ES2049332T3 - Procedimiento para la reduccion de la heterogeneidad de los anticuerpos monoclonales. - Google Patents
Procedimiento para la reduccion de la heterogeneidad de los anticuerpos monoclonales.Info
- Publication number
- ES2049332T3 ES2049332T3 ES89309851T ES89309851T ES2049332T3 ES 2049332 T3 ES2049332 T3 ES 2049332T3 ES 89309851 T ES89309851 T ES 89309851T ES 89309851 T ES89309851 T ES 89309851T ES 2049332 T3 ES2049332 T3 ES 2049332T3
- Authority
- ES
- Spain
- Prior art keywords
- antibodies
- heterogeneity
- monoclonal antibodies
- procedure
- reduction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
SE DESCUBREN NUEVOS METODOS PARA REDUCIR LA HETEROGENEIDAD DE ANTICUERPOS MONOCLONALES SEGREGADOS. EL PRIMER METODO COMPRENDE INCUBAR LOS ANTICUERPOS HETEROGENEOS A BAJO PH DURANTE UN PERIODO DE TIEMPO SUFICIENTE PARA CONVERTIR LAS FORMAS HETEROGENEAS DE ANTICUERPOS EN FORMAS SUBSTANCIALMENTE HOMOGENEAS. OTRO METODO PRODUCE EL MISMO RESULTADO USANDO ASCOCITOS LIQUIDO, MIENTRAS QUE TODAVIA OTRO METODO PRODUCE EL MISMO RESULTADO USANDO CARBOXIPEPTIDASA. LOS ANTICUERPOS HOMOGENEOS SE PUEDEN ENTONCES PURIFICAR CON GRAN RENDIMIENTO.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25078688A | 1988-09-28 | 1988-09-28 | |
| US25078788A | 1988-09-28 | 1988-09-28 | |
| US25078888A | 1988-09-28 | 1988-09-28 | |
| US07/364,056 US5126250A (en) | 1988-09-28 | 1989-06-09 | Method for the reduction of heterogeneity of monoclonal antibodies |
| CA000613379A CA1332367C (en) | 1988-09-28 | 1989-09-26 | Method for the reduction of heterogeneity of monoclonal antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2049332T3 true ES2049332T3 (es) | 1994-04-16 |
Family
ID=27508376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES89309851T Expired - Lifetime ES2049332T3 (es) | 1988-09-28 | 1989-09-27 | Procedimiento para la reduccion de la heterogeneidad de los anticuerpos monoclonales. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0361902B1 (es) |
| JP (1) | JP2925181B2 (es) |
| CN (1) | CN1041392A (es) |
| AR (1) | AR242986A1 (es) |
| AT (1) | ATE101876T1 (es) |
| AU (1) | AU615576B2 (es) |
| BG (1) | BG60017B2 (es) |
| CA (1) | CA1332367C (es) |
| DE (1) | DE68913251T2 (es) |
| DK (1) | DK475389A (es) |
| ES (1) | ES2049332T3 (es) |
| IE (1) | IE63562B1 (es) |
| IL (1) | IL91778A (es) |
| MX (1) | MX170441B (es) |
| NZ (1) | NZ230786A (es) |
| PL (1) | PL162260B1 (es) |
| RO (1) | RO105652B1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104761637B (zh) | 2006-03-31 | 2021-10-15 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
| EP1878747A1 (en) | 2006-07-11 | 2008-01-16 | greenovation Biotech GmbH | Glyco-engineered antibodies |
| EP2031064A1 (de) * | 2007-08-29 | 2009-03-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Steigerung von Proteintitern |
| ES2595638T3 (es) | 2007-09-26 | 2017-01-02 | Chugai Seiyaku Kabushiki Kaisha | Método para modificar el punto isoeléctrico de un anticuerpo mediante la sustitución de aminoácidos en una CDR |
| KR101680906B1 (ko) | 2007-09-26 | 2016-11-30 | 추가이 세이야쿠 가부시키가이샤 | 항체 정상영역 개변체 |
| KR102057826B1 (ko) | 2008-04-11 | 2019-12-20 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| TWI440469B (zh) * | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| JP5717624B2 (ja) | 2009-03-19 | 2015-05-13 | 中外製薬株式会社 | 抗体定常領域改変体 |
| EP2826789A1 (en) | 2009-03-19 | 2015-01-21 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
| EP2647706B1 (en) | 2010-11-30 | 2023-05-17 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
| CN103282509A (zh) * | 2010-12-28 | 2013-09-04 | 中外制药株式会社 | 动物细胞的培养方法 |
| PL3489254T3 (pl) | 2012-04-30 | 2023-01-30 | Biocon Limited | Ukierunkowujące/immunomodulujące białko fuzyjne i sposoby jego otrzymywania |
| CA2902830C (en) | 2013-03-12 | 2023-09-19 | Biocon Ltd. | Fusion immunomodulatory proteins and methods for making same |
| US10782290B2 (en) | 2013-06-11 | 2020-09-22 | National Center Of Neurology And Psychiatry | Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (RRMS) patient, and method for determining applicability of novel therapy |
| CA2972393A1 (en) | 2015-02-27 | 2016-09-01 | Chugai Seiyaku Kabushiki Kaisha | Composition for treating il-6-related diseases |
| US10697883B2 (en) | 2015-05-19 | 2020-06-30 | National Center Of Neurology And Psychiatry | Method for determining application of therapy to multiple sclerosis (MS) patient |
| HRP20210830T1 (hr) * | 2016-10-17 | 2021-08-20 | Enzene Biosciences Ltd. | Kontinuirani proces smanjenja heterogenosti terapijskog proteina |
| WO2018203545A1 (ja) | 2017-05-02 | 2018-11-08 | 国立研究開発法人国立精神・神経医療研究センター | Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法 |
| JP7235249B2 (ja) | 2017-10-20 | 2023-03-08 | 学校法人兵庫医科大学 | 抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物 |
| WO2019151418A1 (ja) | 2018-01-31 | 2019-08-08 | 元一 加藤 | Ｉｌ－６阻害剤を含有する喘息の治療剤 |
| EP3957324A4 (en) | 2019-04-17 | 2023-02-08 | Hiroshima University | THERAPEUTIC FOR UROLOGICAL ONCOLOGY CHARACTERIZED BY BEING ADMINISTRATED IN COMBINATION WITH IL-6 INHIBITOR AND CCR2 INHIBITOR |
| EP4159236A4 (en) | 2020-05-29 | 2024-08-21 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing formulation |
-
1989
- 1989-09-26 IL IL9177889A patent/IL91778A/en not_active IP Right Cessation
- 1989-09-26 BG BG089846A patent/BG60017B2/bg unknown
- 1989-09-26 NZ NZ230786A patent/NZ230786A/xx unknown
- 1989-09-26 CA CA000613379A patent/CA1332367C/en not_active Expired - Fee Related
- 1989-09-26 RO RO141765A patent/RO105652B1/ro unknown
- 1989-09-26 AR AR89310004A patent/AR242986A1/es active
- 1989-09-27 AU AU42343/89A patent/AU615576B2/en not_active Ceased
- 1989-09-27 ES ES89309851T patent/ES2049332T3/es not_active Expired - Lifetime
- 1989-09-27 DK DK475389A patent/DK475389A/da not_active Application Discontinuation
- 1989-09-27 DE DE68913251T patent/DE68913251T2/de not_active Expired - Fee Related
- 1989-09-27 IE IE309489A patent/IE63562B1/en not_active IP Right Cessation
- 1989-09-27 EP EP89309851A patent/EP0361902B1/en not_active Expired - Lifetime
- 1989-09-27 MX MX017721A patent/MX170441B/es unknown
- 1989-09-27 PL PL89281598A patent/PL162260B1/pl unknown
- 1989-09-27 AT AT89309851T patent/ATE101876T1/de not_active IP Right Cessation
- 1989-09-28 JP JP1256890A patent/JP2925181B2/ja not_active Expired - Fee Related
- 1989-09-28 CN CN89107508.9A patent/CN1041392A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AR242986A1 (es) | 1993-06-30 |
| EP0361902A3 (en) | 1990-08-16 |
| IL91778A (en) | 1994-10-07 |
| JP2925181B2 (ja) | 1999-07-28 |
| MX170441B (es) | 1993-08-23 |
| EP0361902A2 (en) | 1990-04-04 |
| BG60017B2 (bg) | 1993-06-30 |
| CA1332367C (en) | 1994-10-11 |
| IE63562B1 (en) | 1995-05-17 |
| DK475389A (da) | 1990-03-29 |
| AU4234389A (en) | 1990-04-05 |
| ATE101876T1 (de) | 1994-03-15 |
| RO105652B1 (ro) | 1992-11-30 |
| EP0361902B1 (en) | 1994-02-23 |
| PL162260B1 (pl) | 1993-09-30 |
| DE68913251D1 (de) | 1994-03-31 |
| NZ230786A (en) | 1991-11-26 |
| DK475389D0 (da) | 1989-09-27 |
| JPH02163096A (ja) | 1990-06-22 |
| AU615576B2 (en) | 1991-10-03 |
| DE68913251T2 (de) | 1994-06-23 |
| CN1041392A (zh) | 1990-04-18 |
| IE893094L (en) | 1990-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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