ES2048133T3 - Sistema de descarga de farmacos para el colon. - Google Patents

Sistema de descarga de farmacos para el colon.

Info

Publication number
ES2048133T3
ES2048133T3 ES91910743T ES91910743T ES2048133T3 ES 2048133 T3 ES2048133 T3 ES 2048133T3 ES 91910743 T ES91910743 T ES 91910743T ES 91910743 T ES91910743 T ES 91910743T ES 2048133 T3 ES2048133 T3 ES 2048133T3
Authority
ES
Spain
Prior art keywords
colon
matrix
medicinal product
stomach
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91910743T
Other languages
English (en)
Other versions
ES2048133T1 (es
Inventor
Amnon Sintov
Abraham Rubinstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Perio Products Ltd
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Perio Products Ltd
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24065163&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2048133(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Perio Products Ltd, Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Perio Products Ltd
Publication of ES2048133T1 publication Critical patent/ES2048133T1/es
Application granted granted Critical
Publication of ES2048133T3 publication Critical patent/ES2048133T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Surgical Instruments (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Memory System Of A Hierarchy Structure (AREA)

Abstract

SE SUMINISTRA UN SISTEMA COLONICO DE SUMINISTRO PARA EL SUMINISTRO DEUN MEDICAMENTO EN EL COLON. EL SISTEMA INCLUYE UN MEDICAMENTO EN COMBINACION CON UNA MATRIZ, EN DONDE LA MATRIZ COMPRENDE UN POLIMERO QUE CONTIENE UN SACARIDO. SEGUN LA INVENCION, LA MATRIZ ES RESISTENTE A LA DEGRADACION QUIMICA Y ENZIMATICA EN EL ESTOMAGO Y EN EL INTESTINO DELGADO. LA MATRIZ SE DEGRADA EN EL COLON POR LA ACCION ENZIMATICA BACTERIANA Y SE LIBERA EL MEDICAMENTO. EL SISTEMA ES UTIL PARA MEDICAMENTOS CUYO BLANCO SEA EL COLON CON EL FIN DE TRATAR ENFERMEDADES COLONICAS. EL SISTEMA TAMBIEN ES UTIL PARA LA ADMINISTRACION ENTERICA DE MEDICAMENTOS TALES COMO PROTEINAS Y PEPTIDOS QUE, DE LO CONTRARIO, SE DEGRADAN EN EL ESTOMAGO Y EN EL INTESTINO DELGADO.
ES91910743T 1990-05-04 1991-05-02 Sistema de descarga de farmacos para el colon. Expired - Lifetime ES2048133T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51871490A 1990-05-04 1990-05-04

Publications (2)

Publication Number Publication Date
ES2048133T1 ES2048133T1 (es) 1994-03-16
ES2048133T3 true ES2048133T3 (es) 2000-01-16

Family

ID=24065163

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91910743T Expired - Lifetime ES2048133T3 (es) 1990-05-04 1991-05-02 Sistema de descarga de farmacos para el colon.

Country Status (17)

Country Link
EP (1) EP0527942B1 (es)
JP (1) JPH05508631A (es)
KR (1) KR100194161B1 (es)
AT (1) ATE185267T1 (es)
AU (1) AU660147B2 (es)
BR (1) BR9106419A (es)
CA (1) CA2082156A1 (es)
DE (2) DE69131688T2 (es)
DK (1) DK0527942T3 (es)
ES (1) ES2048133T3 (es)
FI (1) FI924984L (es)
GR (2) GR940300025T1 (es)
HU (1) HU210497B (es)
MC (1) MC2288A1 (es)
NO (1) NO306096B1 (es)
RU (1) RU2113221C1 (es)
WO (1) WO1991016881A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4209160A1 (de) * 1992-03-20 1993-09-30 Bauer Kurt Heinz Prof Dr Vernetzte Polysaccharide, Verfahren zu ihrer Herstellung und ihre Verwendung
US5656290A (en) * 1993-02-26 1997-08-12 The Procter & Gamble Company Bisacodyl dosage form with multiple enteric polymer coatings for colonic delivery
CA2176719C (en) * 1993-11-17 2007-09-18 Geoffrey Anisson Fatty acid delivery system
AU695906B2 (en) * 1993-11-17 1998-08-27 Commonwealth Scientific And Industrial Research Organisation Fatty acid delivery system
DE4340057A1 (de) * 1993-11-24 1995-06-01 Falk Pharma Gmbh Budesonid-Arzneimittel zur Verbesserung der enteralen Flüssigkeitsresorption, insbesondere nach postoperativen Zuständen
ATE226090T1 (de) 1994-04-22 2002-11-15 Yamanouchi Pharma Co Ltd Kolon-spezifisches arzneistofffreisetzungssystem
US5849327A (en) * 1994-07-29 1998-12-15 Advanced Polymer Systems, Inc. Delivery of drugs to the lower gastrointestinal tract
US5656294A (en) * 1995-06-07 1997-08-12 Cibus Pharmaceutical, Inc. Colonic delivery of drugs
US5811388A (en) * 1995-06-07 1998-09-22 Cibus Pharmaceutical, Inc. Delivery of drugs to the lower GI tract
GB9516268D0 (en) 1995-08-08 1995-10-11 Danbiosyst Uk Compositiion for enhanced uptake of polar drugs from the colon
DK0876142T3 (da) * 1996-01-16 2001-11-19 Advanced Polymer Systems Inc Topisk tilførsel af lægemidler til den nedre mavetarmkanal
FR2752843B1 (fr) * 1996-08-30 1998-10-16 Sod Conseils Rech Applic Copolymeres reticules a base de polymeres polycarboxyliques et leur utilisation comme support de composition pharmaceutique
WO1998026767A2 (en) * 1996-12-17 1998-06-25 Poli Industria Chimica S.P.A. Site-specific controlled release dosage formulation for mesalamine
US6229009B1 (en) 1997-08-29 2001-05-08 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Polycarboxylic based cross-linked copolymers
AU2484399A (en) * 1998-01-30 1999-08-16 Scios Inc. Controlled release delivery of peptide or protein
KR20000011247A (ko) * 1998-07-23 2000-02-25 김윤 다당류를이용한대장선택성약물전달조성물및약학제제
IT1303735B1 (it) * 1998-11-11 2001-02-23 Falorni Italia Farmaceutici S Acidi ialuronici reticolati e loro usi medici.
IT1303738B1 (it) * 1998-11-11 2001-02-23 Aquisitio S P A Processo di reticolazione di polisaccaridi carbossilati.
WO2000074720A1 (fr) 1999-06-09 2000-12-14 Mochida Pharmaceutical Co., Ltd. Systeme de liberation dans les voies digestives inferieures
FR2799196B1 (fr) * 1999-10-04 2002-02-08 Sod Conseils Rech Applic Copolymeres reticules a base de copolymeres polycarboxyliques non reticules
RU2188000C1 (ru) * 2001-09-27 2002-08-27 Нестерук Владимир Викторович Лекарственное средство на основе тамоксифена
WO2004066750A1 (en) * 2003-01-31 2004-08-12 Dsm Ip Assets B.V. Novel compositions comprising carotenoids
US7670624B2 (en) 2004-01-29 2010-03-02 Astella Pharma Inc. Gastrointestinal-specific multiple drug release system
RU2375047C2 (ru) * 2004-03-26 2009-12-10 Лек Фармасьютиклз Д.Д. Фармацевтическая лекарственная форма, устойчивая к действию желудочного сока, включающая n-(2-(2-фталимидоэтокси)ацетил)-l-аланил-d-глутаминовую кислоту (lk 423)
GB0607534D0 (en) * 2006-04-13 2006-05-24 Univ London Pharmacy Colonic drug delivery formulation
KR101122845B1 (ko) 2009-07-30 2012-03-21 부산대학교 산학협력단 경구용 염증성 장질환 치료제
EP2830599B1 (en) 2012-03-29 2018-08-15 Therabiome, Llc Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix
US9907755B2 (en) 2013-03-14 2018-03-06 Therabiome, Llc Targeted gastrointestinal tract delivery of probiotic organisms and/or therapeutic agents
WO2016114397A1 (ja) * 2015-01-16 2016-07-21 生化学工業株式会社 コンドロイチン硫酸架橋体、並びにこれを含有する組成物、及び眼疾患処置剤

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7504049L (sv) * 1975-04-09 1976-10-10 Haessle Ab Colonpreparation
DE2717707C3 (de) * 1977-04-21 1979-11-22 Chephasaar Chemisch-Pharmazeutische Fabrik Gmbh, 6670 St Ingbert Karamellisierte Lactulose
US4668517A (en) * 1985-04-04 1987-05-26 Norwich Eaton Pharmaceuticals, Inc. Furazolidone dosage form
IL85538A (en) * 1987-02-27 1991-09-16 Lilly Co Eli Sustained release matrix tablet formulations containing hydrophilic and enteric polymers
DK110188D0 (da) * 1988-03-02 1988-03-02 Claus Selch Larsen High molecular weight prodrug derivatives of antiinflammatory drugs
US4857331A (en) * 1988-03-31 1989-08-15 Warner-Lambert Company Sugarless pectin delivery system
IT1219942B (it) * 1988-05-13 1990-05-24 Fidia Farmaceutici Esteri polisaccaridici
DE4006521A1 (de) * 1990-03-02 1991-09-05 Bayer Ag Zuckerhaltige polymere zur umhuellung und einbettung von arzneistoffen

Also Published As

Publication number Publication date
HU9203451D0 (en) 1993-05-28
NO924227L (no) 1992-12-30
DK0527942T3 (da) 2000-03-27
DE69131688T2 (de) 2000-05-25
EP0527942A4 (en) 1993-10-13
ES2048133T1 (es) 1994-03-16
FI924984A7 (fi) 1992-11-04
AU660147B2 (en) 1995-06-15
FI924984A0 (fi) 1992-11-04
WO1991016881A1 (en) 1991-11-14
NO924227D0 (no) 1992-11-03
EP0527942A1 (en) 1993-02-24
DE69131688D1 (de) 1999-11-11
EP0527942B1 (en) 1999-10-06
GR940300025T1 (es) 1994-05-31
NO306096B1 (no) 1999-09-20
BR9106419A (pt) 1993-05-04
GR3031906T3 (en) 2000-02-29
DE527942T1 (de) 1994-03-03
FI924984L (fi) 1992-11-04
HU210497B (en) 1995-04-28
AU8087791A (en) 1991-11-27
HUT64210A (en) 1993-12-28
RU2113221C1 (ru) 1998-06-20
CA2082156A1 (en) 1991-11-05
ATE185267T1 (de) 1999-10-15
KR100194161B1 (ko) 1999-06-15
JPH05508631A (ja) 1993-12-02
MC2288A1 (fr) 1993-07-14

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