ES2052730T3 - Mejoras en o relativas a antagonistas de leucotrienos. - Google Patents
Mejoras en o relativas a antagonistas de leucotrienos.Info
- Publication number
- ES2052730T3 ES2052730T3 ES88307429T ES88307429T ES2052730T3 ES 2052730 T3 ES2052730 T3 ES 2052730T3 ES 88307429 T ES88307429 T ES 88307429T ES 88307429 T ES88307429 T ES 88307429T ES 2052730 T3 ES2052730 T3 ES 2052730T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- formula
- ring
- leucotrene
- relative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000005557 antagonist Substances 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- KJUGUADJHNHALS-UHFFFAOYSA-N 1H-tetrazole Substances C=1N=NNN=1 KJUGUADJHNHALS-UHFFFAOYSA-N 0.000 abstract 1
- -1 ACETOXY GROUP Chemical group 0.000 abstract 1
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical group [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003536 tetrazoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA INVENCION SE REFIERE A TETRAZOLES DISUSTITUIDOS QUE ANTAGONIZAN EL EFECTO DE LEUCOTRIENOS C4, D4 O E4 O CUALQUIER COMBINACION DE ESTO EN TEJIDOS SELECCIONADOS, QUE SON DE LA FORMULA(I) DONDE R1 ES C1 AC8 ALQUILO O FENILO; R2 ES C3 A C10 ALQUILIDENO O FENILO; [TET] ES UN ANILLO 1H O 2H TETRAZOLITO DISUSTITUIDO, DE FORMULA(II); L2 ES 1)UN GRUPO ALQUILIDENO C1 A C10, O 2) UN GRUPO BENCILO DE LA FORMULA(III) DONDE R7 ES UN ATOMO DE HIDROGENO, GRUPO HIDROXI O ACETOXI, Y N ES DE 0 A 3; Y EL GRUPO METILENO UNICO UNIDO AL ANILLO ESTA TAMBIEN UNIDO AL ANILLO TETRAZOLITO[TET]; O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE ESTO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/085,588 US4820723A (en) | 1987-08-14 | 1987-08-14 | Disubstituted tetrazole leukotriene antagonists and methods for their use thereas |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2052730T3 true ES2052730T3 (es) | 1994-07-16 |
Family
ID=22192636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES88307429T Expired - Lifetime ES2052730T3 (es) | 1987-08-14 | 1988-08-11 | Mejoras en o relativas a antagonistas de leucotrienos. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4820723A (es) |
| EP (1) | EP0303478B1 (es) |
| JP (1) | JPS6466174A (es) |
| KR (1) | KR890003716A (es) |
| CN (1) | CN1012434B (es) |
| AU (1) | AU610218B2 (es) |
| DE (1) | DE3875030T2 (es) |
| DK (1) | DK449388A (es) |
| ES (1) | ES2052730T3 (es) |
| HU (1) | HUT50462A (es) |
| NZ (1) | NZ225791A (es) |
| PH (1) | PH26259A (es) |
| PT (1) | PT88244B (es) |
| ZA (1) | ZA885887B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4820722A (en) * | 1987-08-14 | 1989-04-11 | Eli Lilly And Company | Disubstituted tetrazoles and their use as leukotriene antagonists |
| EP0408509B1 (de) * | 1989-07-14 | 1996-03-06 | Ciba-Geigy Ag | Substituierte Benzonitrile |
| DE4124942A1 (de) * | 1991-07-27 | 1993-01-28 | Thomae Gmbh Dr K | 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| CN101544614B (zh) * | 2008-03-24 | 2011-07-20 | 合肥合源药业有限公司 | 磷酸二酯酶ⅲ抑制剂、其制法及其医药用途 |
| NZ719169A (en) | 2013-12-20 | 2018-08-31 | Novartis Ag | Heteroaryl butanoic acid derivatives as lta4h inhibitors |
| CN112513026B (zh) | 2018-07-31 | 2025-02-25 | 诺华股份有限公司 | Lta4h抑制剂的晶型 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4661505A (en) * | 1982-11-03 | 1987-04-28 | Eli Lilly And Company | Leukotriene antagonists |
| US4663332A (en) * | 1985-10-10 | 1987-05-05 | Hoffman-La Roche Inc. | 5-substituted N-alkylated tetrazoles |
| PT85110A (en) * | 1986-06-23 | 1987-07-01 | Merck Frosst Canada Inc | Process for preparing benzenealkanoic acid derivatives useful as leukotriene antagonists |
| CA1315279C (en) * | 1987-01-12 | 1993-03-30 | Nancy Grace Bollinger | Anti-inflammatory agents |
-
1987
- 1987-08-14 US US07/085,588 patent/US4820723A/en not_active Expired - Fee Related
-
1988
- 1988-08-10 ZA ZA885887A patent/ZA885887B/xx unknown
- 1988-08-10 JP JP63202627A patent/JPS6466174A/ja active Pending
- 1988-08-11 DK DK449388A patent/DK449388A/da not_active Application Discontinuation
- 1988-08-11 PT PT88244A patent/PT88244B/pt not_active IP Right Cessation
- 1988-08-11 DE DE8888307429T patent/DE3875030T2/de not_active Expired - Fee Related
- 1988-08-11 ES ES88307429T patent/ES2052730T3/es not_active Expired - Lifetime
- 1988-08-11 EP EP88307429A patent/EP0303478B1/en not_active Expired - Lifetime
- 1988-08-11 NZ NZ225791A patent/NZ225791A/xx unknown
- 1988-08-11 AU AU20967/88A patent/AU610218B2/en not_active Expired - Fee Related
- 1988-08-11 PH PH37399A patent/PH26259A/en unknown
- 1988-08-12 CN CN88106046A patent/CN1012434B/zh not_active Expired
- 1988-08-12 HU HU884343A patent/HUT50462A/hu unknown
- 1988-08-12 KR KR1019880010274A patent/KR890003716A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| PT88244B (pt) | 1995-03-01 |
| DE3875030D1 (de) | 1992-11-05 |
| EP0303478A1 (en) | 1989-02-15 |
| US4820723A (en) | 1989-04-11 |
| AU2096788A (en) | 1989-02-16 |
| JPS6466174A (en) | 1989-03-13 |
| EP0303478B1 (en) | 1992-09-30 |
| KR890003716A (ko) | 1989-04-17 |
| HUT50462A (en) | 1990-02-28 |
| CN1031224A (zh) | 1989-02-22 |
| DE3875030T2 (de) | 1993-03-04 |
| ZA885887B (en) | 1990-04-25 |
| PT88244A (pt) | 1989-06-30 |
| CN1012434B (zh) | 1991-04-24 |
| PH26259A (en) | 1992-04-01 |
| DK449388D0 (da) | 1988-08-11 |
| DK449388A (da) | 1989-02-15 |
| AU610218B2 (en) | 1991-05-16 |
| NZ225791A (en) | 1990-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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