ES2048653A1 - Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil) propionico por transesterificacion enantioselectiva catalizada enzimaticamente en un disolvente organico. - Google Patents

Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil) propionico por transesterificacion enantioselectiva catalizada enzimaticamente en un disolvente organico.

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Publication number
ES2048653A1
ES2048653A1 ES9201190A ES9201190A ES2048653A1 ES 2048653 A1 ES2048653 A1 ES 2048653A1 ES 9201190 A ES9201190 A ES 9201190A ES 9201190 A ES9201190 A ES 9201190A ES 2048653 A1 ES2048653 A1 ES 2048653A1
Authority
ES
Spain
Prior art keywords
opt
ester
benzoylphenyl
propionic acid
catalysed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9201190A
Other languages
English (en)
Other versions
ES2048653B1 (es
Inventor
Carganico
Casellas Mauleon
Benet Palomer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Menarini SA
Original Assignee
Laboratorios Menarini SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Menarini SA filed Critical Laboratorios Menarini SA
Priority to ES9201190A priority Critical patent/ES2048653B1/es
Priority to DE69316238T priority patent/DE69316238D1/de
Priority to EP93912796A priority patent/EP0672165B1/en
Priority to AU43182/93A priority patent/AU4318293A/en
Priority to PCT/EP1993/001322 priority patent/WO1993025704A1/en
Priority to AT93912796T priority patent/ATE161890T1/de
Publication of ES2048653A1 publication Critical patent/ES2048653A1/es
Application granted granted Critical
Publication of ES2048653B1 publication Critical patent/ES2048653B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCESO PARA LA PRODUCCION DE ACIDO S-(+)-2-(3-BENZOILFENIL) PROPIONICO POR TRANSESTERIFICACION ENANTIOSELECTIVA CATALIZADA ENZIMATICAMENTE EN UN DISOLVENTE ORGANICO. LA PRESENTE INVENCION CORRESPONDE A UN PROCEDIMIENTO PARA LA OBTENCION DEL ACIDO S-(+)-2-(3-BENZOILFENIL) PROPIONICO POR TRANSESTERIFICACION ESTEREOSELECTIVA CATALIZADA POR UNA LIPASA EN MEDIO ORGANICO, DEL ENANTIOMERO R DE UN ESTER ACTIVADO DEL ACIDO RACEMICO 2-(3-BENZOILFENIL) PROPIONICO CON UN ALCOHOL ALQUIRAL. LA MEZCLA DE ESTERES OBTENIDA SE SOMETE A UN TRATAMIENTO EN MEDIO ACUOSO ALCALINO DE FORMA QUE EL ESTER ACTIVADO REMANENTE SE HIDROLICE QUEMOSELECTIVAMENTE. EL S-ACIDO FINAL RESULTANTE Y EL R-ESTER SE SEPARAN POR EXTRACCION EN MEDIO BASICO CON UN DISOLVENTE ORGANICO INMISCIBLE EN AGUA, QUEDANDO EL ESTER EN LA FASE ORGANICA Y EN LA ACUOSA EL ACIDO S-(+)-2-(3-BENZOILFENIL) PROPIONICO OPTICAMENTE ACTIVO RESULTANTE. EL COMPUESTO DEL TITULO ASI COMO SUS SALES FARMACEUTICAMENTE ACEPTABLES TIENEN PROPIEDADES ANTI-INFLAMATORIAS Y ANALGESICAS.
ES9201190A 1992-06-08 1992-06-08 Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil) propionico por transesterificacion enantioselectiva catalizada enzimaticamente en un disolvente organico. Expired - Fee Related ES2048653B1 (es)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES9201190A ES2048653B1 (es) 1992-06-08 1992-06-08 Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil) propionico por transesterificacion enantioselectiva catalizada enzimaticamente en un disolvente organico.
DE69316238T DE69316238D1 (de) 1992-06-08 1993-05-26 Verfahren zur herstellung von s-(+)-2-(-3benzoylphenyl)propionsäure durch enzym katalysierte enanthioselektieve umesterung in einem organischen lösungsmittel.
EP93912796A EP0672165B1 (en) 1992-06-08 1993-05-26 A process for the preparation of s-(+)-2-(3-benzoylphenyl)propionic acid by enzyme-catalysed enantioselective transesterification in an organic solvent
AU43182/93A AU4318293A (en) 1992-06-08 1993-05-26 A process for the preparation of s-(+)-2-(3-benzoylphenyl)propionic acid by enzyme-catalysed enantioselective transesterification in an organic solvent
PCT/EP1993/001322 WO1993025704A1 (en) 1992-06-08 1993-05-26 A process for the preparation of s-(+)-2-(3-benzoylphenyl)propionic acid by enzyme-catalysed enantioselective transesterification in an organic solvent
AT93912796T ATE161890T1 (de) 1992-06-08 1993-05-26 Verfahren zur herstellung von s-(+)-2-(- 3benzoylphenyl)propionsäure durch enzym katalysierte enanthioselektieve umesterung in einem organischen lösungsmittel.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9201190A ES2048653B1 (es) 1992-06-08 1992-06-08 Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil) propionico por transesterificacion enantioselectiva catalizada enzimaticamente en un disolvente organico.

Publications (2)

Publication Number Publication Date
ES2048653A1 true ES2048653A1 (es) 1994-03-16
ES2048653B1 ES2048653B1 (es) 1994-12-16

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ID=8277266

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9201190A Expired - Fee Related ES2048653B1 (es) 1992-06-08 1992-06-08 Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil) propionico por transesterificacion enantioselectiva catalizada enzimaticamente en un disolvente organico.

Country Status (1)

Country Link
ES (1) ES2048653B1 (es)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0396447A1 (fr) * 1989-05-02 1990-11-07 Rhone-Poulenc Chimie Procédé de séparation énantiomériquement sélective des esters des acides halogéno-2 propioniques
EP0407033A2 (en) * 1989-06-05 1991-01-09 Rhone-Poulenc Inc. Lipase and isozymes, notably of Candida rugosa, and their use
EP0498706A1 (fr) * 1991-02-08 1992-08-12 Synthelabo Procédé de préparation du (-)-(2R,3S)-2,3-époxy-3-(4-méthoxyphényl)propionate de méthyle
ES2033203A1 (es) * 1990-05-17 1993-03-01 Zambon Spa Procedimiento para la preparacion de intermediarios utiles para la sintesis de benzotiacepinas.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0396447A1 (fr) * 1989-05-02 1990-11-07 Rhone-Poulenc Chimie Procédé de séparation énantiomériquement sélective des esters des acides halogéno-2 propioniques
EP0407033A2 (en) * 1989-06-05 1991-01-09 Rhone-Poulenc Inc. Lipase and isozymes, notably of Candida rugosa, and their use
ES2033203A1 (es) * 1990-05-17 1993-03-01 Zambon Spa Procedimiento para la preparacion de intermediarios utiles para la sintesis de benzotiacepinas.
EP0498706A1 (fr) * 1991-02-08 1992-08-12 Synthelabo Procédé de préparation du (-)-(2R,3S)-2,3-époxy-3-(4-méthoxyphényl)propionate de méthyle

Also Published As

Publication number Publication date
ES2048653B1 (es) 1994-12-16

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Effective date: 20000401