09-27 | 2009-05-05 | Qualcomm Mems Technologies, Inc. | Method of making prestructure for MEMS systems |
| FR2882370B1 (fr) * | 2005-02-22 | 2010-12-03 | Alain Rambach | Detection d'une souche de microorganismes dans un echantillon liquide |
| WO2007053487A2 (en) * | 2005-10-28 | 2007-05-10 | Binax, Inc. | Methods and devices for detection of the strain of a pathogen |
| FR2903421B1 (fr) * | 2006-07-10 | 2008-10-03 | Alain Rambach | Milieu de culture solide pour la detection et/ou la discrimination au niveau de l'espece des enterocoques resistants aux glycopeptides |
| CA2681619C (en) * | 2006-12-19 | 2017-03-14 | Becton, Dickinson And Company | Chromogenic medium for the detection and identification of vancomycin resistant enterococci and method therfor |
| EP2062978A1 (en) * | 2007-11-23 | 2009-05-27 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | System for detecting microbial contamination |
| US8198434B2 (en) * | 2008-05-07 | 2012-06-12 | Idexx Laboratories, Inc. | Process for preparing cefsulodin sodium |
| WO2010151772A1 (en) | 2009-06-27 | 2010-12-29 | Pilots Point Llc | Method and reagents for detecting the presence or absence of a target substance in a test sample |
| US20110256583A1 (en) * | 2010-03-23 | 2011-10-20 | Edberg Stephen C | Method and medium for accelerating target analyte growth in a test sample |
| EP2729804B1 (en) | 2011-07-07 | 2018-03-14 | Geoffrey N. Roth | Method utilizing enzyme substrates producing insoluble fluorescent products and chromogens, and use in combination with enzyme substrates producing soluble products |
| EP2972227B1 (en) | 2013-03-12 | 2020-05-06 | Ventana Medical Systems, Inc. | Digitally enhanced microscopy for multiplexed histology |
| WO2017013673A1 (en) | 2015-07-21 | 2017-01-26 | M/S Xcellence In Bio Innovation And Technologies Pvt. Ltd. | An invention relating to microbiological testing apparatus |
| EP3740585B1 (en) * | 2018-01-17 | 2023-09-27 | Bactobyte Ltd. | Improving detection of microorganisms |
| US11536666B2 (en) | 2019-11-11 | 2022-12-27 | Auburn University | Matrices for detecting volatile organic compounds |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3496066A (en) * | 1966-03-29 | 1970-02-17 | Boehringer & Soehne Gmbh | Diagnostic aids for use in the detection of bacteria in biological and other fluids |
| NL7208092A (es) * | 1972-06-14 | 1973-12-18 | ||
| US3870601A (en) * | 1973-05-04 | 1975-03-11 | Schering Corp | Novel diagnostic system for differentiation of enterobacteriaceae |
| US4129483A (en) * | 1977-03-03 | 1978-12-12 | Bochner Barry R | Device, composition and method for identifying microorganisms |
| FR2405301A1 (fr) * | 1977-10-04 | 1979-05-04 | Api Labor | Substrats et procede permettant l'identification rapide de bacteries du genre streptococcus |
| US4208480A (en) * | 1978-08-23 | 1980-06-17 | American Home Products Corporation | Method, reagents and apparatus for the rapid identification of Neisseria gonorrhoeae and Neisseria meningitidis |
| US4245043A (en) * | 1979-06-29 | 1981-01-13 | Minnesota Mining And Manufacturing Company | Negative control media device and method for microbiologic biochemical tests |
| DE2965379D1 (en) * | 1979-09-12 | 1983-06-16 | Alain Rambach | Chromogenic chemical substrates for identification of microbial colonies |
| JPS5817598B2 (ja) * | 1979-10-31 | 1983-04-08 | 味の素株式会社 | 微生物の迅速検出方法 |
| WO1982003090A1 (en) * | 1981-03-03 | 1982-09-16 | James Richard | Method and kit for identification of beta-lactamases |
| US4526865A (en) * | 1981-10-01 | 1985-07-02 | Amb Systems Corp. | Microorganism identification technique |
| JPS59192099A (ja) * | 1983-04-12 | 1984-10-31 | Ajinomoto Co Inc | 微生物菌数の測定法 |
| DE3327839A1 (de) * | 1983-08-02 | 1985-02-14 | Merck Patent Gmbh, 6100 Darmstadt | Verfahren und mittel zur empfindlichkeitspruefung von bakterien |
| US4803162A (en) * | 1984-05-15 | 1989-02-07 | Fluorodiagnostic Limited Partners | Composition, article and process for detecting a microorganism |
| DE3419327A1 (de) * | 1984-05-24 | 1985-11-28 | Flow Laboratories GmbH, 5309 Meckenheim | Verfahren zur quantitativen bestimmung des wachstums von bakterien |
| US4812409A (en) * | 1986-01-31 | 1989-03-14 | Eastman Kodak Company | Hydrolyzable fluorescent substrates and analytical determinations using same |
-
1986
- 1986-06-30 US US06/880,305 patent/US4925789A/en not_active Expired - Lifetime
- 1986-12-19 DE DE3687232T patent/DE3687232T3/de not_active Expired - Lifetime
- 1986-12-19 ES ES86117754T patent/ES2044835T5/es not_active Expired - Lifetime
- 1986-12-19 AT AT86117754T patent/ATE83010T1/de not_active IP Right Cessation
- 1986-12-19 EP EP86117754A patent/EP0254771B2/en not_active Expired - Lifetime
-
1987
- 1987-01-27 CA CA000528265A patent/CA1288322C/en not_active Expired - Lifetime
- 1987-01-30 IE IE25287A patent/IE60884B1/en not_active IP Right Cessation
- 1987-02-03 NZ NZ219147A patent/NZ219147A/en unknown
- 1987-02-24 JP JP62041220A patent/JPH074272B2/ja not_active Expired - Fee Related
- 1987-06-23 BR BR8703173A patent/BR8703173A/pt not_active IP Right Cessation
- 1987-06-29 DK DK198703326A patent/DK175229B1/da not_active IP Right Cessation
- 1987-06-29 AU AU74795/87A patent/AU597675B2/en not_active Expired
-
1992
- 1992-12-16 GR GR920402926T patent/GR3006553T3/el unknown
-
2000
- 2000-03-16 GR GR20000400677T patent/GR3032977T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU7479587A (en) | 1988-01-07 |
| AU597675B2 (en) | 1990-06-07 |
| DK175229B1 (da) | 2004-07-19 |
| NZ219147A (en) | 1990-11-27 |
| ES2044835T3 (es) | 1994-01-16 |
| DE3687232T2 (de) | 1993-04-08 |
| US4925789A (en) | 1990-05-15 |
| BR8703173A (pt) | 1988-03-08 |
| EP0254771A2 (en) | 1988-02-03 |
| JPS6314699A (ja) | 1988-01-21 |
| DE3687232T3 (de) | 2000-09-07 |
| DK332687A (da) | 1987-12-31 |
| EP0254771A3 (en) | 1988-08-24 |
| EP0254771B1 (en) | 1992-12-02 |
| EP0254771B2 (en) | 2000-02-02 |
| IE60884B1 (en) | 1994-08-24 |
| DK332687D0 (da) | 1987-06-29 |
| DE3687232D1 (es) | 1993-01-14 |
| JPH074272B2 (ja) | 1995-01-25 |
| CA1288322C (en) | 1991-09-03 |
| ATE83010T1 (de) | 1992-12-15 |
| GR3032977T3 (en) | 2000-07-31 |
| GR3006553T3 (es) | 1993-06-30 |
| IE870252L (en) | 1988-12-30 |
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