ES2054380T3 - Composiciones estables para administracion por via parenteral y metodo para su elaboracion. - Google Patents

Composiciones estables para administracion por via parenteral y metodo para su elaboracion.

Info

Publication number
ES2054380T3
ES2054380T3 ES91100650T ES91100650T ES2054380T3 ES 2054380 T3 ES2054380 T3 ES 2054380T3 ES 91100650 T ES91100650 T ES 91100650T ES 91100650 T ES91100650 T ES 91100650T ES 2054380 T3 ES2054380 T3 ES 2054380T3
Authority
ES
Spain
Prior art keywords
parenteral administration
preparation
stable compositions
compositions
fat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91100650T
Other languages
English (en)
Inventor
William Steber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ES2054380T3 publication Critical patent/ES2054380T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

LA INVENCION SE REFIERE A CIERTAS COMPOSICIONES DE MICROESFERAS ESTABLES APROPIADAS PARA LA ADMINISTRACION PARENTERAL CONTENIENDO EN ELLAS UNA MEZCLA GRASA O DE CERA; UNA PROTEINA ACTIVA BIOLOGICAMENTE, PEPTIDA O POLIPEPTIDA; Y UN ACEITE, GRASA SEMISUAVE, DERIVADO DE ACIDO GRASO O SUS MEZCLAS. LA INVENCION TAMBIEN SE REFIERE A UN METODO PARA HACER LAS COMPOSICIONES DE MICROESFERAS.
ES91100650T 1990-03-30 1991-01-21 Composiciones estables para administracion por via parenteral y metodo para su elaboracion. Expired - Lifetime ES2054380T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/502,382 US5213810A (en) 1990-03-30 1990-03-30 Stable compositions for parenteral administration and method of making same

Publications (1)

Publication Number Publication Date
ES2054380T3 true ES2054380T3 (es) 1994-08-01

Family

ID=23997559

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91100650T Expired - Lifetime ES2054380T3 (es) 1990-03-30 1991-01-21 Composiciones estables para administracion por via parenteral y metodo para su elaboracion.

Country Status (29)

Country Link
US (1) US5213810A (es)
EP (1) EP0448930B1 (es)
JP (1) JP2966564B2 (es)
KR (1) KR0159778B1 (es)
CN (1) CN1063941C (es)
AR (1) AR248085A1 (es)
AT (1) ATE106240T1 (es)
AU (1) AU641994B2 (es)
BG (1) BG60850B1 (es)
CA (1) CA2039491C (es)
CZ (1) CZ283053B6 (es)
DE (1) DE69102176T2 (es)
DK (1) DK0448930T3 (es)
ES (1) ES2054380T3 (es)
FI (1) FI101676B1 (es)
HK (1) HK1000004A1 (es)
HU (1) HU219584B (es)
IE (1) IE65970B1 (es)
IL (1) IL97145A (es)
MX (1) MX172602B (es)
NO (1) NO300717B1 (es)
NZ (1) NZ237509A (es)
PL (1) PL167692B1 (es)
PT (1) PT97160B (es)
RO (1) RO106191B1 (es)
RU (1) RU2011377C1 (es)
SK (1) SK279461B6 (es)
YU (1) YU47650B (es)
ZA (1) ZA912398B (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE134873T1 (de) * 1991-07-23 1996-03-15 American Cyanamid Co Stabile zusammensetzungen für parenterale verabrechung und ihre verwendung
AU6029694A (en) * 1993-01-19 1994-08-15 Pharmacia P-L Biochemicals, Inc. Storage and delivery of purified protein reagents with carrier wax
US5599660A (en) * 1993-01-19 1997-02-04 Pharmacia Biotech Inc. Method and preparation for sequential delivery of wax-embedded, inactivated biological and chemical reagents
US5683720A (en) * 1994-10-28 1997-11-04 Fuisz Technologies Ltd. Liquiflash particles and method of making same
US6083430A (en) * 1994-10-28 2000-07-04 Fuisz Technologies Ltd. Method of preparing a dosage unit by direct tableting and product therefrom
PT750854E (pt) * 1995-06-29 2002-04-29 Nestle Sa Processo para a encapsulacao de um material de nucleo com um polimero por tratamento a alta pressao
CA2302275C (en) 1997-09-19 2009-12-08 Shire Laboratories, Inc. Solid solution beadlet
AU2002300572B2 (en) * 1997-09-19 2004-11-25 Shire Laboratories, Inc. Solid Solution Beadlet
US6117452A (en) * 1998-08-12 2000-09-12 Fuisz Technologies Ltd. Fatty ester combinations
US8663692B1 (en) * 1999-05-07 2014-03-04 Pharmasol Gmbh Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same
BR0010354A (pt) * 1999-05-07 2002-03-05 Pharmasol Gmbh Partìculas de lipìdeo à base em misturas de lipìdeos lìquidos e sólidos e método para a sua produção
ES2246238T3 (es) * 1999-06-07 2006-02-16 Altana Pharma Ag Nueva preparacion y forma de administracion que comprende un inhibidor de las bombas de protones labil en medio acido.
AU767837B2 (en) * 1999-08-18 2003-11-27 Ipsen Pharma S.A.S. Sustained release formulation of a peptide
IES990700A2 (en) * 1999-08-18 2001-08-22 Kinerton Ltd Process to make a sustained release formulation
WO2001080831A2 (en) 2000-04-27 2001-11-01 Verion Inc. Zero order release and temperature-controlled microcapsules and process for the preparation thereof
CA2413109C (en) * 2000-06-26 2007-11-27 Martek Biosciences Boulder Corporation Improved methods of incorporating polyunsaturated fatty acids in milk
US6541030B2 (en) 2000-09-27 2003-04-01 Verion Inc. Instant water dissolvable encapsulate and process
ATE392887T1 (de) * 2000-10-10 2008-05-15 Wyeth Corp Stabilisierte arzneizusammensetzungen zur parenteralen vearbreichung
FR2852843B1 (fr) 2003-03-24 2008-05-23 Karim Ioualalen Systeme galenique permettant le masquage du gout
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
CA2547597A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate compositions with improved stability
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
MXPA06005913A (es) * 2003-12-04 2006-06-27 Pfizer Prod Inc Formas de dosificacion de multiparticulas de azitromicina por procedimientos basados en liquidos.
KR100844628B1 (ko) * 2003-12-04 2008-07-07 화이자 프로덕츠 인크. 제약상 다입자의 제조 방법
EP1701702A1 (en) * 2003-12-04 2006-09-20 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate azithromycin compositions containing preferably a poloxamer and a glyceride
ES2600577T3 (es) * 2003-12-04 2017-02-09 Bend Research, Inc. Procedimiento de pulverización-solidificación que usa un extrusor para preparar composiciones en multipartículas de fármacos cristalinos
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
US8221809B2 (en) * 2006-06-22 2012-07-17 Martek Biosciences Corporation Encapsulated labile compound compositions and methods of making the same
EP2359808B1 (en) 2006-08-09 2013-05-22 Intarcia Therapeutics, Inc Osmotic delivery systems and piston assemblies
WO2008133908A2 (en) 2007-04-23 2008-11-06 Intarcia Therapeutics, Inc. Suspension formulations of insulinotropic peptides and uses thereof
CA2726861C (en) 2008-02-13 2014-05-27 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
SI2341905T2 (sl) 2008-09-04 2024-02-29 Amylin Pharmaceuticals, Llc Formulacije s podaljšanim sproščanjem z uporabo brezvodnih nosilcev
JP5494957B2 (ja) 2009-06-11 2014-05-21 株式会社リコー 静電荷像現像用トナー、現像剤、画像形成方法及び画像形成装置
RU2547990C2 (ru) 2009-09-28 2015-04-10 Интарсия Терапьютикс, Инк. Быстрое достижение и/или прекращение существенной стабильной доставки лекарственного средства
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US9364549B2 (en) * 2011-11-30 2016-06-14 Andreas Voigt Hydrophobic drug-delivery material, method for manufacturing thereof and methods for delivery of a drug-delivery composition
US20160151286A1 (en) * 2013-05-29 2016-06-02 Therakine Biodelivery Gmbh Hydrophilic Microparticles, Drug-Delivery Material, Method For Manufacturing Thereof And Methods For Delivery of A Drug-Delivery Composition
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
RU2730996C2 (ru) 2015-06-03 2020-08-26 Интарсия Терапьютикс, Инк. Системы установки и извлечения имплантата
KR102574993B1 (ko) 2016-05-16 2023-09-06 인타르시아 세라퓨틱스 인코포레이티드 글루카곤-수용체 선택적 폴리펩티드 및 이들의 이용 방법
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
JP7286542B2 (ja) 2017-01-03 2023-06-05 インターシア セラピューティクス，インコーポレイティド Ｇｌｐ－１受容体アゴニストの持続的投与及び薬物の同時投与を含む方法
KR20220013540A (ko) 2019-02-21 2022-02-04 크로마덱스 아이엔씨. 니코틴아미드 리보사이드, 니코틴산 리보사이드, 환원 니코티닐 리보사이드 화합물, 및 니코티닐 리보사이드 화합물 유도체의 제형에서의 용도

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3147187A (en) * 1962-09-10 1964-09-01 Don Hall Lab Sustained release pharmaceutical
CH637297A5 (fr) * 1978-12-05 1983-07-29 Nestle Sa Microbille comprenant un microorganisme et son procede de fabrication.
JPS56140915A (en) * 1980-04-07 1981-11-04 Yamanouchi Pharmaceut Co Ltd Pharmaceutical preparation for solid drug
US4331654A (en) * 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
DE3024416C2 (de) * 1980-06-28 1982-04-15 Gödecke AG, 1000 Berlin Verfahren zur Herstellung von Arzneimitteln mit retardierter Wirkstoff-Freisetzung
US4666839A (en) * 1982-12-01 1987-05-19 Amgen Methods and materials for obtaining microbial expression of polypeptides including bovine prolactin
US4452775A (en) * 1982-12-03 1984-06-05 Syntex (U.S.A.) Inc. Cholesterol matrix delivery system for sustained release of macromolecules
US4603044A (en) * 1983-01-06 1986-07-29 Technology Unlimited, Inc. Hepatocyte Directed Vesicle delivery system
US4568559A (en) * 1984-02-06 1986-02-04 Biotek, Inc. Composite core coated microparticles and process of preparing same
US4568536A (en) * 1985-02-08 1986-02-04 Ethicon, Inc. Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition
US4755387A (en) * 1985-03-21 1988-07-05 The Procter & Gamble Company Therapeutic particles
DE3527356A1 (de) * 1985-07-31 1987-02-05 Degussa Verfahren zur verbesserung der fruchtbarkeit von haustieren
SE462894B (sv) * 1985-10-28 1990-09-17 Biogram Ab Mikrokapslar, foerfarande foer framstaellning daerav samt anvaendning
US4837381A (en) * 1986-08-11 1989-06-06 American Cyanamid Company Compositions for parenteral administration and their use
US4911928A (en) * 1987-03-13 1990-03-27 Micro-Pak, Inc. Paucilamellar lipid vesicles

Also Published As

Publication number Publication date
DE69102176D1 (de) 1994-07-07
KR910016322A (ko) 1991-11-05
CZ283053B6 (cs) 1997-12-17
PL289657A1 (en) 1992-01-13
YU57091A (sh) 1994-01-20
AU641994B2 (en) 1993-10-07
SK279461B6 (sk) 1998-11-04
FI101676B (fi) 1998-08-14
RO106191B1 (ro) 1993-03-31
AR248085A1 (es) 1995-06-30
DE69102176T2 (de) 1995-01-05
KR0159778B1 (ko) 1998-12-01
DK0448930T3 (da) 1994-06-20
CA2039491A1 (en) 1991-10-01
IL97145A (en) 1996-06-18
HUT59834A (en) 1992-07-28
JPH04221319A (ja) 1992-08-11
CN1063941C (zh) 2001-04-04
HU911054D0 (en) 1991-10-28
PL167692B1 (en) 1995-10-31
PT97160B (pt) 1998-07-31
BG93923A (bg) 1993-12-24
YU47650B (sh) 1995-12-04
NZ237509A (en) 1993-04-28
ZA912398B (en) 1992-01-29
EP0448930A1 (en) 1991-10-02
MX172602B (es) 1993-01-03
US5213810A (en) 1993-05-25
NO300717B1 (no) 1997-07-14
CA2039491C (en) 2001-09-04
PT97160A (pt) 1991-11-29
ATE106240T1 (de) 1994-06-15
IL97145A0 (en) 1992-05-25
BG60850B1 (bg) 1996-05-31
NO911228L (no) 1991-10-01
FI911531A0 (fi) 1991-03-28
IE911041A1 (en) 1991-10-09
CN1055293A (zh) 1991-10-16
RU2011377C1 (ru) 1994-04-30
JP2966564B2 (ja) 1999-10-25
IE65970B1 (en) 1995-11-29
HU219584B (hu) 2001-05-28
HK1000004A1 (en) 1997-10-03
FI911531L (fi) 1991-10-01
FI101676B1 (fi) 1998-08-14
EP0448930B1 (en) 1994-06-01
AU7397291A (en) 1991-10-03
NO911228D0 (no) 1991-03-26

Similar Documents

Publication Publication Date Title
ES2054380T3 (es) Composiciones estables para administracion por via parenteral y metodo para su elaboracion.
AR017866A1 (es) Metodo para incrementar las inmunorespuestas de vacunas de acidos nucleicos, composiciones farmaceuticas de aplicacion en dicho metodo, procedimientopara preparar dichas composiciones y vacunas utilizadas en dicho metodo.
ES2039219T3 (es) Composiciones para administracion parenteral y su uso.
DK0817614T3 (da) Stabile protein:phospholipid-sammensætninger og fremgangsmåder til fremstilling deraf
BR9107206A (pt) Processo para produzir uma variante de proteina que evoca uma resposta imunogenica diminuida em animais,produtos obtidos,composicao e uso
ATE103932T1 (de) Fusionsprotein bestehend aus gm-csf und il-3.
FI972431A7 (fi) Sytotoksisten T-lymfosyyttivasteiden induktio
MX9305729A (es) Formulas de proteinas de liberacion sostenida.
AR000610A1 (es) Un método para la expresión de un polipéptido recombinante por una célula huésped
NO965621L (no) Nye hIL-4-mutantproteiner som antagonister eller partielle agonister for det humane interleukin 4
FR2442054A1 (fr) Proteines purifiees, notamment interferon, procede de preparation et compositions pharmaceutiques les contenant
ES550891A0 (es) Procedimiento para solubilizar drogas en propulsores de aerosol a base de clorofluorcarburos
FI20000060L (fi) Vesiliukoisten peptidien pitkäaikaisesti vapautuvat koostumukset
DE68929043D1 (de) Für androgen-rezeptor-protein kodierende dna
ES2068791T1 (es) Metodos y acido desoxirribonucleico para la preparacion de proteina de factor de tejido.
EA199901013A1 (ru) Гели пролонгированного действия
FI912144A0 (fi) Stabilisering av somatotropiner och andra proteiner genom modifiering av kysteingrupper.
ES2150583T3 (es) Mezclas detergentes suaves.
PT1014947E (pt) Metodo de preparacao de composicoes farmaceuticas de particulas lipidicas compreendendo um agente lipidico e uma proteina
DK0506748T3 (da) Aminosyrer, peptider eller derivater deraf bundet til fedtstoffer
PT975334E (pt) Microparticulas biodegradaveis para a libertacao sustentada de farmacos terapeuticos
HUP9900506A2 (hu) Protrombinszármazékok
DK403384A (da) Enteralt effektivt, biologisk aktivt peptid- eller proteinmiddel ogfremgangsmaader til fremstilling deraf
IT1116840B (it) Perfezionamento nelle composizioni farmaceutiche contenenti prostaglandina
AR004377A1 (es) UNA PROTEINA BIOLOGICAMENTE ACTIVA INHIBIDORA DE KAPA B (NF k B), UNA SECUENCIA DE ACIDO NUCLEICO, UN VECTOR DE EXPRESION, UN ANTICUERPO CONTRADICHA PROTEINA, UN PROCESO PARA SU PREPARACION, UNA COMPOSICION FARMACEUTICA Y EL USO DE DICHA PROTEINA PARA LA PREPARACION DE COMPOSICIONES FARMACEUTICAS.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 448930

Country of ref document: ES